Conservative Management of Keratocystic Odontogenic Tumors of Jaws

Purpose. The aim of this study was to evaluate different surgical treatment methods for keratocystic odontogenic tumors (KCOTs) and the outcome of those treatments over a 9-year period. Patients and Methods. A retrospective review was performed on 43 KCOTs in 39 patients. In radiographic evaluations for diagnosis, follow ups and before and after treatment, panoramic, 3D CT and MR images were used. The three groups of different surgical treatment were (1) enucleation for small unilocular lesions without certainty of histology; (2) enucleation with Carnoy's solution, for small unilocular lesions after previous histological confirmation of KOCT; (3) marsupialization followed by enucleation with Carnoy's solution implemented for large often multilocular KCOTs with intact or destruction of cortical bone without infiltration of neighbouring tissue. Results. 43 KCOT cases were mostly localized in mandible (76.7%), radiologically unilocular (72%), and parakeratocysts (88.4%). Inflammation and satellite cysts (daughter cysts) were detected histopathologically in 14 (32.5%) and 7 (16.3%), respectively. Among the 43 cysts, 20 (46.5%) were associated with the impacted third molar and of 21 (48.8%) was in tooth bearing area, and 5 (11, 6%) located on edentulous areas. It was located mostly in the anterior region of maxilla (90%) and in mandibular molar and ramus (62.8%). The treatments of KCOTs were 18 (41.9%) for group 1, and 10 (23.3%) group 2, and 15 (34.8%) group 3. A statistically significant relationship was found between the radiographic appearance and treatment methods (P = 0.00). No recurrence was found on 40.54 ± 23.02 months follow up. Conclusion. We concluded that successful treatment methods were enucleation and Carnoy's solution in small lesions and marsupialization in lesions that have reached a very large size, but because KCOT was observed in second decade mostly, long-term follows up are suggested

Yield and Quality in Purple-Grained Wheat Isogenic Lines

Breeding programs for purple wheat are underway in many countries but there is a lack of information on the effects of Pp (purple pericarp) genes on agronomic and quality traits in variable environments and along the product chain (grain-flour-bread). This study was based on unique material: two pairs of isogenic lines in a spring wheat cv. Saratovskaya-29 (S29) background differing only in Pp genes and grain color. In 2017, seven experiments were conducted in Kazakhstan, Russia, and Turkey with a focus on genotype and environment interaction and, in 2018, one experiment in Turkey with a focus on grain, flour, and bread quality. The eect of environment was greater compared to genotype for the productivity and quality traits studied. Nevertheless, several important traits, such as grain color and anthocyanin content, are closely controlled by genotype, offering the opportunity for selection. Phenolic content in purple-grained lines was not significantly higher in whole wheat flour than in red-colored lines. However, this trait was significantly higher in bread. For antioxidant activities, no differences between the genotypes were detected in both experiments. Comparison of two sources of Pp genes demonstrated that the lines originating from cv. Purple Feed had substantially improved productivity and quality traits compared to those from cv. Purple

Shall We Resect the Tip of Manubrium Mallei in Tympanoplasty?

ObjectivesIn tympanoplasty operations if perforation is related with malleus handle, malleus handle is desepithelised. We planned this research to investigate whether the epithelial remnants remain as a result of this desepithelisation or not.MethodsThe 35 patients who were performed tympanoplasty operation were divided into two groups. In the first group which included 13 patients the tip portion of manubrium mallei were cut off without desepithelisation. In the second group which included 22 patients the tip portions of manubrium mallei were cut off after the meticulous desepithelisation. The presence of squamous epithelium was examined histopathologically on the specimens.ResultsSquamous epithelium was observed in 9 of the 13 non-desepithelised specimens and in 6 of 22 desepithelised specimens.ConclusionIn tympanoplasty operations despite careful desepithelisation, squamous epithelial remnants may remain on the malleus handle. So the tip of manubrium mallei could be resected to prevent the future development of cholesteatoma

The Effects of Intravitreal Dexamethasone Implant (Ozurdex®) on Intraocular Pressure and Anterior Chamber Angle

Amaç: İntravitreal deksametazon enjeksiyonunun göz içi basıncı (GİB) ve ön kamara açısı (ÖKA) üzerine etkisini incelemek. Gereç ve Yöntem: Otuz sekiz hastanın 40 gözü incelendi. Hastaların yaş ortalaması 61.39 yıl (aralık: 36-83) olup, %63.2’i kadın, %36.8’i erkekti. %70'i retina ven tıkanıklığı, %20’i diabet, %7.5‘i arka üveit ve %2.5’i psödofakik makula ödemi olgusuydu. GİB Goldmann ap- lanasyon tonometresi ile ölçüldü. GİB ve gonyoskopik muayene enjeksiyondan önce ve enjeksiyondan sonra 1.hafta, 1. 3. ve 6. aylarda ölçüldü. Spektral domain optik koherans tomografi (OKT) enjeksiyon öncesi ve sonrası 1. ay, 3. ay ve 6. ay da üst, nazal, alt, temporal kad- ranlardan alındı. OKT ile ön kamara açı derecesi (ÖKA), trabeküler iris yüzey alanı (TIYA500) ve açı açılma mesafesi (AAM500) ölçüldü. Bulgular: Enjeksiyon yapılan gözlerin GİB'ı enjeksiyon öncesi, enjeksiyon sonrası 1. hafta, 1. ve 3. aylardakine göre anlamlı düşük sap- tandı (sırasıyla p= 0.004, p= 0.002, p= 0.003). Enjeksiyon sonrası 6. ay ile enjeksiyon öncesi arasında ortalama GİB değerleri açısından anlamlı fark izlenmedi. Nazal kadranda enjeksiyon öncesi ve sonrası 1. haftadaki gonyoskopik derece, enjeksiyon sonrası 3. ve 6. aylara göre anlamlı yüksek saptandı (p= 0.007, p= 0,006; p= 0.008, p= 0,008). Gonyoskopide diğer kadranlarda anlamlı fark saptanmadı. Nazal kadranda OKT-ÖKA'nın enjeksiyon sonrası 3. ve 6. aydaki değerleri, enjeksiyon öncesi ve sonrası 1. aya göre anlamlı dar saptandı (p= 0.008, p= 0,008; p= 0.009, p= 0,008). Üst kadranda göz kapağı güvenilir ölçüm alınmasına engel olmuştur. Uygulama yapılan gözlerin alt kadran 3. ve 6. aylardaki OKT-AAM500 ve TİYA500 sonucu enjeksiyon öncesinden anlamlı olarak düşük saptanmıştır (p= 0.002, p= 0.004; p= 0.005, p= 0.001). Sonuç: İntravitreal deksametazon enjeksiyonu sonrası göz içi basıncı artabilir fakat çoğu olguda medikal tedaviyle kontrol altına alınabilir. Enjeksiyon sonrası gonyoskopide ve OKT’de bazı kadranlarda ön kamara açısında daralma olabilir.Purpose: To investigate the effects of intravitreal dexamethasone injection on intraocular pressure (IOP) and anterior chamber angle (ACA). Materials and Methods: Forty eyes of 38 patients were studied. The mean age of the patients was 61.39 years (range: 36-83), 63.2% female and 36.8% male. 70% were retinal vein occlusion, 20% were diabetic, 7.5% were posterior uveitis and 2.5% were pseudophakic macular edema. IOP was measured by Goldman applanation tonometry. IOP and gonioscopic examination were performed before and after injection on the 1st week 1st, 3rd, and 6th months. Spectral domain optic coherence tomography (OCT) was performed on the superior, nasal, inferior, temporal quadrants before and after injection on the 1st, 3rd, and 6th months. Anterior chamber angle (ACA), trabecular iris surface area (TISA500) and angle opening distance (AOD500) were measured by OCT

Documenting and predicting topic changes in Computers in Biology and Medicine: A bibliometric keyword analysis from 1990 to 2017

The Computers in Biology and Medicine (CBM) journal promotes the use of com-puting machinery in the fields of bioscience and medicine. Since the first volume in 1970, the importance of computers in these fields has grown dramatically, this is evident in the diversification of topics and an increase in the publication rate. In this study, we quantify both change and diversification of topics covered in CBM. This is done by analysing the author supplied keywords, since they were electronically captured in 1990. The analysis starts by selecting 40 keywords, related to Medical (M) (7), Data (D)(10), Feature (F) (17) and Artificial Intelligence (AI) (6) methods. Automated keyword clustering shows the statistical connection between the selected keywords. We found that the three most popular topics in CBM are: Support Vector Machine (SVM), Elec-troencephalography (EEG) and IMAGE PROCESSING. In a separate analysis step, we bagged the selected keywords into sequential one year time slices and calculated the normalized appearance. The results were visualised with graphs that indicate the CBM topic changes. These graphs show that there was a transition from Artificial Neural Network (ANN) to SVM. In 2006 SVM replaced ANN as the most important AI algo-rithm. Our investigation helps the editorial board to manage and embrace topic change. Furthermore, our analysis is interesting for the general reader, as the results can help them to adjust their research directions

Sonlu elemanlar yöntemi ile termo-mekanik analizi yapılan balistik füzeler için kanat hamili tasarımı.

During the flight of missiles, depending on the flight conditions, rotation of missiles around its centerline can cause instabilities. To override this issue, missile generally is designed in 2 sections. In the missile, the rear tail section and the front section are to rotate freely by means of bearings. Tail section on which bearings are mounted is designed according to thermal loads due to flow of hot gasses through the nozzle and mechanical loads due to inertial load, interference fit and thread preload which appear during flight of missile. The purpose of this thesis is to determine the most suitable structural parameters according to the flight conditions of missile. The geometrical and load parameters which have effect on the results were determined. Finite element model is formed by using FEA software. After that, transient nonlinear thermo-mechanical analyses are performed and the most effective parameter on VM (Von-Mises) stress and force is determined. DOE (Design of Experiments) method was used to determine the most suitable values for the structural parameters. Totally 27 different configurations are studied to achieve to the most suitable values for variable set. It is observed that VM stress and force results for all configurations are within the ±%5 ranges. So this means parameters don’t affect the systems response very much. By taking manufacturing processes into consideration, configuration with the highest bearing inner/outer ring interference is taken. From the comparison of the results, the most suitable configuration is obtained after checking forces and VM stress on the bearings.M.S. - Master of Scienc

Technology, health, education, and economic growth nexus: evidence from high income OECD countries

Annual World Congress of the Academy for Global Business Advancement (18. : 2022)Human capital and technology, along with physical capital, have been the subject of extensive empirical studies of economic growth since 1980. In this study, we added human capital to the model in the form of health and education, and technology in the form of domestic and foreign technologies. We also divided the education variable into primary, secondary, and tertiary. The research covers 27 high-income OECD countries for the period 1990-2020. In the analysis, the FGLS estimator, which is resistant to heteroscedasticity, cross-section dependence and panel-specific autocorrelation, is employed. As a result, a unit increase in foreign technology increases national income by 0.037%, and a domestic technology by 0.023%. It is clear that foreign technology has higher impact on economic growth compared to the domestic technology. While primary school education has no significant effect on growth, that secondary school education increased growth by ≅0.069% and tertiary by ≅0.30%. Accordingly, it is seen that tertiary education has a much greater effect on economic growth than the effect of physical capital (≅0.22%). It can be said that this situation reveals the importance of tertiary education in the production and spillover of technology.No sponso

Technology, human capital, and economic growth: evidence from high income OECD countries

In this study, technology in the form of domestic and foreign technology and human capital in the form of education and health are included in the model, and their effects on growth are examined. The education variable is further broken down into elementary, secondary, and tertiary levels. The research covers high-income OECD countries over the period 1990–2020. In the analysis, the FGLS estimator, which resists to heteroscedasticity, cross-section dependence and panel-specific autocorrelation, is employed. Results indicate that a unit increase in foreign technology increases national income by 0.037%, and a domestic technology by 0.023%. Foreign technology has a greater impact on economic growth than domestic technology. Although primary education did not have a significant effect on growth, secondary education increased growth by 0.069% and tertiary education by 0.30%. The effect of physical capital on economic growth (0.22%) is lower than tertiary education.No sponso