O processo criativo do objeto-livro-poético Poor Fish Memories / The creative process of object-book-poetic Poor Fish Memories

O trabalho PoorFish Memories (2016) é um aglomerado poético de memórias, sonhos e invenções que nunca se imaginariam amalgamados na mesma fantasia. A análise de seu processo criativo revela a dinâmica poética do “discurso das conjunções”, capaz de revelar um mundo pleno de sintonias secretas,onde as coisas poderiam aliar-se da maneira mais contraditória e evidenciar afinidades indefinidas.Esse dom de produzir e perceber semelhançasnos conduz ao desafio de atravessar o mundo sob a perspectiva do “e”, acolhendo paradoxos, convivendo com ambivalências, afinidades e aversões. A alternativa entre uma-coisa-ou-outra não é necessária na imaginativa criadora. Ambas as alternativas são inseridas no contexto fabular como igualmente possíveis.Desse modo  as conjunções da arte confrontam e expressam o infinito

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Voos: registrando e divulgando a biodiversidade

O VOOS é o primeiro projeto de extensão oriundo do Laboratório de Representação Científica da UFRJ (LaRC), e tem como objetivo compartilhar conhecimento, proporcionando um mundo melhor por meio da educação, pesquisa, extensão e inovação. A equipe que compõe o LaRC é formada por profissionais de diferentes áreas do conhecimento, favorecendo a transdisciplinaridade. A UFRJ está compartimentada em diferentes campi, cada um com suas particularidades e diferentes fauna e flora. Por exemplo, há registros de mais de 220 aves, visitantes e moradoras, que circulam no campus da Ilha da Cidade Universitária, no Rio de Janeiro. Já no Observatório do Valongo (OV), uma das Unidades do Centro de Ciências Matemáticas e da Natureza (CCMN), localizado no centro da cidade, esse número chega a 39. O projeto VOOS pretende apresentar, representar e instigar as pessoas a conhecerem o ambiente que as cerca através de material especialmente produzido para essa finalidade.   Pretendemos promover uma aproximação entre o público e a biodiversidade da UFRJ, a partir da apresentação, representação e divulgação da fauna e da flora nativas de diferentes campi, utilizando criações científicas-lúdicas-artísticas, acionando linguagens variadas (textos, desenhos, pinturas, fotografias). Todo material produzido será publicado ou publicitado em várias plataformas (produtos, impressos, mídias sociais). A divulgação das informações tem o objetivo de despertar no público em geral o interesse em se aproximar dessa diversidade de espécies que coabitam a UFRJ. Intentamos despertar a curiosidade científica e a atenção artística do público sobre esses habitats e seus habitantes, divulgando e valorizando as produções artístico científicas dos aglomerados vivos que atravessam a UFRJ. Buscamos contribuir para o encurtamento das distâncias entre arte e ciência, assim como para as produções que se inserem nas fronteiras desses campos de conhecimento.   Buscamos contribuir para o encurtamento das distâncias entre arte e ciência, assim como para as produções que se inserem nas fronteiras desses campos de conhecimento, pois acreditamos na indissociação desses saberes e/ou na sobreposição de seus limites. Embora a informação seja transmitida de forma simplificada e acessível, todo esse projeto tem sido feito com a participação de ornitólogos, designers, ilustradores e também contamos com a participação de observadores e fotógrafos de aves que possuem um conhecimento prático nessa questão. As pesquisas mais recentes nessas áreas assim como na área de desenho científico estão presentes. Quando for possível o retorno presencial, roteiros especiais serão criados com a finalidade de observar a biodiversidade.     Embora seja um projeto desenvolvido para a UFRJ, ele é facilmente aplicável a qualquer região da cidade

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research