La Pensée du roman

Thomas Pavel: La Pensée du roman, Paris 2003 (Gallimard)

Samuel Richardsons brevromaner

En litteraturhistorisk placering The Epistolary Novels of Samuel Richardson: Reconsidering the Historical PerspectiveThe epistolary novels of Samuel Richardson were received with enthusiasm throughout Britain and Europe upon their publication in the 1740s and 50s, and they have had their unquestioned place in the literary canon and the literary history of the 18th century, as well as in the many rivalling Rise of the Novel narratives, ever since. The qualities of Richardson’s novels praised by contemporary reading audiences and professional critics were to some extent the qualities we still acknowledge in the the works. And yet I propose to reconsider and modify our ‘historical’ understanding of Richardson’s novels. Richardson scholars from the 1970s onward have deepened our understanding of the contexts of Richardson’s life and writing, and they have shown to what extent both the style, the form, the motifs, and the themes of his novels must be placed alongside the works of rival authors, today much less known, and the comedies and tragedies of the restoration period, just to mention two important fields of inspiration for Richardson. On the basis of their findings we must conclude that the novels we read today when considering Richardson’s works as part of a formal literary history are not quite the same as the novels contemporary readers cherished. There are important differences as well as correspondences between the contemporary reception of Richardson’s works and the reception of professional scholars in the twentieth and twenty-first centuries

The cost-benefit of salmonella control in Swedish pigs

Analysis of the expected costs and benefits of salmonella control pre-harvest in the pork production has been performed on EU level (1). As optimal measures to begin salmonella control in pig production in a high prevalence situation are not known, estimates of the costs for initiating such a control include large uncertainties. However the costs for running a salmonella control program can be estimated in countries where such programs are in place. In Sweden, where approximately 3 million pigs are slaughtered yearly and the prevalence of salmonella is low, the cost of the control is shared by the tax payers and the producers

Interactions between visual and semantic processing during object recognition revealed by modulatory effects of age of acquisition

The age of acquisition (AoA) of objects and their names is a powerful determinant of processing speed in adulthood, with early-acquired objects being recognized and named faster than late-acquired objects. Previous research using fMRI (Ellis et al., 2006. Traces of vocabulary acquisition in the brain: evidence from covert object naming. NeuroImage 33, 958–968) found that AoA modulated the strength of BOLD responses in both occipital and left anterior temporal cortex during object naming. We used magnetoencephalography (MEG) to explore in more detail the nature of the influence of AoA on activity in those two regions. Covert object naming recruited a network within the left hemisphere that is familiar from previous research, including visual, left occipito-temporal, anterior temporal and inferior frontal regions. Region of interest (ROI) analyses found that occipital cortex generated a rapid evoked response (~ 75–200 ms at 0–40 Hz) that peaked at 95 ms but was not modulated by AoA. That response was followed by a complex of later occipital responses that extended from ~ 300 to 850 ms and were stronger to early- than late-acquired items from ~ 325 to 675 ms at 10–20 Hz in the induced rather than the evoked component. Left anterior temporal cortex showed an evoked response that occurred significantly later than the first occipital response (~ 100–400 ms at 0–10 Hz with a peak at 191 ms) and was stronger to early- than late-acquired items from ~ 100 to 300 ms at 2–12 Hz. A later anterior temporal response from ~ 550 to 1050 ms at 5–20 Hz was not modulated by AoA. The results indicate that the initial analysis of object forms in visual cortex is not influenced by AoA. A fastforward sweep of activation from occipital and left anterior temporal cortex then results in stronger activation of semantic representations for early- than late-acquired objects. Top-down re-activation of occipital cortex by semantic representations is then greater for early than late acquired objects resulting in delayed modulation of the visual response

Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis

Most human aneuploidies originate maternally, due in part to the presence of highly stringent checkpoints during male meiosis. Indeed, male sterility is common among aneuploid mice used to study chromosomal abnormalities, and male germline transmission of exogenous DNA has been rarely reported. Here we show that, despite aberrant testis architecture, males of the aneuploid Tc1 mouse strain produce viable sperm and transmit human chromosome 21 to create aneuploid offspring. In these offspring, we mapped transcription, transcriptional initiation, enhancer activity, non-methylated DNA, and transcription factor binding in adult tissues. Remarkably, when compared with mice derived from female passage of human chromosome 21, the chromatin condensation during spermatogenesis and the extensive epigenetic reprogramming specific to male germline transmission resulted in almost indistinguishable patterns of transcriptional deployment. Our results reveal an unexpected tolerance of aneuploidy during mammalian spermatogenesis, and the surprisingly robust ability of mouse developmental machinery to accurately deploy an exogenous chromosome, regardless of germline transmission.This research was supported by Cancer Research UK (CE, CK, FC, TFR, ML, DTO), the European Molecular Biology Laboratory (NE), the Wellcome Trust (106563/Z/14/A: SJA and 098024/Z/11/Z: RJK) and the European Research Council (DTO)

Bjergensomhed som motiv hos Jean-Jacques Rousseau: Eller: Hvorfor Rousseau ikke er romantiker

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