72 research outputs found
Seamounts and oceanic igneous features in the NE Atlantic: a link between plate motions and mantle dynamics
A new regional compilation of seamount-like oceanic igneous features (SOIFs) in the NE Atlantic points to three distinct oceanic areas of abundant seamount clusters. Seamounts on oceanic crust dated 54â50 Ma are formed on smooth oceanic basement, which resulted from high spreading rates and magmatic productivity enhanced by higher than usual mantle plume activity. Late EoceneâEarly Miocene SOIF clusters are located close to newly formed tectonic features on rough oceanic crust in the Irminger, Iceland and Norway basins, reflecting an unstable tectonic regime prone to local readjustments of mid-ocean ridge and fracture zone segments accompanied by extra igneous activity. A SOIF population observed on Mid-MioceneâPresent rough oceanic basement in the Greenland and Lofoten basins, and on conjugate Kolbeinsey Ridge flanks, coincides with an increase in spreading rate and magmatic productivity. We suggest that both tectonic/kinematic and magmatic triggers produced Mid-MioceneâPresent SOIFs, but the Early Miocene westwards ridge relocation may have played a role in delaying SOIF formation south of the Jan Mayen Fracture Zone. We conclude that Iceland plume episodic activity combined with regional changes in relative plate motion led to local mid-ocean ridge readjustments, which enhanced the likelihood of seamount formation
A Bayesian approach to linking archaeological, paleoenvironmental and documentary datasets relating to the settlement of Iceland (LandnĂĄm)
YesIcelandic settlement (LandnĂĄm) period farmsteads offer opportunities to explore the nature and timing of anthropogenic activities and environmental impacts of the first Holocene farming communities. We employ Bayesian statistical modelling of archaeological, paleoenvironmental and documentary datasets to present a framework for improving chronological robustness of archaeological events. Specifically, we discuss events relevant to the farm HrĂsbrĂș, an initial and complex settlement site in southwest Iceland. We demonstrate that tephra layers are key in constraining reliable chronologies, especially when combined with related datasets and treated in a Bayesian framework. The work presented here confirms earlier interpretations of the chronology of the site while providing increased confidence in the robustness of the chronology. Most importantly, integrated modelling of AMS radiocarbon dates on Hordeum vulgare grains, palynological data, documented evidence from textual records and typologically diagnostic artefacts yield increased dating reliability. The analysis has also shown that AMS radiocarbon dates on bone collagen need further scrutiny. Specifically for the HrĂsbrĂș farm, first anthropogenic footprint palynomorph taxa are estimated to around AD 830â881 (at 95.4% confidence level), most likely before the tephra fall out of AD 877 ± 1 (the LandnĂĄm tephra layer), demonstrating the use of arable fields before the first known structures were built at HrĂsbrĂș (AD 874â951) and prior to the conventionally accepted date of the settlement of Iceland. Finally, we highlight the importance of considering multidisciplinary factors for other archaeological and paleoecological studies of early farming communities of previously uninhabited island areas
A review of the NE Atlantic conjugate margins based on seismic refraction data
The NE Atlantic region evolved through several rift episodes, leading to break-up in the Eocene that was associated with voluminous magmatism along the conjugate margins of East Greenland and NW Europe. Existing seismic refraction data provide good constraints on the overall tectonic development of the margins, despite data gaps at the NE Greenland shear margin and the southern Jan Mayen microcontinent. The maximum thickness of the initial oceanic crust is 40 km at the GreenlandâIcelandâFaroe Ridge, but decreases with increasing distance to the Iceland plume. High-velocity lower crust interpreted as magmatic underplating or sill intrusions is observed along most margins but disappears north of the East Greenland Ridge and the Lofoten margin, with the exception of the Vestbakken Volcanic Province at the SW Barents Sea margin. South of the narrow Lofoten margin, the European side is characterized by wide margins. The opposite trend is seen in Greenland, with a wide margin in the NE and narrow margins elsewhere. The thin crust beneath the basins is generally underlain by rocks with velocities of >7 km sâ1 interpreted as serpentinized mantle in the Porcupine and southern Rockall basins; while off Norway, alternative interpretations such as eclogite bodies and underplating are also discussed
Moho and basement depth in the NE Atlantic Ocean based on seismic refraction data and receiver functions
Seismic refraction data and results from receiver functions were used to compile the depth to the basement and Moho in the NE Atlantic Ocean. For interpolation between the unevenly spaced data points, the kriging technique was used. Free-air gravity data were used as constraints in the kriging process for the basement. That way, structures with little or no seismic coverage are still presented on the basement map, in particular the basins off East Greenland. The rift basins off NW Europe are mapped as a continuous zone with basement depths of between 5 and 15 km. Maximum basement depths off NE Greenland are 8 km, but these are probably underestimated. Plate reconstructions for Chron C24 (c. 54 Ma) suggest that the poorly known Ammassalik Basin off SE Greenland may correlate with the northern termination of the Hatton Basin at the conjugate margin. The most prominent feature on the Moho map is the GreenlandâIcelandâFaroe Ridge, with Moho depths >28 km. Crustal thickness is compiled from the Moho and basement depths. The oceanic crust displays an increased thickness close to the volcanic margins affected by the Iceland plume
Crustal structure beneath western and eastern Iceland from surface waves and receiver functions
We determine the crustal structures beneath 14 broad-band seismic stations, deployed in western, eastern, central and southern Iceland, using surface wave dispersion curves and receiver functions. We implement a method to invert receiver functions using constraints obtained from genetic algorithm inversion of surface waves. Our final models satisfy both data sets. The thickness of the upper crust, as defined by the velocity horizon Vs= 3.7 km sâ1, is fairly uniform at âŒ6.5â9 km beneath the Tertiary intraplate areas of western and eastern Iceland, and unusually thick at 11 km beneath station HOT22 in the far south of Iceland. The depth to the base of the lower crust, as defined by the velocity horizon Vs= 4.1 km sâ1 is âŒ20â26 km in western Iceland and âŒ27â33 km in eastern Iceland. These results agree with those of explosion profiles that detect a thinner crust beneath western Iceland than beneath eastern Iceland. An earlier report of a substantial low-velocity zone beneath the Middle Volcanic Zone in the lower crust is confirmed by a similar observation beneath an additional station there. As was found in previous receiver function studies, the most reliable feature of the results is the clear division into an upper sequence that is a few kilometres thick where velocity gradients are high, and a lower, thicker sequence where velocity gradients are low. The transition to typical mantle velocities is variable, and may range from being very gradational to being relatively sharp and clear. A clear Moho, by any definition, is rarely seen, and there is thus uncertainty in estimates of the thickness of the crust in many areas. Although a great deal of seismic data are now available constraining the structures of the crust and upper mantle beneath Iceland, their geological nature is not well understood
An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1
Frizzled 7 and PIPâ binding by syntenin PDZâ domain supports Frizzled 7 trafficking and signalling
PDZ domain-containing proteins work as intracellular scaffolds to control spatio-temporal aspects of cell signalling. This function is supported by the ability of their PDZ domains to bind other proteins such as receptors, but also phosphoinositide lipids important for membrane trafficking. Here we report a crystal structure of the syntenin PDZ tandem in complex with the carboxy-terminal fragment of Frizzled 7 and phosphatidylinositol 4,5-bisphosphate (PIPâ). The crystal structure reveals a tripartite interaction formed via the second PDZ domain of syntenin. Biophysical and biochemical experiments establish co-operative binding of the tripartite complex and identify residues crucial for membrane PIPâ-specific recognition. Experiments with cells support the importance of the synteninâPIPâ interaction for plasma membrane targeting of Frizzled 7 and c-jun phosphorylation. This study contributes to our understanding of the biology of PDZ proteins as key players in membrane compartmentalization and dynamics
A study of the genetic basis of C4A protein deficiency. Detection of C4A gene deletion by long-range PCR and its associated haplotypes
Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases
Background: Complement C2 deficiency is the most common genetically determined complete complement deficiency and is associated with a number of diseases. Most prominent are the associations with recurrent serious infections in young children and the development of systemic lupus erythematosus (SLE) in adults. The links with these diseases reflect the important role complement C2 plays in both innate immunity and immune tolerance. Infusions with normal fresh frozen plasma for the treatment of associated disease have demonstrated therapeutic effects but so far protein replacement therapy has not been evaluated. Results: Human complement C2 was cloned and expressed in a mammalian cell line. The purity of recombinant human C2 (rhC2) was greater than 95% and it was characterized for stability and activity. It was sensitive to C1s cleavage and restored classical complement pathway activity in C2-deficient serum both in a complement activation ELISA and a hemolytic assay. Furthermore, rhC2 could increase C3 fragment deposition on the human pathogen Streptococcus pneumoniae in C2-deficient serum to levels equal to those with normal serum. Conclusions: Taken together these data suggest that recombinant human C2 can restore classical complement pathway activity and may serve as a potential therapeutic for recurring bacterial infections or SLE in C2-deficient patients
Volcanic impacts on the Holocene vegetation history of Britain and Ireland? A review and meta-analysis of the pollen evidence
Volcanic ash layers show that the products of Icelandic volcanism reached Britain and Ireland many times during the Holocene. Historical records suggest that at least one eruption, that of Laki in a.d. 1783, was associated with impacts on vegetation. These results raise the question: did Icelandic volcanism affect the Holocene vegetation history of Britain and Ireland? Several studies have used pollen data to address this issue but no clear consensus has been reached. We re-analyse the palynological data using constrained ordination with various representations of potential volcanic impacts. We find that the palynological evidence for volcanic impacts on vegetation is weak but suggest that this is a case of absence of evidence and is not necessarily evidence of absence of impact. To increase the chances of identifying volcanic impacts, future studies need to maximise temporal resolution, replicate results, and investigate a greater number of tephras in a broader range of locations, including more studies from lake sediments
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