Development of optically interrogated diagnostic systems within materials ageing experiments

This research project aimed to develop diagnostic options for in situ use within future materials ageing experiments in complex engineering environments. The techniques developed were required to be suitable for multi-decade deployment and have minimal impact upon the experimental chemical ageing evolution. Optical fibre based diagnostic options for measuring temperature, barometric pressure, and gaseous concentrations were reviewed. The long-term suitability of fibre Bragg grating (FBG) temperature sensors, fibre Fabry-Pérot (FFP) pressure sensors, O2sensing fluorescence probes, and optical fibre switches were assessed experimentally in experiments that lasted up to 1 year. A bespoke fibre-coupled multi-pass spectroscopic gas cell was developed for the detection of H2O with a path-length of (6.47±0.05)m, along with novel techniques to package FBG and FFP sensors, hermetically pass optical fibres into the experimental volume, and route optical fibres. Custom optical fibre connectors for use both inside and outside the experiment were designed and evaluated. To support the diagnostics investigated, a bespoke interrogation system was created, with a design focus on modularity, redundancy, and long-term support. The research was evaluated against the project requirements, and together formed a potential concept for future materials ageing experiments requiring comprehensive and enhanced embedded diagnostic capabilities. The developed technologies were assessed as ranging in technology readiness level (TRL) from 2 to 6. For use in an experiment, further work would be required to mature the techniques up to TRL 9, and potential maturation routes are presented.Engineering and Physical Sciences Research Council (EPSRC) Grant number EP/L01596X/1

Reef-Top Sediment Bodies: Windward O‘ahu, Hawai‘i.

v. ill. 23 cm.QuarterlyHawaiian fringing reefs display sand bodies on their surfaces that are potentially important components of littoral sediment budgets. This work provides a regional survey of modern reef-top sediment storage and investigated geologic controls on sediment storage potential. Sand bodies are formed when sediment accumulates in topographic depressions that are the result of meteoric water eroding the emerged carbonate reef platform during periods of lower sea level. The relief of some depressions may be modified by Holocene reef accretion. Depression morphology exerts a strong control on volume and internal distribution of sediment. In this study a total of 205 jet probe thickness measurements was collected from 54 major sand bodies on the fringing reef (0–20 m depth) adjacent to 22 km of Southeast O‘ahu coastline (Kailua, Lanikai, and Waima¯nalo). Volumes were determined and synthesized with previous volume estimates of coastal subaerial and deeper submarine sediment bodies (20–200 m depth), giving the total sediment storage within the coastal system. Sand bodies range from 50 to 2,800 m from shore. Measured thickness varied from 0 to greater than 3.0 m with a mean of 0.95 m. For this study sand bodies were classified into three dominate morphologies: channel, field, and karst depression. The volume of sediment stored in channels was 58;253G618 _ 103 m3, fields contained 171G6 _ 103 m3, and karst depressions contained 1;332G248 _ 103 m3. Correlation of sediment body distribution with reef and coastal plain morphology revealed potential geologic controls on sand body formation in this region. Meteoric runoff and reef slope are important controls on spatial distribution of sand bodies

A comparison of univariate, bivariate, and trivariate whole-genome linkage screens of genetically correlated electrophysiological endophenotypes

We used a maximum-likelihood based multipoint linkage approach implemented in SOLAR to examine simultaneously linkage for three electrophysiological endophenotypes from the Collaborative Study of the Genetics of Alcoholism: TTTH1, TTTH2, and TTTH3. These endophenotypes have been identified as markers of alcohol dependence susceptibility. Data were from 905 individuals in 143 families. Measured covariates considered included sex, age at electrophysiology data collection, habitual smoking status, and the maximum number of drinks consumed in a 24-hour period. Comparisons were made among genome-wide univariate, bivariate, and trivariate linkage analyses using genotypes based on microsatellite markers supplied by the Center for Inherited Disease Research, and genotypes based on single-nucleotide polymorphism markers provided by Illumina. All LODs were corrected to a standard equivalent to 1 degree of freedom. Using the trivariate approach and the microsatellite-based genotypes, we estimated a maximum multipoint linkage signal of LOD = 2.66 on chromosome 7q at 157 cM. Analyses using the Illumina SNP genotypes produced similar results, yielding a maximum multipoint LOD of 2.95 on 7q at 174 cM. These regions of interest correspond to those identified in the univariate and bivariate linkage screens. Our results suggest that trivariate multipoint linkage analyses have utility in the further characterization of chromosomal regions potentially containing genes influencing the phenotypes being examined. Based on a comparison of the number of LOD scores achieving statistical significance, our results suggest that the microsatellite- and Illumina SNP-based genotypes have similar utility for detecting genomic regions of interest

Pre-End-Stage Renal Disease Hemoglobin Variability Predicts Post-End-Stage Renal Disease Mortality in Patients Transitioning to Dialysis.

BackgroundHemoglobin variability (Hb-var) has been associated with increased mortality both in non-dialysis dependent chronic kidney disease (NDD-CKD) and end-stage renal disease (ESRD) patients. However, the impact of Hb-var in advanced NDD-CKD on outcomes after dialysis initiation remains unknown.MethodsAmong 11,872 US veterans with advanced NDD-CKD transitioning to dialysis between October 2007 through September 2011, we assessed Hb-var calculated from the residual SD of at least 3 Hb values during the last 6 months before dialysis initiation (prelude period) using within-subject linear regression models, and stratified into quartiles. Outcomes included post-transition all-cause, cardiovascular, and infection-related mortality, assessed in Cox proportional hazards models and adjusted for demographics, comorbidities, length of hospitalization, medications, estimated glomerular filtration rate (eGFR), type of vascular access, Hb parameters (baseline Hb [i.e., intercept] and change in Hb [i.e., slope]), and number of Hb measurements.ResultsHigher prelude Hb-var was associated with use of iron and antiplatelet agents, tunneled dialysis catheter use, higher levels of baseline Hb, change in Hb, eGFR, and serum ferritin. After multivariable adjustment, higher prelude Hb-var was associated with higher post-ESRD all-cause and infection-related mortality, but not cardiovascular mortality (adjusted hazard ratios [95% CI] for the highest [vs. lowest] quartile of Hb-var, 1.10 [1.02-1.19], 1.28 [0.93-1.75], and 0.93 [0.79-1.10], respectively).ConclusionsHigh pre-ESRD Hb-var is associated with higher mortality, particularly from infectious causes rather than cardiovascular causes. Further research is required to clarify the underlying mechanisms and true causal nature of the observed association

'To live and die [for] Dixie': Irish civilians and the Confederate States of America

Around 20,000 Irishmen served in the Confederate army in the Civil War. As a result, they left behind, in various Southern towns and cities, large numbers of friends, family, and community leaders. As with native-born Confederates, Irish civilian support was crucial to Irish participation in the Confederate military effort. Also, Irish civilians served in various supporting roles: in factories and hospitals, on railroads and diplomatic missions, and as boosters for the cause. They also, however, suffered in bombardments, sieges, and the blockade. Usually poorer than their native neighbours, they could not afford to become 'refugees' and move away from the centres of conflict. This essay, based on research from manuscript collections, contemporary newspapers, British Consular records, and Federal military records, will examine the role of Irish civilians in the Confederacy, and assess the role this activity had on their integration into Southern communities. It will also look at Irish civilians in the defeat of the Confederacy, particularly when they came under Union occupation. Initial research shows that Irish civilians were not as upset as other whites in the South about Union victory. They welcomed a return to normalcy, and often 'collaborated' with Union authorities. Also, Irish desertion rates in the Confederate army were particularly high, and I will attempt to gauge whether Irish civilians played a role in this. All of the research in this paper will thus be put in the context of the Drew Gilpin Faust/Gary Gallagher debate on the influence of the Confederate homefront on military performance. By studying the Irish civilian experience one can assess how strong the Confederate national experiment was. Was it a nation without a nationalism

Interobserver reliability of classification and characterization of proximal humeral fractures: a comparison of two and three-dimensional CT

Interobserver reliability for the classification of proximal humeral fractures is limited. The aim of this study was to test the null hypothesis that interobserver reliability of the AO classification of proximal humeral fractures, the preferred treatment, and fracture characteristics is the same for two-dimensional (2-D) and three-dimensional (3-D) computed tomography (CT). Members of the Science of Variation Group--fully trained practicing orthopaedic and trauma surgeons from around the world--were randomized to evaluate radiographs and either 2-D CT or 3-D CT images of fifteen proximal humeral fractures via a web-based survey and respond to the following four questions: (1) Is the greater tuberosity displaced? (2) Is the humeral head split? (3) Is the arterial supply compromised? (4) Is the glenohumeral joint dislocated? They also classified the fracture according to the AO system and indicated their preferred treatment of the fracture (operative or nonoperative). Agreement among observers was assessed with use of the multirater kappa (κ) measure. Interobserver reliability of the AO classification, fracture characteristics, and preferred treatment generally ranged from "slight" to "fair." A few small but statistically significant differences were found. Observers randomized to the 2-D CT group had slightly but significantly better agreement on displacement of the greater tuberosity (κ = 0.35 compared with 0.30, p < 0.001) and on the AO classification (κ = 0.18 compared with 0.17, p = 0.018). A subgroup analysis of the AO classification results revealed that shoulder and elbow surgeons, orthopaedic trauma surgeons, and surgeons in the United States had slightly greater reliability on 2-D CT, whereas surgeons in practice for ten years or less and surgeons from other subspecialties had slightly greater reliability on 3-D CT. Proximal humeral fracture classifications may be helpful conceptually, but they have poor interobserver reliability even when 3-D rather than 2-D CT is utilized. This may contribute to the similarly poor interobserver reliability that was observed for selection of the treatment for proximal humeral fractures. The lack of a reliable classification confounds efforts to compare the outcomes of treatment methods among different clinical trials and reports

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

PTF1 J082340.04+081936.5: A Hot Subdwarf B Star with a Low-mass White Dwarf Companion in an 87-minute Orbit

We present the discovery of the hot subdwarf B star (sdB) binary PTF1 J082340.04+081936.5. The system has an orbital period of P_(orb) = 87.49668(1) minutes (0.060761584(10) days), making it the second-most compact sdB binary known. The light curve shows ellipsoidal variations. Under the assumption that the sdB primary is synchronized with the orbit, we find a mass of M_(sdB) = 0.45_(-0.07)^(+0.09) M_⊙, a companion white dwarf mass of M_(WD) = 0.46_(-0.09)^(+0.12) M_⊙, and a mass ratio of q = M_(WD)/M_(sdB) = 1.03_(-0.08)^(+0.10). The future evolution was calculated using the MESA stellar evolution code. Adopting a canonical sdB mass of M_(sdB) = 0.47 M_⊙, we find that the sdB still burns helium at the time it will fill its Roche lobe if the orbital period was less than 106 minutes at the exit from the last common envelope (CE) phase. For longer CE exit periods, the sdB will have stopped burning helium and turned into a C/O white dwarf at the time of contact. Comparing the spectroscopically derived log g and T_(eff) with our MESA models, we find that an sdB model with a hydrogen envelope mass of 5 x 10^(-4) M_⊙ matches the measurements at a post-CE age of 94 Myr, corresponding to a post-CE orbital period of 109 minutes, which is close to the limit to start accretion while the sdB is still burning helium