Impact of Correlated Mobility on Delay-Throughput Performance in Mobile Ad-Hoc Networks

Abstract—We extend the analysis of the scaling laws of wireless ad hoc networks to the case of correlated nodes movements, which are commonly found in real mobility processes. We consider a simple version of the Reference Point Group Mobility model, in which nodes belonging to the same group are constrained to lie in a disc area, whose center moves uniformly across the network according to the i.i.d. model. We assume fast mobility conditions, and take as primary goal the maximization of pernode throughput. We discover that correlated node movements have huge impact on asymptotic throughput and delay, and can sometimes lead to better performance than the one achievable under independent nodes movements. I. INTRODUCTION AND RELATED WORK In the last few years the store-carry-forward communication paradigm, which allows nodes to physically carry buffered dat

How much can large-scale Video-On-Demand benefit from users' cooperation?'

International audienceWe propose an analytical framework to tightly characterize the scaling laws for the additional bandwidth that servers must supply to guarantee perfect service in peer-assisted Video-on-Demand systems, taking into account essential aspects such as peer churn, bandwidth heterogeneity, and Zipf-like video popularity. Our results reveal that the catalog size and the content popularity distribution have a huge effect on the system performance. We show that users' cooperation can effectively reduce the servers' burden for a wide range of system parameters, confirming to be an attractive solution to limit the costs incurred by content providers as the system scales to large populations of users

Metastable States of Multiscale Brain Networks Are Keys to Crack the Timing Problem

The dynamics of the environment where we live in and the interaction with it, predicting events, provided strong evolutionary pressures for the brain functioning to process temporal information and generate timed responses. As a result, the human brain is able to process temporal information and generate temporal patterns. Despite the clear importance of temporal processing to cognition, learning, communication and sensory, motor and emotional processing, the basal mechanisms of how animals differentiate simple intervals or provide timed responses are still under debate. The lesson we learned from the last decade of research in neuroscience is that functional and structural brain connectivity matter. Specifically, it has been accepted that the organization of the brain in interacting segregated networks enables its function. In this paper we delineate the route to a promising approach for investigating timing mechanisms. We illustrate how novel insight into timing mechanisms can come by investigating brain functioning as a multi-layer dynamical network whose clustered dynamics is bound to report the presence of metastable states. We anticipate that metastable dynamics underlie the real-time coordination necessary for the brain's dynamic functioning associated to time perception. This new point of view will help further clarifying mechanisms of neuropsychiatric disorders

Stochastic Analysis of Self-Sustainability in Peer-Assisted VoDSystems

Abstract—We consider a peer-assisted Video-on-demand system, in which video distribution is supported both by peers caching the whole video and by peers concurrently downloading it. We propose a stochastic fluid framework that allows to characterize the additional bandwidth requested from the servers to satisfy all users watching a given video. We obtain analytical upper bounds to the server bandwidth needed in the case in which users download the video content sequentially. We also present a methodology to obtain exact solutions for special cases of peer upload bandwidth distribution. Our bounds permit to tightly characterize the performance of peer-assisted VoD systems as the number of users increases, for both sequential and nonsequential delivery schemes. In particular, we rigorously prove that the simple sequential scheme is asymptotically optimal both in the bandwidth surplus and in the bandwidth deficit mode, and that peer-assisted systems become totally self-sustaining in the surplus mode as the number of users grows large. I

Performance analysis of non-stationary peer-assisted VoD systems

Abstract—We analyze a peer-assisted Video-on-Demand system in which users contribute their upload bandwidth to the redistribution of a video that they are downloading or that they have cached locally. Our target is to characterize the additional bandwidth that servers must supply to immediately satisfy all requests to watch a given video. We develop an approximate fluid model to compute the required server bandwidth in the sequential delivery case. Our approach is able to capture several stochastic effects related to peer churn, upload bandwidth heterogeneity, non-stationary traffic conditions, which have not been documented or analyzed before. We provide an analytical methodology to design efficient peer-assisted VoD systems and optimal resource allocation strategies. I

Brain structural covariance networks in obsessive-compulsive disorder : a graph analysis from the ENIGMA Consortium

In the largest brain structural covariance study of OCD to date, Yun et al. show a less segregated organization of structural covariance networks and a reorganization of brain hubs, including cingulate and orbitofrontal regions, in OCD. The findings point to altered trajectories of brain development and maturation. Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z -score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K = 0.10-0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P < 0.0001), lower modularity (P < 0.0001), and lower small-worldness (P = 0.017). Detection of community membership emphasized lower network segregation in OCD compared to healthy controls. At the regional level, there were lower (rank-transformed) centrality values in OCD for volume of caudate nucleus and thalamus, and surface area of paracentral cortex, indicative of altered distribution of brain hubs. Centrality of cingulate and orbito-frontal as well as other brain areas was associated with OCD illness duration, suggesting greater involvement of these brain areas with illness chronicity. In summary, the findings of this study, the largest brain structural covariance study of OCD to date, point to a less segregated organization of structural covariance networks in OCD, and reorganization of brain hubs. The segregation findings suggest a possible signature of altered brain morphometry in OCD, while the hub findings point to OCD-related alterations in trajectories of brain development and maturation, particularly in cingulate and orbitofrontal regions

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses.Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods.Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models.Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data