Conception de noyaux de systèmes embarqués reconfigurables

The vision of the emergence of a global environment for the information management where most of the physical object around us will be equipped with processors, communication capabilities and interconnected through various networks forces us to redesign the computing systems. Instead of heavy, monolithic and non evolutive systems, we must design light, flexible and reconfigurable systems.This work presents a new architecture allowing the conception and development of flexible and reconfigurable operating system kernels for embedded systems.La perspective de l'émergence d'un environnement global du traitement de l'information dans lequel la plupart des objets physiques qui nous entourent seront équipés de processeurs, dotés de capacités de communication et interconnectés par le biais de réseaux divers, nous oblige à repenser les systèmes informatiques. Aux systèmes traditionnels, lourds, monolithiques, et peu évolutifs, nous devons préférer les systèmes légers, flexibles, et reconfigurables.Cette thèse présente une architecture permettant la conception et le développement de noyaux de systèmes d'exploitation flexibles et reconfigurables à destination du monde de l'embarqué

Polarization-dependent fluorescence from an anisotropic gold/polymer hybrid nano-emitter

Based on nanoscale photopolymerization triggered by the dipolar surface plasmon mode, we developed a light-emitting gold nanoparticle/Eosin Y-doped polymer hybrid nanostructure. Due to the anisotropic spatial distribution of the dipolar surface plasmon mode during photopolymerization, this nano-emitter is anisotropic in both geometry and emission. The trapped dye molecules in the hybrid nanostructure display fluorescence intensity that is dependent upon the polarization of the incident excitation light. This nano-emitter further allows the photo-selection of fluorescence configuration (i.e., molecule concentration and refractive index of active medium) by controlling the incident polarization. (C) 2014 AIP Publishing LLC

Planck pre-launch status : The Planck mission

Peer reviewe

Conception de noyaux de systèmes embarqués reconfigurables

The vision of the emergence of a global environment for the information management where most of the physical object around us will be equipped with processors, communication capabilities and interconnected through various networks forces us to redesign the computing systems. Instead of heavy, monolithic and non evolutive systems, we must design light, flexible and reconfigurable systems.This work presents a new architecture allowing the conception and development of flexible and reconfigurable operating system kernels for embedded systems.La perspective de l'émergence d'un environnement global du traitement de l'information dans lequel la plupart des objets physiques qui nous entourent seront équipés de processeurs, dotés de capacités de communication et interconnectés par le biais de réseaux divers, nous oblige à repenser les systèmes informatiques. Aux systèmes traditionnels, lourds, monolithiques, et peu évolutifs, nous devons préférer les systèmes légers, flexibles, et reconfigurables.Cette thèse présente une architecture permettant la conception et le développement de noyaux de systèmes d'exploitation flexibles et reconfigurables à destination du monde de l'embarqué

Silver(I) and copper(I) complexes with bis-NHC ligands : dinuclear complexes, cubanes and coordination polymers.

International audienceSilver(I) and copper(I) complexes containing neutral bis(N-heterocyclic carbene) (NHC) ligands and coordinated or non-coordinated chloride, bromide, iodide, or tetrafluoroborate anions, were synthesised. The nature of the anions impacts deeply the structural features of the complexes in the solid-state and neutral cubane-, neutral coordination polymer-, or dicationic bridged-type architectures have been characterised. The structures of (1,3-bis(3′-butylimidazol-2′-ylidene)benzene)disilver(I) dichloride (2a), bis(μ-1,3-bis(3′-butylimidazol-2′-ylidene)benzene-κ-C)tetra-μ3-bromotetrasilver(I) (2b), bis(1,3-bis(3′-butylimidazol-2′-ylidene)benzene)disilver(I) tetrafluoroborate (2d) in 2d·CH2Cl2, (1,3-bis(3′-butylimidazol-2′-ylidene)benzene)dicopper(I) dichloride (3a) and (1,3-bis(3′-butylimidazol-2′-ylidene)benzene)dicopper(I) dibromide (3b) were established by X-ray diffraction

Expression of neurotensin receptor 1 in endometrial adenocarcinoma is correlated with histological grade and clinical outcome

International audienceThe promalignant effects of neurotensin (NTS) are sustained in many solid tumors, including hormone-dependent cancers. As the endometrium is also subjected to hormonal regulation, we evaluated the contribution of NTS to endometrial carcinogenesis. Neurotensin receptor 1 (NTSR1) expression and NTSR1 promoter methylation (HM450) were analyzed in 385 cases of endometrial carcinoma from The Cancer Genome Atlas (TCGA). Additionally, from a series of 100 endometrial carcinomas, and 66 benign endometrium samples, NTS and NTSR1 labeling was evaluated by immunohistochemistry. Using TCGA series, NTSR1 messenger RNA (mRNA) level was negatively correlated with overall survival (OS) and progression-free survival (PFS) (p = 0.0012 and p = 0.0116, respectively), and positively correlated with the grade (p = 0.0008). When including only endometrioid carcinomas, NTSR1 mRNA level continued to be negatively correlated with OS (log-rank: p < 0.0001) and PFS (log-rank: p = 0.002). A higher NTSR1 mRNA level was significantly associated with a loss of NTSR1 promoter methylation. Immunohistochemical expression of NTS and NTSR1 was significantly increased in adenocarcinoma (n = 100), as compared to benign endometrium (p < 0.001). NTSR1 expression was positively correlated with grade (p = 0.004). High immunohistochemical expression of cytoplasmic NTSR1 was significantly correlated with a shorter OS and PFS (p < 0.001 and p = 0.001, respectively). This correlation remained significant when excluding non-endometrioid subtypes (p = 0.04 and p = 0.02, respectively). In multivariate analysis, the expression of NTSR1 was an independent prognostic factor (p = 0.004). NTSR1 overexpression is a poor prognostic factor in endometrial cancer, highlighting the contribution of NTS in endometrial cancer progression and its uses as a prognostic marker, and as a potential therapeutic target