Planet X probe: A fresh new look at an old familiar place

Planet X Probe utilizes a Get Away Special (GAS) payload to provide a large student population with a remote Earth sensing experimental package. To provide a cooperative as well as a competitive environment, the effort is targeted at all grade levels and at schools in different geographical regions. LANDSAT capability allows students to investigate the Earth, its physical makeup, its resources, and the impact of man. This project also serves as an educational device to get students to stand back and take a fresh look at their home planet. The key element is to treat the familiar Earth as an unknown planet with knowledge based only on what is observable and provable from the images obtained. Through participation, a whole range of experiences will include: (1) mission planning; (2) research and pilot projects to train teams; (3) identification and recruitment of scientific mentors and dialogue; (4) selection of a student advisory team to be available during the mission; (5) analysis of data and compilation of findings; (6) report preparation, constucted along sound scientific principles; and (7) presentation and defense of findings before a meeting of competitive student groups and scientist in the field

Severity and Treatment of Alcohol Withdrawal in Elderly Versus Younger Patients

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65425/1/j.1530-0277.1994.tb00903.x.pd

Treatment Outcome of Alcoholics with and without Cocaine Disorders

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65587/1/j.1530-0277.1994.tb00939.x.pd

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Suppressor analysis of fimbrin (Sac6p) overexpression in yeast.

Yeast fimbrin (Sac6p) is an actin filament-bundling protein that is lethal when overexpressed. To identify the basis for this lethality, we sought mutations that can suppress it. A total of 1326 suppressor mutations were isolated and analyzed. As the vast majority of mutations were expected to simply decrease the expression of Sac6p to tolerable levels, a rapid screen was devised to eliminate these mutations. A total of 1324 mutations were found to suppress by reducing levels of Sac6p in the cell. The remaining 2 mutations were both found to be in the actin gene and to make the novel changes G48V (act1-20) and K50E (act1-21). These mutations suppress the defect in cytoskeletal organization and cell morphology seen in ACT1 cells that overexpress SAC6. These findings indicate that the lethal phenotype caused by Sac6p overexpression is mediated through interaction with actin. Moreover, the altered residues lie in the region of actin previously implicated in the binding of Sac6p, and they result in a reduced affinity of actin for Sac6p. These results indicate that the two mutations most likely suppress by reducing the affinity of actin for Sac6p in vivo. This study suggests it should be possible to use this type of suppressor analysis to identify other pairs of physically interacting proteins and suggests that it may be possible to identify sites where such proteins interact with each other