Understanding the Role of Research Universities in Improving College Preparation and Access at Local Urban High Schools

Urban colleges and universities not only have a responsibility to engage in activities designed to improve the educational attainment of local urban youth, but also have extensive financial, human, intellectual, and organizational resources that may be directed productively toward this purpose. This article describes the multipronged approach that the University of Pennsylvania is using to improve college opportunities for students attending Philadelphia high schools. We conclude by offering lessons that other institutions may draw from this example

Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells

In patients with Huntington's disease (HD), the proteolytic activity of the ubiquitin proteasome system (UPS) is reduced in the brain and other tissues. The pathological hallmark of HD is the intraneuronal nuclear protein aggregates of mutant huntingtin. We determined how to enhance UPS function and influence catalytic protein degradation and cell survival in HD. Proteasome activators involved in either the ubiquitinated or the non-ubiquitinated proteolysis were overexpressed in HD patients' skin fibroblasts or mutant huntingtin-expressing striatal neurons. Following compromise of the UPS, overexpression of the proteasome activator subunit PA28γ, but not subunit S5a, recovered proteasome function in the HD cells. PA28γ also improved cell viability in mutant huntingtin-expressing striatal neurons exposed to pathological stressors, such as the excitotoxin quinolinic acid and the reversible proteasome inhibitor MG132. These results demonstrate the specific functional enhancements of the UPS that can provide neuroprotection in HD cells

Tick-borne viruses and biological processes at the tick-host-virus interface

Ticks are efficient vectors of arboviruses, although less than 10% of tick species are known to be virus vectors. Most tick-borne viruses (TBV) are RNA viruses some of which cause serious diseases in humans and animals world-wide. Several TBV impacting human or domesticated animal health have been found to emerge or re-emerge recently. In order to survive in nature, TBV must infect and replicate in both vertebrate and tick cells, representing very different physiological environments. Information on molecular mechanisms that allow TBV to switch between infecting and replicating in tick and vertebrate cells is scarce. In general, ticks succeed in completing their blood meal thanks to a plethora of biologically active molecules in their saliva that counteract and modulate different arms of the host defense responses (haemostasis, inflammation, innate and acquired immunity, and wound healing). The transmission of TBV occurs primarily during tick feeding and is a complex process, known to be promoted by tick saliva constituents. However, the underlying molecular mechanisms of TBV transmission are poorly understood. Immunomodulatory properties of tick saliva helping overcome the first line of defense to injury and early interactions at the tick-host skin interface appear to be essential in successful TBV transmission and infection of susceptible vertebrate hosts. The local host skin site of tick attachment, modulated by tick saliva, is an important focus of virus replication. Immunomodulation of the tick attachment site also promotes co-feeding transmission of viruses from infected to non-infected ticks in the absence of host viraemia (non-viraemic transmission). Future research should be aimed at identification of the key tick salivary molecules promoting virus transmission, and a molecular description of tick-host-virus interactions and of tick-mediated skin immunomodulation. Such insights will enable the rationale design of anti-tick vaccines that protect against disease caused by tick-borne viruses

A Case Study of Pipeline Route Selection and Design Through Discontinuous Permafrost Terrain in Northwestern Alberta

As the natural gas pipeline system in Western Canada expands northward, it traverses the discontinuous permafrost zone. As the ground temperature of the frozen soil in this zone is just below freezing, it can be expected that within the design life of a pipeline the permafrost adjacent to it will melt due to the disturbance of the insulating cover by construction activities. Differential settlement at the thawing frozen/unfrozen soil interfaces gives rise to pipeline strain. Based on the calculated settlement and resulting strain level, a cost effective mechanical or civil design solution can be selected to mitigate the differential settlement problem. Since these design solutions can be costly, it is desirable to combine them with a pipeline route that traverses the least amount of discontinuous permafrost terrain while minimizing the overall length of the pipeline."/jats:p" "jats:p"This paper will detail the framework utilized to select the routing for a package of pipeline projects in northwestern Alberta. The process began with a review of the state of the art in permafrost engineering in order to benefit from past experiences. Airphoto interpretation and terrain mapping were performed for potential pipeline corridors. Preliminary routing options through the corridors were chosen from this mapping information that minimized both pipeline length and amount of permafrost terrain traversed. The next step was to collect field data for each route that would determine the extent and characteristics of the permafrost. Essentially two sets of field data were collected: geophysical mapping of representative sections of each terrain type and physical sampling of the permafrost. Boreholes were located following field interpretation of the geophysical data to ensure they were optimally located to help in calibration of the geophysical data. Permafrost samples were tested in the laboratory for thaw settlement. Anticipated thaw settlements were used to estimate pipe strain levels. This information was then extrapolated for the entire proposed pipeline route and used to finalize both the pipeline route and the differential settlement design options. Monitoring sites will be instrumented to obtain data on the longer term performance of the pipeline, as well as for assessing permafrost degradation effects on the right-of-way such as settlement and impact on drainage patterns."/jats:p" "jats:p"It is believed that the increased front end effort will result in lower operating costs and an overall reduced life-cycle cost. This basic design methodology can be applied to any project that traverses discontinuous permafrost terrain

University–Community Partnerships Using a Participatory Action Research Model to Evaluate the Impact of Dance for Health

Little is known about fostering sustainable, collaborative community-academic partnerships that effectively improve physical activity and health in residents of under resourced communities using Participatory Action Research (PAR) driven models. The purpose of this PAR study was to evaluate the impact of an urban, intergenerational, and physical activity dance program by identifying community preferred measurable outcomes that promote program participation and sustainability. A descriptive, qualitative design was employed using semi-structured interview guides to facilitate discussions for two adult focus groups and one youth focus group. Exactly 19 community-residing adults and six youth who lived in urban neighborhoods in West Philadelphia participated in the discussions. The audiotapes were transcribed and analyzed using directed content analysis. Five outcome themes emerged and included: (1). Enhancing the psychological and emotional well-being of the individual, (2). Enhancement of social well-being and management of interpersonal relationships and responsibilities (3). Enhancing and promoting physiologic well-being (4). Changes in health promoting behaviors and skill acquisition, and (5). Concerns about accessibility of dance for health and other physical activity programs in the community. Focused attention to measuring community preferred outcomes can promote sustainability of Dance for Health and possibly other urban-based physical activity dance programs

The Influence of Environmental Conditions on Intake Behavior and Activity by Feedlot Steers Fed Corn or Barley-Based Diets

This study evaluated the influence of diet and environmental conditions on intake behavior and activity of feedlot steers. Feedlot rations used were comprised of a main concentrate: (1) corn or (2) barley. A GrowSafe system measured individual animal intake and behavior and HOBO accelerometers measured steer standing time. An Onset weather station collected on site weather data. Steer daily intake displayed a diet by temperature class interaction (p ≤ 0.05). Relative temperature change had no effect on variation in intake (p = 0.60); however, diet influenced variation of intake (p < 0.01), where corn-fed steers had a greater coefficient of variation (CV) than barley-fed steers (21.89 ± 1.46 vs. 18.72 ± 1.46%). Time spent eating (min d−1) and eating rate (g min−1) both displayed a diet by temperature class interaction (p ≤ 0.05). Diet did not affect steer lying activity (p ≥ 0.12), however, time spent lying (min d−1) and frequency of lying bouts (bouts d−1) increased on relatively cold days while the duration of lying bouts (min bout−1; p < 0.01) decreased. Short-term environmental temperature changes interacted with diet influencing feedlot beef cattle intake behavior; however, they did not interact with basal diet in respect to steer activity

Diurnal Ruminal pH and Temperature Patterns of Steers Fed Corn or Barley-Based Finishing Diets

This study evaluated the effects of corn or barley finishing diets on ruminal pH and temperature and their relationship to feed intake events using continuous reticulorumen monitoring of feedlot steers. Average daily ruminal pH and temperature were not impacted (p ≥ 0.17) by diet. However, diet did affect daily variation of ruminal pH and temperature (p < 0.01). Average hourly ruminal pH displayed a diet by hour post-feeding interaction (p < 0.01), where barley-fed steers had greater (p < 0.01) ruminal pH than corn-fed steers at 0, 1, 18, 19, 20, 21, 22 and 23 h post feeding, but had lower (p ≤ 0.05) ruminal pH than corn-fed steers at 6, 7, and 8 h post-feeding. Variation in ruminal pH hour post-feeding also displayed a diet by hour post-feeding interaction (p < 0.01), where barley-fed steers had greater (p ≤ 0.03) variation in ruminal pH at hours 1–17 post-feeding but did not differ (p ≥ 0.16) at 0, 18, 19, 20, 21, 22 and 23 h post-feeding. Additionally, average hourly ruminal temperature exhibited a diet by hour post-feeding interaction (p < 0.01). In summary, basal grain interacted with time post-feeding influencing ruminal pH and temperature in feedlot steers