Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis

Indexación: Scopus.Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis (MS). Here, we analyzed the immune response after EAE induction in the adult offspring gestated in Hpx. Mice gestated in Hpx showed an early appearance of EAE symptoms and the increase of all parameters of the disease such as: the pathological score, spinal cord demyelination, and immune cell infiltration in comparison to the adult offspring gestated in euthyroidism. Isolated CD4+CD25+ T cells from spleen of the offspring gestated in Hpx that suffer EAE showed reduced capacity to suppress proliferation of effector T cells (TEff) after being stimulated with anti-CD3 and anti-CD28 antibodies. Moreover, adoptive transfer experiments of CD4+CD25+ T cells from the offspring gestated in Hpx suffering EAE to mice that were induced with EAE showed that the receptor mice suffer more intense EAE pathological score. Even though, no significant differences were detected in the frequency of Treg cells and IL-10 content in the blood, spleen, and brain between mice gestated in Hpx or euthyroidism, T cells CD4+CD25+ from spleen have reduced capacity to differentiate in vitro to Treg and to produce IL-10. Thus, our data support the notion that maternal Hpx can imprint the immune response of the offspring suffering EAE probably due to a reduced capacity to trigger suppression. Such "imprints" on the immune system could contribute to explaining as to why adult offspring gestated in Hpx suffer earlier and more intense EAE. © 2018 Haensgen, Albornoz, Opazo, Bugueño, Jara Fernández, Binzberger, Rivero-Castillo, Venegas Salas, Simon, Cabello-Verrugio, Elorza, Kalergis, Bueno and Riedel.https://www.frontiersin.org/articles/10.3389/fimmu.2018.01257/ful

Mediciones anuales comparadas de viento y energía producida en un sistema eólico aislado para escuela rural

El presente trabajo exhibe la comparación de series anuales de datos de viento con estación automática, la predicción energética asociada, y la energía realmente producida por el sistema eólico de 4kw nominales ( 5 turbinas de 800w) instalado en una escuela rural aislada en la provincia de santa cruz. estas mediciones se realizaron durante 2001 utilizando una estación de viento NRG EXPLORER y un equipo SISMED-01/48 de adquisición de datos. los cálculos de energía de viento disponible fueron realizados utilizando software comercial NRG y planillas específicas para los parámetros de Weibull y estimación de energía, basadas en un tiempo de muestreo de 10 minutos. los cálculos de energía eléctrica son almacenados en forma de promedios diarios para cada aerogenerador. los datos permiten obtener varias conclusiones de interés, entre ellas la influencia de la pérdida de rendimiento ocasionada por la desadaptación de impedancias entre el aerogenerador de iman permanente y el banco de baterías.This paper presents results derived from compared measurements of wind intensity, direction and power in an isolated battery-charging system for a rural school in patagonia. the 2001 databases from an nrg logger and a sismed-01 specialized data acquisition system are processed using nrg software and conventional spreadsheets, allowing for a number of performance issues to be described.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Mediciones anuales comparadas de viento y energía producida en un sistema eólico aislado para escuela rural

El presente trabajo exhibe la comparación de series anuales de datos de viento con estación automática, la predicción energética asociada, y la energía realmente producida por el sistema eólico de 4kw nominales ( 5 turbinas de 800w) instalado en una escuela rural aislada en la provincia de santa cruz. estas mediciones se realizaron durante 2001 utilizando una estación de viento NRG EXPLORER y un equipo SISMED-01/48 de adquisición de datos. los cálculos de energía de viento disponible fueron realizados utilizando software comercial NRG y planillas específicas para los parámetros de Weibull y estimación de energía, basadas en un tiempo de muestreo de 10 minutos. los cálculos de energía eléctrica son almacenados en forma de promedios diarios para cada aerogenerador. los datos permiten obtener varias conclusiones de interés, entre ellas la influencia de la pérdida de rendimiento ocasionada por la desadaptación de impedancias entre el aerogenerador de iman permanente y el banco de baterías.This paper presents results derived from compared measurements of wind intensity, direction and power in an isolated battery-charging system for a rural school in patagonia. the 2001 databases from an nrg logger and a sismed-01 specialized data acquisition system are processed using nrg software and conventional spreadsheets, allowing for a number of performance issues to be described.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Mediciones anuales comparadas de viento y energía producida en un sistema eólico aislado para escuela rural

El presente trabajo exhibe la comparación de series anuales de datos de viento con estación automática, la predicción energética asociada, y la energía realmente producida por el sistema eólico de 4kw nominales ( 5 turbinas de 800w) instalado en una escuela rural aislada en la provincia de santa cruz. estas mediciones se realizaron durante 2001 utilizando una estación de viento NRG EXPLORER y un equipo SISMED-01/48 de adquisición de datos. los cálculos de energía de viento disponible fueron realizados utilizando software comercial NRG y planillas específicas para los parámetros de Weibull y estimación de energía, basadas en un tiempo de muestreo de 10 minutos. los cálculos de energía eléctrica son almacenados en forma de promedios diarios para cada aerogenerador. los datos permiten obtener varias conclusiones de interés, entre ellas la influencia de la pérdida de rendimiento ocasionada por la desadaptación de impedancias entre el aerogenerador de iman permanente y el banco de baterías.This paper presents results derived from compared measurements of wind intensity, direction and power in an isolated battery-charging system for a rural school in patagonia. the 2001 databases from an nrg logger and a sismed-01 specialized data acquisition system are processed using nrg software and conventional spreadsheets, allowing for a number of performance issues to be described.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Primordial Nucleosynthesis

Primordial nucleosynthesis, or Big-Bang Nucleosynthesis (BBN), is one of the three evidences for the Big-Bang model, together with the expansion of the Universe and the Cosmic Microwave Background. There is a good global agreement over a range of nine orders of magnitude between abundances of 4He, D, 3He and 7Li deduced from observations, and calculated in primordial nucleosynthesis. This comparison was used to determine the baryonic density of the Universe. For this purpose, it is now superseded by the analysis of the Cosmic Microwave Background (CMB) radiation anisotropies. However, there remain, a yet unexplained, discrepancy of a factor 3-5, between the calculated and observed lithium primordial abundances, that has not been reduced, neither by recent nuclear physics experiments, nor by new observations. We review here the nuclear physics aspects of BBN for the production of 4He, D, 3He and 7Li, but also 6Li, 9Be, 11B and up to CNO isotopes. These are, for instance, important for the initial composition of the matter at the origin of the first stars. Big-Bang nucleosynthesis, that has been used, to first constrain the baryonic density, and the number of neutrino families, remains, a valuable tool to probe the physics of the early Universe, like variation of "constants" or alternative theories of gravity.Comment: Invited Plenary Talk given at the 11th International Conference on Nucleus-Nucleus Collisions (NN2012), San Antonio, Texas, USA, May 27-June 1, 2012. To appear in the NN2012 Proceedings in Journal of Physics: Conference Series (JPCS

Clonal dissemination of Klebsiella pneumoniae ST258 harbouring KPC-2 in Argentina

AbstractThe present work describes the abrupt emergence of Klebsiella pneumoniae carbapenemase (KPC) and characterizes the first 79 KPC-producing enterobacteria from Argentina (isolated from 2006 to 2010). The emergence of blaKPC-2 was characterized by two patterns of dispersion: the first was the sporadic occurrence in diverse enterobacteria from distant geographical regions, harbouring plasmids of different incompatibility groups and blaKPC-2 in an unusual genetic environment flanked by ISKpn8-ΔblaTEM-1 and ISKpn6-like. blaKPC-2 was associated with IncL/M transferable plasmids; the second was the abrupt clonal spread of K. pneumoniae ST258 harbouring blaKPC-2 in Tn4401a

Anatomía de la raíz y endófitos radicales en Podocarpus parlatorei (Podocarpaceae)

Root anatomy and root endophytes in Podocarpus parlatorei (Podocarpaceae). Podocarpus parlatorei Pilg. known as “mountain pine” is a tree up to 20 m tall, grows in mountain forests between 1500 and 2000 m asl and is the native only representative of the Gymnosperma in the NOA. The aim of this study was to characterize the anatomy of the root system and root endophytes in P. parlatoreicomparatively between individuals of Tucuman and Catamarca. We applied conventional histological techniques and staining. The results showed that individuals from both provinces had the same structural feature in the different stages of development, differing in the number of layers in the cortical tissue. We observed the presence of arbuscular mycorrhizal with morphology Arum and Paris, both in root and nodules. For this species is recorded for the first time the presence of cells with non-lignified secondary thickening in the cortical parenchyma of the primary roots and nodules, whose function would be mechanical and absorption. The presence of arbuscular mycorrhizal fungi and dark septate endophytes in P. parlatorei is also reported for the first time for Argentina, and the morphology of these root endophytes is describedPodocarpus parlatorei Pilg. conocido como “pino del cerro” es un árbol de hasta 20 m de altura, crece en los bosques montanos entre los 1500 y 2000 msm y es el único representante arbóreo autóctono de Gimnosperma en el norte de Argentina. El objetivo de este trabajo fue caracterizar la anatomía de la raíz y los endófitos radicales en P. parlatorei, comparativamente entre individuos de Tucumán y Catamarca. Se aplicaron técnicas histológicas y tinción convencionales. Los resultados evidenciaron que los individuos provenientes de ambas provincias presentaron la misma característica estructural en los distintos estadios de desarrollo, difiriendo en la cantidad de estratos en el tejido cortical. Se observó la presencia de endomicorrizas arbusculares con los tipos morfológicos Arum y Paris, tanto en raíces como en nódulos. Para la especie en estudio se cita por primera vez la presencia de células con engrosamientos secundarios no lignificados en el parénquima cortical de las raíces primarias y de los nódulos, cuya función sería mecánica y de absorción. Además, se cita por primera vez para Argentina la presencia de hongos micorrícicos arbusculares y de septados oscuros y se describe la morfología de ambos endófitos radicales en P. parlatorei

Light neutralino dark matter in the MSSM and its implication for LHC searches for staus

It was shown in a previous study that a lightest neutralino with mass below 30 GeV was severely constrained in the minimal supersymmetric standard model (MSSM), unless it annihilates via a light stau and thus yields the observed dark matter abundance. In such a scenario, while the stau is the next-to-lightest supersymmetric particle (NLSP), the charginos and the other neutralinos as well as sleptons of the first two families are also likely to be not too far above the mass bounds laid down by the Large Electron Positron (LEP) collider. As the branching ratios of decays of the charginos and the next-to-lightest neutralino into staus are rather large, one expects significant rates of tau-rich final states in such a case. With this in view, we investigate the same-sign ditau and tri-tau signals of this scenario at the Large Hadron Collider (LHC) for two MSSM benchmark points corresponding to light neutralino dark matter. The associated signal rates for these channels are computed, for the centre-of-mass energy of 14 TeV. We find that both channels lead to appreciable rates if the squarks and the gluino are not too far above a TeV, thus allowing to probe scenarios with light neutralinos in the 14 TeV LHC run with 10-100 fb^{-1}.Comment: 19p, 4 Fig

New measurement of neutron capture resonances of 209Bi

The neutron capture cross section of Bi209 has been measured at the CERN n TOF facility by employing the pulse-height-weighting technique. Improvements over previous measurements are mainly because of an optimized detection system, which led to a practically negligible neutron sensitivity. Additional experimental sources of systematic error, such as the electronic threshold in the detectors, summing of gamma-rays, internal electron conversion, and the isomeric state in bismuth, have been taken into account. Gamma-ray absorption effects inside the sample have been corrected by employing a nonpolynomial weighting function. Because Bi209 is the last stable isotope in the reaction path of the stellar s-process, the Maxwellian averaged capture cross section is important for the recycling of the reaction flow by alpha-decays. In the relevant stellar range of thermal energies between kT=5 and 8 keV our new capture rate is about 16% higher than the presently accepted value used for nucleosynthesis calculations. At this low temperature an important part of the heavy Pb-Bi isotopes are supposed to be synthesized by the s-process in the He shells of low mass, thermally pulsing asymptotic giant branch stars. With the improved set of cross sections we obtain an s-process fraction of 19(3)% of the solar bismuth abundance, resulting in an r-process residual of 81(3)%. The present (n,gamma) cross-section measurement is also of relevance for the design of accelerator driven systems based on a liquid metal Pb/Bi spallation target.Comment: 10 pages, 5figures, recently published in Phys. Rev.

First record of the miniature catfish Malacoglanis gelatinosus Myers & Weitzman, 1966 (Siluriformes, Trichomycteridae) in the Orinoco river basin

Malacoglanis gelatinosus, a species of miniature catfish of the family Trichomycteridae, is only known from 4 specimens from the Amazon basin. Recently, we collected 3 specimens from the upper basin of the Meta River, a tributary of the Orinoco. This is the first record of M. gelatinosus from the Orinoco river basin, which significantly expands the known geographic distribution of this species, making it one of the most broadly distributed species within the subfamily Sarcoglanidinae. High-resolution photographs of specimens, remarks on character variation, and an updated distribution in Colombia are provided