168 research outputs found
Internet: a safe tool for patients?
oai:ojs.medicinainterna.net.pe:article/1No hay duda de que el advenimiento de la Internet ha facilitado de manera insospechada el acceso a todo tipo de información. En una frase, simplementepuede encontrarse de todo. Basta un teléfono celular y literalmente tendrå lo deseado al alcance de la mano
ÂżâNos enfrentamos y nos abrazamosâ? Un nuevo recorrido por los usos oficiales del pasado durante el bicentenario de la RevoluciĂłn de Mayo
El presente trabajo analiza, en primer lugar, los modos en que la historia argentina se tradujo, durante los festejos oficiales del bicentenario de la RevoluciĂłn de Mayo, en artefactos culturales y festivos dirigidos a atraer un pĂșblico vasto, prestando especial atenciĂłn a los usos del pasado allĂ exhibidos. En segundo lugar, pone en relaciĂłn dichas operaciones con las variaciones ocurridas en el nivel de las prĂĄcticas polĂticas gubernamentales tras la crisis polĂtica de 2008. En Ășltima instancia, se plantea que el gobierno de Cristina FernĂĄndez de Kirchner se inclinĂł, al momento de proyectar el festejo patrio en cuestiĂłn, por una lĂłgica discursiva liberalâcentrada, especialmente, en el consenso inclusivo y la aceptaciĂłn de las diferenciasâcon el fin de matizar la particiĂłn del espacio socio-polĂtico, exhibir una naciĂłn reconciliada, interpelar a la sociedad argentina en su conjunto y, de ese modo, contribuir a la reconstrucciĂłn de su hegemonĂa polĂtica.Firstly, this paper analyzes how Argentinian history was translated, during the national celebrations of the May Revolution bicentennial, into cultural and festive devices aimed at attracting a massive audience, paying special attention to the uses of the past displayed. Secondly, it illustrates the relations between these operations and the variations of government policy that occurred after the 2008 political crisis. Ultimately, it claims that the Cristina FernĂĄndez de Kirchner administration adopted, when it came to planning this national holiday, a liberal discursive logic â mainly characterized by inclusive consensus and pluralism â in order to ease the division of the social and political space, display a reconciled nation, address the entire Argentinean society and, thereby, contribute to the reconstruction of Kirchnerist hegemony.Fil: Amorebieta y Vera, MarĂa Laura. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de Investigaciones en Humanidades y Ciencias Sociales. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la EducaciĂłn. Instituto de Investigaciones en Humanidades y Ciencias Sociales; Argentin
Diseño y desarrollo de un sistema de alerta temprana para pacientes hospitalizados por COVID-19
La pandemia por COVID-19 planteĂł un desafĂo para el sistema salud, debido a la gran demanda de pacientes hospitalizados. La identificaciĂłn temprana de pacientes hospitalizados con riesgo de evoluciĂłn desfavorable es vital para asistir en forma oportuna y planificar la demanda de recursos. El propĂłsito de este estudio fue identificar las variables predictivas de mala evoluciĂłn en pacientes hospitalizados por COVID-19 y crear un modelo predictivo que pueda usarse como herramienta de triage. A travĂ©s de una revisiĂłn narrativa, se obtuvieron 44 variables vinculadas a una evoluciĂłn desfavorable de la enfermedad COVID-19, incluyendo variables clĂnicas, de laboratorio y radiogrĂĄficas. Luego se utilizĂł un procesamiento por mĂ©todo Delphi modificado de 2 rondas para seleccionar una lista final de variables incluidas en el score llamado COVID-19 Severity Index. Luego se calculĂł el Ărea Bajo la Curva (AUC) del score para predecir el pase a terapia intensiva en las prĂłximas 24 horas. El score presentĂł un AUC de 0,94 frente a 0,80 para NEWS-2. Finalmente se agregĂł el COVID-19 Severity Index a la historia clĂnica electrĂłnica de un hospital universitario de alta complejidad. Se programĂł para que el mismo se actualice de manera automĂĄtica, facilitando la planificaciĂłn estratĂ©gica, organizaciĂłn y administraciĂłn de recursos a travĂ©s de la identificaciĂłn temprana de pacientes hospitalizados con mayor riesgo de transferencia a la Unidad de Cuidados Intensivos.Pandemics pose a major challenge for public health preparedness, requiring a coordinated international response and the development of solid containment plans. Early and accurate identifica tion of high-risk patients in the course of the current COVID-19 pandemic is vital for planning and making proper use of available resources. The purpose of this study was to identify the key variables that account for worse outcomes to create a predictive model that could be used effectively for triage. Through literature review, 44 variables that could be linked to an unfavorable course of COVID-19 disease were obtained, including clinical, laboratory, and X-ray variables. These were used for a 2-round modified Delphi processing with 14 experts to select a final list of variables with the greatest predictive power for the construction of a scoring system, leading to the creation of a new scoring system: the COVID-19 Severity Index. The analysis of the area under the curve for the COVID-19 Severity Index was 0.94 to predict the need for ICU admission in the following 24 hours against 0.80 for NEWS-2. Additionally, the digital medical record of the Hospital Italiano de Buenos Aires was electronically set for an automatic calculation and constant update of the COVID-19 Severity Index. Specifically designed for the current COVID-19 pandemic, COVID-19 Severity Index could be used as a reliable tool for strategic planning, organization, and administration of resources by easily identifying hospitalized patients with a greater need of intensive care.Fil: Huespe, Ivan. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Carboni Bisso, Indalecio. Hospital Italiano; ArgentinaFil: Gemelli, Nicolas A.. Hospital Italiano; ArgentinaFil: Terrasa, Sergio Adrian. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Di Stefano, Sabrina. Hospital Italiano; ArgentinaFil: Burgos, Valeria Laura. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Sinner, Jorge. Hospital Italiano; ArgentinaFil: Oubiña, Mailen. Hospital Italiano; ArgentinaFil: Bezzati, Marina. Hospital Italiano; ArgentinaFil: Delgado, Pablo. Hospital Italiano; ArgentinaFil: Las Heras, Marcos. Hospital Italiano; ArgentinaFil: Risk, Marcelo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentin
Diseño y desarrollo de un sistema de alerta temprana para pacientes hospitalizados por COVID-19
La pandemia por COVID-19 planteĂł un desafĂo para el sistema salud, debido a la gran demanda de pacientes hospitalizados. La identificaciĂłn temprana de pacientes hospitalizados con riesgo de evoluciĂłn desfavorable es vital para asistir en forma oportuna y planificar la demanda de recursos. El propĂłsito de este estudio fue identificar las variables predictivas de mala evoluciĂłn en pacientes hospitalizados por COVID-19 y crear un modelo predictivo que pueda usarse como herramienta de triage. A travĂ©s de una revisiĂłn narrativa, se obtuvieron 44 variables vinculadas a una evoluciĂłn desfavorable de la enfermedad COVID-19, incluyendo variables clĂnicas, de laboratorio y radiogrĂĄficas. Luego se utilizĂł un procesamiento por mĂ©todo Delphi modificado de 2 rondas para seleccionar una lista final de variables incluidas en el score llamado COVID-19 Severity Index. Luego se calculĂł el Ărea Bajo la Curva (AUC) del score para predecir el pase a terapia intensiva en las prĂłximas 24 horas. El score presentĂł un AUC de 0,94 frente a 0,80 para NEWS-2. Finalmente se agregĂł el COVID-19 Severity Index a la historia clĂnica electrĂłnica de un hospital universitario de alta complejidad. Se programĂł para que el mismo se actualice de manera automĂĄtica, facilitando la planificaciĂłn estratĂ©gica, organizaciĂłn y administraciĂłn de recursos a travĂ©s de la identificaciĂłn temprana de pacientes hospitalizados con mayor riesgo de transferencia a la Unidad de Cuidados Intensivos.Pandemics pose a major challenge for public health preparedness, requiring a coordinated international response and the development of solid containment plans. Early and accurate identifica tion of high-risk patients in the course of the current COVID-19 pandemic is vital for planning and making proper use of available resources. The purpose of this study was to identify the key variables that account for worse outcomes to create a predictive model that could be used effectively for triage. Through literature review, 44 variables that could be linked to an unfavorable course of COVID-19 disease were obtained, including clinical, laboratory, and X-ray variables. These were used for a 2-round modified Delphi processing with 14 experts to select a final list of variables with the greatest predictive power for the construction of a scoring system, leading to the creation of a new scoring system: the COVID-19 Severity Index. The analysis of the area under the curve for the COVID-19 Severity Index was 0.94 to predict the need for ICU admission in the following 24 hours against 0.80 for NEWS-2. Additionally, the digital medical record of the Hospital Italiano de Buenos Aires was electronically set for an automatic calculation and constant update of the COVID-19 Severity Index. Specifically designed for the current COVID-19 pandemic, COVID-19 Severity Index could be used as a reliable tool for strategic planning, organization, and administration of resources by easily identifying hospitalized patients with a greater need of intensive care.Fil: Huespe, Ivan. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Carboni Bisso, Indalecio. Hospital Italiano; ArgentinaFil: Gemelli, Nicolas A.. Hospital Italiano; ArgentinaFil: Terrasa, Sergio Adrian. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Di Stefano, Sabrina. Hospital Italiano; ArgentinaFil: Burgos, Valeria Laura. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Sinner, Jorge. Hospital Italiano; ArgentinaFil: Oubiña, Mailen. Hospital Italiano; ArgentinaFil: Bezzati, Marina. Hospital Italiano; ArgentinaFil: Delgado, Pablo. Hospital Italiano; ArgentinaFil: Las Heras, Marcos. Hospital Italiano; ArgentinaFil: Risk, Marcelo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentin
Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries
IMPORTANCE: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS).
OBJECTIVES: To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation management, and use of adjuncts-for example prone positioning-in routine clinical practice for patients fulfilling the ARDS Berlin Definition.
DESIGN, SETTING, AND PARTICIPANTS:The Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients undergoing invasive or noninvasive ventilation, conducted during 4 consecutive weeks in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across 5 continents.
EXPOSURES:Acute respiratory distress syndrome.
MAIN OUTCOMES AND MEASURES: The primary outcome was ICU incidence of ARDS. Secondary outcomes included assessment of clinician recognition of ARDS, the application of ventilatory management, the use of adjunctive interventions in routine clinical practice, and clinical outcomes from ARDS.
RESULTS: Of 29,144 patients admitted to participating ICUs, 3022 (10.4%) fulfilled ARDS criteria. Of these, 2377 patients developed ARDS in the first 48 hours and whose respiratory failure was managed with invasive mechanical ventilation. The period prevalence of mild ARDS was 30.0% (95% CI, 28.2%-31.9%); of moderate ARDS, 46.6% (95% CI, 44.5%-48.6%); and of severe ARDS, 23.4% (95% CI, 21.7%-25.2%). ARDS represented 0.42 cases per ICU bed over 4 weeks and represented 10.4% (95% CI, 10.0%-10.7%) of ICU admissions and 23.4% of patients requiring mechanical ventilation. Clinical recognition of ARDS ranged from 51.3% (95% CI, 47.5%-55.0%) in mild to 78.5% (95% CI, 74.8%-81.8%) in severe ARDS. Less than two-thirds of patients with ARDS received a tidal volume 8 of mL/kg or less of predicted body weight. Plateau pressure was measured in 40.1% (95% CI, 38.2-42.1), whereas 82.6% (95% CI, 81.0%-84.1%) received a positive end-expository pressure (PEEP) of less than 12 cm H2O. Prone positioning was used in 16.3% (95% CI, 13.7%-19.2%) of patients with severe ARDS. Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning. Hospital mortality was 34.9% (95% CI, 31.4%-38.5%) for those with mild, 40.3% (95% CI, 37.4%-43.3%) for those with moderate, and 46.1% (95% CI, 41.9%-50.4%) for those with severe ARDS.
CONCLUSIONS AND RELEVANCE: Among ICUs in 50 countries, the period prevalence of ARDS was 10.4% of ICU admissions. This syndrome appeared to be underrecognized and undertreated and associated with a high mortality rate. These findings indicate the potential for improvement in the management of patients with ARDS
Optimal liability sharing and court errors: an exploratory analysis
We focus in this paper on the effects of court errors on the optimal sharing of liability between firms and financiers, as an environmental policy instrument. Using a structural model of the interactions between firms, financial institutions, governments and courts we show, through numerical simulations, the distortions in liability sharing between firms and financiers that the imperfect implementation of government policies implies. We consider in particular the role played by the efficiency of the courts in avoiding Type I (finding an innocent firm guilty of inappropriate care) and Type II (finding a guilty firm innocent of inappropriate care) errors. This role is considered in a context where liability sharing is already distorted (when compared with first best values) due not only to the courts' own imperfect assessment of safety care levels exerted by firm but also to the presence of moral hazard and adverse selection in financial contracting, as well as of noncongruence of objectives between firms and financiers on the one hand and social welfare maximization on the other. Our results indicate that an increase in the efficiency of the court system in avoiding errors raises safety care levels, thereby reducing the probability of accident, and allowing the social welfare maximizing government to impose a lower liability [higher] share for firms [financiers] as well as a lower standard level of care
In-beam spectroscopic study of 244Cf
The ground-state rotational band of the neutron-deficient californium (Z = 98) isotope 244Cf was identified for the first time and measured up to a tentative spin and parity of I = 20+. The observation of the rotational band indicates that the nucleus is deformed. The kinematic and dynamic moments of inertia were deduced from the measured gamma-ray transition energies. The behavior of the dynamic moment of inertia revealed an up-bend due to a possible alignment of coupled nucleons in high-j orbitals starting at a rotational frequency of about hw = 0.20 MeV. The results were compared with the systematic behavior of the even-even N = 146 isotones as well as with available theoretical calculations that have been performed for nuclei in the region
In-beam spectroscopic study of Cf-244
The ground-state rotational band of the neutron-deficient californium (Z = 98) isotope 244Cf was identified for the first time and measured up to a tentative spin and parity of I I-pi = 20(+). The observation of the rotational band indicates that the nucleus is deformed. The kinematic and dynamic moments of inertia were deduced from the measured gamma-ray transition energies. The behavior of the dynamic moment of inertia revealed an up-bend due to a possible alignment of coupled nucleons in high-j orbitals starting at a rotational frequency of about (h) over bar (omega) = 0.20 MeV. The results were compared with the systematic behavior of the even-even N = 146 isotones as well as with available theoretical calculations that have been performed for nuclei in the region.Peer reviewe
Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects
While the essential role of the adenosine deaminase ADAR2 in RNA editing is well established, how it is regulated remains largely unknown. Here, the prolyl isomerase Pin1 and the E3 ubiquitin ligase WWP2 are shown to play a role in regulating ADAR2 localisation and stability
Tensile Deformation of Oriented Poly(Δ-caprolactone) and Its Miscible Blends with Poly(vinyl methyl ether)
The structural evolution of micromolded poly(Δ-caprolactone)
(PCL) and its miscible blends with noncrystallizable poly(vinyl
methyl ether) (PVME) at the nanoscale was investigated as a function of
deformation ratio and blend composition using in situ synchrotron smallangle
X-ray scattering (SAXS) and scanning SAXS techniques. It was
found that the deformation mechanism of the oriented samples shows a
general scheme for the process of tensile deformation: crystal block slips
within the lamellae occur at small deformations followed by a stressinduced
fragmentation and recrystallization process along the drawing
direction at a critical strain where the average thickness of the crystalline
lamellae remains essentially constant during stretching. The value of the
critical strain depends on the amount of the amorphous component
incorporated in the blends, which could be traced back to the lower
modulus of the entangled amorphous phase and, therefore, the reduced network stress acting on the crystallites upon addition of
PVME. When stretching beyond the critical strain the slippage of the fibrils (stacks of newly formed lamellae) past each other
takes place resulting in a relaxation of stretched interlamellar amorphous chains. Because of deformation-induced introduction of
the amorphous PVME into the interfibrillar regions in the highly oriented blends, the interactions between fibrils becomes
stronger upon further deformation and thus impeding sliding of the fibrils to some extent leading finally to less contraction of the
interlamellar amorphous layers compared to the pure PCLNational Natural Science Foundation of China (21204088 and 21134006). This
work is within the framework of the RCUK/EPSRC Science Bridges China project of UKâChina Advanced Materials Research Institute (AMRI)
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