Mechanistic and Treatment Implications of ΔNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma

Hidradenocarcinomas are rare, aggressive adnexal tumors of sweat gland origin that demonstrate a high potential for local recurrence, metastasis and poor outcome. These neoplasms can derive from preexisting clear cell hidradenomas, but more commonly appear de novo with the molecular events responsible for the pathogenesis currently unknown. Molecular markers of pathogenesis as well as effective forms of adjuvant chemotherapy are missing due to the lack of accurate diagnosis, paucity of cases and confusion with other visceral solid tumors. Here, we report a 37-year-old man who presented with a rapidly growing, painful palpable mass located in the right inguinal area. The patient was a nonsmoker, did not consume alcohol and had a medical history remarkable only for a lower abdominal superficial skin lesion in the same area that had been excised 11 years earlier. Although initially slow growing, the lesion eventually expanded, was surgically excised and was diagnosed as a hidradenoma. There was no family history of malignancy and the patient had not experienced any constitutional symptoms. We probed the immunohistochemical status and detected negative staining for the estrogen, progesterone and Her2 receptors, while strong, diffuse nuclear staining was seen in the majority of cells consistent with p53 overexpression. Similarly, strong nuclear reactivity was seen with p63 and p73 antibodies. The p63 gene contains 2 separate promoters which express at least 6 major transcripts that lead to 2 fundamentally different classes of proteins; 3 isoforms (TAp63α, β and γ) encode proteins that induce apoptosis, whereas the other 3 isoforms (ΔNp63α, β and γ) may exert inhibitory effects on p53. Interest in p63 stems from this ‘two genes in one’-concept. Importantly, the nuclear presence of ΔNp63 was detected widespread throughout the tumor. We have identified a subtype of hidradenocarcinomas that express ΔNp63 and uncovered an unforeseen commonality with triple-negative breast tumors. To our knowledge, this is the first report of a sweat gland tumor that displayed expression of both ΔNp63 and p73 and demonstrated a triple-negative receptor status. Such a link between 2 seemingly disparate tumor types indicates a mutual pathway of tumorigenesis and suggests the potential for common therapeutic regimens

Lead immobilization in thermally remediated soils and igneous rocks

This is the final report for a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The principal goal of this project was to investigate the speciation of lead in the environment at LANL and to determine the feasibility of using thermal remediation methods to immobilize lead in the environment. Lead occurs as pyromorphite [Pb(PO{sub 4}){sub 3}(Cl, OH)], cerussite (PbCO{sub 3}) and galena (PbS) in vapor-phase-altered Bandelier Tuff samples. LANL soils primarily contain cerussite and PbO. Thermal remediation experiments at high temperatures (up to 400 C) suggest that thermal immobilization of highly-reactive Pb compounds in the environment may be feasible, but that this technique is not optimal for more refractory lead phases such as cerussite and PbO

Clinical Practice Guideline for the Evaluation of Fever and Infection in Older Adult Residents of Long-Term Care Facilities: 2008 Update by the Infectious Diseases Society of America

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65801/1/j.1532-5415.2009.02175.x.pd

Die invloed van die rekenaar op die funksionering van 'n bepaalde sektor in 'n tersiëre bedryf

Thesis (M.Econ.) -- Universiteit van Stellenbosch, 1978.Full text to be digitised and attached to bibliographic record

Educational Ideals in the Major Work of Paul Ernst

The way to recognition has been a slow and difficult one for Paul Ernst. The earlier literary historians were wont to dismiss him with a brief reference to his neo-classicism. His plays found very little response, and his name was often confused with that of the story writer, Otto Ernst. It was not until after 1927 that thge literary histories of W. Nahrholz, A. Soergel, P. Fechter and H. Langenbucher devoted more space to the work of Ernst. Near the end of his life he received governmental recognition. He was also elected to membership in the Dichterakademie, and efforts were made to produce his plays on the stage. Meanwhile, in Germany, several dissertations have been written, and the Paul-Ernst Gesellschaft has taken an active interest in collecting hitherato unpublished matter: research articles, testimonials, biblioghraphy, etc., and publishing them in the form of annual reports (Jahrbucher). In america also, an active interest is being displayed as is manifest by a Paul-Ernst society, and by recent articles in literary magazines, in the German Quarterly and in the Monatshefte fur Deutschen Unterricht. Also text-books of Ernst\u27s stories are appearing in this country, and there are several theses and dissertations. One master\u27s theses is at Chapel Hill university, and the other at Catholic university. The doctor\u27s dissertations are: P.E. and Schiller , Hans Boening, Michigan, 1938; Social and Economic Ideas in the Works of P.E. , Walter Fahrer, Iowa, 1940