The Polarized 3-He Target

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

Commissioning of inline ECE system within waveguide based ECRH transmission systems on ASDEX upgrade

A CW capable inline electron cyclotron emission (ECE) separation system for feedback control, featuring oversized corrugated waveguides, is commissioned on ASDEX upgrade (AUG). The system is based on a combination of a polarization independent, non-resonant, Mach-Zehnder diplexer equipped with dielectric plate beam splitters [2, 3] employed as corrugated oversized waveguide filter, and a resonant Fast Directional Switch, FADIS [4, 5, 6, 7] as ECE/ECCD separation system. This paper presents an overview of the system, the low power characterisation tests and first high power commissioning on AUG

LIGO and VIRGO: large interferometers searching for gravitational waves

International audienceThe largest interferometric detectors for gravitational waves, LIGO and Virgo, have reached (or are close to) the design sensitivity and have started taking science data. The operation of such detectors is reviewed and the expected sources and detection rates are discussed. LIGO and Virgo might make the first detection, but more advanced detectors will be needed to truly open the field of gravitational wave astronomy: the current ideas and plans for the upgrades of the existing interferometers are presented

Noise budget and noise hunting in VIRGO

International audienc

Data Acquisition System of the Virgo Gravitational Waves Interferometric Detector

International audienceVirgo is an experiment aiming at the detection of gravitational waves emitted by astrophysical sources. Its detector, based on a 3km arms interferometer, is a complex setup which requires several digital control loops running up to 10kHz, an accurate and reliable central timing system and an efficient data acquisition, all of them being distributed over 3km. We overview here the main hardware and software components developed for the data acquisition system (DAQ) and its current architecture. Then, we briefly discuss its connections with interferometer's controls, especially through the automation of the interferometer's startup procedure. Then, we describe the tools used to monitor the DAQ and the performances we measured with them. Finally, are described also the tools developped for the online detector monitoring, mandatory complement of the DAQ for the commissioning of the Virgo detector

GRB 050915a & the Virgo detector

GravitationalWaves (GWs) are expected to be emitted in association with Gamma-Ray Bursts (GRBs). In this context, we are analyzing data collected by the Virgo interferometer during 2005 to develop a method aimed to search for coincidences between GW bursts and GRBs. Our analysis is currently focused on Virgo C7 run and the long GRB 050915a, observed by the Swift satellite. The goal of such analysis is either to identify significant events around the GRB trigger time or, in the absence of such events, to set a limit on the strength of the associated GW emission. This study is a prototype for evaluating Virgo capability in constraining the GW output associated with a typical long GRB. Here we give an overview of the procedure we are following in our analysis

Data Acquisition System of the Virgo Gravitational Waves Interferometric Detector

Virgo is an experiment aiming at the detection of gravitational waves emitted by astrophysical sources. Its detector, based on a 3km arms interferometer, is a complex setup which requires several digital control loops running up to 10kHz, an accurate and reliable central timing system and an efficient data acquisition, all of them being distributed over 3km. We overview here the main hardware and software components developed for the data acquisition system (DAQ) and its current architecture. Then, we briefly discuss its connections with interferometer's controls, especially through the automation of the interferometer's startup procedure. Then, we describe the tools used to monitor the DAQ and the performances we measured with them. Finally, are described also the tools developped for the online detector monitoring, mandatory complement of the DAQ for the commissioning of the Virgo detector

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.

BACKGROUND: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. METHOD: We performed a fine-scale mapping study of a 700 kb region including 441 genotyped and more than 1300 imputed genetic variants in 48,155 cases and 43,612 controls of European descent, 6269 cases and 6624 controls of East Asian descent and 1116 cases and 932 controls of African descent in the Breast Cancer Association Consortium (BCAC; http://bcac.ccge.medschl.cam.ac.uk/ ), and in 15,252 BRCA1 mutation carriers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Stepwise regression analyses were performed to identify independent association signals. Data from the Encyclopedia of DNA Elements project (ENCODE) and the Cancer Genome Atlas (TCGA) were used for functional annotation. RESULTS: Analysis of data from European descendants found evidence for four independent association signals at 12p11, represented by rs7297051 (odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.06-1.12; P = 3 × 10(-9)), rs805510 (OR = 1.08, 95 % CI = 1.04-1.12, P = 2 × 10(-5)), and rs1871152 (OR = 1.04, 95 % CI = 1.02-1.06; P = 2 × 10(-4)) identified in the general populations, and rs113824616 (P = 7 × 10(-5)) identified in the meta-analysis of BCAC ER-negative cases and BRCA1 mutation carriers. SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P < 0.05 in East Asians, but none of the associations were statistically significant in African descendants. Multiple candidate functional variants are located in putative enhancer sequences. Chromatin interaction data suggested that PTHLH was the likely target gene of these enhancers. Of the six variants with the strongest evidence of potential functionality, rs11049453 was statistically significantly associated with the expression of PTHLH and its nearby gene CCDC91 at P < 0.05. CONCLUSION: This study identified four independent association signals at 12p11 and revealed potentially functional variants, providing additional insights into the underlying biological mechanism(s) for the association observed between variants at 12p11 and breast cancer risk.UK funding includes Cancer Research UK and NIH.This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s13058-016-0718-

All-sky search for long-duration gravitational wave transients with initial LIGO

We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society

All-sky search for long-duration gravitational wave transients with initial LIGO

We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society