Complementary and alternative medicine use and cost in functional bowel disorders: a six month prospective study in a large HMO

Abstract Background Functional Bowel Disorders (FBD) are chronic disorders that are difficult to treat and manage. Many patients and doctors are dissatisfied with the level of improvement in symptoms that can be achieved with standard medical care which may lead them to seek alternatives for care. There are currently no data on the types of Complementary and Alternative Medicine (CAM) used for FBDs other than Irritable Bowel Syndrome (IBS), or on the economic costs of CAM treatments. The aim of this study is to determine prevalence, types and costs of CAM in IBS, functional diarrhea, functional constipation, and functional abdominal pain. Methods 1012 Patients with FBD were recruited through a health care maintenance organization and followed for 6 months. Questionnaires were used to ascertain: Utilization and expenditures on CAM, symptom severity (IBS-SS), quality of life (IBS-QoL), psychological distress (BSI) and perceived treatment effectiveness. Costs for conventional medical care were extracted from administrative claims. Results CAM was used by 35% of patients, at a median yearly cost of $200. The most common CAM types were ginger, massage therapy and yoga. CAM use was associated with female gender, higher education, and anxiety. Satisfaction with physician care and perceived effectiveness of prescription medication were not associated with CAM use. Physician referral to a CAM provider was uncommon but the majority of patients receiving this recommendation followed their physician's advice. Conclusion CAM is used by one-third of FBD patients. CAM use does not seem to be driven by dissatisfaction with conventional care. Physicians should discuss CAM use and effectiveness with their patients and refer patients if appropriate

Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome

Abstract Background Children with cyclic vomiting syndrome (CVS) have a high degree of maternal inheritance of functional gastrointestinal and neurological disorders. CVS in children is also associated with an increased prevalence of mitochondrial DNA single-nucleotide polymorphisms (mtDNA SNPs) 16519 T and 3010A. Preliminary data suggests that age of onset of symptoms (pediatric vs. adult) may be a determinant of the presence of such mtDNA SNP’s. We sought to examine the degree of maternal inheritance pattern of functional disorders and the prevalence of mtDNA SNP’s16519T and 3010A in adults with CVS and correlate this with age of onset of disease. Methods A Quantitative Pedigree Analysis (QPA) was performed in 195 of a total of 216 patients and all were genotyped using Restriction Fragment Length Polymorphism (RFLP) or sequencing. Results Adults with CVS had a higher degree of probable maternal inheritance (PMI) of functional disorders than controls (12% vs. 1%, p < 0.001). However, the prevalence of mitochondrial SNP’s 16519 T, 3010A and the AT genotype were similar in Haplogroup H CVS patients compared to historical controls. There was no correlation between age of onset of disease and prevalence of these mtDNA SNP’s. Conclusions A subset of adults with CVS has a significantly higher degree of maternal inheritance pattern of functional disorders than controls. There was no association with mtDNA SNP’s 16519 T and 3010A as seen in children and future studies sequencing the entire mitochondrial and nuclear genome to identify potential causes for this maternal inheritance pattern in adults are warranted

Measurement of polarization amplitudes and CP asymmetries in B-0 -> phi K*(892)(0)

An angular analysis of the decay B (0) -> phi K (*)(892)(0) is reported based on a pp collision data sample, corresponding to an integrated luminosity of 1.0 fb(-1), collected at a centre-of-mass energy of root S = 7 TeV with the LHCb detector. The P-wave amplitudes and phases are measured with a greater precision than by previous experiments, and confirm about equal amounts of longitudinal and transverse polarization. The S-wave K+ pi(-) and K+ K- contributions are taken into account and found to be significant. A comparison of the B (0) -> phi K (*)(892)(0) and results shows no evidence for direct CP violation in the rate asymmetry, in the triple-product asymmetries or in the polarization amplitudes and phases

Search for the rare decay K0S→μ+μ−

A search for the decay K0S→μ+μ− is performed, based on a data sample of 1.0 fb−1 of pp collisions at &#8730;&lt;span style="text-decoration:overline"&gt;s&lt;/span&gt;=7 TeV collected by the LHCb experiment at the Large Hadron Collider. The observed number of candidates is consistent with the background-only hypothesis, yielding an upper limit of B(K0S→μ+μ−) &#60; 11(9) × 10−9 at 95 (90)% confidence level. This limit is a factor of thirty below the previous measurement

Search for the rare decays Bs -> mu+ mu- and B0 -> mu+ mu-

A search for the decays Bs -> mu+ mu- and B0 -> mu+ mu- is performed with 0.37 fb^-1 of pp collisions at sqrt{s} = 7 TeV collected by the LHCb experiment in 2011. The upper limits on the branching fractions are BR (Bs -> mu+ mu-) < 1.6 x 10^-8 and BR(B0 -> mu+ mu-) < 3.6 x 10^-9 at 95% confidence level. A combination of these results with the LHCb limits obtained with the 2010 dataset leads to BR (Bs -> mu+ mu-) mu+ mu-) < 3.2 x 10^-9 at 95% confidence level.Comment: 6+19 pages, 9 figures; minor changes; matches version accepted in Phys. Lett.

Measurement of forward top pair production in the dilepton channel in <i>pp</i> collisions at √s=13 TeV

Forward top quark pair production is studied in $pp$ collisions in the $\mu eb$ final state using a data sample corresponding to an integrated luminosity of 1.93 fb$^{-1}$ collected with the LHCb experiment at a centre-of-mass energy of 13 TeV. The cross-section is measured in a fiducial region where both leptons have a transverse momentum greater than 20 GeV and a pseudorapidity between 2.0 and 4.5. The quadrature sum of the azimuthal separation and the difference in pseudorapidities, denoted $\Delta R$, between the two leptons must be larger than 0.1. The $b$-jet axis is required to be separated from both leptons by a $\Delta R$ of 0.5, and to have a transverse momentum in excess of 20 GeV and a pseudorapidity between 2.2 and 4.2. The cross-section is measured to be $$\sigma_{t\bar{t}}= 126\pm19\,(\mathrm{stat})\pm16\,(\mathrm{syst})\pm5\,(\mathrm{lumi})\,\,\mathrm{ fb}$$ where the first uncertainty is statistical, the second is systematic, and the third is due to the luminosity determination. The measurement is compatible with the Standard Model prediction.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2017-050.htm

Measurement of indirect CP asymmetries in D-0 -&gt; K-K+ and D-0 -&gt; pi(-)pi(+) decays using semileptonic B decays

Time-dependent $CP$ asymmetries in the decay rates of the singly Cabibbo-suppressed decays $D^0\rightarrow K^-K^+$ and $D^0\rightarrow \pi^-\pi^+$ are measured in $pp$ collision data corresponding to an integrated luminosity of 3.0 fb$^{-1}$ collected by the LHCb experiment. The $D^0$ mesons are produced in semileptonic $b$-hadron decays, where the charge of the accompanying muon is used to determine the initial state as $D^0$ or $\bar{D}^0$. The asymmetries in effective lifetimes between $D^0$ and $\bar{D}^0$ decays, which are sensitive to indirect $CP$ violation, are determined to be \begin{align*} A_{\Gamma}(K^-K^+) = (-0.134 \pm 0.077 \; {}^{+0.026}_{-0.034})\% \, A_{\Gamma}(\pi^-\pi^+) = (-0.092\pm 0.145 \; {}^{+0.025}_{-0.033})\% \, \end{align*} where the first uncertainties are statistical and the second systematic. This result is in agreement with previous measurements and with the hypothesis of no indirect $CP$ violation in $D^0$ decays.Comment: 20 pages, 4 figure

Study of eta-eta ' mixing from measurement of B-(s)(0) -&gt; J/psi eta((')) decay rates

A study of B and Bs meson decays into J/ψ η and J/ψ η′ final states is performed using a data set of proton-proton collisions at centre-of-mass energies of 7 and 8 TeV, collected by the LCHb experiment and corresponding to 3.0 fb−1 of integrated luminosity. The decay B0 → J/ψ η′ is observed for the first time. The following ratios of branching fractions are measured: B(B0→J/ψη′)B(B0s→ J/ψη′)=(2.28±0.65 (stat)±0.10 (syst)±0.13 (fs/fd))×10−2,B(B0→ J/ψη)B(B0s→ J/ψη)=(1.85±0.61 (stat)±0.09 (syst)±0.11 (fs/fd))×10−2, where the third uncertainty is related to the present knowledge of fs/fd, the ratio between the probabilities for a b quark to form a Bs or a B0 meson. The branching fraction ratios are used to determine the parameters of η − η′ meson mixing. In addition, the first evidence for the decay Bs → ψ(2S)η′ is reported, and the relative branching fraction is measured, B(B0s→ ψ(2S)η′)B(B0s→ J/ψη′)=(38.7±9.0 (stat)±1.3 (syst)±0.9(B))×10−2, where the third uncertainty is due to the limited knowledge of the branching fractions of J/ψ and ψ(2S) mesons

Search for decays of neutral beauty mesons into four muons

A search for the non-resonant decays $B^0_s \rightarrow \mu^{+}\mu^{-}\mu^{+}\mu^{-}$ and $B^0 \rightarrow \mu^{+}\mu^{-}\mu^{+}\mu^{-}$ is presented. The measurement is performed using the full Run 1 data set collected in proton-proton collisions by the LHCb experiment at the LHC. The data correspond to integrated luminosities of $1$ and $2~\mathrm{fb}^{-1}$ collected at centre-of-mass energies of $7$ and $8~\mathrm{TeV}$, respectively. No signal is observed and upper limits on the branching fractions of the non-resonant decays at $95\%$ confidence level are determined to be \mathcal{B}(B^0_s \rightarrow \mu^{+}\mu^{-}\mu^{+}\mu^{-}) & < 2.5 \times 10^{-9} \mathcal{B}(B^0 \rightarrow \mu^{+}\mu^{-}\mu^{+}\mu^{-}) & < 6.9 \times 10^{-10}.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-043.htm

Search for long-lived particles decaying to jet pairs

A search is presented for long-lived particles with a mass between 25 and 50 GeV$/c^2$ and a lifetime between 1 and 200 ps in a sample of proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=7$ TeV, corresponding to an integrated luminosity of 0.62 fb$^{-1}$, collected by the LHCb detector. The particles are assumed to be pair-produced by the decay of a Standard Model-like Higgs boson. The experimental signature of the long-lived particle is a displaced vertex with two associated jets. No excess above the background is observed and limits are set on the production cross-section as a function of the long-lived particle mass and lifetime