Long gamma-ray bursts and core-collapse supernovae have different environments

When massive stars exhaust their fuel they collapse and often produce the extraordinarily bright explosions known as core-collapse supernovae. On occasion, this stellar collapse also powers an even more brilliant relativistic explosion known as a long-duration gamma-ray burst. One would then expect that long gamma-ray bursts and core-collapse supernovae should be found in similar galactic environments. Here we show that this expectation is wrong. We find that the long gamma-ray bursts are far more concentrated on the very brightest regions of their host galaxies than are the core-collapse supernovae. Furthermore, the host galaxies of the long gamma-ray bursts are significantly fainter and more irregular than the hosts of the core-collapse supernovae. Together these results suggest that long-duration gamma-ray bursts are associated with the most massive stars and may be restricted to galaxies of limited chemical evolution. Our results directly imply that long gamma-ray bursts are relatively rare in galaxies such as our own Milky Way.Comment: 27 pages, 4 figures, submitted to Nature on 22 August 2005, revised 9 February 2006, online publication 10 May 2006. Supplementary material referred to in the text can be found at http://www.stsci.edu/~fruchter/GRB/locations/supplement.pdf . This new version contains minor changes to match the final published versio

The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

As early as 1926 Mellanby (1) was able to show that introduction of bile into the duodenum of anesthetized cats produces a copious flow of pancreatic juice. In conscious dogs, Ivy & Lueth (2) reported, bile is only a weak stimulant of pancreatic secretion. Diversion of bile from the duodenum, however, did not influence pancreatic volume secretion stimulated by a meal (3,4). Moreover, Thomas & Crider (5) observed that bile not only failed to stimulate the secretion of pancreatic juice but also abolished the pancreatic response to intraduodenally administered peptone or soap

The ultra-long GRB 220627A at z=3.08

GRB 220627A is a rare burst with two distinct gamma-ray emission episodes separated by almost 1000 s that triggered the Fermi Gamma-ray Burst Monitor twice. High-energy GeV emission was detected by the Fermi Large Area Telescope coincident with the first emission episode but not the second. The discovery of the optical afterglow with MeerLICHT led to MUSE observations which secured the burst redshift to z=3.08, making this the most distant ultra-long gamma-ray burst (GRB) detected to date. The progenitors of some ultra-long GRBs have been suggested in the literature to be different to those of normal long GRBs. Our aim is to determine whether the afterglow and host properties of GRB 220627A agree with this interpretation. We performed empirical and theoretical modelling of the afterglow data within the external forward shock framework, and determined the metallicity of the GRB environment through modelling the absorption lines in the MUSE spectrum. Our optical data show evidence for a jet break in the light curve at ~1.2 days, while our theoretical modelling shows a preference for a homogeneous circumburst medium. Our forward shock parameters are typical for the wider GRB population, and we find that the environment of the burst is characterised by a sub-solar metallicity. Our observations and modelling of GRB 220627A do not suggest that a different progenitor compared to the progenitor of normal long GRBs is required. We find that more observations of ultra-long GRBs are needed to determine if they form a separate population with distinct prompt and afterglow features, and possibly distinct progenitors.Comment: 17 pages, accepted for publication in A&

Optical and near-infrared observations of the GRB020405 afterglow

(Abridged) We report on observations of the optical and NIR afterglow of GRB020405. Ground-based optical observations started about 1 day after the GRB and spanned a period of ~10 days; archival HST data extended the coverage up to 70 days after the GRB. We report the first detection of the afterglow in NIR bands. The detection of emission lines in the optical spectrum indicates that the GRB is located at z = 0.691. Absorptions are also detected at z = 0.691 and at z = 0.472. The latter system is likely caused by clouds in a galaxy located 2 arcsec southwest of the GRB host. Hence, for the first time, the galaxy responsible for an intervening absorption system in the spectrum of a GRB afterglow is identified. Optical and NIR photometry indicates that the decay in all bands follows a single power law of index alpha = 1.54. The late-epoch VLT and HST points lie above the extrapolation of this power law, so that a plateau is apparent in the VRIJ light curves at 10-20 days after the GRB. The light curves at epochs later than day ~20 after the GRB are consistent with a power-law decay with index alphaprime = 1.85. We suggest that this deviation can be modeled with a SN having the same temporal profile as SN2002ap, but 1.3 mag brighter at peak, and located at the GRB redshift. Alternatively, a shock re-energization may be responsible for the rebrightening. A polarimetric R-band measurement shows that the afterglow is polarized, with P = 1.5 % and theta = 172 degrees. Optical-NIR spectral flux distributions show a change of slope across the J band which we interpret as due to the presence of nu_c. The analysis of the multiwavelength spectrum within the fireball model suggests that a population of relativistic electrons produces the optical-NIR emission via synchrotron in an adiabatically expanding blastwave, and the X-rays via IC.Comment: 17 pages, 10 figures, 4 tables, accepted for publication on A&A, main journa

Late-epoch optical and near-infrared observations of the GRB000911 afterglow and its host galaxy

We present the results of an optical and near-infrared (NIR) monitoring campaign of the counterpart of Gamma-Ray Burst (GRB) 000911, located at redshift z=1.06, from 5 days to more than 13 months after explosion. Our extensive dataset is a factor of 2 larger and spans a time interval about 4 times longer than the ones considered previously for this GRB afterglow; this allows a more thorough analysis of its light curve and of the GRB host galaxy properties. The afterglow light curves show a single power-law temporal decline, modified at late times by light from a host galaxy with moderate intrinsic extinction, and possibly by an emerging supernova (SN). The afterglow evolution is interpreted within the classical "fireball" scenario as a weakly collimated adiabatic shock propagating in the interstellar medium. The presence of a SN light curve superimposed on the non-thermal afterglow emission is investigated: while in the optical bands no significant contribution to the total light is found from a SN, the NIR J-band data show an excess which is consistent with a SN as bright as the known hypernova SN1998bw. If the SN interpretation is true, this would be the farthest GRB-associated SN, as well as the farthest core-collapse SN, discovered to date. However, other possible explanations of this NIR excess are also investigated. Finally, we studied the photometric properties of the host, and found that it is likely to be a slightly reddened, subluminous, extreme starburst compact galaxy, with luminosity about 0.1 L*, an age of about 0.5 Gyr and a specific Star Formation Rate (SFR) of approximately 30 Msol yr-1 (L/L*)-1. This is the highest specific SFR value for a GRB host inferred from optical/NIR data.Comment: 13 pages, 6 figures, 3 tables. Accepted for publication in A&A, main journa

A deep search for the host galaxies of GRBs with no detected optical afterglow

Gamma-Ray Bursts can provide information about star formation at high redshifts. Even in the absence of a optical/near-infrared/radio afterglow, the high detection rate of X-ray afterglows by swift/XRT and its localization precision of 2-3 arcsec facilitates the identification and study of GRB host galaxies. We focus on the search for the host galaxies of a sample of 17 bursts with XRT error circles but no detected long-wavelength afterglow. Three of these events can also be classified as truly dark bursts: the observed upper limit on the optical flux of the afterglow was less than expected based on the X-ray flux. Our study is based on deep R and K-band observations performed with ESO/VLT instruments, supported by GROND and NEWFIRM. To be conservative, we searched for host galaxies in an area with a radius twice the 90% swift/XRT error circle. For 15 of the 17 bursts we find at least one galaxy inside the doubled XRT error circle. In seven cases we discover extremely red objects in the error circles. The most remarkable case is the host of GRB 080207 which as a colour of R-K~4.7 mag (AB), one of the reddest galaxies ever associated with a GRB. As a by-product of our study we identify the optical afterglow of GRB 070517A. Optically dim afterglows result from cosmological Lyman drop out and dust extinction, but the former process is only equired for a minority of cases (<1/3). Extinction by dust in the host galaxies might explain all other events. Thereby, a seemingly non-negligible fraction of these hosts are globally dust-enshrouded, extremely red galaxies. This suggests that bursts with optically dim afterglows trace a subpopulation of massive starburst galaxies, which are markedly different from the main body of the GRB host galaxy population, namely the blue, subluminous, compact galaxies.Comment: 29 pages, 31 figures, accepted for publication in A&

External validation suggests Integrin beta 3 as prognostic biomarker in serous ovarian adenocarcinomas

<p>Abstract</p> <p>Background</p> <p>The majority of women with ovarian cancer are diagnosed in late stages, and the mortality rate is high. The use of biomarkers as prognostic factors may improve the treatment and clinical outcome of these patients. We performed an external validation of the potential biomarkers CLU, ITGB3, CAPG, and PRAME to determine if the expression levels are relevant to use as prognostic factors.</p> <p>Methods</p> <p>We analysed the gene expression of CLU, ITGB3, CAPG, and PRAME in 30 advanced staged serous adenocarcinomas with quantitative real-time polymerase chain reaction (QPCR) and the protein levels were analysed in 98 serous adenocarcinomas with western blot for semiquantitative analysis. Statistical differences in mRNA and protein expressions between tumours from survivors and tumours from deceased patients were evaluated using the Mann-Whitney U test.</p> <p>Results</p> <p>The gene and protein ITGB3 (Integrin beta 3) were significantly more expressed in tumours from survivors compared to tumours from deceased patients, which is in concordance with our previous results. However, no significant differences were detected for the other three genes or proteins CLU, CAPG, and PRAME.</p> <p>Conclusion</p> <p>The loss of ITGB3 expression in tumours from deceased patients and high expression in tumours from survivors could be used as a biomarker for patients with advanced serous tumours.</p

Tidally-induced thermonuclear Supernovae

We discuss the results of 3D simulations of tidal disruptions of white dwarfs by moderate-mass black holes as they may exist in the cores of globular clusters or dwarf galaxies. Our simulations follow self-consistently the hydrodynamic and nuclear evolution from the initial parabolic orbit over the disruption to the build-up of an accretion disk around the black hole. For strong enough encounters (pericentre distances smaller than about 1/3 of the tidal radius) the tidal compression is reversed by a shock and finally results in a thermonuclear explosion. These explosions are not restricted to progenitor masses close to the Chandrasekhar limit, we find exploding examples throughout the whole white dwarf mass range. There is, however, a restriction on the masses of the involved black holes: black holes more massive than $2\times 10^5$ M$_\odot$ swallow a typical 0.6 M$_\odot$ dwarf before their tidal forces can overwhelm the star's self-gravity. Therefore, this mechanism is characteristic for black holes of moderate masses. The material that remains bound to the black hole settles into an accretion disk and produces an X-ray flare close to the Eddington limit of $L_{\rm Edd} \simeq 10^{41} {\rm erg/s} M_{\rm bh}/1000 M$_\odot$), typically lasting for a few months. The combination of a peculiar thermonuclear supernova together with an X-ray flare thus whistle-blows the existence of such moderate-mass black holes. The next generation of wide field space-based instruments should be able to detect such events.Comment: 8 pages, 2 figures, EuroWD0

Avian Influenza Viruses in Wild Birds: Virus Evolution in a Multihost Ecosystem.

Wild ducks and gulls are the major reservoirs for avian influenza A viruses (AIVs). The mechanisms that drive AIV evolution are complex at sites where various duck and gull species from multiple flyways breed, winter, or stage. The Republic of Georgia is located at the intersection of three migratory flyways: the Central Asian flyway, the East Africa/West Asia flyway, and the Black Sea/Mediterranean flyway. For six complete study years (2010 to 2016), we collected AIV samples from various duck and gull species that breed, migrate, and overwinter in Georgia. We found a substantial subtype diversity of viruses that varied in prevalence from year to year. Low-pathogenic AIV (LPAIV) subtypes included H1N1, H2N3, H2N5, H2N7, H3N8, H4N2, H6N2, H7N3, H7N7, H9N1, H9N3, H10N4, H10N7, H11N1, H13N2, H13N6, H13N8, and H16N3, and two highly pathogenic AIVs (HPAIVs) belonging to clade 2.3.4.4, H5N5 and H5N8, were found. Whole-genome phylogenetic trees showed significant host species lineage restriction for nearly all gene segments and significant differences in observed reassortment rates, as defined by quantification of phylogenetic incongruence, and in nucleotide sequence diversity for LPAIVs among different host species. Hemagglutinin clade 2.3.4.4 H5N8 viruses, which circulated in Eurasia during 2014 and 2015, did not reassort, but analysis after their subsequent dissemination during 2016 and 2017 revealed reassortment in all gene segments except NP and NS. Some virus lineages appeared to be unrelated to AIVs in wild bird populations in other regions, with maintenance of local AIVs in Georgia, whereas other lineages showed considerable genetic interrelationships with viruses circulating in other parts of Eurasia and Africa, despite relative undersampling in the area.IMPORTANCE Waterbirds (e.g., gulls and ducks) are natural reservoirs of avian influenza viruses (AIVs) and have been shown to mediate the dispersal of AIVs at intercontinental scales during seasonal migration. The segmented genome of influenza viruses enables viral RNA from different lineages to mix or reassort when two viruses infect the same host. Such reassortant viruses have been identified in most major human influenza pandemics and several poultry outbreaks. Despite their importance, we have only recently begun to understand AIV evolution and reassortment in their natural host reservoirs. This comprehensive study illustrates AIV evolutionary dynamics within a multihost ecosystem at a stopover site where three major migratory flyways intersect. Our analysis of this ecosystem over a 6-year period provides a snapshot of how these viruses are linked to global AIV populations. Understanding the evolution of AIVs in the natural host is imperative to mitigating both the risk of incursion into domestic poultry and the potential risk to mammalian hosts, including humans