Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours

Item does not contain fulltextAIM: Gangliogliomas (GGs) and dysembryoplastic neuroepithelial tumours (DNTs) represent the most common histological entities within the spectrum of glioneuronal tumours (GNTs). The wide variability of morphological features complicates histological classification, including discrimination from prognostically distinct diffuse low-grade astrocytomas (AIIs). This study was performed to increase our understanding of these tumours. METHODS: We studied chromosomal copy number aberrations (CNAs) by genome-wide sequencing in a large cohort of GNTs and linked these to comprehensive histological analysis and clinical characteristics. One hundred fourteen GNTs were studied: 50 GGs and 64 DNTs. Also, a data set of CNAs from 38 diffuse AIIs was included. RESULTS: The most frequent CNAs in both GGs and DNTs were gains at chromosomes 5 and 7, often concurrent, and gain at chromosome 6. None of the CNAs was linked to histological subtype, immunohistochemical features or to clinical characteristics. Comparison of AIIs and diffuse GNTs revealed that gain at whole chromosome 5 is only observed in GNTs. CNA patterns indicative of chromothripsis were detected in three GNTs. CONCLUSION: We conclude that GNTs with diverse morphologies share molecular features, and our findings support the need to improve classification and differential diagnosis of tumour entities within the spectrum of GNTs, as well as their distinction from other gliomas

A 3D view of dwarf galaxies with Gaia and VLT/FLAMES. I. The Sculptor dwarf spheroidal

International audienceWe present a new homogeneous survey of VLT/FLAMES LR8 line-of-sight radial velocities (vlos) for 1604 resolved red giant branch stars in the Sculptor dwarf spheroidal galaxy. In addition, we provide reliable Ca II triplet metallicities, [Fe/H], for 1339 of these stars. From this combination of new observations (2257 individual spectra) with ESO archival data (2389 spectra), we obtain the largest and most complete sample of vlos and [Fe/H] measurements for individual stars in any dwarf galaxy. Our sample includes VLT/FLAMES LR8 spectra for ∼55% of the red giant branch stars at G 70% of the brightest stars, G < 18.75. Our spectroscopic velocities are combined with Gaia DR3 proper motions and parallax measurements for a new and more precise membership analysis. We look again at the global characteristics of Sculptor, deriving a mean metallicity of ⟨[Fe/H]⟩ = −1.82 ± 0.45 and a mean line-of-sight velocity of ⟨vlos⟩ = + 111.2 ± 0.25 km s−1. There is a clear metallicity gradient in Sculptor, −0.7deg dex−1, with the most metal-rich population being the most centrally concentrated. Furthermore, the most metal-poor population in Sculptor, [Fe/H]< − 2.5, appears to show kinematic properties distinct from the rest of the stellar population. Finally, we combine our results with the exquisite Gaia DR3 multi-colour photometry to further investigate the colour-magnitude diagram of the resolved stellar population in Sculptor. Our detailed analysis shows a similar global picture as previous studies, but with much more precise detail, revealing that Sculptor has more complex properties than previously thought. This survey emphasises the role of the stellar spectroscopy technique and this galaxy as a benchmark system for modelling galaxy formation and evolution on small scales

A 3D view of dwarf galaxies with

We present a new homogeneous survey of VLT/FLAMES LR8 line-of-sight radial velocities (vlos) for 1604 resolved red giant branch stars in the Sculptor dwarf spheroidal galaxy. In addition, we provide reliable Ca II triplet metallicities, [Fe/H], for 1339 of these stars. From this combination of new observations (2257 individual spectra) with ESO archival data (2389 spectra), we obtain the largest and most complete sample of vlos and [Fe/H] measurements for individual stars in any dwarf galaxy. Our sample includes VLT/FLAMES LR8 spectra for ∼55% of the red giant branch stars at G  70% of the brightest stars, G < 18.75. Our spectroscopic velocities are combined with Gaia DR3 proper motions and parallax measurements for a new and more precise membership analysis. We look again at the global characteristics of Sculptor, deriving a mean metallicity of ⟨[Fe/H]⟩ = −1.82 ± 0.45 and a mean line-of-sight velocity of ⟨vlos⟩ = + 111.2 ± 0.25 km s−1. There is a clear metallicity gradient in Sculptor, −0.7deg dex−1, with the most metal-rich population being the most centrally concentrated. Furthermore, the most metal-poor population in Sculptor, [Fe/H]<  − 2.5, appears to show kinematic properties distinct from the rest of the stellar population. Finally, we combine our results with the exquisite Gaia DR3 multi-colour photometry to further investigate the colour-magnitude diagram of the resolved stellar population in Sculptor. Our detailed analysis shows a similar global picture as previous studies, but with much more precise detail, revealing that Sculptor has more complex properties than previously thought. This survey emphasises the role of the stellar spectroscopy technique and this galaxy as a benchmark system for modelling galaxy formation and evolution on small scales

Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours

Aim: Gangliogliomas (GGs) and dysembryoplastic neuroepithelial tumours (DNTs) represent the most common histological entities within the spectrum of glioneuronal tumours (GNTs). The wide variability of morphological features complicates histological classification, including discrimination from prognostically distinct diffuse low-grade astrocytomas (AIIs). This study was performed to increase our understanding of these tumours. Methods: We studied chromosomal copy number aberrations (CNAs) by genome-wide sequencing in a large cohort of GNTs and linked these to comprehensive histological analysis and clinical characteristics. One hundred fourteen GNTs were studied: 50 GGs and 64 DNTs. Also, a data set of CNAs from 38 diffuse AIIs was included. Results: The most frequent CNAs in both GGs and DNTs were gains at chromosomes 5 and 7, often concurrent, and gain at chromosome 6. None of the CNAs was linked to histological subtype, immunohistochemical features or to clinical characteristics. Comparison of AIIs and diffuse GNTs revealed that gain at whole chromosome 5 is only observed in GNTs. CNA patterns indicative of chromothripsis were detected in three GNTs. Conclusion: We conclude that GNTs with diverse morphologies share molecular features, and our findings support the need to improve classification and differential diagnosis of tumour entities within the spectrum of GNTs, as well as their distinction from other gliomas