Síguense diez estudios del grupo CIM

Este trabajo se enmarca en el proyecto Cancionero, Romancero y Fuentes Impresas del Ministerio de Economía, Industria y Competitividad (FFI2017-86313-P), financiado por la Agencia Estatal de Investigación (AEI) y el Fondo Europeo de Desarrollo Regional (FEDER), cuyo investigador principal es Josep Lluís Martos

Leyendo los Quarenta cantos de Alonso de Fuentes: materialidad y estructura de la editio princeps de 1550

En 1550 fue impresa en Sevilla, en el taller de Dominico de Robertis, la primera edición de los Quarenta cantos de diuersas y peregrinas historias, declarados y moralizados por el magnifico cauallero Alonso de Fuentes. El estudio de la materialidad y de la estructura de la editio princeps de 1550, a partir de tres ejemplares conservados —dos de la BNE de Madrid y uno de la BnF de París—, lleva a interrogar las tensiones observables entre las obligaciones sociales, la moda del Romancero, el gusto por la Historia, las ambiciones culturales y los imperativos de la fe. Detrás de la evidencia de una forma simbólicamente armoniosa que prioriza la Biblia, el examen de la estructura de los Quarenta cantos revela desequilibrios a favor de la historia romana, y las imperfecciones materiales denuncian cierta urgencia, la de ofrecer al público culto de Sevilla de mediados del siglo xvi, un producto editorial capaz de promover el ya antiguo pero muy de moda «canto o romance», como fuente de una reflexión histórica y moral.En 1550 fut imprimée à Séville, dans l’atelier de Dominico de Robertis, la première édition des Quarenta cantos de diuersas y peregrinas historias, declarados y moralizados por el magnifico cauallero Alonso de Fuentes. L’étude de la matérialité et de la structure de l’editio princeps de 1550, à partir des trois exemplaires conservés —deux de la BNE de Madrid et un de la Bnf de Paris—, conduit à interroger les tensions observables entre les obligations sociales, la mode du Romancero, le goût pour l’Histoire, les ambitions culturelles et les impératifs de la foi. Au-delà de l’évidence d’une forme symboliquement harmonieuse qui fait de la Bible une priorité, l’examen de la structure des Quarenta cantos révèle des déséquilibres en faveur de l’histoire romaine. Les imperfections matérielles dénoncent par ailleurs une forme d’urgence, celle d’offrir au public cultivé de la Séville du milieu du xvie siècle un produit éditorial capable de promouvoir le chant ou romance, déjà ancien, mais très à la mode, comme source d’une réflexion à la fois historique et morale.In 1550 was printed in Seville, by Dominico de Robertis, the first edition of the Quarenta cantos de diuersas y peregrinas historias, declarados y moralizados por el magnifico cauallero Alonso de Fuentes. The analysis of the materiality and structure of the editio princeps of 1550, based on three preserved copies —two from the BNE in Madrid and one from the BnF in Paris— leads to questioning the observable tensions between social obligations, Romancero fashion, taste for History, cultural ambitions and imperatives of faith. Behind the evidence of a symbolically harmonious form that prioritizes the Bible, the examination of the structure of the Quarenta cantos reveals imbalances in favor of Roman history, and the material imperfections denounce a certain urgency, that of offering to the cultured public of mid-16th century Seville, an editorial product capable of promoting the already old but very fashionable «canto o romance», as a source for an historical and moral reflection.Este trabajo se enmarca en el proyecto Cancionero, Romancero y Fuentes Impresas del Ministerio de Economía, Industria y Competitividad (FFI2017-86313-P), financiado por la Agencia Estatal de Investigación (AEI) y el Fondo Europeo de Desarrollo Regional (FEDER), cuyo investigador principal es Josep Lluís Martos

Changes in cerebral vascular reactivity and structure following prolonged exposure to high altitude in humans.

Although high-altitude exposure can lead to neurocognitive impairment, even upon return to sea level, it remains unclear the extent to which brain volume and regional cerebral vascular reactivity (CVR) are altered following high-altitude exposure. The purpose of this study was to simultaneously determine the effect of 3 weeks at 5050 m on: (1) structural brain alterations; and (2) regional CVR after returning to sea level for 1 week. Healthy human volunteers (n = 6) underwent baseline and follow-up structural and functional magnetic resonance imaging (MRI) at rest and during a CVR protocol (end-tidal PCO2 reduced by -10, -5 and increased by +5, +10, and +15 mmHg from baseline). CVR maps (% mmHg(-1)) were generated using BOLD MRI and brain volumes were estimated. Following return to sea level, whole-brain volume and gray matter volume was reduced by 0.4 ± 0.3% (P < 0.01) and 2.6 ± 1.0% (P < 0.001), respectively; white matter was unchanged. Global gray matter CVR and white matter CVR were unchanged following return to sea level, but CVR was selectively increased (P < 0.05) in the brainstem (+30 ± 12%), hippocampus (+12 ± 3%), and thalamus (+10 ± 3%). These changes were the result of improvement and/or reversal of negative CVR to positive CVR in these regions. Three weeks of high-altitude exposure is reflected in loss of gray matter volume and improvements in negative CVR

Dos muertos y ningun difunto :comedia en dos actos

Representada por primera vez en el Teatro de la Cruz, el día 24 de diciembre de 1843Copia digital. Madrid : Ministerio de Cultura. Dirección General del Libro, Archivos y Bibliotecas, 2010Pie de imprenta tomado del colofónSign.:1-2(4º)Texto a dos col.Colección de comedias representadas con éxito en los Teatros de Madri

Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation

Research detailing the normal vascular adaptions to high altitude is minimal and often confounded by pathology (e.g. chronic mountain sickness) and methodological issues. We examined vascular function and structure in: (1) healthy lowlanders during acute hypoxia and prolonged ( 2 weeks) exposure to high altitude, and (2) high-altitude natives at 5050 m (highlanders). In 12 healthy lowlanders (aged 32 ± 7 years) and 12 highlanders(Sherpa; 33 ± 14 years) we assessed brachial endothelium-dependent flow-mediated dilatation(FMD), endothelium-independent dilatation (via glyceryl trinitrate; GTN), common carotid intima–media thickness (CIMT) and diameter (ultrasound), and arterial stiffness via pulse wave velocity (PWV; applanation tonometry). Cephalic venous biomarkers of free radical-mediated lipid peroxidation (lipid hydroperoxides, LOOH), nitrite (NO2 –) and lipid soluble antioxidants were also obtained at rest. In lowlanders, measurements were performed at sea level (334 m) and between days 3–4 (acute high altitude) and 12–14 (chronic high altitude) following arrival to 5050 m. Highlanders were assessed once at 5050 m. Compared with sea level, acute high altitude reduced lowlanders’ FMD (7.9 ± 0.4 vs. 6.8 ± 0.4%; P = 0.004) and GTN-induced dilatation (16.6 ± 0.9 vs. 14.5 ± 0.8%; P = 0.006), and raised central PWV (6.0 ± 0.2 vs. 6.6 ± 0.3 m s−1; P = 0.001). These changes persisted at days 12–14, and after allometricallyscaling FMD to adjust for altered baseline diameter. Compared to lowlanders at sea level and high altitude, highlanders had a lower carotid wall:lumen ratio ( 19%, P 0.04), attributable to a narrower CIMT and wider lumen. Although both LOOH and NO2 – increased with high altitude in lowlanders, only LOOH correlated with the reduction in GTN-induced dilatation evident during acute (n = 11, r=−0.53) and chronic (n = 7, r=−0.69; P 0.01) exposure to 5050 m. In a follow-up, placebo-controlled experiment (n=11 healthy lowlanders) conducted in a normobaric hypoxic chamber (inspiredO2 fraction (FIO2 )=0.11; 6 h), a sustained reduction in FMD was evident within 1 h of hypoxic exposure when compared to normoxic baseline (5.7±1.6 vs. 8.0 ±1.3%; P < 0.01); this decline in FMD was largely reversed following α1-adrenoreceptor blockade. In conclusion, high-altitude exposure in lowlanders caused persistent impairment in vascular function, which was mediated partially via oxidative stress and sympathoexcitation. Although a lifetime of high-altitude exposure neither intensifies nor attenuates the impairments seen with short-term exposure, chronic high-altitude exposure appears to be associated with arterial remodelling

Cocoa-flavanols enhance moderate-intensity pulmonary [Formula: see text] kinetics but not exercise tolerance in sedentary middle-aged adults.

INTRODUCTION: Cocoa flavanols (CF) may exert health benefits through their potent vasodilatory effects, which are perpetuated by elevations in nitric oxide (NO) bioavailability. These vasodilatory effects may contribute to improved delivery of blood and oxygen (O2) to exercising muscle. PURPOSE: Therefore, the objective of this study was to examine how CF supplementation impacts pulmonary O2 uptake ([Formula: see text]) kinetics and exercise tolerance in sedentary middle-aged adults. METHODS: We employed a double-blind cross-over, placebo-controlled design whereby 17 participants (11 male, 6 female; mean ± SD, 45 ± 6 years) randomly received either 7 days of daily CF (400 mg) or placebo (PL) supplementation. On day 7, participants completed a series of 'step' moderate- and severe-intensity exercise tests for the determination of [Formula: see text] kinetics. RESULTS: During moderate-intensity exercise, the time constant of the phase II [Formula: see text] kinetics ([Formula: see text]) was decreased by 15% in CF as compared to PL (mean ± SD; PL 40 ± 12 s vs. CF 34 ± 9 s, P = 0.019), with no differences in the amplitude of [Formula: see text] (A[Formula: see text]; PL 0.77 ± 0.32 l min-1 vs. CF 0.79 ± 0.34 l min-1, P = 0.263). However, during severe-intensity exercise, [Formula: see text], the amplitude of the slow component ([Formula: see text]) and exercise tolerance (PL 435 ± 58 s vs. CF 424 ± 47 s, P = 0.480) were unchanged between conditions. CONCLUSION: Our data show that acute CF supplementation enhanced [Formula: see text] kinetics during moderate-, but not severe-intensity exercise in middle-aged participants. These novel effects of CFs, in this demographic, may contribute to improved tolerance of moderate-activity physical activities, which appear commonly present in daily life. TRIAL REGISTRATION: Registered under ClinicalTrials.gov Identifier no. NCT04370353, 30/04/20 retrospectively registered

Vers une renégociation de l'Accord économique commercial et global entre l'Union européenne et le Canada

National audience[No abstract