Appreciating the power of words and imaginative organizing: A triadic model of ethics practiced in everyday conversations

This thesis provides an alternative framework to analyze power and ethics practiced in everyday conversations, which constitute processes of organizing. Drawing upon narrative frameworks, the analyses of messages posted on an online message board demonstrate people’s imaginative capacity to create relevant stories, in respect of their precise grasp of factual understandings, contextual relevance and evaluative/moral appropriateness, by appropriating others’ words. Based on the empirical analyses, the thesis indicates that studies on power and ethics in organizations can be re-oriented towards appreciating irremediable power imbalances by offering alternative ways of member’s denoting experiences of power

Investigating the mode of action of Bacillus subtilis C-3102 probiotic.

Bacillus probiotics have been utilized to improve body weight gain or feed conversion ratio in poultry production since 1970s, however, the mechanisms of action of Bacillus probiotics are not well delineated. Two major pathways were hypothesized; a direct pathway mediated by probiotic organism and an indirect pathway mediated via modified host intestinal microbiota. Two new gnotobiotic experimental systems were developed to differentiate these pathways. Firstly, the direct hypothesis was accessed by combination of in ovo inoculation and sterilized individual HEPA-filtered containers. Bacillus subtilis C-3102 spores (BS) were delivered to amniotic fluid at E17 by in ovo inoculation. Vegetative growth and mono-association by BS was observed at hatch. Multiple direct effects were observed including modified body and organ weight as well inflammation, barrier function, and nutrient digestion gene expression. The response to mono-association with other bacteria, including Enterococcus faecalis (ENT03), Lactobacillus salivarius (LCT01), Escherichia coli (ECL01 and ECL02), Bacteroides fragilis (BCT06), and Clostridium butyricum (CLS01), representing taxonomic families dominant in chicken were also investigated. Live but not heat-killed E.coli inoculation were lethal before E20. Other strains demonstrated variation in colonization density, and intestinal gene expression of inflammation and barrier function. Mixture of 5 bacterial species, Simplified Microbiota (SM) inoculant, were administered to 1-day-old germ-free birds in HEPA-filtered isolators. In 2 of 4 isolators, irradiated feed was supplemented with BS. At 14 day of age, culture of intestinal contents demonstrated colonization with all SM species without contamination. Vegetative BS was observed in BS supplemented SM birds associated with reduced abundance of ECL01 and ENT01. BS reduced relative organ weight, increased digestion and nutrient transport gene expression. Observations suggest probiotic actions of B. subtilis in broilers result from both direct and indirect mechanisms. Direct mechanisms increasing digestive and absorptive capacity are supported by observations in ovo and in SM model. Colonization patterns observed in SM model suggest competitive reduction of E.faecalis and E.coli, may be indirect mechanisms. The in ovo and SM models developed here to simplify the intestinal microbial environment were demonstrated to aid in the differentiation of direct and indirect mechanisms of action of gut modifiers such as probiotic bacteria

肝細胞癌患者におけるGlypican-3陽性循環腫瘍細胞の臨床的意義

広島大学(Hiroshima University)博士(医学)Doctor of Philosophy in Medical Sciencedoctora

MEASUREMENTS OF THE TERMINAL VELOCITY OF RELATIVELY COARSE PARTICLES

ArticleJournal of the Faculty of Textile Science and Technology, Shinshu University. Ser. B, Engineering 21: 1-9(1991)departmental bulletin pape

Prediction of Performance Penalty due to Pump-Signal Overlap in Raman-amplified Systems

We present an efficient numerical model to predict the performance penalty induced by Rayleigh backscattered light arising from counter-propagating pumps in Ramanamplified ultra-wide-band transmission systems. The model is validated through comparison with experimental findings

HAPTEN-SPECIFIC IgE ANTIBODY RESPONSES IN MICE : II. COOPERATIVE INTERACTIONS BETWEEN ADOPTIVELY TRANSFERRED T AND B LYMPHOCYTES IN THE DEVELOPMENT OF IgE RESPONSE

The present studies have established conditions for the demonstration of cooperative interactions between specific T and B lymphocyte populations in the development of IgE antibody responses in vivo in mice. This has been accomplished by utilizing a system which permits the successful adoptive transfer to irradiated recipients of DNP-specific secondary IgE responses with spleen cells from suitably primed syngeneic donor mice. Thus, adoptively transferred DNP-KLH or DNP-ASC-primed spleen cells produced high levels of anti-DNP antibodies of both IgE and IgG antibody classes in response to challenge with the appropriate homologous priming conjugate but failed to develop more than meager responses to the reciprocal heterologous conjugate. However, when spleen cells from donors primed to the second carrier were concomitantly transferred with hapten-primed lymphocytes, secondary IgE ant-DNP responses were consistently obtained upon challenge with the heterologous conjugate. Moreover, we have been able to elicit augmented primary IgE anti-DNP antibody responses to either DNP-ASC or DNP-KLH after adoptive transfer of spleen cells from donors primed only to the carrier, ASC or KLH, respectively. This adoptive transfer system has enabled us to provide direct proof for the participation of θ-bearing T lymphocytes in antibody responses of the IgE class. Thus, the capacity of ASC-primed spleen cells to effectively cooperate with the DNP-KLH-primed lymphocytes in the adoptive secondary response to DNP-ASC could be abolished by in vitro treatment of such cells with anti-θ serum plus complement. This was true not only for the anti-DNP response of the IgG antibody class, but for the IgE antibody class as well. These studies have, furthermore, demonstrated the capacity to stimulate secondary anti-DNP antibody production in vivo by the concomitant administration of the DNP and relevant carrier determinants on separate molecules. This was more readily seen in the IgE than in the IgG antibody class. Thus, DNP-ASC-primed cells developed significant IgE, but more variable IgG, anti-DNP responses upon challenge with DNP-KLH plus unconjugated ASC. Antibody responses of both classes elicited in this manner were appreciably improved by the transfer of additional carrier (ASC)-primed cells. These and other results presented herein suggest that IgE B lymphocyte precursors may be inherently more sensitive than IgG B cells to at least certain of the functions of T lymphocytes concerned with regulatory mechanisms involved in antibody production