Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Measurement of D s ^± production asymmetry in pp collisions at √s=7 and 8 TeV

The inclusive $D_s^{\pm}$ production asymmetry is measured in $pp$ collisions collected by the LHCb experiment at centre-of-mass energies of $\sqrt{s} =7$ and 8 TeV. Promptly produced $D_s^{\pm}$ mesons are used, which decay as $D_s^{\pm}\to\phi\pi^{\pm}$, with $\phi\to K^+K^-$. The measurement is performed in bins of transverse momentum, $p_{\rm T}$, and rapidity, $y$, covering the range $2.5<p_{\rm T}<25.0$ GeV$/c$ and $2.0<y<4.5$. No kinematic dependence is observed. Evidence of nonzero $D_s^{\pm}$ production asymmetry is found with a significance of 3.3 standard deviations.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2018-010.htm

Search for CP violation in Λb0→pK− and Λb0→pπ− decays

A search for CP violation in Λb0→pK− and Λb0→pπ− decays is presented using a sample of pp collisions collected with the LHCb detector and corresponding to an integrated luminosity of 3.0fb−1. The CP -violating asymmetries are measured to be ACPpK−=−0.020±0.013±0.019 and ACPpπ−=−0.035±0.017±0.020, and their difference ACPpK−−ACPpπ−=0.014±0.022±0.010, where the first uncertainties are statistical and the second systematic. These are the most precise measurements of such asymmetries to date

Observation of Two New Excited Ξb0 States Decaying to Λb0 K-π+

Two narrow resonant states are observed in the Λb0K-π+ mass spectrum using a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the LHCb experiment and corresponding to an integrated luminosity of 6 fb-1. The minimal quark content of the Λb0K-π+ system indicates that these are excited Ξb0 baryons. The masses of the Ξb(6327)0 and Ξb(6333)0 states are m[Ξb(6327)0]=6327.28-0.21+0.23±0.12±0.24 and m[Ξb(6333)0]=6332.69-0.18+0.17±0.03±0.22 MeV, respectively, with a mass splitting of Δm=5.41-0.27+0.26±0.12 MeV, where the uncertainties are statistical, systematic, and due to the Λb0 mass measurement. The measured natural widths of these states are consistent with zero, with upper limits of Γ[Ξb(6327)0]&lt;2.20(2.56) and Γ[Ξb(6333)0]&lt;1.60(1.92) MeV at a 90% (95%) credibility level. The significance of the two-peak hypothesis is larger than nine (five) Gaussian standard deviations compared to the no-peak (one-peak) hypothesis. The masses, widths, and resonant structure of the new states are in good agreement with the expectations for a doublet of 1D Ξb0 resonances

Model-independent measurement of mixing parameters in D0 → K S 0 π+π− decays

The first model-independent measurement of the charm mixing parameters in the decay D 0 → K S 0 π + π − is reported, using a sample of pp collision data recorded by the LHCb experiment, corresponding to an integrated luminosity of 1.0 fb−1 at a centre-of-mass energy of 7 TeV. The measured values are x=(−0.86±0.53±0.17)×10−2,y=(+0.03±0.46±0.13)×10−2, x=(−0.86±0.53±0.17)×10−2,y=(+0.03±0.46±0.13)×10−2, where the first uncertainties are statistical and include small contributions due to the external input for the strong phase measured by the CLEO collaboration, and the second uncertainties are systematic

First experimental study of photon polarization in radiative B-s(0) decays

The polarization of photons produced in radiative B0s decays is studied for the first time. The data are recorded by the LHCb experiment in pp collisions corresponding to an integrated luminosity of 3  fb−1 at center-of-mass energies of 7 and 8 TeV. A time-dependent analysis of the B0s→ϕγ decay rate is conducted to determine the parameter AΔ, which is related to the ratio of right- over left-handed photon polarization amplitudes in b→sγ transitions. A value of AΔ=−0.98+0.46−0.52+0.23−0.20 is measured. This result is consistent with the standard model prediction within 2 standard deviations

Measurement of CPCP asymmetry in Bs0→Ds∓K±B_s^0 \to D_s^{\mp} K^{\pm} decays

We report the measurements of the $CP$-violating parameters in $B_s^0 \to D_s^{\mp} K^{\pm}$ decays observed in $pp$ collisions, using a data set corresponding to an integrated luminosity of $3.0\,\text{fb}^{-1}$ recorded with the LHCb detector. We measure $C_f = 0.73 \pm 0.14 \pm 0.05$, $A^{\Delta \Gamma}_f = 0.39 \pm 0.28 \pm 0.15$, $A^{\Delta \Gamma}_{\overline{f}} = 0.31 \pm 0.28 \pm 0.15$, $S_f = -0.52 \pm 0.20 \pm 0.07$, $S_{\overline{f}} = -0.49 \pm 0.20 \pm 0.07$, where the uncertainties are statistical and systematic, respectively. These parameters are used together with the world-average value of the $B_s^0$ mixing phase, $-2\beta_s$, to obtain a measurement of the CKM angle $\gamma$ from $B_s^0 \to D_s^{\mp} K^{\pm}$ decays, yielding \gamma = (128\,_{-22}^{+17})^\circ modulo $180^\circ$, where the uncertainty contains both statistical and systematic contributions. This corresponds to $3.8\,\sigma$ evidence for $CP$ violation in the interference between decay and decay after mixing.We report the measurements of the CP -violating parameters in B$_{s}^{0}$  → D$_{s}^{∓}$ K$^{±}$ decays observed in pp collisions, using a data set corresponding to an integrated luminosity of 3.0 fb$^{−1}$ recorded with the LHCb detector. We measure C$_{f}$ = 0.73 ± 0.14 ± 0.05, A$_{f}^{ΔΓ}$  = 0.39 ± 0.28 ± 0.15, ${A}_{\overline{f}}^{\varDelta \varGamma }=0.31\pm 0.28\pm 0.15$ , S$_{f}$ = −0.52 ± 0.20 ± 0.07, ${S}_{\overline{f}}=-0.49\pm 0.20\pm 0.07$ , where the uncertainties are statistical and systematic, respectively. These parameters are used together with the world-average value of the B$_{s}^{0}$ mixing phase, −2β$_{s}$ , to obtain a measurement of the CKM angle γ from B$_{s}^{0}$  → D$_{s}^{∓}$ K$^{±}$ decays, yielding γ = (128$_{− 22}^{+ 17}$ )° modulo 180°, where the uncertainty contains both statistical and systematic contributions. This corresponds to 3.8 σ evidence for CP violation in the interference between decay and decay after mixing

Measurement of the electron reconstruction efficiency at LHCb

The single electron track-reconstruction efficiency is calibrated using a sample corresponding to 1.3 fb−1 of pp collision data recorded with the LHCb detector in 2017. This measurement exploits B+→ J/ψ(e+e−)K+ decays, where one of the electrons is fully reconstructed and paired with the kaon, while the other electron is reconstructed using only the information of the vertex detector. Despite this partial reconstruction, kinematic and geometric constraints allow the B meson mass to be reconstructed and the signal to be well separated from backgrounds. This in turn allows the electron reconstruction efficiency to be measured by matching the partial track segment found in the vertex detector to tracks found by LHCb's regular reconstruction algorithms. The agreement between data and simulation is evaluated, and corrections are derived for simulated electrons in bins of kinematics. These correction factors allow LHCb to measure branching fractions involving single electrons with a systematic uncertainty below 1%