Tratamiento de la hipercolesterolemia con inhibidores de la PCSK9 en receptores de trasplante cardiaco: primera experiencia en España

Carta científic

Numerical Simulation of Debris Flows of the Catastrophic Event of February 2019 in Mirave – Peru

Debris flows are geophysical phenomena, caused by torrential rain, which occur in mountainous areas, characterized by the detachment of slope and riverbed materials and their consequent dislodge through watersheds and streams. Debris flows usually carry sludge, water and rocks, and can destroy everything in their path. On February 8th, 2019, an event of this type occurred and destroyed Mirave’s community in Peru, which was located in the areas of transport and deposition of debris flows. This research presents the modeling and numerical simulation to reproduce the transport and deposition processes of the debris flow that occurred in Mirave. The initiation process of the debris flow in streams was represented by hydrographs obtained from the estimated rain runoff volumes and solid materials found at each evaluated micro watershed. The numerical simulation results show acceptable results in terms of reproduction of the extension of the affectation and deposition areas of solids related to the studied debris flow. The resulting velocity field shows an adequate representation of the erosion zones observed in the area. The model used for evaluating the disaster risk by debris flows can predict and delimit, with acceptable accuracy, the potentially dangerous areas for a mudslide event. The application of the proposed methodology for assessing the disaster risk due to debris flows at watersheds and streams is useful to understand the extent of debris flow affectation during extreme weather events, as well as to develop emergency plans, and to formulate disaster management policies in Peru or in other countries with similar conditions.Os fluxos de detritos são fenômenos geofísicos provocados por chuvas torrenciais, que ocorrem em áreas montanhosas, e se caracterizam pelo desprendimento de materiais de declives e de leitos de rios e seu consequente arraste água abaixo através de bacias e córregos. Os fluxos de detritos carregam consigo, em geral, lodo, água e rochas, e podem destruir tudo o que está em seu caminho. No dia 8 de fevereiro de 2019 ocorreu um evento deste tipo que destruiu a comunidade de Mirave, no Peru, que estava localizada nas áreas de trânsito e deposição dos fluxos de detritos. Esta pesquisa apresenta a modelagem e simulação numérica para reproduzir os processos de iniciação e deposição de fluxos de detritos ocorrido em Mirave. O processo de iniciação dos fluxos de detritos nos desfiladeiros foi representado por hidrogramas obtidos a partir dos volumes estimados de escoamento de água da chuva e materiais sólidos encontrados em cada microbacia avaliada. Os resultados das simulações numéricas mostram resultados aceitáveis em termos de reprodução da extensão do impacto nas áreas de deposição de sólidos relacionados ao fluxo de detritos estudado. O campo de velocidades resultantes mostra uma adequada representação das zonas de erosão observadas in loco. O modelo usado para a avaliação do risco de desastres por fluxos de detritos é capaz de prever e delimitar, com uma aproximação aceitável, as áreas potencialmente perigosas para um evento de deslizamento de terra com um período de retorno determinado. A aplicação da metodologia proposta para avaliação do risco de desastres devido aos fluxos de detritos, a bacias e riachos, é útil para entender a extensão dos impactos gerados pelos fluxos de detritos durante eventos climáticos extremos, bem como para o desenvolvimento de planos de emergência e formulação de políticas de gestão de desastres no Peru

SQL injection attack detection in network flow data

[EN] SQL injections rank in the OWASP Top 3. The literature shows that analyzing network datagrams allows for detecting or preventing such attacks. Unfortunately, such detection usually implies studying all packets flowing in a computer network. Therefore, routers in charge of routing significant traffic loads usually cannot apply the solutions proposed in the literature. This work demonstrates that detecting SQL injection attacks on flow data from lightweight protocols is possible. For this purpose, we gathered two datasets collecting flow data from several SQL injection attacks on the most popular database engines. After evaluating several machine learning-based algorithms, we get a detection rate of over 97% with a false alarm rate of less than 0.07% with a Logistic Regression-based model.SIInstituto Nacional de Ciberseguridad de España (INCIBE)Universidad de Leó

Biogenerated polymers: an enviromental alternative

Bio-generated polymers are generally of great interest for Industry, due to the tendency of reducing the use of materials derived from oil. Nonetheless, its development costs are high and the benefit is still too low. Nowadays, in about ten percent of the plastic market, there are biodegradable alternatives available for bio-generated polymers. Its consumption is estimated at 50.000 tons per year in Europe, with an inferior amount of 1%; in this regard, the main objective of this review is to expose the relevance of bio-generated polymer production in the manufacturing of biodegradable materials, from its formulation, which contains macromolecules of natural origin such as oligomers o monomers. With this goal, some topics will be examined related to several types of bio generated polymers, such as chitosan, starch, polybutylene succyanate, and polylactic acid, which have been used in the development of bio generated polymer materials by different research groups.En general los polímeros biogenerados son de gran interés para la industria, debido a la tendencia a reducir el uso de materiales derivados del petróleo. Sin embargo, sus costos de desarrollo son altos y el beneficio es todavía bajo. En la actualidad, se dispone de alternativas biodegradables de polímeros biogenerados en aproximadamente el 10% del mercado de plásticos. Su consumo se estima en 50.000 ton/año en Europa, con una cuota inferior al 1%. En este orden de ideas, el objetivo de esta revisión es mostrar la importancia de la producción de polímeros biogenerados en la fabricación de materiales biodegradables, a partir de su formulación que contiene macromoléculas de origen natural como oligómeros o monómeros. Con este fin, examinaremos temas relacionados con varios tipos de polímeros biogenerados, como el quitosano, el almidón, el succinato de polibutileno y el ácido poliláctico, que han sido utilizados para el desarrollo de materiales poliméricos biogenerados por diferentes grupos de investigació

Una estación de AEMET para estudiar el frío en el Parque Nacional de Ordesa y Monte Perdido

Ponencia presentada en: XXXIV Jornadas Científicas de la AME y el XVII Encuentro Hispano Luso de Meteorología celebrado en Teruel, del 29 de febrero al 2 de marzo de 2016

Multiple roles of integrin-α3 at the neuromuscular junction

The neuromuscular junction (NMJ) is the synapse between motoneurons and skeletal muscle, and is responsible for eliciting muscle contraction. Neurotransmission at synapses depends on the release of synaptic vesicles at sites called active zones (AZs). Various proteins of the extracellular matrix are crucial for NMJ development; however, little is known about the identity and functions of the receptors that mediate their effects. Using genetically modified mice, we find that integrin-α3 (encoded by Itga3), an adhesion receptor at the presynaptic membrane, is involved in the localisation of AZ components and efficient synaptic vesicle release. Integrin-α3 also regulates integrity of the synapse – mutant NMJs present with progressive structural changes and upregulated autophagy, features commonly observed during ageing and in models of neurodegeneration. Unexpectedly, we find instances of nerve terminal detachment from the muscle fibre; to our knowledge, this is the first report of a receptor that is required for the physical anchorage of pre- and postsynaptic elements at the NMJ. These results demonstrate multiple roles of integrin-α3 at the NMJ, and suggest that alterations in its function could underlie defects that occur in neurodegeneration or ageing

Búsqueda de empleo activo y mejora de la empleabilidad en el Grado en Educación Social

El desarrollo de este trabajo tiene como objetivo mejorar la tasa de empleabilidad de los egresados en el Grado en Educación Social de la Universidad Complutense de Madrid, así como la búsqueda de empleo activo, al proporcionar diferentes recursos y estrategias y crear redes y espacios de diálogo con las asociaciones profesionales del sector. Parte de la necesidad del fomento de la inserción laboral y el emprendimiento entre los estudiantes, el desarrollo de la orientación laboral como una herramienta básica para el estudio y el análisis del fortalecimiento del empleo para educadores sociales y la búsqueda activa del mismo. Igualmente, se apoya en postulados y paradigmas como el de educación para el bien común y sostenible, en un marco de educación permanente, humanista y con vocación para la transformación social

Common genetic variation in KATNAL1 non-coding regions is involved in the susceptibility to severe phenotypes of male infertility

Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546047/Background: Previous studies in animal models evidenced that genetic mutations of KATNAL1, resulting in dysfunction of its encoded protein, lead to male infertility through disruption of microtubule remodelling and premature germ cell exfoliation. Subsequent studies in humans also suggested a possible role of KATNAL1 single nucleotide polymorphisms in the development of male infertility as a consequence of severe spermatogenic failure. Objectives: The main objective of the present study is to evaluate the effect of the common genetic variation of KATNAL1 in a large and phenotypically well-characterised cohort of infertile men because of severe spermatogenic failure. Materials and methods: A total of 715 infertile men because of severe spermato genic failure, including 210 severe oligospermia and 505 non-obstructive azoospermia patients, as well as 1058 unaffected controls were genotyped for three KATNAL1 single-nucleotide polymorphism taggers (rs2077011, rs7338931 and rs2149971). Case–control association analyses by logistic regression assuming different models and in silico functional characterisation of risk variants were conducted. Results: Genetic associations were observed between the three analysed taggers and different severe spermatogenic failure groups. However, in all cases, the haplotype model (rs2077011*C | rs7338931*T | rs2149971*A) better explained the observed associations than the three risk alleles independently. This haplotype was associated with non-obstructive azoospermia (adjusted p = 4.96E-02, odds ratio = 2.97), Sertoli cell only syndrome (adjusted p = 2.83E-02, odds ratio = 5.16) and testicular sperm extraction unsuccessful outcomes (adjusted p = 8.99E-04, odds ratio = 6.13). The in silico analyses indicated that the effect on severe spermatogenic failure predisposition could be because of an alteration of the KATNAL1 splicing pattern. Conclusions: Specific allelic combinations of KATNAL1 genetic polymorphisms may confer a risk of developing severe male infertility phenotypes by favouring the overrepresentation of a short non-functional transcript isoform in the testis.This work was supported by the Spanish Ministry of Economy and Competitiveness through the Spanish National Plan for Scientific and Technical Research and Innovation (refs. SAF2016-78722-R and PID2020-120157RB-I00), the ‘Instituto de Salud Carlos III’ (Fondo de Investigaciones Sanitarias)/Fondo Europeo de Desarrollo Regional ‘Una manera de hacer Europa’ (FIS/FEDER) (ref. DTS18/00101 to Sara Larriba), the Generalitat de Catalunya (ref. 2017SGR191), the ‘Ramón y Cajal’ program (ref. RYC-2014-16458) and the ‘Juan de la Cierva Incorporación’ program (ref. IJC2018-038026-I), as well as the Andalusian Government through the R&D&i Projects Grants for Universities and Public Research Entities (ref. PY20_00212), which include FEDER funds. Andrea Guzmán-Jiménez was a recipient of a grant from the Spanish Ministry of Education and Professional Training (‘Becas de Colaboración en Departamentos Universitarios para el curso académico 2020/2021’). Patricia I. Marques is supported by the FCT post-doctoral fellowship (SFRH/BPD/120777/2016), financed from the Portuguese State Budget of the Ministry for Science, Tech nology and High Education and from the European Social Fund, available through the ‘Programa Operacional do Capital Humano’. João Gonçalves was partially funded by FCT/MCTES through national funds attributed to the Centre for Toxicogenomics and Human Health— ToxOmics (UID/BIM/00009/2016 and UIDB/00009/2020). Sara Larriba is sponsored by the Researchers Consolidation Program (ISCIII SNS/Dpt. Salut Generalitat de Catalunya) (CES09/020).info:eu-repo/semantics/publishedVersio

Common genetic variation in KATNAL1 non‐coding regions is involved in the susceptibility to severe phenotypes of male infertility

© 2022 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Background: Previous studies in animal models evidenced that genetic mutations of KATNAL1, resulting in dysfunction of its encoded protein, lead to male infertility through disruption of microtubule remodelling and premature germ cell exfoliation. Subsequent studies in humans also suggested a possible role of KATNAL1 single-nucleotide polymorphisms in the development of male infertility as a consequence of severe spermatogenic failure. Objectives: The main objective of the present study is to evaluate the effect of the common genetic variation of KATNAL1 in a large and phenotypically well-characterised cohort of infertile men because of severe spermatogenic failure. Materials and methods: A total of 715 infertile men because of severe spermatogenic failure, including 210 severe oligospermia and 505 non-obstructive azoospermia patients, as well as 1058 unaffected controls were genotyped for three KATNAL1 single-nucleotide polymorphism taggers (rs2077011, rs7338931 and rs2149971). Case-control association analyses by logistic regression assuming different models and in silico functional characterisation of risk variants were conducted. Results: Genetic associations were observed between the three analysed taggers and different severe spermatogenic failure groups. However, in all cases, the haplotype model (rs2077011*C | rs7338931*T | rs2149971*A) better explained the observed associations than the three risk alleles independently. This haplotype was associated with non-obstructive azoospermia (adjusted p = 4.96E-02, odds ratio = 2.97), Sertoli-cell only syndrome (adjusted p = 2.83E-02, odds ratio = 5.16) and testicular sperm extraction unsuccessful outcomes (adjusted p = 8.99E-04, odds ratio = 6.13). The in silico analyses indicated that the effect on severe spermatogenic failure predisposition could be because of an alteration of the KATNAL1 splicing pattern. Conclusions: Specific allelic combinations of KATNAL1 genetic polymorphisms may confer a risk of developing severe male infertility phenotypes by favouring the overrepresentation of a short non-functional transcript isoform in the testis.This work was supported by the Spanish Ministry of Economy and Competitiveness through the Spanish National Plan for Scientific and Technical Research and Innovation (refs. SAF2016-78722-R and PID2020-120157RB-I00), the ‘Instituto de Salud Carlos III’ (Fondo de Investigaciones Sanitarias)/Fondo Europeo de Desarrollo Regional ‘Una manera de hacer Europa’ (FIS/FEDER) (ref. DTS18/00101 to Sara Larriba), the Generalitat de Catalunya (ref. 2017SGR191), the ‘Ramón y Cajal’ program (ref. RYC-2014-16458) and the ‘Juan de la Cierva Incorporación’ program (ref. IJC2018-038026-I), as well as the Andalusian Government through the R&D&i Projects Grants for Universities and Public Research Entities (ref. PY20_00212), which include FEDER funds. Andrea Guzmán-Jiménez was a recipient of a grant from the Spanish Ministry of Education and Professional Training (‘Becas de Colaboración en Departamentos Universitarios para el curso académico 2020/2021’). Patricia I. Marques is supported by the FCT post-doctoral fellowship (SFRH/BPD/120777/2016), financed from the Portuguese State Budget of the Ministry for Science, Technology and High Education and from the European Social Fund, available through the ‘Programa Operacional do Capital Humano’. João Gonçalves was partially funded by FCT/MCTES through national funds attributed to the Centre for Toxicogenomics and Human Health—ToxOmics (UID/BIM/00009/2016 and UIDB/00009/2020). Sara Larriba is sponsored by the Researchers Consolidation Program (ISCIII SNS/Dpt. Salut Generalitat de Catalunya) (CES09/020).info:eu-repo/semantics/publishedVersio

Correlation of biocapping agents with cytotoxic effects of silver nanoparticles on human tumor cells

10.1039/C3RA41346BRSC Advances314329-1433