MARS: Exploiting Multi-Level Parallelism for DNN Workloads on Adaptive Multi-Accelerator Systems

Along with the fast evolution of deep neural networks, the hardware system is also developing rapidly. As a promising solution achieving high scalability and low manufacturing cost, multi-accelerator systems widely exist in data centers, cloud platforms, and SoCs. Thus, a challenging problem arises in multi-accelerator systems: selecting a proper combination of accelerators from available designs and searching for efficient DNN mapping strategies. To this end, we propose MARS, a novel mapping framework that can perform computation-aware accelerator selection, and apply communication-aware sharding strategies to maximize parallelism. Experimental results show that MARS can achieve 32.2% latency reduction on average for typical DNN workloads compared to the baseline, and 59.4% latency reduction on heterogeneous models compared to the corresponding state-of-the-art method.Comment: Accepted by 60th DA

Strategies for protein synthetic biology

Proteins are the most versatile among the various biological building blocks and a mature field of protein engineering has lead to many industrial and biomedical applications. But the strength of proteins—their versatility, dynamics and interactions—also complicates and hinders systems engineering. Therefore, the design of more sophisticated, multi-component protein systems appears to lag behind, in particular, when compared to the engineering of gene regulatory networks. Yet, synthetic biologists have started to tinker with the information flow through natural signaling networks or integrated protein switches. A successful strategy common to most of these experiments is their focus on modular interactions between protein domains or domains and peptide motifs. Such modular interaction swapping has rewired signaling in yeast, put mammalian cell morphology under the control of light, or increased the flux through a synthetic metabolic pathway. Based on this experience, we outline an engineering framework for the connection of reusable protein interaction devices into self-sufficient circuits. Such a framework should help to ‘refacture’ protein complexity into well-defined exchangeable devices for predictive engineering. We review the foundations and initial success stories of protein synthetic biology and discuss the challenges and promises on the way from protein- to protein systems design

Negative feedback regulation of the ERK1/2 MAPK pathway

The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signalling pathway regulates many cellular functions, including proliferation, differentiation, and transformation. To reliably convert external stimuli into specific cellular responses and to adapt to environmental circumstances, the pathway must be integrated into the overall signalling activity of the cell. Multiple mechanisms have evolved to perform this role. In this review, we will focus on negative feedback mechanisms and examine how they shape ERK1/2 MAPK signalling. We will first discuss the extensive number of negative feedback loops targeting the different components of the ERK1/2 MAPK cascade, specifically the direct posttranslational modification of pathway components by downstream protein kinases and the induction of de novo gene synthesis of specific pathway inhibitors. We will then evaluate how negative feedback modulates the spatiotemporal signalling dynamics of the ERK1/2 pathway regarding signalling amplitude and duration as well as subcellular localisation. Aberrant ERK1/2 activation results in deregulated proliferation and malignant transformation in model systems and is commonly observed in human tumours. Inhibition of the ERK1/2 pathway thus represents an attractive target for the treatment of malignant tumours with increased ERK1/2 activity. We will, therefore, discuss the effect of ERK1/2 MAPK feedback regulation on cancer treatment and how it contributes to reduced clinical efficacy of therapeutic agents and the development of drug resistance

The Drosophila melanogaster Genetic Reference Panel

A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of Drosophila genetics

Covert Communication for Integrated Satellite–Terrestrial Relay Networks with Cooperative Jamming

We explore the influence of cooperative jamming on covert communication for integrated satellite–terrestrial relay networks (ISTRN) in this article, where one full-duplex relay is utilized to support communications and acts as a jammer to confuse eavesdroppers. A cooperative scheme is first proposed to efficiently achieve covert communication in this specific scenario. Further, the probability of detection error (PDE) is derived. Subsequently, the minimum PDE is calculated using the optimal detection threshold. Moreover, a closed-form expression of outage probability (OP) is acquired to quantify the system’s covert performance. Based on this, we design a power optimization algorithm to enhance the effective covert rate under covertness constraints. Lastly, numerical simulation results are given to verify the efficiency of our cooperative jamming scheme when interrupting the eavesdroppers. Notably, an optimal power allocation factor can be obtained, leading to a higher effective covert rate

Covert Communication for Integrated Satellite–Terrestrial Relay Networks with Cooperative Jamming

We explore the influence of cooperative jamming on covert communication for integrated satellite–terrestrial relay networks (ISTRN) in this article, where one full-duplex relay is utilized to support communications and acts as a jammer to confuse eavesdroppers. A cooperative scheme is first proposed to efficiently achieve covert communication in this specific scenario. Further, the probability of detection error (PDE) is derived. Subsequently, the minimum PDE is calculated using the optimal detection threshold. Moreover, a closed-form expression of outage probability (OP) is acquired to quantify the system’s covert performance. Based on this, we design a power optimization algorithm to enhance the effective covert rate under covertness constraints. Lastly, numerical simulation results are given to verify the efficiency of our cooperative jamming scheme when interrupting the eavesdroppers. Notably, an optimal power allocation factor can be obtained, leading to a higher effective covert rate

Covert Performance for Integrated Satellite Multiple Terrestrial Relay Networks with Partial Relay Selection

Integrated satellite multiple terrestrial relay network (ISMTRN) is a new network architecture that combines satellite communication with terrestrial communication. It both utilizes the advantages of the two systems and overcomes their shortcomings. However, security issues inevitably arise in the ISMTRN resulting from the broad coverage of the satellite beams and the openness of wireless communication. One of the promising methods to achieve secure transmission is covert communication technology, which has been a hot discussion topic in recent years. In this paper, we investigate the performance of covert communication in the ISMTRN with partial relay selection. Particularly, when the satellite transmits its signal to the user, we consider the scenario that the selected relay opportunistically sends covert information to the destination. Furthermore, the closed-form error detection probability and average covert communication rate are derived. Finally, numerical simulation results are provided to reveal the impact of critical parameters on system covert performance

Hydrogen-bonded supramolecular adhesives: Synthesis, responsiveness, and application

Adhesive bonding to diverse substances is vital to a great number of the established, cutting-edge and emerging applications. We have witnessed, in the last few years, the transformative progress in achieving robust adhesive bonding and tunable debonding behavior, which mostly employing the supramolecular forces. Among the diverse supramolecular forces, the contribution of hydrogen-bonds (H-bonds) to adhesives, on the modality of directionality, selectivity and sensitivity, can function as nano-scaled bonding agents for improved interfacial interactions, thus paved novel perspectives to the design and creation of glue materials with outstanding performance. On account of the dynamic and reversible feature, a characteristic principally determined for H-bonding (macro)molecules could be employed as adhesive platform for affording outstanding attaching, connecting and on demand disconnecting, arising from the combination of adhesion/cohesion process via H-bonding interactions and the responsive characteristics. Thus, H-bonded adhesives with abundant diverse molecular configuration furnish a rich toolbox that can fulfill universal yet specific needs with unique advantages, demonstrating great opportunities for fundamental researches and practical applications. Herein we outline and summarize the design and creation of H-bonded adhesives, responsive attaching/detaching, and applications in advanced materials. We propose the guidance for further designing H-bonded adhesives, in concert with biomedical science, physics, mechanical and electric, informatics or robotics of promising future

Hydrogen‐Bonded Supramolecular Polymer Adhesives: Straightforward Synthesis and Strong Substrate Interaction

International audienceHigh-performance adhesives are of great interest in view of industrial demand. We herein identify a straightforward synthetic strategy towards universal hydrogen-bonded (H-bonded) polymeric adhesives, using a side-chain barbiturate (Ba) and Hamilton wedge (HW) functionalized copolymer. Starting from a rubbery copolymer containing thiolactone derivatives, Ba and HW moieties are tethered as pendant groups via an efficient one-pot two-step amine-thiol-bromo conjugation. Hetero-complementary Ba/HW interactions thus yield H-bonded supramolecular polymeric networks. In addition to an enhanced polymeric network integrity induced by specific Ba/HW association, the presence of individual Ba or HW moieties enables strong binding to a range of substrates, outstanding compared to commercial glues and reported adhesive