617 research outputs found
Evaluation of the therapeutic potential of ant-TLR4-antibody MTS510 in experimental stroke and significa of different routes of application
Toll-like receptors (TLRs) are central sensors for the inflammatory response in ischemia-reperfusion injury. We therefore investigated whether TLR4 inhibition could be used to treat stroke in a standard model of focal cerebral ischemia. Anti-TLR4/MD2-antibody (mAb clone MTS510) blocked TLR4-induced cell activation in vitro, as reported previously. Here, different routes of MTS510 application in vivo were used to study the effects on stroke outcome up to 2d after occlusion of the middle cerebral artery (MCAO) for 45 min in adult male C57Bl/6 wild-type mice. Improved neurological performance, reduced infarct volumes, and reduced brain swelling showed that intravascular application of MTS510 had a protective effect in the model of 45 min MCAO. Evaluation of potential long-term adverse effects of anti-TLR4-mAb-treament revealed no significant deleterious effect on infarct volumes nor neurological deficit after 14d of reperfusion in a mild model of stroke (15 min MCAO). Interestingly, inhibition of TLR4 resulted in an altered adaptive immune response at 48 hours after reperfusion. We conclude that blocking TLR4 by the use of specific mAb is a promising strategy for stroke therapy. However, long-term studies with increased functional sensitivity, larger sampling sizes and use of other species are required before a clinical use could be envisaged
Comparison of different exoplanet mass detection limit methods using a sample of main-sequence intermediate-type stars
The radial velocity (RV) technique is a powerful tool for detecting
extrasolar planets and deriving mass detection limits that are useful for
constraining planet pulsations and formation models. Detection limit methods
must take into account the temporal distribution of power of various origins in
the stellar signal. These methods must also be able to be applied to large
samples of stellar RV time series We describe new methods for providing
detection limits. We compute the detection limits for a sample of ten main
sequence stars, which are of G-F-A type, in general active, and/or with
detected planets, and various properties. We use them to compare the
performances of these methods with those of two other methods used in the
litterature. We obtained detection limits in the 2-1000 day period range for
ten stars. Two of the proposed methods, based on the correlation between
periodograms and the power in the periodogram of the RV time series in specific
period ranges, are robust and represent a significant improvement compared to a
method based on the root mean square of the RV signal. We conclude that two of
the new methods (correlation-based method and local power analysis, i.e. LPA,
method) provide robust detection limits, which are better than those provided
by methods that do not take into account the temporal sampling.Comment: 18 pages, 15 figures Accepted in Astronomy & Astrophysic
Assessing the ecological vulnerability of the shallow steppe Lake Neusiedl (Austria-Hungary) to climate-driven hydrological changes using a palaeolimnological approach
9openInternationalBothLake Neusiedl, the largest steppe lake in Europe, is particularly sensitive to climate variations due to its extreme shallowness (zmax = 1.8 m) and low ratio of catchment to lake area (3.5 : 1). Changes in water budget, salinity and turbidity have key implications for the lake’s ecology and management. Here, we present a multi-proxy palaeolimnological reconstruction of the evolution of Lake Neusiedl since the end of its last complete desiccation (1865–1868), based on an undisturbed radiometrically dated core taken from the open water portion of the lake. Geochemical and biological (algal) proxies outline the succession of three major ecological stages since 1873 ± 16 yrs, with the first major changes appearing already in the 1930s as driven by climate related hydrological variability. Subfossil diatoms proved to be reliable for tracking long-term changes in the trophic conditions of Lake Neusiedl while diatom-inferred lake conductivity revealed to be unreliable due to a combination of lake environmental settings and the absence of a site-specific training set. Nonetheless, multivariate statistical analyses and comparisons with limnological data confirm a great potential of subfossil diatoms for revealing past ecological changes and tipping points of shallow lakes, as long as studies rely on a multi-proxy approach. In agreement with limnological surveys, the sediment record corroborates the high vulnerability of Lake Neusiedl, both in present and past times, towards climate-driven changes in water level and salinity, and allows the prediction, by analogy with the past, of future ecological changes in a context of global warming and increasing nutrient inputs from non-point sources.openTolotti, M.; Guella, G.; Herzig, A.; Rodeghiero, M.; Rose, N.L.; Soja, G.; Zechmeister, T.; Yang, H.; Teubner, K.Tolotti, M.; Guella, G.; Herzig, A.; Rodeghiero, M.; Rose, N.L.; Soja, G.; Zechmeister, T.; Yang, H.; Teubner, K
Long-lived, long-period radial velocity variations in Aldebaran: A planetary companion and stellar activity
We investigate the nature of the long-period radial velocity variations in
Alpha Tau first reported over 20 years ago. We analyzed precise stellar radial
velocity measurements for Alpha Tau spanning over 30 years. An examination of
the Halpha and Ca II 8662 spectral lines, and Hipparcos photometry was also
done to help discern the nature of the long-period radial velocity variations.
Our radial velocity data show that the long-period, low amplitude radial
velocity variations are long-lived and coherent. Furthermore, Halpha equivalent
width measurements and Hipparcos photometry show no significant variations with
this period. Another investigation of this star established that there was no
variability in the spectral line shapes with the radial velocity period. An
orbital solution results in a period of P = 628.96 +/- 0.90 d, eccentricity, e
= 0.10 +/- 0.05, and a radial velocity amplitude, K = 142.1 +/- 7.2 m/s.
Evolutionary tracks yield a stellar mass of 1.13 +/- 0.11 M_sun, which
corresponds to a minimum companion mass of 6.47 +/- 0.53 M_Jup with an orbital
semi-major axis of a = 1.46 +/- 0.27 AU. After removing the orbital motion of
the companion, an additional period of ~ 520 d is found in the radial velocity
data, but only in some time spans. A similar period is found in the variations
in the equivalent width of Halpha and Ca II. Variations at one-third of this
period are also found in the spectral line bisector measurements. The 520 d
period is interpreted as the rotation modulation by stellar surface structure.
Its presence, however, may not be long-lived, and it only appears in epochs of
the radial velocity data separated by 10 years. This might be due to an
activity cycle. The data presented here provide further evidence of a planetary
companion to Alpha Tau, as well as activity-related radial velocity variations.Comment: 18 pages, 14 figures. Accepted for publication in Astronomy and
Astrophysic
Humans store about 1.5 megabytes of information during language acquisition
We introduce theory-neutral estimates of the amount of information learners possess about how language works. We provide estimates at several levels of linguistic analysis: phonemes, wordforms, lexical semantics, word frequency and syntax. Our best guess is that the average English-speaking adult has learned 12.5 million bits of information, the majority of which is lexical semantics. Interestingly, very little of this information is syntactic, even in our upper bound analyses. Generally, our results suggest that learners possess remarkable inferential mechanisms capable of extracting, on average, nearly 2000 bits of information about how language works each day for 18 years
The quest for companions to post-common envelope binaries: III. A reexamination of HW Virginis
We report new mid-eclipse times of the short-period sdB/dM binary HW Vir,
which differ substantially from the times predicted by a previous model. The
proposed orbits of the two planets in that model are found to be unstable. We
present a new secularly stable solution, which involves two companions orbiting
HW VIr with periods of 12.7 yr and 55 +/-15 yr. For orbits coplanar with the
binary, the inner companion is a giant planet with mass M_3 sin i_3 = 14 M_Jup
and the outer one a brown dwarf or low-mass star with a mass of M_4 sin i_4 =
30-120 M_Jup. Using the mercury6 code, we find that such a system would be
stable over more than 10^7 yr, in spite of the sizeable interaction. Our model
fits the observed eclipse-time variations by the light-travel time effect
alone, without invoking any additional process, thereby providing support for
the planetary hypothesis of the eclipse-time variations in close binaries. The
signature of non-Keplerian orbits may be visible in the data.Comment: accepted by A&
Amplitudes and lifetimes of solar-like oscillations observed by CoRoT* Red-giant versus main-sequence stars
Context. The advent of space-borne missions such as CoRoT or Kepler providing
photometric data has brought new possibilities for asteroseismology across the
H-R diagram. Solar-like oscillations are now observed in many stars, including
red giants and main- sequence stars. Aims. Based on several hundred identified
pulsating red giants, we aim to characterize their oscillation amplitudes and
widths. These observables are compared with those of main-sequence stars in
order to test trends and scaling laws for these parameters for both
main-sequence stars and red giants. Methods. An automated fitting procedure is
used to analyze several hundred Fourier spectra. For each star, a modeled
spectrum is fitted to the observed oscillation spectrum, and mode parameters
are derived. Results. Amplitudes and widths of red-giant solar-like
oscillations are estimated for several hundred modes of oscillation. Amplitudes
are relatively high (several hundred ppm) and widths relatively small (very few
tenths of a {\mu}Hz). Conclusions. Widths measured in main-sequence stars show
a different variation with the effective temperature than red giants. A single
scaling law is derived for mode amplitudes of both red giants and main-sequence
stars versus their luminosity to mass ratio. However, our results suggest that
two regimes may also be compatible with the observations.Comment: Accepted in A&A on 2011 February 8th, now includes corrections
(results now more precise on \Gamma and A_max in Section 4.3 and 4.4, fig. 7
corrected consequently
Detection of frequency spacings in the young O-type binary HD 46149 from CoRoT photometry
Using the CoRoT space based photometry of the O-type binary HD46149, stellar
atmospheric effects related to rotation can be separated from pulsations,
because they leave distinct signatures in the light curve. This offers the
possibility of characterising and exploiting any pulsations seismologically.
Combining high-quality space based photometry, multi-wavelength photometry,
spectroscopy and constraints imposed by binarity and cluster membership, the
detected pulsations in HD46149 are analyzed and compared with those for a grid
of stellar evolutionary models in a proof-of-concept approach. We present
evidence of solar-like oscillations in a massive O-type star, and show that the
observed frequency range and spacings are compatible with theoretical
predictions. Thus, we unlock and confirm the strong potential of this
seismically unexplored region in the HR diagram.Comment: 11 pages, 12 figures, accepted for publication in A&
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