Evaluation of the therapeutic potential of ant-TLR4-antibody MTS510 in experimental stroke and significa of different routes of application

Toll-like receptors (TLRs) are central sensors for the inflammatory response in ischemia-reperfusion injury. We therefore investigated whether TLR4 inhibition could be used to treat stroke in a standard model of focal cerebral ischemia. Anti-TLR4/MD2-antibody (mAb clone MTS510) blocked TLR4-induced cell activation in vitro, as reported previously. Here, different routes of MTS510 application in vivo were used to study the effects on stroke outcome up to 2d after occlusion of the middle cerebral artery (MCAO) for 45 min in adult male C57Bl/6 wild-type mice. Improved neurological performance, reduced infarct volumes, and reduced brain swelling showed that intravascular application of MTS510 had a protective effect in the model of 45 min MCAO. Evaluation of potential long-term adverse effects of anti-TLR4-mAb-treament revealed no significant deleterious effect on infarct volumes nor neurological deficit after 14d of reperfusion in a mild model of stroke (15 min MCAO). Interestingly, inhibition of TLR4 resulted in an altered adaptive immune response at 48 hours after reperfusion. We conclude that blocking TLR4 by the use of specific mAb is a promising strategy for stroke therapy. However, long-term studies with increased functional sensitivity, larger sampling sizes and use of other species are required before a clinical use could be envisaged

Comparison of different exoplanet mass detection limit methods using a sample of main-sequence intermediate-type stars

The radial velocity (RV) technique is a powerful tool for detecting extrasolar planets and deriving mass detection limits that are useful for constraining planet pulsations and formation models. Detection limit methods must take into account the temporal distribution of power of various origins in the stellar signal. These methods must also be able to be applied to large samples of stellar RV time series We describe new methods for providing detection limits. We compute the detection limits for a sample of ten main sequence stars, which are of G-F-A type, in general active, and/or with detected planets, and various properties. We use them to compare the performances of these methods with those of two other methods used in the litterature. We obtained detection limits in the 2-1000 day period range for ten stars. Two of the proposed methods, based on the correlation between periodograms and the power in the periodogram of the RV time series in specific period ranges, are robust and represent a significant improvement compared to a method based on the root mean square of the RV signal. We conclude that two of the new methods (correlation-based method and local power analysis, i.e. LPA, method) provide robust detection limits, which are better than those provided by methods that do not take into account the temporal sampling.Comment: 18 pages, 15 figures Accepted in Astronomy & Astrophysic

Assessing the ecological vulnerability of the shallow steppe Lake Neusiedl (Austria-Hungary) to climate-driven hydrological changes using a palaeolimnological approach

9openInternationalBothLake Neusiedl, the largest steppe lake in Europe, is particularly sensitive to climate variations due to its extreme shallowness (zmax = 1.8 m) and low ratio of catchment to lake area (3.5 : 1). Changes in water budget, salinity and turbidity have key implications for the lake’s ecology and management. Here, we present a multi-proxy palaeolimnological reconstruction of the evolution of Lake Neusiedl since the end of its last complete desiccation (1865–1868), based on an undisturbed radiometrically dated core taken from the open water portion of the lake. Geochemical and biological (algal) proxies outline the succession of three major ecological stages since 1873 ± 16 yrs, with the first major changes appearing already in the 1930s as driven by climate related hydrological variability. Subfossil diatoms proved to be reliable for tracking long-term changes in the trophic conditions of Lake Neusiedl while diatom-inferred lake conductivity revealed to be unreliable due to a combination of lake environmental settings and the absence of a site-specific training set. Nonetheless, multivariate statistical analyses and comparisons with limnological data confirm a great potential of subfossil diatoms for revealing past ecological changes and tipping points of shallow lakes, as long as studies rely on a multi-proxy approach. In agreement with limnological surveys, the sediment record corroborates the high vulnerability of Lake Neusiedl, both in present and past times, towards climate-driven changes in water level and salinity, and allows the prediction, by analogy with the past, of future ecological changes in a context of global warming and increasing nutrient inputs from non-point sources.openTolotti, M.; Guella, G.; Herzig, A.; Rodeghiero, M.; Rose, N.L.; Soja, G.; Zechmeister, T.; Yang, H.; Teubner, K.Tolotti, M.; Guella, G.; Herzig, A.; Rodeghiero, M.; Rose, N.L.; Soja, G.; Zechmeister, T.; Yang, H.; Teubner, K

Long-lived, long-period radial velocity variations in Aldebaran: A planetary companion and stellar activity

We investigate the nature of the long-period radial velocity variations in Alpha Tau first reported over 20 years ago. We analyzed precise stellar radial velocity measurements for Alpha Tau spanning over 30 years. An examination of the Halpha and Ca II 8662 spectral lines, and Hipparcos photometry was also done to help discern the nature of the long-period radial velocity variations. Our radial velocity data show that the long-period, low amplitude radial velocity variations are long-lived and coherent. Furthermore, Halpha equivalent width measurements and Hipparcos photometry show no significant variations with this period. Another investigation of this star established that there was no variability in the spectral line shapes with the radial velocity period. An orbital solution results in a period of P = 628.96 +/- 0.90 d, eccentricity, e = 0.10 +/- 0.05, and a radial velocity amplitude, K = 142.1 +/- 7.2 m/s. Evolutionary tracks yield a stellar mass of 1.13 +/- 0.11 M_sun, which corresponds to a minimum companion mass of 6.47 +/- 0.53 M_Jup with an orbital semi-major axis of a = 1.46 +/- 0.27 AU. After removing the orbital motion of the companion, an additional period of ~ 520 d is found in the radial velocity data, but only in some time spans. A similar period is found in the variations in the equivalent width of Halpha and Ca II. Variations at one-third of this period are also found in the spectral line bisector measurements. The 520 d period is interpreted as the rotation modulation by stellar surface structure. Its presence, however, may not be long-lived, and it only appears in epochs of the radial velocity data separated by $\sim$ 10 years. This might be due to an activity cycle. The data presented here provide further evidence of a planetary companion to Alpha Tau, as well as activity-related radial velocity variations.Comment: 18 pages, 14 figures. Accepted for publication in Astronomy and Astrophysic

Humans store about 1.5 megabytes of information during language acquisition

We introduce theory-neutral estimates of the amount of information learners possess about how language works. We provide estimates at several levels of linguistic analysis: phonemes, wordforms, lexical semantics, word frequency and syntax. Our best guess is that the average English-speaking adult has learned 12.5 million bits of information, the majority of which is lexical semantics. Interestingly, very little of this information is syntactic, even in our upper bound analyses. Generally, our results suggest that learners possess remarkable inferential mechanisms capable of extracting, on average, nearly 2000 bits of information about how language works each day for 18 years

The quest for companions to post-common envelope binaries: III. A reexamination of HW Virginis

We report new mid-eclipse times of the short-period sdB/dM binary HW Vir, which differ substantially from the times predicted by a previous model. The proposed orbits of the two planets in that model are found to be unstable. We present a new secularly stable solution, which involves two companions orbiting HW VIr with periods of 12.7 yr and 55 +/-15 yr. For orbits coplanar with the binary, the inner companion is a giant planet with mass M_3 sin i_3 = 14 M_Jup and the outer one a brown dwarf or low-mass star with a mass of M_4 sin i_4 = 30-120 M_Jup. Using the mercury6 code, we find that such a system would be stable over more than 10^7 yr, in spite of the sizeable interaction. Our model fits the observed eclipse-time variations by the light-travel time effect alone, without invoking any additional process, thereby providing support for the planetary hypothesis of the eclipse-time variations in close binaries. The signature of non-Keplerian orbits may be visible in the data.Comment: accepted by A&

Amplitudes and lifetimes of solar-like oscillations observed by CoRoT* Red-giant versus main-sequence stars

Context. The advent of space-borne missions such as CoRoT or Kepler providing photometric data has brought new possibilities for asteroseismology across the H-R diagram. Solar-like oscillations are now observed in many stars, including red giants and main- sequence stars. Aims. Based on several hundred identified pulsating red giants, we aim to characterize their oscillation amplitudes and widths. These observables are compared with those of main-sequence stars in order to test trends and scaling laws for these parameters for both main-sequence stars and red giants. Methods. An automated fitting procedure is used to analyze several hundred Fourier spectra. For each star, a modeled spectrum is fitted to the observed oscillation spectrum, and mode parameters are derived. Results. Amplitudes and widths of red-giant solar-like oscillations are estimated for several hundred modes of oscillation. Amplitudes are relatively high (several hundred ppm) and widths relatively small (very few tenths of a {\mu}Hz). Conclusions. Widths measured in main-sequence stars show a different variation with the effective temperature than red giants. A single scaling law is derived for mode amplitudes of both red giants and main-sequence stars versus their luminosity to mass ratio. However, our results suggest that two regimes may also be compatible with the observations.Comment: Accepted in A&A on 2011 February 8th, now includes corrections (results now more precise on \Gamma and A_max in Section 4.3 and 4.4, fig. 7 corrected consequently

Detection of frequency spacings in the young O-type binary HD 46149 from CoRoT photometry

Using the CoRoT space based photometry of the O-type binary HD46149, stellar atmospheric effects related to rotation can be separated from pulsations, because they leave distinct signatures in the light curve. This offers the possibility of characterising and exploiting any pulsations seismologically. Combining high-quality space based photometry, multi-wavelength photometry, spectroscopy and constraints imposed by binarity and cluster membership, the detected pulsations in HD46149 are analyzed and compared with those for a grid of stellar evolutionary models in a proof-of-concept approach. We present evidence of solar-like oscillations in a massive O-type star, and show that the observed frequency range and spacings are compatible with theoretical predictions. Thus, we unlock and confirm the strong potential of this seismically unexplored region in the HR diagram.Comment: 11 pages, 12 figures, accepted for publication in A&