1,000 research outputs found
DESIGN, SYNTHESIS, CHARACTERIZATION OF SOME NEW SUBSTITUTED CHALCONES AND STUDIES THEIR ANTIMICROBIAL ACTIVITIES
Eight designed chalcones, named [1(p-benzenesulphonamidophenyl)-3-p-chloro-2-propene-1-one][2], [1(p-benzenesulphonamidophenyl)-3-p-nitro-2-propene-1-one][3], [1(4-Ureido)phenyl-3-p-chlorophenyl-2-propene-1-one][5], [1(4-Ureido)phenyl-3-p-nitroophenyl-2-propene-1-one][6], [1(4(p-N-methylaminophenyl)azophenyl-3-p-chlorophenyl-2-propene-1-one][8], [1(4(p-N-methylaminophenyl)azophenyl-3-p-nitroophenyl-2-propene-1-one][9], [1(p-aminophenyl)-3-p-chlorophenyl-2-propene-1-one][10] and [1(p-aminophenyl)-3-p-nitrophenyl-2-propene-1-one][11], were synthesised by condensation of synthesised p-acetylphenylbenzene- sulphonamide, p-acetylphenylurea and p-acetyl-p'-(N-methylamino)azobenzene, with p-chlorobenzaldehyde and p nitrobenzaldehyde in basic media respectively.
All synthesised compounds are characterized by its melting points, FTIR, 1H NMR, 13C NMR and Mass spectral analysis.
All synthesised compounds are examined their antimicrobial activities against Gram-Ve bactria (Serratia marcescens, Pseudmonas aeroginosa) and Gram+Ve bacterial (Stphylococcus aureus, Streptococcus pyogenes), and Candida albicans fungi.
Result showed good to moderate inhibition effect against some bacteria and fungi, in comparison with some pharmaceutical antibiotic and antifungal treatments like Cephalexin, Amoxicillin, Tetracycline, Lincomycine, Nystatine and Fluconazole respectively
Implementasi Kewenangan Diskresi Kepolisian Dalam Penyelesaian Perkara Kecelakaan Lalu Lintas Di Luar Pengadilan (Studi Di Polresta Malang),
Dalam penulisan skripsi ini penulis membahas tentang Implementasi Kewenangan Diskresi Kepolisian dalam Penyelesaian Perkara Kecelakaan Lalu Lintas Di Luar Pengadilan (Studi di Polresta Malang). Hal ini dilatarbelakangi dengan masih tingginya angka kecelakaan lalu lintas khususnya di Kota Malang baik yang mengakibatkan korban meninggal dunia, luka berat maupun luka ringan. Anggota Polresta Malang dalam menyelesaikan perkara kecelakaan lalu lintas tidak jarang menggunakan jalur penyelesaian di luar pengadilan sebagai perwujudan dari diskresi kepolisian. Ada kriteria-kriteria tertentu penggunaan diskresi kepolisian dalam menyelesaikan perkara kecelakaan lalu lintas di luar pengadilan. Penelitian ini disusun untuk mengetahui dan menganalisis kriteria kepolisian dalam menggunakan kewenangan diskresi dalam penyelesaian perkara kecelakaan lalu lintas di luar pengadilan dan implementasinya di Polresta Malang. Dalam upaya mengetahui lebih lanjut kriteria kepolisian dalam menggunakan kewenangan diskresi dalam penyelesaian perkara kecelakaan lalu lintas di luar pengadilan dan implementasinya di Polresta Malang, maka digunakan metode pendekatan yuridis sosiologis. Penelitian dilakukan terhadap keadaan nyata di masyarakat dengan maksud dan tujuan untuk menemukan fakta kemudian mengidentifikasi masalah, dan pada akhirnya memperoleh penyelesaian masalah. Hasil data penelitian tersebut diolah dan dianalisis secara diskriptif analisis. Berdasarkan hasil penelitian, penulis memperoleh jawaban dari permasalahan yang ada bahwa anggota Polresta Malang dalam menggunakan kewenangan diskresi dalam penyelesaian perkara kecelakaan lalu lintas di luar pengadilan berdasarkan dua kriteria, yaitu : Kecelakaan lalu lintas tersebut bukan merupakan tindak pidana kesengajaan serta adanya itikad baik dari pelaku dan korban kecelakaan lalu lintas untuk menyelesaikan perkara di luar pengadilan yang diwujudkan dalam surat kesepakatan perdamaian. Implementasi kewenangan diskresi kepolisian dalam penyelesaian perkara kecelakaan di luar pengadilan di Polresta Malang diwujudkan dengan diselesaikannya 140 perkara dari 222 perkara kecelakaan lalu lintas melalui perdamaian / jalur di luar pengadilan, ada dua mekanisme untuk menyelesaikan perkara kecelakaan di luar pengadilan yaitu sebelum diterbitkan laporan kepolisian dan sesudah diterbitkan laporan kepolisian, serta adanya faktor-faktor pendorong anggota kepolisian untuk menggunakan kewenangan diskresi dari ix internal kepolisian yaitu adanya peraturan yang menjamin tindakan diskresi kepolisian dan instruksi dari pihak pimpinan untuk menyelesaikan perkara kecelakaan di luar pengadilan serta faktor eksternal kepolisian yaitu dukungan dari tokoh masyarakat setempat dan budaya dari tempat tinggal korban untuk menyelesaikan perkara kecelakaan di luar pengadilan
Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
Background: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an
attempt to develop a formulation with accelerated wound healing effect, the present study was performed to examine in vivo efficacy of asiaticoside-rich hydrogel formulation in rabbits.
Methods: Asiaticoside-rich fraction was prepared from C. asiatica aerial part and then incorporated into polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogel. The hydrogel was subjected to wound healing investigation using the in vivo incision model.
Results: The results obtained demonstrated that: i) the hydrogel formulation did not cause any signs of irritation
on the rabbitsâ skin and; ii) enhanced wound healing 15% faster than the commercial cream and > 40% faster than the untreated wounds. The skin healing process was seen in all wounds marked by formation of a thick epithelial
layer, keratin, and moderate formation of granulation tissues, fibroblasts and collagen with no fibrinoid necrosis detected.
Conclusion: The asiaticoside-rich hydrogel developed using the freeze-thaw method was effective in accelerating wound healing in rabbit
Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
Background: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attempt to develop a formulation with accelerated wound healing effect, the present study was performed to examine in vivo efficacy of asiaticoside-rich hydrogel formulation in rabbits. Methods: Asiaticoside-rich fraction was prepared from C. asiatica aerial part and then incorporated into polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogel. The hydrogel was subjected to wound healing investigation using the in vivo incision model. Results: The results obtained demonstrated that: i) the hydrogel formulation did not cause any signs of irritation on the rabbitsâ skin and; ii) enhanced wound healing 15% faster than the commercial cream and > 40% faster than the untreated wounds. The skin healing process was seen in all wounds marked by formation of a thick epithelial layer, keratin, and moderate formation of granulation tissues, fibroblasts and collagen with no fibrinoid necrosis detected. Conclusion: The asiaticoside-rich hydrogel developed using the freeze-thaw method was effective in accelerating wound healing in rabbits
In vitro and In vivo wound healing studies of methanolic fraction of Centella asiatica extract
Ethnopharmacological relevance: Asiaticoside is claimed as a bioactive compound capable of wound healing. In order to ensure that the pharmacological activity of the extract is traceable and measurable, the present study attempted to evaluate the bioactivity of rich fractionated extract of asiaticoside. Aim of the study: The current study evaluates the wound healing efficacy via in vitro scratch assay and in vivo circular wound excision model. Materials and methods: The ethanol extract was fractionated into seven fractions via vacuum liquid chromatography. The compound of interest in the fractions was qualitatively identified using thin layer chromatography and the positive fraction containing asiaticoside was further quantified using reverse-phase HPLC. The asiaticoside-rich fraction was subjected to (i) colorimetric MTT (methylthiazoltetrazolium) cytotoxicity assay following incubation with human dermal fibroblast (HDF) and human dermal keratinocyte (HaCaT); (ii) in vitro 12-well plate scratch assay (using HDF and HaCaT cells) and (iii) topically apply (40%, 10% and 2.5%, w/w) on in vivo circular wound excision of rabbits. Data on wound contraction, epithelisation period, hydroxyproline content and histophatological analysis was collected from in vivo study. Results: The results showed that the methanol fraction of the extract contained about 2.4% asiaticoside. Based on the results of colorimetric MTT (methylthiazoltetrazolium) cytotoxicity assay, both HDF and HaCaT showed significant stimulation upon application of the methanolic fraction of extract at concentrations of 100 ÎŒg/mL and 0.19 ÎŒg/mL. The methanol fraction showed almost no toxicity effect at the concentrations tested since their IC50 could not be determined in concentrations ranging from 100 ÎŒg/mL to 0.19 ÎŒg/mL. Since all the concentrations tested allowed for more than 90% cell viability, the concentrations chosen for the scratch assay were randomly chosen and designated as highest (100 ÎŒg/mL), medium (6 ÎŒg/mL) and lowest (0.2 ÎŒg/mL) concentrations. In the scratch assay, methanol fraction of extract with concentration of 0.2 ÎŒg/mL and 100 ÎŒg/mL showed significant effect on HDF and HaCaT compared to the positive control (p < 0.05). In vivo, it was shown that the methanol fraction of the extract induced collagen synthesis. Histopathology data also concluded that dose-dependent effect of the tested extract as a wound healer was present. Conclusions: Taken together, recent findings suggest that methanol fraction of C. asiatica demonstrated remarkable polyvalent activity, and thus has potential as an effective wound healer. In conclusion, the claim of the presence of wound healing properties in C. asiatica had been well supported based on the results obtained in this study
Measurement of the Forward-Backward Asymmetry in the B -> K(*) mu+ mu- Decay and First Observation of the Bs -> phi mu+ mu- Decay
We reconstruct the rare decays , , and in a data sample
corresponding to collected in collisions at
by the CDF II detector at the Fermilab Tevatron
Collider. Using and decays we report the branching ratios. In addition, we report
the measurement of the differential branching ratio and the muon
forward-backward asymmetry in the and decay modes, and the
longitudinal polarization in the decay mode with respect to the squared
dimuon mass. These are consistent with the theoretical prediction from the
standard model, and most recent determinations from other experiments and of
comparable accuracy. We also report the first observation of the {\mathcal{B}}(B^0_s \to
\phi\mu^+\mu^-) = [1.44 \pm 0.33 \pm 0.46] \times 10^{-6}27 \pm 6B^0_s$ decay observed.Comment: 7 pages, 2 figures, 3 tables. Submitted to Phys. Rev. Let
Measurements of the properties of Lambda_c(2595), Lambda_c(2625), Sigma_c(2455), and Sigma_c(2520) baryons
We report measurements of the resonance properties of Lambda_c(2595)+ and
Lambda_c(2625)+ baryons in their decays to Lambda_c+ pi+ pi- as well as
Sigma_c(2455)++,0 and Sigma_c(2520)++,0 baryons in their decays to Lambda_c+
pi+/- final states. These measurements are performed using data corresponding
to 5.2/fb of integrated luminosity from ppbar collisions at sqrt(s) = 1.96 TeV,
collected with the CDF II detector at the Fermilab Tevatron. Exploiting the
largest available charmed baryon sample, we measure masses and decay widths
with uncertainties comparable to the world averages for Sigma_c states, and
significantly smaller uncertainties than the world averages for excited
Lambda_c+ states.Comment: added one reference and one table, changed order of figures, 17
pages, 15 figure
Search for a New Heavy Gauge Boson Wprime with Electron + missing ET Event Signature in ppbar collisions at sqrt(s)=1.96 TeV
We present a search for a new heavy charged vector boson decaying
to an electron-neutrino pair in collisions at a center-of-mass
energy of 1.96\unit{TeV}. The data were collected with the CDF II detector
and correspond to an integrated luminosity of 5.3\unit{fb}^{-1}. No
significant excess above the standard model expectation is observed and we set
upper limits on . Assuming standard
model couplings to fermions and the neutrino from the boson decay to
be light, we exclude a boson with mass less than
1.12\unit{TeV/}c^2 at the 95\unit{%} confidence level.Comment: 7 pages, 2 figures Submitted to PR
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