2,301 research outputs found
Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice
BACKGROUND/AIMS: Recent reports suggest that the adipose tissue and adipokines are potent modulators of inflammation. However, there is only scarce knowledge on the functional role and regulation of endogenous adiponectin in non-fat tissues such as the liver under conditions of acute inflammation.
METHODS: In the present study, we investigated adiponectin expression in healthy murine liver tissue and under inflammatory conditions in vivo.
RESULTS: Adiponectin mRNA was readily detectable in healthy liver tissue and further increased in ConA-mediated acute liver failure. Adiponectin protein expression was mainly found in hepatic endothelial cells. In vitro adiponectin mRNA expression was detectable in several cell types, including primary hepatic sinusoidal endothelial cells, stellate cells, and macrophages. Mice pretreated with adiponectin before ConA administration developed reduced hepatic injury as shown by decreased release of transaminases and reduced hepatocellular apoptotis. Of note, TNF-alpha levels were not affected by adiponectin, whereas IL-10 production was increased. Neutralisation of IL-10 diminished the protective effect of adiponectin.
CONCLUSIONS: Adiponectin expression is up-regulated in ConA-mediated acute liver failure. Therefore, adiponectin might play a role in the control and limitation of inflammation in the liver. Moreover, our data suggest a role for IL-10 in adiponectin-mediated hepatoprotection
Dust in the inner regions of debris disks around A stars
We present infrared interferometric observations of the inner regions of two
A-star debris disks, beta Leo and zeta Lep, using the FLUOR instrument at the
CHARA interferometer on both short (30 m) and long (>200 m) baselines. For the
target stars, the short baseline visibilities are lower than expected for the
stellar photosphere alone, while those of a check star, delta Leo, are not. We
interpret this visibility offset of a few percent as a near-infrared excess
arising from dust grains which, due to the instrumental field of view, must be
located within several AU of the central star. For beta Leo, the near-infrared
excess producing grains are spatially distinct from the dust which produces the
previously known mid-infrared excess. For zeta Lep, the near-infrared excess
may be spatially associated with the mid-infrared excess producing material. We
present simple geometric models which are consistent with the near and
mid-infrared excess and show that for both objects, the near-infrared producing
material is most consistent with a thin ring of dust near the sublimation
radius with typical grain sizes smaller than the nominal radiation pressure
blowout radius. Finally, we discuss possible origins of the near-infrared
emitting dust in the context of debris disk evolution models.Comment: 20 pages, 2 figures, to appear in the Astrophysical Journa
Evidence of a Precursor Superconducting Phase at Temperatures as High as 180 K in RBa₂Cu₃O<sub>7-δ</sub> (R=Y,Gd,Eu) Superconducting Crystals from Infrared Spectroscopy
We show that a multilayer analysis of the infrared c-axis response of RBa₂Cu₃O7-δ (R=Y,Gd,Eu) provides important new information about the anomalous normal-state properties of underdoped cuprate high temperature superconductors. In addition to competing correlations which give rise to a pseudogap that depletes the low-energy electronic states below T*≫Tc, it enables us to identify the onset of a precursor superconducting state below Tons>Tc. We map out the doping phase diagram of Tons which reaches a maximum of 180 K at strong underdoping and present magnetic field dependent data which confirm our conclusions
Formation and Evolution of Planetary Systems (FEPS): Properties of Debris Dust around Solar-type Stars
We present Spitzer photometric (IRAC and MIPS) and spectroscopic (IRS low
resolution) observations for 314 stars in the Formation and Evolution of
Planetary Systems (FEPS) Legacy program. These data are used to investigate the
properties and evolution of circumstellar dust around solar-type stars spanning
ages from approximately 3 Myr to 3 Gyr. We identify 46 sources that exhibit
excess infrared emission above the stellar photosphere at 24um, and 21 sources
with excesses at 70um. Five sources with an infrared excess have
characteristics of optically thick primordial disks, while the remaining
sources have properties akin to debris systems. The fraction of systems
exhibiting a 24um excess greater than 10.2% above the photosphere is 15% for
ages < 300 Myr and declines to 2.7% for older ages. The upper envelope to the
70um fractional luminosity appears to decline over a similar age range. The
characteristic temperature of the debris inferred from the IRS spectra range
between 60 and 180 K, with evidence for the presence of cooler dust to account
for the strength of the 70um excess emission. No strong correlation is found
between dust temperature and stellar age. Comparison of the observational data
with disk models containing a power-law distribution of silicate grains suggest
that the typical inner disk radius is > 10 AU. Although the interpretation is
not unique, the lack of excess emission shortwards of 16um and the relatively
flat distribution of the 24um excess for ages <300~Myr is consistent with
steady-state collisional models.Comment: 85 pages, 18 figures, 4 tables; accepted for publication in ApJ
Coordinated optimization of visual cortical maps (II) Numerical studies
It is an attractive hypothesis that the spatial structure of visual cortical
architecture can be explained by the coordinated optimization of multiple
visual cortical maps representing orientation preference (OP), ocular dominance
(OD), spatial frequency, or direction preference. In part (I) of this study we
defined a class of analytically tractable coordinated optimization models and
solved representative examples in which a spatially complex organization of the
orientation preference map is induced by inter-map interactions. We found that
attractor solutions near symmetry breaking threshold predict a highly ordered
map layout and require a substantial OD bias for OP pinwheel stabilization.
Here we examine in numerical simulations whether such models exhibit
biologically more realistic spatially irregular solutions at a finite distance
from threshold and when transients towards attractor states are considered. We
also examine whether model behavior qualitatively changes when the spatial
periodicities of the two maps are detuned and when considering more than 2
feature dimensions. Our numerical results support the view that neither minimal
energy states nor intermediate transient states of our coordinated optimization
models successfully explain the spatially irregular architecture of the visual
cortex. We discuss several alternative scenarios and additional factors that
may improve the agreement between model solutions and biological observations.Comment: 55 pages, 11 figures. arXiv admin note: substantial text overlap with
arXiv:1102.335
Water abundances in high-mass protostellar envelopes: Herschel observations with HIFI
We derive the dense core structure and the water abundance in four massive
star-forming regions which may help understand the earliest stages of massive
star formation. We present Herschel-HIFI observations of the para-H2O 1_11-0_00
and 2_02-1_11 and the para-H2-18O 1_11-0_00 transitions. The envelope
contribution to the line profiles is separated from contributions by outflows
and foreground clouds. The envelope contribution is modelled using Monte-Carlo
radiative transfer codes for dust and molecular lines (MC3D and RATRAN), with
the water abundance and the turbulent velocity width as free parameters. While
the outflows are mostly seen in emission in high-J lines, envelopes are seen in
absorption in ground-state lines, which are almost saturated. The derived water
abundances range from 5E-10 to 4E-8 in the outer envelopes. We detect cold
clouds surrounding the protostar envelope, thanks to the very high quality of
the Herschel-HIFI data and the unique ability of water to probe them. Several
foreground clouds are also detected along the line of sight. The low H2O
abundances in massive dense cores are in accordance with the expectation that
high densities and low temperatures lead to freeze-out of water on dust grains.
The spread in abundance values is not clearly linked to physical properties of
the sources.Comment: 8 pages, 5 figures, accepted for publication the 15/07/2010 by
Astronomy&Astrophysics as a letter in the Herschel-HIFI special issu
Water in massive star-forming regions: HIFI observations of W3 IRS5
We present Herschel observations of the water molecule in the massive
star-forming region W3 IRS5. The o-H17O 110-101, p-H18O 111-000, p-H2O 22
202-111, p-H2O 111-000, o-H2O 221-212, and o-H2O 212-101 lines, covering a
frequency range from 552 up to 1669 GHz, have been detected at high spectral
resolution with HIFI. The water lines in W3 IRS5 show well-defined
high-velocity wings that indicate a clear contribution by outflows. Moreover,
the systematically blue-shifted absorption in the H2O lines suggests expansion,
presumably driven by the outflow. No infall signatures are detected. The p-H2O
111-000 and o-H2O 212-101 lines show absorption from the cold material (T ~ 10
K) in which the high-mass protostellar envelope is embedded. One-dimensional
radiative transfer models are used to estimate water abundances and to further
study the kinematics of the region. We show that the emission in the rare
isotopologues comes directly from the inner parts of the envelope (T > 100 K)
where water ices in the dust mantles evaporate and the gas-phase abundance
increases. The resulting jump in the water abundance (with a constant inner
abundance of 10^{-4}) is needed to reproduce the o-H17O 110-101 and p-H18O
111-000 spectra in our models. We estimate water abundances of 10^{-8} to
10^{-9} in the outer parts of the envelope (T < 100 K). The possibility of two
protostellar objects contributing to the emission is discussed.Comment: Accepted for publication in the A&A HIFI special issu
Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography
BACKGROUND: Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration. METHODOLOGY/PRINCIPAL FINDINGS: We achieved to adapt a commercial 3(rd) generation OCT system to obtain and quantify high-resolution morphological sections of the mouse retina which so far required in vitro histology. OCT and histology were compared in models with developmental defects, light damage, and inherited retinal degenerations. In conditional knockout mice deficient in retinal retinoblastoma protein Rb, the gradient of Cre expression from center to periphery, leading to a gradual reduction of retinal thickness, was clearly visible and well topographically quantifiable. In Nrl knockout mice, the layer involvement in the formation of rosette-like structures was similarly clear as in histology. OCT examination of focal light damage, well demarcated by the autofluorescence pattern, revealed a practically complete loss of photoreceptors with preservation of inner retinal layers, but also more subtle changes like edema formation. In Crb1 knockout mice (a model for Leber's congenital amaurosis), retinal vessels slipping through the outer nuclear layer towards the retinal pigment epithelium (RPE) due to the lack of adhesion in the subapical region of the photoreceptor inner segments could be well identified. CONCLUSIONS/SIGNIFICANCE: We found that with the OCT we were able to detect and analyze a wide range of mouse retinal pathology, and the results compared well to histological sections. In addition, the technique allows to follow individual animals over time, thereby reducing the numbers of study animals needed, and to assess dynamic processes like edema formation. The results clearly indicate that OCT has the potential to revolutionize the future design of respective short- and long-term studies, as well as the preclinical assessment of therapeutic strategies
An overview of the mid-infrared spectro-interferometer MATISSE: science, concept, and current status
MATISSE is the second-generation mid-infrared spectrograph and imager for the
Very Large Telescope Interferometer (VLTI) at Paranal. This new interferometric
instrument will allow significant advances by opening new avenues in various
fundamental research fields: studying the planet-forming region of disks around
young stellar objects, understanding the surface structures and mass loss
phenomena affecting evolved stars, and probing the environments of black holes
in active galactic nuclei. As a first breakthrough, MATISSE will enlarge the
spectral domain of current optical interferometers by offering the L and M
bands in addition to the N band. This will open a wide wavelength domain,
ranging from 2.8 to 13 um, exploring angular scales as small as 3 mas (L band)
/ 10 mas (N band). As a second breakthrough, MATISSE will allow mid-infrared
imaging - closure-phase aperture-synthesis imaging - with up to four Unit
Telescopes (UT) or Auxiliary Telescopes (AT) of the VLTI. Moreover, MATISSE
will offer a spectral resolution range from R ~ 30 to R ~ 5000. Here, we
present one of the main science objectives, the study of protoplanetary disks,
that has driven the instrument design and motivated several VLTI upgrades
(GRA4MAT and NAOMI). We introduce the physical concept of MATISSE including a
description of the signal on the detectors and an evaluation of the expected
performances. We also discuss the current status of the MATISSE instrument,
which is entering its testing phase, and the foreseen schedule for the next two
years that will lead to the first light at Paranal.Comment: SPIE Astronomical Telescopes and Instrumentation conference, June
2016, 11 pages, 6 Figure
Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism - the Find-AF 2 study - rationale and design
Background
Atrial fibrillation (AF) is one of the most frequent causes of stroke. Several randomized trials have shown that prolonged monitoring increases the detection of AF, but the effect on reducing recurrent cardioembolism, i.e. ischemic stroke and systemic embolism, remains unknown. We aim to evaluate whether a risk-adapted, intensified heart rhythm monitoring with consequent guideline conform treatment, which implies initiation of oral anticoagulation (OAC), leads to a reduction of recurrent cardioembolism.
Methods
Find-AF 2 is a randomized, controlled, open-label parallel multicenter trial with blinded endpoint assessment. 5,200 patients ≥ 60 years of age with symptomatic ischemic stroke within the last 30 days and without known AF will be included at 52 study centers with a specialized stroke unit in Germany. Patients without AF in an additional 24-hour Holter ECG after the qualifying event will be randomized in a 1:1 fashion to either enhanced, prolonged and intensified ECG-monitoring (intervention arm) or standard of care monitoring (control arm). In the intervention arm, patients with a high risk of underlying AF will receive continuous rhythm monitoring using an implantable cardiac monitor (ICM) whereas those without high risk of underlying AF will receive repeated 7-day Holter ECGs. The duration of rhythm monitoring within the control arm is up to the discretion of the participating centers and is allowed for up to 7 days. Patients will be followed for at least 24 months. The primary efficacy endpoint is the time until recurrent ischemic stroke or systemic embolism occur.
Conclusions
The Find-AF 2 trial aims to demonstrate that enhanced, prolonged and intensified rhythm monitoring results in a more effective prevention of recurrent ischemic stroke and systemic embolism compared to usual care
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