Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: A combined ERP and DTI study

Background—Several theories of schizophrenia have emphasized the role of aberrant neural timing in the etiology of the disease, possibly as a consequence of conduction delays caused by structural damage to the white-matter fasciculi. Consistent with this theory, increased interhemispheric transmission times (IHTTs) to unilaterally-presented visual stimuli have been reported in patients with schizophrenia. The present study investigated whether or not these IHTT abnormalities could be underpinned by structural damage to the visual fibers of the corpus callosum. Methods—30 schizophrenia patients and 22 matched controls underwent Event Related Potential (ERP) recording, and a subset of 19 patients and 16 controls also underwent 3T Diffusion-Tensor Imaging (DTI). Unilateral visual stimuli (squares, 2 × 2 degrees) were presented 6 degrees lateral to either side of a central fixation point. IHTTs (ipsilateral minus contralateral latencies) were calculated for the P1 and N1 components at occipital-temporal sites in current source densitytransformed ERPs. The visual fibers of the corpus callosum were extracted with streamline tractography and the diffusion metrics of Fractional Anisotropy (FA) and Mode calculated. Results—While both subject groups exhibited highly significant IHTTs across a range of posterior electrode pairs, and significantly shorter IHTTs from left-to-right hemisphere than vice versa, no significant groupwise differences in IHTT were observed. However, participants’ IHTTs were linearly related to their FA and Mode, with longer IHTTs being associated with lower FA and more prolate diffusion ellipsoids. Conclusions—These results suggest that IHTTs are estimable from DTI measures of white matter integrity. In light of the range of diffusion abnormalities that have been reported in patients with schizophrenia, particularly in frontal fasciculi, these results support the conjecture that schizophrenia is ultimately underpinned by abnormalities in neural timing

Raising the voices of Pacific Island women to inform climate adaptation policies

Policymakers and natural resource managers are increasingly recognizing the importance of broader geographic and gender participation in assessing climate vulnerability and developing effective adaptation policies. When such participation is limited, climate mitigation and adaptation polices may miss key opportunities to support vulnerable communities, and thus inadvertently reinforce the vulnerability of marginalized groups. This paper reports rich qualitative data from women leaders in conservation, development and climate adaptation projects to support local communities across seven Pacific Island nations. The results indicate the following priorities to support climate adaptation policies in the Pacific: (1) increased recognition for the importance of traditional knowledge; (2) greater support for local women's groups, including strategic planning and training to access climate finance mechanisms; and (3) climate policies that consider alternative metrics for women's empowerment and inclusion, formalize women's land rights, and provide land for climate refugees. Existing evidence is discussed which supports the importance of these priorities in the Pacific. Their input identifies research gaps in climate adaptation and provides important guidance for governments, non-governmental organizations, and development agencies leading climate adaptation efforts

Restricted home ranges reduce children’s opportunities to connect to nature: demographic, environmental and parental influences

While many studies have documented the decline in the extent of children’s independent movements, none have explicitly evaluated the impact of this change in behaviour on opportunities to connect with nature. We estimate and compare the biodiversity values within urban children’s home ranges, and relate exposure to biodiversity to children’s perceptions and use of their neighbourhoods. We interviewed 178 children aged 9–11 years in three New Zealand cities. While children often had biodiverse areas present within 500 m of their home, their restricted home range size meant many of these natural areas fell outside of the range of their daily movements. Children’s declining independent mobility, strongly influenced by parental restrictions, appears to limit their freedom to use diverse and natural habitats within their urban neighbourhood, with use instead focused on private gardens and formal greenspaces. Development of a connection to nature in urban areas must therefore take place primarily in private gardens, which are threatened by urban planning approaches that promote dense residential developments with public rather than private greenspace

Gynecological cancer survivors: Assessment of psychological distress and unmet supportive care needs

This study highlights psychosocial needs of gynecological cancer survivors, contributing to evaluation of the Cancer Survivors Unmet Needs measure. Of the 45 participants, 28.9% reported clinical anxiety, 20.0% mild-to-severe depression, and 15.6% had probable posttraumatic stress disorder. Strength of unmet needs was associated with anxiety, depression, posttraumatic stress, poorer quality of life, younger age, and greater time since diagnosis. Linear regressions showed clinical measures, quality of life, optimism, and self-blaming coping style explained 56.4% of strength of unmet needs. Anxiety, functional well-being, posttraumatic stress, and emotional well-being accounted for 40.7% of variance in fear of recurrence, with emotional well-being the strongest predictor.Olivia A. Urbaniec, Kathryn Collins, Linley A. Denson and Hayley S. Whitfor