Selective Area Laser Deposition Joining of Aluminum Oxide

Selective area laser deposition (SALD) is a chemical vapor deposition technique used to deposit ceramic material. The technique allows localized deposition in the area of the laser spot; complex depositions can be achieved through the use of a computer control program. It is possible to free form fabricate arbitrary shapes. In particular by defining the space between two work pieces as the envelope for deposition, it is possible to form a monolithic joint. The use of a trimethylaluminum and diethyl ether precursor system is explored as a means of depositing aluminum oxide. The alumina is used as joint fill material for alumina SALD joining.Mechanical Engineerin

Gas Phase Solid Freeform for Fabrication of Three-dimensional Ceramic Structures

Solid free form of ceramic materials can be achieved by deposition from the gas phase. The Selective Area Laser Deposition, or SALD, technique can be utilized to make ceramic depositions with a uniform chemical composition. In order to make all classes of ceramics, including carbides, nitrides, and oxides, selection of a precursor is an essential step. Often the correct precursor for the deposition requires a special environment, namely, one that can be uniformly heated. System design for a heated deposition chamber is discussed as well as preliminary tests of the system functionality. Silicon Carbide depositions were performed as a means of evaluating system parameters.Mechanical Engineerin

Selective Area Laser Deposition for Silicon Nitride Joining

Ceramic joining is a difficult step in ceramic manufacturing. Joining ceramics, in a chemically homogeneous way, can be performed through the repurposing of an additive manufacturing technique involving local deposition of ceramics from the gas phase. Selective area laser deposition uses a gas phase precursor environment and a laser heat source to form ceramic deposits. These deposits can be positioned with great spatial resolution; as such, it is possible to form the joint with the ceramic material to create a monolithic structure. Silicon nitride is explored as a joining material for silicon nitride work pieces. The experimental conditions are described and the joint formation is characterized.Mechanical Engineerin

Can R CrB stars form from the merger of two helium white dwarfs?

Due to orbital decay by gravitational-wave radiation, some close-binary helium white dwarfs are expected to merge within a Hubble time. The immediate merger products are believed to be helium-rich sdO stars, essentially helium main-sequence stars. We present new evolution calculations for these post-merger stars beyond the core helium-burning phase. The most massive He-sdO's develop a strong helium-burning shell and evolve to become helium-rich giants. We include nucleosynthesis calculations following the merger of $0.4 \rm M_{\odot}$ helium white-dwarf pairs with metallicities $Z = 0.0001, 0.004, 0.008$ and 0.02. The surface chemistries of the resulting giants are in partial agreement with the observed abundances of R Coronae Borealis and extreme helium stars. Such stars might represent a third, albeit rare, evolution channel for the latter, in addition to the CO+He white dwarf merger and the very-late thermal pulse channels proposed previously. We confirm a recent suggestion that lithium seen in R\,CrB stars could form naturally during the hot phase of a merger in the presence of \iso{3}{He} from the donor white dwarf.Comment: 5 pages, 3 figures. Accepted for publication in MNRAS letter

Conditions for propagation and block of excitation in an asymptotic model of atrial tissue

Detailed ionic models of cardiac cells are difficult for numerical simulations because they consist of a large number of equations and contain small parameters. The presence of small parameters, however, may be used for asymptotic reduction of the models. Earlier results have shown that the asymptotics of cardiac equations are non-standard. Here we apply such a novel asymptotic method to an ionic model of human atrial tissue in order to obtain a reduced but accurate model for the description of excitation fronts. Numerical simulations of spiral waves in atrial tissue show that wave fronts of propagating action potentials break-up and self-terminate. Our model, in particular, yields a simple analytical criterion of propagation block, which is similar in purpose but completely different in nature to the `Maxwell rule' in the FitzHugh-Nagumo type models. Our new criterion agrees with direct numerical simulations of break-up of re-entrant waves.Comment: Revised manuscript submitted to Biophysical Journal (30 pages incl. 10 figures

Patterns of herpes simplex virus shedding over 1 month and the impact of acyclovir and HIV in HSV-2-seropositive women in Tanzania

Objectives Few studies have examined the frequency and duration of genital herpes simplex virus (HSV) shedding in sub-Saharan Africa. This study describes HSV shedding patterns among a sample of HSV-2-seropositive women enrolled in a placebo-controlled trial of HSV suppressive therapy (acyclovir 400 mg twice a day) in Tanzania.Methods Trial participants were invited to participate in a substudy involving 12 clinic visits over 4 weeks. At each visit, cervical, vaginal and external skin swabs were taken and analysed for HSV DNA using inhouse real-time PCR.Results HSV shedding was mainly subclinical (90%; 57/63 shedding days in the placebo arm). The most frequent shedding site was the external skin, but HSV DNA was detected from all three sites on 42% (27/63) of shedding days. In HIV-negative women, HSV DNA was detected on 3% (9/275) of days in the acyclovir versus 11% (33/309) in the placebo arm, while in HIV-positive women, detection was on 14% (23/160) versus 19% (30/155) of days, respectively.Conclusions HSV shedding was common, varying greatly by individual. Shedding rates were similar to studies in African and non-African settings. Among HIV-negative women, shedding rates were lower in the acyclovir arm; however, acyclovir did not substantially impact on HSV shedding in HIV-positive women

Melting and differentiation of early-formed asteroids: The perspective from high precision oxygen isotope studies

A number of distinct methodologies are available for determining the oxygen isotope composition of minerals and rocks, these include laser-assisted fluorination, secondary ion mass spectrometry (SIMS)and UV laser ablation. In this review we focus on laser-assisted fluorination, which currently achieves the highest levels of precision available for oxygen isotope analysis. In particular, we examine how results using this method have furthered our understanding of early-formed differentiated meteorites. Due to its rapid reaction times and low blank levels, laser-assisted fluorination has now largely superseded the conventional externally-heated Ni “bomb” technique for bulk analysis. Unlike UV laser ablation and SIMS analysis, laser-assisted fluorination is not capable of focused spot analysis. While laser fluorination is now a mature technology, further analytical improvements are possible via refinements to the construction of sample chambers, clean-up lines and the use of ultra-high resolution mass spectrometers. High-precision oxygen isotope analysis has proved to be a particularly powerful technique for investigating the formation and evolution of early-formed differentiated asteroids and has provided unique insights into the interrelationships between various groups of achondrites. A clear example of this is seenin samples that lie close to the terrestrial fractionation line (TFL). Based on the data from conventional oxygen isotope analysis, it was suggested that the main-group pallasites, the howardite eucrite diogenite suite (HEDs) and mesosiderites could all be derived from a single common parent body. However,high precision analysis demonstrates that main-group pallasites have a Δ17O composition that is fully resolvable from that of the HEDs and mesosiderites, indicating the involvement of at least two parent bodies. The range of Δ17O values exhibited by an achondrite group provides a useful means of assessing the extent to which their parent body underwent melting and isotopic homogenization. Oxygen isotope analysis can also highlight relationships between ungrouped achondrites and the more well-populated groups. A clear example of this is the proposed link between the evolved GRA 06128/9 meteorites and the brachinites. The evidence from oxygen isotopes, in conjunction with that from other techniques, indicates that we have samples from approximately 110 asteroidal parent bodies (∼60 irons, ∼35 achondrites and stony-iron, and ∼15 chondrites) in our global meteorite collection. However, compared to the likely size of the original protoplanetary asteroid population, this is an extremely low value. In addition, almost all of the differentiated samples (achondrites, stony-iron and irons) are derived from parent bodies that were highly disrupted early in their evolution. High-precision oxygen isotope analysis of achondrites provides some important insights into the origin of mass-independent variation in the early Solar System. In particular, the evidence from various primitive achondrite groups indicates that both the slope 1 (Y&R) and CCAM lines are of primordial significance. Δ17O differences between water ice and silicate-rich solids were probably the initial source of the slope 1 anomaly. These phases most likely acquired their isotopic composition as a result of UV photo-dissociation of CO that took place either in the early solar nebula or precursor giant molecular cloud. Such small-scale isotopic heterogeneities were propagated into larger-sized bodies, such as asteroids and planets, as a result of early Solar System processes, including dehydration, aqueous alteration,melting and collisional interactions

Impurity Effect on the In-plane Penetration Depth of the Organic Superconductors κ\kappa-(BEDT-TTF)2X_2X (XX = Cu(NCS)2_2 and Cu[N(CN)2_2]Br)

We report the in-plane penetration depth $\lambda_{\parallel}$ of single crystals $\kappa$-(BEDT-TTF)$_2X$ ($X=$ Cu(NCS)$_2$ and Cu[N(CN)$_2$]Br) by means of the reversible magnetization measurements under the control of cooling-rate. In $X$ = Cu(NCS)$_2$, $\lambda_{\parallel}(0)$ as an extrapolation toward $T$ = 0 K does not change by the cooling-rate within the experimental accuracy, while $T_{\textrm{c}}$ is slightly reduced. On the other hand, in $X$ = Cu[N(CN)$_2$]Br, $\lambda_{\parallel}(0)$ indicates a distinct increase by cooling faster. The different behavior of $\lambda_{\parallel}(0)$ on cooling-rate between the two salts is quantitatively explained in terms of the local-clean approximation (London model), considering that the former salt belongs to the very clean system and the later the moderate clean one. The good agreement with this model demonstrates that disorders of ethylene-group in BEDT-TTF introduced by cooling faster increase the electron(quasiparticle)-scattering, resulting in shorter mean free path.Comment: 8 pages, 9 figure

States, Social Policies and Globalisations

Summaries The debate about future social policies in OECD countries is framed in the light of rich country concerns, notably of a ‘welfare state at risk’. Because globalisation processes can plausibly be presented as a major source of threat, there is a temptation to generalise the analysis globally, and to assume that social policy issues in poor countries are fundamentally the same as in OECD states. The debate about the future of social policy in poor countries should not be framed in terms of OECD concerns. Three more specific points underpin this general argument: (a) Economic globalisation is not necessarily a threat. There are good historical reasons for believing that it may create political pressures to extend as well as to shrink social provision in poor countries; (b) There is a fundamental problem of state incapacity in much of the poor world that makes many OECD?based arguments about the proper role of the state appear redundant. Greater state capacity will itself lead to more effective social policies; and (c) It makes little sense for poor countries to resist, on grounds of potential adverse impacts on social policy, the trends toward the adoption of either New Public Management practices or the broader shift from ‘positive’ to regulatory states. Whatever changes occur in the architecture of poor states, more effective regulation will remain an urgent need