Identifying Dark Matter Burners in the Galactic center

If the supermassive black hole (SMBH) at the center of our Galaxy grew adiabatically, then a dense "spike" of dark matter is expected to have formed around it. Assuming that dark matter is composed primarily of weakly interacting massive particles (WIMPs), a star orbiting close enough to the SMBH can capture WIMPs at an extremely high rate. The stellar luminosity due to annihilation of captured WIMPs in the stellar core may be comparable to or even exceed the luminosity of the star due to thermonuclear burning. The model thus predicts the existence of unusual stars, i.e. "WIMP burners", in the vicinity of an adiabatically grown SMBH. We find that the most efficient WIMP burners are stars with degenerate electron cores, e.g. white dwarfs (WD) or degenerate cores with envelopes. If found, such stars would provide evidence for the existence of particle dark matter and could possibly be used to establish its density profile. In our previous paper we computed the luminosity from WIMP burning for a range of dark matter spike density profiles, degenerate core masses, and distances from the SMBH. Here we compare our results with the observed stars closest to the Galactic center and find that they could be consistent with WIMP burners in the form of degenerate cores with envelopes. We also cross-check the WIMP burner hypothesis with the EGRET observed flux of gamma-rays from the Galactic center, which imposes a constraint on the dark matter spike density profile and annihilation cross-section. We find that the EGRET data is consistent with the WIMP burner hypothesis. New high precision measurements by GLAST will confirm or set stringent limits on a dark matter spike at the Galactic center, which will in turn support or set stringent limits on the existence of WIMP burners at the Galactic center.Comment: 2 pages, 2 figures; to appear in the Proc. of the First Int. GLAST Symp. (Stanford, Feb. 5-8, 2007), eds. S.Ritz, P.F.Michelson, and C.Meegan, AIP Conf. Pro

Time Domain Studies of X-ray Shot Noise in Cygnus X-1

We investigate the variability of Cygnus X-1 in the context of shot moise models, and employ a peak detection algorithm to select individual shots. For a long observation of the low, hard state, the distribution of time intervals between shots is found to be consistent with a purely random process, contrary to previous claims in the literature. The detected shots are fit to several model templates and found to have a broad range of shapes. The fitted shots have a distribution of timescales from below 10 milliseconds to above 1 second. The coherence of the cross spectrum of light curves of these data in different energy bands is also studied. The observed high coherence implies that the transfer function between low and high energy variability is uniform. The uniformity of the tranfer function implies that the observed distribution of shot widths cannot have been acquired through Compton scattering. Our results in combination with other results in the literature suggest that shot luminosities are correlated with one another. We discuss how our experimental methodology relates to non-linear models of variability.Comment: Accepted for publication in Astrophysical Journal on July 16, 200

Dark matter burners

We show that a star orbiting close enough to an adiabatically grown supermassive black hole (SMBH) can capture weakly interacting massive particles (WIMPs) at an extremely high rate. The stellar luminosity due to annihilation of captured WIMPs in the stellar core may be comparable to or even exceed the luminosity of the star due to thermonuclear burning. The model thus predicts the existence of unusual stars, essentially WIMP burners, in the vicinity of a SMBH. We find that the most efficient WIMP burners are stars with degenerate electron cores, e.g. white dwarfs (WDs); such WDs may have a very high surface temperature. If found, such stars would provide evidence for the existence of particle dark matter and can possibly be used to establish its density profile. On the other hand, the lack of such unusual stars may provide constraints on the WIMP density near the SMBH, as well as the WIMP-nucleus scattering and pair annihilation cross-sections.Comment: 4 pages, 4 figures, emulateapj.cls; Astrophysical Journal Letters, accepte

Vegetable diversity in relation with subclinical atherosclerosis and 15-year atherosclerotic vascular disease deaths in older adult women

Increasing vegetable intake and diversity are recommended to maintain better health. Evidence for the health benefits of vegetable diversity, separate from total intake, is scarce. We aimed to investigate the associations of vegetable diversity with subclinical measures of atherosclerosis and atherosclerotic vascular disease (ASVD) mortality

Can Astrophysical Gamma Ray Sources Mimic Dark Matter Annihilation in Galactic Satellites?

The nature of the cosmic dark matter is unknown. The most compelling hypothesis is that dark matter consists of weakly interacting massive particles (WIMPs) in the 100 GeV mass range. Such particles would annihilate in the galactic halo, producing high-energy gamma rays which might be detectable in gamma ray telescopes such as the GLAST satellite. We investigate the ability of GLAST to distinguish between the WIMP annihilation spectrum and the spectrum of known astrophysical source classes. Focusing on the emission from the galactic satellite halos predicted by the cold dark matter model, we find that the WIMP gamma-ray spectrum is unique; the separation from known source classes can be done in a convincing way. We discuss the follow-up of possible WIMP sources with Imaging Atmospheric Cerenkov Telescopes. Finally we discuss the impact that Large Hadron Collider data might have on the study of galactic dark matter

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. We identified an IDH mutant-enriched subtype with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number. Leveraging the multi-platform data, we observed that ARID1A exhibited DNA hypermethylation and decreased expression in the IDH mutant subtype. More broadly, we found that IDH mutations are associated with an expanded histological spectrum of liver tumors with molecular features that stratify with CCA. Our studies reveal insights into the molecular pathogenesis and heterogeneity of cholangiocarcinoma and provide classification information of potential therapeutic significance