Some evidence for large gravitational redshift in Seyfert galaxy NGC 4151

The photon spectra of two Seyfert galaxies NGC 4151 and MCG 8-11-11 are good experimentally established in the X-ray and gamma range. The annihilation of the high temperature positrons with cold electrons is proposed as the possible mechanism of photon production in the Seyfert galaxy NGC 4151. The photon spectrum of NGC 4151 with its observed features from the soft X to the gamma ray range is described by annihilation of positrons and electrons at temperatures 3 x 10 to the 12th power K and 10 to the 8th power K respectively. The photon spectra from annihilation of unthermalized plasma with above parameters should be shifted to the lower energy by redshift z = 100. In that case the source of photons should be placed closely to the black hole horizon (r approximately equal to 1.0001 r sub g

Unthermalized positrons in gamma ray burst sources

The spectra of the broadening 0.511 MeV annihilation line produced by high temperatures was calculated in the case of unthermalized plasma; i.e., T sub e(+) is not = T sub e(-). The flattening in the spectrum of the annihilation lines for large differences of electron and positron temperatures is a strong indication that the observed features of the hard tailed spectrum of the gamma bursts can be well described by annihilation of unthermalized positrons. It is proposed that the charge separation occurring in Eddington limited accretion onto a neutron star or the one photon pair production in strong magnetic fields as a mechanism for the production of unthermalized positrons in the sources of gamma bursts. From the best fit of experimental spectra by the model, the parameters of sources for which the regions with different plasma temperatures can exist is evaluated

Virgo cluster as a high energy cosmic rays source

The extragalactic charged particles are reflecting from the Galaxy by its magnetic field. Assuming magnetic field in the Galaxy as quasilongitudinal, the mean transparency of Galaxy has been evaluated for extragalactic protons defined as a fraction of particles at a given energy from a given direction passing by the galactic plane. The anisotropy caused by the Galactic magnetic field reflection of protons can explain observed arrival directions of extensive air showers at large angle to the galactic plane. Our analysis shows that the increase with energy observed in sin b sup 11 is self-consistent with changing in the cosmic ray energy spectrum at high energy (E 10 to the 19th power eV) in the case when extragalactic cosmic ray source with spectral index -2.2 is at the position of the Virgo Cluster

Unthermalized plasma in bursts sources

The pair e(+)-e(-) annihilation phenomena in hot plasma was studied in order to evaluate the photon energy spectrum. The spectra of the broadening 0.511 MeV annihilation line was calculated in the case of unthermalized plasma, i.e., T sub e(-) does not equal T sub e(+). The energy spectra from annihilation process for unthermalized positrons are characterized by the presence of flat part for energies greater than 0.511 MeV. The flattening in the spectrum of annihilation unthermalized plasma is a strong indication that the observed features of the hard tailed spectrum of the gamma bursts can be well described by annihilation of hot positrons and cold electrons. It is proposed that the mechanism for the production of unthermalized positrons is associated with the charge separation in Eddington limited accretion onto a neutron star

Some evidence for high energy gamma-ray sources at large galactic latitudes

The arrival directions of the gamma-quanta with energies of about 10 to 15th power eV which were registrated by Tien Shan experiment were compared with COS-B observations. On the basis of the Monte Carlo simulations it was shown with low probability that arrival directions of Tien Shan gamma-quanta initiated showers are not uniformly distributed. It is shown that in the region not seen by COS-B mission, the high energy gamma-ray sources should be located at position of 90 deg. 1 sup 11 130 deg and b sup 11 or = 50 deg. The integral intensity of these sources should be I ( 10 to the 15th power eV) = 4.8 + or - 1.7).10 to the 13th power/sq cm/s/str. There is no coincidence between the gamma-quanta registrated by Tien Shan experiment with Geminga intense COS-B gamma source. So it is shown that the integral photon spectrum of Geminga (I(e) approx E sup-Beta, where Beta = 0.8 for E 1 GeV) becomes steeper (Beta 1.2) in high energy region with probability 99.9.%

Search for the Supersymmetric Partner of the Top-Quark in ppˉp \bar{p} Collisions at s=1.8TeV\sqrt{s} = 1.8 {\rm TeV}

We report on a search for the supersymmetric partner of the top quark (stop) produced in $t \bar{t}$ events using $110 {\rm pb}^{-1}$ of $p \bar{p}$ collisions at $\sqrt{s} = 1.8 {\rm TeV}$ recorded with the Collider Detector at Fermilab. In the case of a light stop squark, the decay of the top quark into stop plus the lightest supersymmetric particle (LSP) could have a significant branching ratio. The observed events are consistent with Standard Model $t \bar{t}$ production and decay. Hence, we set limits on the branching ratio of the top quark decaying into stop plus LSP, excluding branching ratios above 45% for a LSP mass up to 40 {\rm GeV/c}$^{2}$.Comment: 11 pages, 4 figure

Measurement of the Associated γ+μ±\gamma + \mu^\pm Production Cross Section in ppˉp \bar p Collisions at s=1.8\sqrt{s} = 1.8 TeV

We present the first measurement of associated direct photon + muon production in hadronic collisions, from a sample of 1.8 TeV $p \bar p$ collisions recorded with the Collider Detector at Fermilab. Quantum chromodynamics (QCD) predicts that these events are primarily from the Compton scattering process $cg \to c\gamma$, with the final state charm quark producing a muon. Hence this measurement is sensitive to the charm quark content of the proton. The measured cross section of $29\pm 9 pb^{-1}$ is compared to a leading-order QCD parton shower model as well as a next-to-leading-order QCD calculation.Comment: 12 pages, 4 figures Added more detailed description of muon background estimat

Inclusive jet cross section in pˉp{\bar p p} collisions at s=1.8\sqrt{s}=1.8 TeV

The inclusive jet differential cross section has been measured for jet transverse energies, $E_T$, from 15 to 440 GeV, in the pseudorapidity region 0.1$\leq | \eta| \leq$0.7. The results are based on 19.5 pb$^{-1}$ of data collected by the CDF collaboration at the Fermilab Tevatron collider. The data are compared with QCD predictions for various sets of parton distribution functions. The cross section for jets with $E_T>200$ GeV is significantly higher than current predictions based on O($\alpha_s^3$) perturbative QCD calculations. Various possible explanations for the high-$E_T$ excess are discussed.Comment: 8 pages with 2 eps uu-encoded figures Submitted to Physical Review Letter

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer

Preventing breast cancer will require the development of targeted strategies that can effectively block disease progression. Tamoxifen and aromatase inhibitors are effective in addressing estrogen receptor–positive (ER+) breast cancer development, but estrogen receptor–negative (ER−) breast cancer remains an unmet challenge due to gaps in pathobiologic understanding. In this study, we used reverse-phase protein array to identify activation of Src kinase as an early signaling alteration in premalignant breast lesions of women who did not respond to tamoxifen, a widely used ER antagonist for hormonal therapy of breast cancer. Src kinase blockade with the small-molecule inhibitor saracatinib prevented the disorganized three-dimensional growth of ER− mammary epithelial cells in vitro and delayed the development of premalignant lesions and tumors in vivo in mouse models developing HER2+ and ER− mammary tumors, extending tumor-free and overall survival. Mechanistic investigations revealed that Src blockade reduced glucose metabolism as a result of an inhibition in ERK1/2–MNK1–eIF4E–mediated cap-dependent translation of c-Myc and transcription of the glucose transporter GLUT1, thereby limiting energy available for cell growth. Taken together, our results provide a sound rationale to target Src pathways in premalignant breast lesions to limit the development of breast cancers

Study of CP violation in Dalitz-plot analyses of B0 --> K+K-KS, B+ --> K+K-K+, and B+ --> KSKSK+

We perform amplitude analyses of the decays $B^0 \to K^+K^-K^0_S$, $B^+ \rightarrow K^+K^-K^+$, and $B^+ \to K^0_S K^0_S K^+$, and measure CP-violating parameters and partial branching fractions. The results are based on a data sample of approximately $470\times 10^6$ $B\bar{B}$ decays, collected with the BABAR detector at the PEP-II asymmetric-energy $B$ factory at the SLAC National Accelerator Laboratory. For $B^+ \to K^+K^-K^+$, we find a direct CP asymmetry in $B^+ \to \phi(1020)K^+$ of $A_{CP}= (12.8\pm 4.4 \pm 1.3)$, which differs from zero by $2.8 \sigma$. For $B^0 \to K^+K^-K^0_S$, we measure the CP-violating phase $\beta_{\rm eff} (\phi(1020)K^0_S) = (21\pm 6 \pm 2)^\circ$. For $B^+ \to K^0_S K^0_S K^+$, we measure an overall direct CP asymmetry of $A_{CP} = (4 ^{+4}_{-5} \pm 2)$. We also perform an angular-moment analysis of the three channels, and determine that the $f_X(1500)$ state can be described well by the sum of the resonances $f_0(1500)$, $f_2^{\prime}(1525)$, and $f_0(1710)$.Comment: 35 pages, 68 postscript figures. v3 - minor modifications to agree with published versio