Policy Integration and Multi-Level Governance: Dealing with the Vertical Dimension of Policy Mix Designs

Multifaceted problems such as sustainable development typically involve complex arrangements of institutions and instruments and the subject of how best to design and operate such 'mixes', 'bundles' or 'portfolios' of policy tools is an ongoing issue in this area. One aspect of this question is that some mixes are more difficult to design and operate than others. The paper argues that, ceteris paribus, complex policy-making faces substantial risks of failure when horizontal or vertical dimensions of policy-making are not well integrated. The paper outlines a model of policy mix types which highlights the design problems associated with more complex arrangements and presents two case studies of similarly structured mixes in the areas of marine parks in Australia and coastal zone management in Europe - one a failure and the other a successful case of integration - to illustrate how such mixes can be better designed and managed more effectively

Governance Solutions to the Tragedy of the Commons That Marine Plastics Have Become

Plastic pollution has become the new millennium's tragedy of the commons. This is particularly true with the marine debris plastic pollution issue, which has seen significant global interest recently. There is long-standing acknowledgment of the difficulty in managing the commons, with regulations, economic and market based instruments and community-based solutions all having a role to play. We review the global plastic pollution issue in the context of governance and policy, providing examples of successes, opportunities and levers for change. We discuss the role of regulation, public perception and social license to operate (SLO) in managing waste that enters the ocean. We argue that while plastic pollution is a tragedy, there are many opportunities for reduction, management, and changes to the global community's relationship with plastic

‘Windows of opportunity’ : exploring the relationship between social media and plastic policies during the COVID-19 Pandemic

Plastic pollution has reached a crisis point due to ineffective waste management, an over-reliance on single-use plastic items and a lack of suitable plastic alternatives. The COVID-19 Pandemic has seen a dramatic increase in the use of single-use plastics including ‘COVID waste’ in the form of items specifically intended to help stop the spread of disease. Many governments have utilised COVID-19 as a window of opportunity to reverse, postpone or remove plastic policies off agendas ostensibly in order to ‘flatten the curve’ of COVID-19 cases. In this paper, we use novel methods of social media analysis relating to three regions (USA, Mexico and Australia) to suggest that health and hygiene were not the only reasons governments utilised this window of opportunity to change plastic policies. Beyond the influence of social media on the plastics agenda, our results highlight the potential of social media as a tool to analyse public reactions to government decisions that can be influenced by industry pressure and a broader political agenda, while not necessarily following responses to consumer behaviour

A datamining approach to identifying spatial patterns of phosphorus forms in the Stormwater Treatment Areas in the Everglades

The Everglades ecosystem in Florida, USA, is naturally phosphorus (P) limited, and faces threats of ecosystem change and associated losses to habitat, biodiversity, and ecosystem function if subjected to high inflows of P and other nutrients. In addition to changes in historic hydropattern, upstream agriculture (sugar cane, vegetable, citrus) and urbanization has placed the Everglades at risk due to nutrient-rich runoff. In response to this threat, the Stormwater Treatment Areas (STAs) were constructed along the northern boundary of the Everglades as engineered ecological systems designed to retain P from water flowing into the Everglades. This research investigated data collected over a period from 2002 to 2014 from the interior of the STAs using data mining and analysis techniques including (a) exploratory methods such as Principal Component Analysis to test for patterns and groupings in the data, and (b) modelling approaches to test for predictive relationships between environmental variables. The purpose of this research was to reveal and compare spatial trends and relationships between environmental variables across the various treatment cells, flow-ways, and STAs. Common spatial patterns and their drivers indicated that the flow-ways do not function along simple linear gradients; instead forming zonal patterns of P distribution that may increasingly align with the predominant flow path over time. Findings also indicate that the primary drivers of the spatial distribution of P in many of these systems relate to soil characteristics. The results suggest that coupled cycles may be a key component of these systems; i.e. the movement and transformation of P is coupled to that of nitrogen (N)

The Grizzly, October 24, 1995

The Results Are In: Chi Rho Psi Recruited the Most Donors per Pledge • Mocktails \u27n More • Senior Class Update • Join the Army! • The Pressures Make us Miserable • De-Americanizing America • Infringing on a Conducive Learning Environment? • Why Keep Pushing? • My View on Abortion • The Million Man Exclusion • It is About Respect • In Need of Answers • Our Perspectives on Homosexuality • Homosexuality: Not an Alternative • Morality of Sexual Preference • Homecoming 1995 • Red & Gold Regulations • Mike Green Gives Advice on Drinking • Brendlinger Named Ursinus Assistant • Team Earns First Conference Win • Field Hockey Defeats Temple, Falls to American U. • Cross Country Competes in Allentown Invitational • Everyone is Invited! • Football Snaps Five-Game Skid • Steigerwalt Honoredhttps://digitalcommons.ursinus.edu/grizzlynews/1366/thumbnail.jp

IAP inhibitors enhance co-stimulation to promote tumor immunity

The inhibitor of apoptosis proteins (IAPs) have recently been shown to modulate nuclear factor κB (NF-κB) signaling downstream of tumor necrosis factor (TNF) family receptors, positioning them as essential survival factors in several cancer cell lines, as indicated by the cytotoxic activity of several novel small molecule IAP antagonists. In addition to roles in cancer, increasing evidence suggests that IAPs have an important function in immunity; however, the impact of IAP antagonists on antitumor immune responses is unknown. In this study, we examine the consequences of IAP antagonism on T cell function in vitro and in the context of a tumor vaccine in vivo. We find that IAP antagonists can augment human and mouse T cell responses to physiologically relevant stimuli. The activity of IAP antagonists depends on the activation of NF-κB2 signaling, a mechanism paralleling that responsible for the cytotoxic activity in cancer cells. We further show that IAP antagonists can augment both prophylactic and therapeutic antitumor vaccines in vivo. These findings indicate an important role for the IAPs in regulating T cell–dependent responses and suggest that targeting IAPs using small molecule antagonists may be a strategy for developing novel immunomodulating therapies against cancer

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes:findings from the ENIGMA Epigenetics Working Group

DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)-three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness