Sounding the Alarm Round 2: Protecting Democracy in Ukraine

In 2010 Freedom House released its first special report on Ukraine, "Sounding the Alarm: Protecting Democracy in Ukraine". That report, as the title suggested, warned that Ukraine was heading in the wrong direction on a number of fronts: consolidation of power in the executive branch at the expense of democratic development, a more restrictive environment for the media, selective prosecution of opposition figures, worrisome instances of intrusiveness by the Security Service of Ukraine (SBU), widely criticized local elections in October 2010, a pliant Verkhovna Rada (Ukraine's parliament), an erosion of basic freedoms of assembly and speech, and widening corruption. "Ukraine under President Yanukovych," last year's report warned, "has become less democratic and, if current trends are left unchecked, may head down a path toward autocracy and kleptocracy."A year later, most of those key concerns remain, and in some cases the problems have grown considerably worse, especially in the area of selective prosecution of opposition figures and corruption. The mayoral election in Obukhiv in March was widely criticized for its alleged rigging and fraud and bodes badly for the upcoming Verkhovna Rada elections. The term "familyization" was commonly used by interlocutors, implying that President Yanukovych's family has not only benefitted personally from his presidency (see the section below on corruption) but is increasingly at the center of power and governance. Freedom House's ranking of Ukraine in its Freedom in the World 2012 report remained in the Partly Free category with a negative trend; the same assessment can be found in Freedom House's just-released "Nations in Transit." Against this backdrop, Freedom House, with support from the Open Society Foundations' Ukrainian arm, the International Renaissance Foundation, undertook this follow-up special report on Ukraine

Crop pests and predators exhibit inconsistent responses to surrounding landscape composition

The idea that noncrop habitat enhances pest control and represents a win–win opportunity to conserve biodiversity and bolster yields has emerged as an agroecological paradigm. However, while noncrop habitat in landscapes surrounding farms sometimes benefits pest predators, natural enemy responses remain heterogeneous across studies and effects on pests are inconclusive. The observed heterogeneity in species responses to noncrop habitat may be biological in origin or could result from variation in how habitat and biocontrol are measured. Here, we use a pest-control database encompassing 132 studies and 6,759 sites worldwide to model natural enemy and pest abundances, predation rates, and crop damage as a function of landscape composition. Our results showed that although landscape composition explained significant variation within studies, pest and enemy abundances, predation rates, crop damage, and yields each exhibited different responses across studies, sometimes increasing and sometimes decreasing in landscapes with more noncrop habitat but overall showing no consistent trend. Thus, models that used landscape-composition variables to predict pest-control dynamics demonstrated little potential to explain variation across studies, though prediction did improve when comparing studies with similar crop and landscape features. Overall, our work shows that surrounding noncrop habitat does not consistently improve pest management, meaning habitat conservation may bolster production in some systems and depress yields in others. Future efforts to develop tools that inform farmers when habitat conservation truly represents a win–win would benefit from increased understanding of how landscape effects are modulated by local farm management and the biology of pests and their enemies

Zwei Krankenversicherungssysteme zwischen Pflichtversicherung und Versicherungspflicht : ein Systemvergleich von Österreich und Deutschland

Eine Krankenversicherung ist ein essentieller Teil einer sozialen Sicherung, beziehungsweise eines wohlfahrtsstaatlichen Modelles. Dennoch gibt es viele unterschiedliche Varianten der Krankenversicherungen. Diese Arbeit soll auf die Differenzen und die Gemeinsamkeiten der Krankenversicherungen in Österreich und Deutschland eingehen. Den ersten Berührungspunkt zwischen den beiden Ländern liefert der Politologe Gøsta Esping-Andersen. Sowohl Österreich, als auch Deutschland werden in Esping-Andersens Kategorisierung von Wohlfahrtsstaatsmodellen dem liberalen Wohlfahrtsstaatstypus zugeordnet. Auch im Rahmen verschiedener ausgewählter Punkte, wie dem Aufbau und der Organisation, den Voraussetzungen für den Erhalt einer Krankenversicherung, den Leistungen, der Finanzierung oder der Risikoselektion, wird schnell deutlich, dass der größte Unterschied zwischen den beiden Systemen die Tatsache ist, dass in Österreich die Pflichtversicherung und in Deutschland die Versicherungspflicht vorherrschend ist. Durch das System der Pflichtversicherung in Österreich, sind alle versicherten Personen an die staatliche Krankenversicherung gebunden, eine private Versicherung ist nur im Rahmen einer privaten Zusatzversicherung möglich. In Deutschland hingegen können die Bewohner/innen, unter der Erfüllung bestimmter Voraussetzungen, frei wählen, ob ein staatliches, oder ein privates Versicherungsverhältnis eingegangen werden soll. Somit entsteht der Effekt einer Wahlfreiheit, wohingegen in Österreich ein Zwang zur staatlichen Versicherung vorherrscht. Auch in den anderen oben genannten Bereichen konnten eine Vielzahl an Differenzen zwischen dem deutschen und dem österreichischen Krankenversicherungssystem aufgedeckt werden, welche (in fast allen Fällen) durch die Versicherungspflicht, beziehungsweise Pflichtversicherung erklärt werden können.Kramer Viktoria B.Sc.Universität Linz, Masterarbeit, 2018(VLID)258184

Contrast-Enhanced µCT for Visualizing and Evaluating Murine Intestinal Inflammation

Rationale: To develop a simple and fast protocol for the assessment of acute and chronic experimental intestinal inflammation using contrast-enhanced µCT. Methods: For the imaging studies, an acute 2% and 3% dextran sodium sulfate (n = 15, female, 8-12 weeks) and a chronic adoptive transfer colitis model (n = 10, female, 8-9 weeks) were established over 9 days or 6 weeks, respectively. Throughout the experiments, longitudinal measurement of murine intestinal wall thickness and time dependent perfusion was performed on a small animal µCT system (90 kV, 160 μA, FOV: 60 mm, scan time: 17 s, image size: 512x512, layer thickness: 118 µm) between 0.5 and 30 min after intravenous bolus injection of an iodine contrast agent. Weight development, small animal endoscopy, and histological ex vivo analysis were compared to contrast-enhanced µCT imaging findings. Results: Murine intestinal wall thickness was significantly increased in inflamed colons of acute colitis at day 9 in comparison to pre-inflamed state. Perfusion analysis revealed a late contrast enhancement in acute inflamed colons and the renal medulla at day 9 compared to control mice. An increasing intestinal wall thickness was monitored 3, 5 and 6 weeks after on-set of chronic colitis in comparison to controls. A good correlation with endoscopic (r = 0.75, p < 0.0001) and histologic degree of inflammation (r = 0.83, p = 0.04) was found. Conclusion: Contrast-enhanced µCT is a simple and fast method to assess acute intestinal inflammation and to monitor disease progression in experimental models of chronic colitis. According to our findings, one single contrast-enhanced µCT-scan is a valid non-invasive modality to quantify the degree of inflammation in the entire digestive tract in murine inflammatory models

In vitro hemo- and cytocompatibility of bacterial nanocelluose small diameter vascular grafts: Impact of fabrication and surface characteristics.

Objective There is an increasing need for small diameter vascular grafts with superior host hemo- and cytocompatibilities, such as low activation of platelets and leukocytes. Therefore, we aimed to investigate whether the preparation of bacterial nanocellulose grafts with different inner surfaces has an impact on in vitro host cytocompatibility. Methods We have synthesized five different grafts in a bioreactor, namely open interface surface (OIS), inverted (INV), partially air dried (PAD), surface formed in air contact (SAC) and standard (STD) that were characterized by a different surface roughness. The grafts (length 55 mm, inner diameter 5 mm) were attached to heparinized polyvinyl chloride tubes, loaded with human blood and rotated at 37 degrees C for 4 hours. Then, blood was analyzed for frequencies of cellular fractions, oxidative products, soluble complement and thrombin factors. The results were compared to clinically approved grafts made of polyethylene terephthalate and expanded polytetrafluoroethylene. Additionally, blood platelets were labelled with(111)Indium-oxine to visualize the distribution of adherent platelets in the loop by scintigraphy. Results SAC nanocellulose grafts with the lowest surface roughness exhibited superior performance with 65% leukocyte and >90% thrombocyte loss. Of note, SAC nanocellulose grafts showed lowest radioactivity with scintigraphy analyses, indicating reduced platelet adhesion. Although the levels of reactive oxygen species and cell free DNA did not differ significantly, the levels of thrombin-antithrombin complexes were lowest in SAC grafts. However, all nanocellulose grafts exhibited enhanced complement activation. Conclusion The systematic variation of the inner surfaces of BNC vascular grafts significantly improves biocompatibility. Especially, SAC grafts exhibited the lowest loss of platelets as well as leukocytes and additionally significantly diminished activation of the coagulation system. Further animal studies are needed to study in vivo biocompatibilities

Data_Sheet_1_3D modeling and printing for complex biventricular repair of double outlet right ventricle.DOCX

BackgroundDouble outlet right ventricle (DORV) describes a group of congenital heart defects where pulmonary artery and aorta originate completely or predominantly from the right ventricle. The individual anatomy of DORV patients varies widely with multiple subtypes classified. Although the majority of morphologies is suitable for biventricular repair (BVR), complex DORV anatomy can render univentricular palliation (UVP) the only option. Thus, patient-specific decision-making is critical for optimal surgical treatment planning. The evolution of image processing and rapid prototyping techniques facilitate the generation of detailed virtual and physical 3D models of the patient-specific anatomy which can support this important decision process within the Heart Team.Materilas and methodsThe individual cardiovascular anatomy of nine patients with complex DORV, in whom surgical decision-making was not straightforward, was reconstructed from either computed tomography or magnetic resonance imaging data. 3D reconstructions were used to characterize the morphologic details of DORV, such as size and location of the ventricular septal defect (VSD), atrioventricular valve size, ventricular volumes, relationship between the great arteries and their spatial relation to the VSD, outflow tract obstructions, coronary artery anatomy, etc. Additionally, physical models were generated. Virtual and physical models were used in the preoperative assessment to determine surgical treatment strategy, either BVR vs. UVP.ResultsMedian age at operation was 13.2 months (IQR: 9.6-24.0). The DORV transposition subtype was present in six patients, three patients had a DORV-ventricular septal defect subtype. Patient-specific reconstruction was feasible for all patients despite heterogeneous image quality. Complex BVR was feasible in 5/9 patients (55%). Reasons for unsuitability for BVR were AV valve chordae interfering with potential intraventricular baffle creation, ventricular hypoplasia and non-committed VSD morphology. Evaluation in particular of qualitative data from 3D models was considered to support comprehension of complex anatomy.ConclusionImage-based 3D reconstruction of patient-specific intracardiac anatomy provides valuable additional information supporting decision-making processes and surgical planning in complex cardiac malformations. Further prospective studies are required to fully appreciate the benefits of 3D technology.</p