Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients

Background: Overexpression of autologous proteins can lead to the formation of autoantibodies and autoimmune diseases. MHC class I polypeptide-related sequence A (MICA) is highly expressed in the enterocytes of patients with celiac disease, which arises in response to gluten. The aim of this study was to investigate anti-MICA antibody formation in patients with celiac disease and its association with other autoimmune processes. Methods: We tested serum samples from 383 patients with celiac disease, obtained before they took up a gluten-free diet, 428 patients with diverse autoimmune diseases, and 200 controls for anti-MICA antibodies. All samples were also tested for anti-endomysium and anti-transglutaminase antibodies. Results: Antibodies against MICA were detected in samples from 41.7% of patients with celiac disease but in only 3.5% of those from controls (P <0.0001) and 8.2% from patients with autoimmune disease (P <0.0001). These antibodies disappeared after the instauration of a gluten-free diet. Anti-MICA antibodies were significantly prevalent in younger patients (P <0.01). Fifty-eight patients with celiac disease (15.1%) presented a concomitant autoimmune disease. Anti-MICA-positive patients had a higher risk of autoimmune disease than MICA antibody-negative patients (P <0.0001; odds ratio = 6.11). The risk was even higher when we also controlled for age (odds ratio = 11.69). Finally, we found that the associated risk of developing additional autoimmune diseases was 16 and 10 times as high in pediatric patients and adults with anti-MICA, respectively, as in those without. Conclusions: The development of anti-MICA antibodies could be related to a gluten-containing diet, and seems to be involved in the development of autoimmune diseases in patients with celiac disease, especially younger ones

Measurement of b jet shapes in proton-proton collisions at root s=5.02 TeV

We present the first study of charged-hadron production associated with jets originating from b quarks in proton-proton collisions at a center-of-mass energy of 5.02 TeV. The data sample used in this study was collected with the CMS detector at the CERN LHC and corresponds to an integrated luminosity of 27.4 pb(-1). To characterize the jet substructure, the differential jet shapes, defined as the normalized transverse momentum distribution of charged hadrons as a function of angular distance from the jet axis, are measured for b jets. In addition to the jet shapes, the per-jet yields of charged particles associated with b jets are also quantified, again as a function of the angular distance with respect to the jet axis. Extracted jet shape and particle yield distributions for b jets are compared with results for inclusive jets, as well as with the predictions from the pythia and herwig++ event generators.Peer reviewe

Measurement of the azimuthal anisotropy of Y(1S) and Y(2S) mesons in PbPb collisions at root s(NN)=5.02 TeV

The second-order Fourier coefficients (v(2)) characterizing the azimuthal distributions of Y(1S) and Y(2S) mesons produced in PbPb collisions at root s(NN) = 5.02 TeV are studied. The Y mesons are reconstructed in their dimuon decay channel, as measured by the CMS detector. The collected data set corresponds to an integrated luminosity of 1.7 nb(-1). The scalar product method is used to extract the v2 coefficients of the azimuthal distributions. Results are reported for the rapidity range vertical bar y vertical bar < 2.4, in the transverse momentum interval 0 < pT < 50 GeV/c, and in three centrality ranges of 10-30%, 30-50% and 50-90%. In contrast to the J/psi mesons, the measured v(2) values for the Y mesons are found to be consistent with zero. (C) 2021 The Author(s). Published by Elsevier B.V.Peer reviewe

Usefulness of guideline recommendations for prognosis in patients with candidemia

We aimed to analyze whether the lack of inclusion of specific recommendations for the management of candidemia is an independent risk factor for early and overall mortality. Multicenter study of adult patients with candidemia in 13 hospitals. We assessed the proportion of patients on whom nine specific ESCMID and IDSA guidelines recommendations had been applied, and analyzed its impact on mortality. 455 episodes of candidemia were documented. Patients who died within the first 48 hours were excluded. Sixty-two percent of patients received an appropriate antifungal treatment. Either echinocandin or amphotericin B therapy were administered in 43% of patients presenting septic shock and in 71% of those with neutropenia. Sixty-one percent of patients with breakthrough candidemia underwent a change in antifungal drug class. Venous catheters were removed in 79% of cases. Follow-up blood cultures were performed in 72% of cases. Ophthalmoscopy and echocardiogram were performed in 48% and 50% of patients, respectively. Length of treatment was appropriate in 78% of cases. Early (2-7 days) and overall (2-30 days) mortality were 8% and 27.7%, respectively. Inclusion of less than 50% of the specific recommendations was independently associated with a higher early (HR = 7.02, 95% CI: 2.97-16.57; P &lt; .001) and overall mortality (HR = 3.55, 95% CI: 2.24-5.64; P &lt; .001). In conclusion, ESCMID and IDSA guideline recommendations were not performed on a significant number of patients. Lack of inclusion of these recommendations proved to be an independent risk factor for early and overall mortality

Discovering HIV related information by means of association rules and machine learning

Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS-so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotated training data. Our system has been able to extract a good number of relationships between HIV-related diseases that have been previously detected in the literature but are scattered and are often little known. Furthermore, a number of plausible new relationships have shown up which deserve further investigation by qualified medical experts

Estudios sociales y administrativos en América Latina

Esta obra contiene la compilación de una serie de investigaciones latinoamericanas en las cuales se presenta los nuevos enfoques investigativos, metodológicos y cientificos. Para la generación de soluciones que contribuyan a la toma de decisiones en variables, sociales, economicas y administrativas en los diferentes contextos organizacionales. Además de estos elementos, en esta obra se presentan nuevas apuestas multidisciplinares cuanti-cualitativas en las cuales se destacan la ingeniería, derecho entre otros.

[Correspondencia de Camilo Díaz Baliño] , 1917-1936

Mss. (algúns en fotocopia) autógrafo e mecanografiadoResumen: Correspondencia recibida por Camilo Díaz Baliño entre os anos 1917-1936 relacionada con asuntos persoais e laboraisBiblioteca de GaliciaForma de ingreso: Depósito. Fuente de ingreso: Díaz Pardo, Isaac. Fecha de ingreso: 2011. Propietario: Herdeiros de Isaac Díaz PardoDixitalización Telefónica-IDP 2012Contén : Cartas de: Manuel Abelenda (1 páx.) -- Cesar Alvarez (1 páx.) -- Carlos Amigo Collía (2 páxs.) -- Banco Hispano-Americano (2 páxs.) -- Alfonso Barreiro (3 páxs.) -- Eliseo Barros Gamallo (1 páx.),(2 páxs.) -- Ramón Beade (2 páxs.) -- Benito(2 páxs.) -- Fernando Blanco(1 páx.) -- José Bouzas y Cardama (1 páx.) -- Albino Bouzó Fernández (1 páx.),(2 páxs) -- José Cabada Vázquez (4 páxs.),(1 páx.),(1 páx.) --Salvador Cabeza (1 páx.) -- Antonio Carballa (1 páx.) -- Leandro y Euxenio Carré (2 páxs.) -- V. Carro (1 páx.) -- Santiago Casares (1 páx.) -- Alvaro Cebreiro (2 páxs.) -- Centro Gallego de Buenos Aires (1 páx.),(1 páx.) -- Compostela (2 páxs.) -- Manolo: Continental (2 páxs.) -- Coral de Ruada (1 páx.),(2 páxs.) -- Amando Cotarelo(1 páx.),(1 páx.) -- Eduardo Dorado Xaneiro (8 páx.) -- Círculo Mercantil e Idustrial: Ramón Fernández (1 páx.) --Virgilio Fernández(3 páxs.) -- Ramón Fernández Mato (2 páxs.) -- B. Ferreiro(1 páx.) -- Jenaro de la Fuente (1 páx.) -- Isaac Fraga: Espéctaculos Empresa Fraga (1 páx.),(1 páx.) -- Antonio Folgar Lema(1 páx.)--Alicio Garcitoral (1 páx.) -- Cándido González Raño (1 páx.) -- Daniel González Rodriguez (2 páxs.),(2 páxs.) -- Edurardo G.del Río (1 páx.) -- Hermanos Hernández (2 páxs.),(1 páx.),(1 páx.),(1 páx.) -- José Iglesias Sánchez (2 páxs.) -- Irmandades da Fala (1 páx.) -- José Silva? (2 páxs.) -- Arturo Longa (1 páx.) -- Casimiro López (1 páx.) -- Edmundo López (1 páx.),(1 páx.) -- Eduardo R. Losada y Rebellón (2 páx.) -- Carlos Maside (1 páx.) -- Enrique Mayer (1 páx.) -- Antonio Méndez Laserna (1 páx.) -- Anselmo Padín (1 páx.) -- Xavier Pardo (1 páx.) -- Partido Republicano Radical Socialista (1 páx.) -- Pérez Bustamante (1 páx.) -- Modesto Piñeiro (2 páxs.) -- Salustiano Portela (2 páxs.) -- José Seijo Rubio (2 páxs.) -- Suarez Picallo (2 páxs.) -- Luis Losada (1 páx), (1 páx.) -- Ricardo Valdés (2 páxs.),(2 páxs.),(2 páxs.),(1 páx.) -- A.Nilo Varela (1 páx.),(2 páxs.),(2 páxs.) -- Juan Varela de Limia (1 páx.) -- Victorino? Varela (1 páx.) -- Jesús Varela (3 páxs.) -- F.Vázquez Suarez (1 páx.) -- Santiago Vidal Gimeno (1 páx.) -- Pedro Vieitez (1 páx.) -- M. Villar (2 páxs.) -- Anónima (1 páx.) -- Anónima (1 páx.

Measurement of quark- and gluon-like jet fractions using jet charge in PbPb and pp collisions at 5.02 TeV

The momentum-weighted sum of the electric charges of particles inside a jet, known as jet charge, is sensitive to the electric charge of the particle initiating the parton shower. This paper presents jet charge distributions in $\sqrt{s_{\mathrm{NN}}}$ = 5.02 TeV lead-lead (PbPb) and proton-proton (pp) collisions recorded with the CMS detector at the LHC. These data correspond to integrated luminosities of 404 μb$^{−1}$ and 27.4 pb$^{−1}$ for PbPb and pp collisions, respectively. Leveraging the sensitivity of the jet charge to fundamental differences in the electric charges of quarks and gluons, the jet charge distributions from simulated events are used as templates to extract the quark- and gluon-like jet fractions from data. The modification of these jet fractions is examined by comparing pp and PbPb data as a function of the overlap of the colliding Pb nuclei (centrality). This measurement tests the color charge dependence of jet energy loss due to interactions with the quark-gluon plasma. No significant modification between different centrality classes and with respect to pp results is observed in the extracted quark- and gluon-like jet fractions

A deep neural network to search for new long-lived particles decaying to jets

International audienceA tagging algorithm to identify jets that are significantly displaced from the proton-proton (pp) collision region in the CMS detector at the LHC is presented. Displaced jets can arise from the decays of long-lived particles (LLPs), which are predicted by several theoretical extensions of the standard model. The tagger is a multiclass classifier based on a deep neural network, which is parameterised according to the proper decay length $\mathrm{c}\tau_0$ of the LLP. A novel scheme is defined to reliably label jets from LLP decays for supervised learning. Samples of pp collision data, recorded by the CMS detector at a centre-of-mass energy of 13 TeV, and simulated events are used to train the neural network. Domain adaptation by backward propagation is performed to improve the simulation modelling of the jet class probability distributions observed in pp collision data. The potential performance of the tagger is demonstrated with a search for long-lived gluinos, a manifestation of split supersymmetric models. The tagger provides a rejection factor of 10 000 for jets from standard model processes, while maintaining an LLP jet tagging efficiency of 30-80% for gluinos with 1 mm $\leq$ $c\tau_0$ $\leq$ 10 m. The expected coverage of the parameter space for split supersymmetry is presented