214 research outputs found
A layered approach to technology transfer of AVIRIS between Earth Search Sciences, Inc. and the Idaho National Engineering Laboratory
Since initial contact between Earth Search Sciences, Inc. (ESSI) and the Idaho National Engineering Laboratory (INEL) in February, 1994, at least seven proposals have been submitted in response to a variety of solicitations to commercialize and improve the AVIRIS instrument. These proposals, matching ESSI's unique position with respect to agreements with the National Aeronautics and Space Administration (NASA) and the Jet Propulsion Laboratory (JPL) to utilize, miniaturize, and commercialize the AVIRIS instrument and platform, are combined with the applied engineering of the INEL. Teaming ESSI, NASA/JPL, and INEL with diverse industrial partners has strengthened the respective proposals. These efforts carefully structure the overall project plans to ensure the development, demonstration, and deployment of this concept to the national and international arenas. The objectives of these efforts include: (1) developing a miniaturized commercial, real-time, cost effective version of the AVIRIS instrument; (2) identifying multiple users for AVIRIS; (3) integrating the AVIRIS technology with other technologies; (4) gaining the confidence/acceptance of other government agencies and private industry in AVIRIS; and (5) increasing the technology base of U.S. industry
Independent Prognostic Significance of Monosomy 17 and Impact of Karyotype Complexity in Monosomal Karyotype/Complex Karyotype Acute Myeloid Leukemia: Results from Four ECOG-ACRIN Prospective Therapeutic Trials
The presence of a monosomal karyotype (MK+) and/or a complex karyotype (CK+) identifies subcategories of AML with poor prognosis. The prognostic significance of the most common monosomies (monosomy 5, monosomy 7, and monosomy 17) within MK+/CK+ AML is not well defined. We analyzed data from 1,592 AML patients age 17â93 years enrolled on ECOG-ACRIN therapeutic trials. The majority of MK+ patients (182/195; 93%) were MK+/CK+ with 87% (158/182) having â„5 clonal abnormalities (CKâ„ 5). MK+ patients with karyotype complexity â€4 had a median overall survival (OS) of 0.4y compared to 1.0y for MK- with complexity â€4 (p < 0.001), whereas no OS difference was seen in MK+ vs. MK- patients with CKâ„ 5 (p = 0.82). Monosomy 5 (93%; 50/54) typically occurred within a highly complex karyotype and had no impact on OS (0.4y; p = 0.95). Monosomy 7 demonstrated no impact on OS in patients with CKâ„ 5 (p = 0.39) or CK †4 (p = 0.44). Monosomy 17 appeared in 43% (68/158) of CKâ„ 5 patients and demonstrated statistically significant worse OS (0.4y) compared to CKâ„ 5 patients without monosomy 17 (0.5y; p = 0.012). Our data suggest that the prognostic impact of MK+ is limited to those with less complex karyotypes and that monosomy 17 may independently predict for worse survival in patients with AML
New Forms of QCD Matter Discovered at RHIC
We discuss two special limiting forms of QCD matter which may be produced at
RHIC. We conclude from the available empirical evidence that an equilibrated,
but strongly coupled Quark Gluon Plasma has been made in such collisions. We
also discuss the growing body of evidence that its source is a Color Glass
Condensate.Comment: RBRC Scientific Artricles Vol.9, New Discoveries at RHIC: the current
case for the strongly interactive QGP, BNL May 14,15 2004. References added
and updated. Typos corrected. Accepted in Nucl.Phys.
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Ancestral origin of ApoE Δ4 Alzheimer disease risk in Puerto Rican and African American populations
The ApoE Δ4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by Δ4, however, differs across populations, with populations of African ancestry showing lower Δ4 risk compared to those of European or Asian ancestry. The cause of this heterogeneity in risk effect is currently unknown; it may be due to environmental or cultural factors correlated with ancestry, or it may be due to genetic variation local to the ApoE region that differs among populations. Exploring these hypotheses may lead to novel, population-specific therapeutics and risk predictions. To test these hypotheses, we analyzed ApoE genotypes and genome-wide array data in individuals from African American and Puerto Rican populations. A total of 1,766 African American and 220 Puerto Rican individuals with late-onset Alzheimer disease, and 3,730 African American and 169 Puerto Rican cognitively healthy individuals (> 65 years) participated in the study. We first assessed average ancestry across the genome (âglobalâ ancestry) and then tested it for interaction with ApoE genotypes. Next, we assessed the ancestral background of ApoE alleles (âlocalâ ancestry) and tested if ancestry local to ApoE influenced Alzheimer disease risk while controlling for global ancestry. Measures of global ancestry showed no interaction with ApoE risk (Puerto Rican: p-value = 0.49; African American: p-value = 0.65). Conversely, ancestry local to the ApoE region showed an interaction with the ApoE Δ4 allele in both populations (Puerto Rican: p-value = 0.019; African American: p-value = 0.005). ApoE Δ4 alleles on an African background conferred a lower risk than those with a European ancestral background, regardless of population (Puerto Rican: OR = 1.26 on African background, OR = 4.49 on European; African American: OR = 2.34 on African background, OR = 3.05 on European background). Factors contributing to the lower risk effect in the ApoE gene Δ4 allele are likely due to ancestry-specific genetic factors near ApoE rather than non-genetic ethnic, cultural, and environmental factors
Earth Search Sciences, Inc. Folder
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Myotonic muscular dystrophy: Calcium-dependent phosphatidate metabolism in the erythrocyte membrane
It has been suggested that the erythrocytes of myotonic dystrophy (MyD) patients have a decreased calcium-stimulated phosphatidic acid (PA) accumulation. This could be the result of a defect in the calcium-stimulated hydrolysis of the polyphosphoinositides (calcium-dependent phosphodiesterase) or in the subsequent formation of PA from its precursors (diacylglycerol kinase).
In vitro assays were established for both enzymes in erythrocyte membranes. Calcium-dependent phosphodiesterase activity was assayed with both endogenous
32P-labeled erythrocyte diphosphoinositide and triphosphoinositide and with the same phospholipids isolated from rat brain. No significant differences in activity were found between MyD patients and normal controls with either method of substrate preparation. No difference in diglyceride kinase activity was found between ghosts prepared from MyD patients and normal controls. Thus, there were no differences in either of the membrane-associated enzymes of phosphatidic acid metabolism
The Concurrent Validity of the Cognitive Levels Test With the Wechsler Intelligence Scale for Childrenârevised for a Sample of Referred Children and Youth
The present investigation compared the Cognitive Levels Test (CLT) and the Wechsler Intelligence Scale for ChildrenâRevised (WISCâR) scores for 55 children who were referred for remedial educational services. A comparison of the correlations for each of the criterion measures from the WISCâR showed a consistent significant positive relationship with the CLT. A repeated measures analysis of variance that compared standard scores for the CLT with those of the WISCâR indicated that significant differences existed between WISCâR IQs and the CLT Cognitive Index. Implications concerning the validity of the Cognitive Levels Test are discussed
Concurrent Validity of the Cognitive Levels Test With Measures of Achievement for a Sample of Referred Children and Youth
The present investigation compared the Cognitive Levels Test (CLT) with the Woodcock Reading Mastery Test (WRMT) and Wide Range Achievement TestâRevised (WRATâR) for 55 children and youth who were referred for remedial/special education services. A comparison of the correlations for the criterion measures for the WRMT and WRATâR showed a consistent significant positive relationship with the CLT. A repeated measures analysis of variance that compared standard scores of the CLT with those of the WRMT and WRATâR indicated that significant differences existed between the test scores. Implications with respect to the concurrent validity of the CLT are discussed
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