Re-making urban segregation: processes of income sorting and neighbourhood change

Segregation studies have mainly focused on urban structures as a whole or have discussed specific (gentrifying or renewing) neighbourhoods. The literature suggests that changes in segregation occur primarily through selective migration. In this paper, we follow up on recent work that has questioned these orthodoxies, suggesting that in situ social mobility, and entries to and exits from the city population should be taken into account as well, and that dynamics in all neighbourhoods should be considered. The paper traces the processes by which segregation changes for the cities of Amsterdam and The Hague for 1999–2006, using a longitudinal individual-level database covering the entire population. It extends previous work by looking at income rather than socio-economic status and by drilling down to the neighbourhood level. Applying an existing measure of segregation (Delta) in a novel way, the analysis focuses on changes in the spatial distribution of household income, measuring the relative contribution of a range of processes to changes in segregation. Results show that segregation rises in both cities but that different processes drive changes in each case. Furthermore, the aggregate change in segregation for each city masks a diversity of changes at the neighbourhood level, some of which tend to increase segregation while others tend to reduce it. Mapping these changes and the individual processes contributing to them shows that they have a distinct geography, which seems to be structured by historically specific trends in state and housing market context.

Serial cardiac biomarkers, pulmonary artery pressures and traditional parameters of fluid status in relation to prognosis in patients with chronic heart failure:Design and rationale of the BioMEMS study

AimsHeart failure (HF), a global pandemic affecting millions of individuals, calls for adequate predictive guidance for improved therapy. Congestion, a key factor in HF-related hospitalizations, further underscores the need for timely interventions. Proactive monitoring of intracardiac pressures, guided by pulmonary artery (PA) pressure, offers opportunities for efficient early-stage intervention, since haemodynamic congestion precedes clinical symptoms.MethodsThe BioMEMS study, a substudy of the MONITOR-HF trial, proposes a multifaceted approach integrating blood biobank data with traditional and novel HF parameters. Two additional blood samples from 340 active participants in the MONITOR-HF trial were collected at baseline, 3-, 6-, and 12-month visits and stored for the BioMEMS biobank. The main aims are to identify the relationship between temporal biomarker patterns and PA pressures derived from the CardioMEMS-HF system, and to identify the biomarker profile(s) associated with the risk of HF events and cardiovascular death.ConclusionSince the prognostic value of single baseline measurements of biomarkers like N-terminal pro-B-type natriuretic peptide is limited, with the BioMEMS study we advocate a dynamic, serial approach to better capture HF progression. We will substantiate this by relating repeated biomarker measurements to PA pressures. This design rationale presents a comprehensive review on cardiac biomarkers in HF, and aims to contribute valuable insights into personalized HF therapy and patient risk assessment, advancing our ability to address the evolving nature of HF effectively.Design and rationale of the BioMEMS study. QoL, quality of life. Graphical abstract is created with BioRender.com imag

A randomised comparison of the effect of haemodynamic monitoring with CardioMEMS in addition to standard care on quality of life and hospitalisations in patients with chronic heart failure: Design and rationale of the MONITOR HF multicentre randomised clinical trial

Background: Assessing haemodynamic congestion based on filling pressures instead of clinical congestion can be a way to further improve quality of life (QoL) and clinical outcome by intervening before symptoms or weight gain occur in heart failure (HF) patients. The clinical efficacy of remote monitoring of pulmonary artery (PA) pressures (CardioMEMS; Abbott Inc., Atlanta, GA, USA) has been demonstrated in the USA. Currently, the PA sensor is not reimbursed in the European Union as its benefit when applied in addition to standard HF care is unknown in Western European countries, including the Netherlands. Aims: To demonstrate the efficacy and cost-effectiveness of haemodynamic PA monitoring in addition to contemporary standard HF care in a high-quality Western European health care system. Methods: The current study is a prospective, multi-centre, randomised clinical trial in 340 patients with chronic HF (New York Heart Association functional class III) randomised to HF care including remote monitoring with the CardioMEMS PA sensor or standard HF care alone. Eligible patients have at least one hospitalisation for HF in 12 months before enrolment and will be randomised in a 1:1 ratio. Minimum follow-up will be 1 year. The primary endpoint is the change in QoL as measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ). Secondary endpoints are the number of HF hospital admissions and changes in health status assessed by EQ-5D-5L questionnaire including healt

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Next Living: Wonen komt bij het Rijk weer door de voordeur

Dit artikel blikt vooruit op de agenda voor wonen in de toekomst. Het is gebaseerd op een essay geschreven in najaar 2016 in opdracht van de Vereniging Deltametrapool, in samenwerking met het Ministerie van Infrastructuur en Milieu, ter voorbereiding van de Nationale Omgevingsvisie

sj-docx-1-mrx-10.1177_01979183231165499 - Supplemental material for Economic Assimilation of the “Third Generation”: An Intergenerational Mobility Perspective

Supplemental material, sj-docx-1-mrx-10.1177_01979183231165499 for Economic Assimilation of the “Third Generation”: An Intergenerational Mobility Perspective by Aslan Zorlu and Wouter van Gent in International Migration Review</p

Next Living: Wonen komt bij het Rijk weer door de voordeur

Dit artikel blikt vooruit op de agenda voor wonen in de toekomst. Het is gebaseerd op een essay geschreven in najaar 2016 in opdracht van de Vereniging Deltametrapool, in samenwerking met het Ministerie van Infrastructuur en Milieu, ter voorbereiding van de Nationale Omgevingsvisie.Urban Development ManagementPractice Chair Urban Area Developmen