5 research outputs found
Functional abdominal pain disorders and patient- and parent- reported outcomes in children with inflammatory bowel disease in remission
- Author
- BERTRAND Valerie
- BOUAZZA Ahlem
- BRETON Anne
- BRIDOUX-HENNO Laure
- CARON Nicolas
- CARRE Emilie
- CHAILLOU-LEGAULT Emilie
- CLOUZEAU Haude
- COOPMAN Stephanie
- DABADIE Alain
- DEGAS Vanessa
- DIMITROV Georges
- DJEDDI Djamal
- DUPONT-LUCAS Claire
- ENAUD Raphael
- GASTINEAU Swellen
- GRANDJEAN Camille
- HUGOT Jean-Pierre
- LACOTTE Edouard
- LAMIREAU Thierry
- LANGUEPIN Jane
- MARTINEZ-VINSON Christine
- MAS Emmanuel
- MOSCA Alexis
- PIGNEUR Benedicte
- RUEMMELE Frank
- SPYCKERELLE Claire
- THOMASSIN Nadege
- TRAN Lea Chantal
- VANRENTERGHEM Audrey
- VIALA Jerome
- WILLOT Stephanie
- Publication venue
- 'Elsevier BV'
- Publication date
- 26/06/2021
- Field of study
BACKGROUND: Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission. AIMS: To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD). METHODS: Patients with IBD for > 1 year, in clinical remission for ≥ 3 months were recruited from a National IBD network. IBD-FAPDs were assessed using the Rome III questionnaire criteria. Patient- or parent- reported outcomes were assessed. RESULTS: Among 102 included patients, 57 (56%) were boys, mean age (DS) was 15.0 (± 2.0) years and 75 (74%) had Crohn's disease. Twenty-two patients (22%) had at least one Functional Gastrointestinal Disorder among which 17 had at least one IBD-FAPD. Past severity of disease or treatments received and level of remission were not significantly associated with IBD-FAPD. Patients with IBD-FAPD reported more fatigue (peds-FACIT-F: 35.9 ± 9.8 vs. 43.0 ± 6.9, p = 0.01) and a lower HR-QoL (IMPACT III: 76.5 ± 9.6 vs. 81.6 ± 9.2, p = 0.04) than patients without FAPD, and their parents had higher levels of State and Trait anxiety than the other parents. CONCLUSIONS: Prevalence of IBD-FAPD was 17%. IBD-FAPD was not associated with past severity of disease, but with fatigue and lower HR-QoL
Indeterminate tcdB using a Clostridium difficile PCR assay: a retrospective cohort study
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mapping the human genetic architecture of COVID-19
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol)
- Author
- Alauze Bertille
- Albarel Frederique
- Bachelot Anne
- Bernard Valérie
- Beyler Constance
- Bismuth Elise
- Bois Emilie
- Bourcigaux Nathalie
- Bourrat Emmanuelle
- Bouvattier Claire
- Brac Aude
- Bretones Patricia
- Bui Quoc Emmanuel
- Carel Jean-Claude
- Chabbert-Buffet Nathalie
- Chanson Philippe
- Chaussain Catherine
- Christin-Maitre Sophie
- Cohen Ariel
- Cohen-Solal Martine
- Coutant Regis
- da Costa Sabrina
- de Filippo Gianpaolo
- de Warren Marguerite
- Delcour Clemence
- Demaret Béatrice
- Donadille Bruno
- Dossier Claire
- Duranteau Lise
- Ederhy Stephane
- Elmaleh Monique
- Eustache Florence
- Fiot Elodie
- Gautheret Lydie
- Gelwane Georges
- Gourbesville Claire
- Grynberg Mickaël
- Gueniche Karinne
- Houang Muriel
- Iserin Laurence
- Jorgensen Carina
- Kerlan Veronique
- Lebrun Charlotte
- Lefevre Christine
- Lengliné Hélène
- Lorenzini Françoise
- Léger Juliane
- Manouvrier Sylvie
- Netchine Irène
- Pienkowski Catherine
- Polak Michel
- Poujol-Robert Armelle
- Reynaud Rachel
- Reznik Yves
- Roulot Dominique
- Samara-Boustani Dinane
- Siffroi Jean-Pierre
- Tabet Anne-Claude
- Tauber Maithé
- Tauveron Igor
- Touraine Philippe
- Vautier Vanessa
- Viala Jerome
- Wambre Sebastien
- Zenaty Delphine
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
International audienceTurner syndrome (TS; ORPHA 881) is a rare condition in which all or part of one X chromosome is absent from some or all cells. It affects approximately one in every 1/2500 liveborn girls. The most frequently observed karyotypes are 45,X (40-50%) and the 45,X/46,XX mosaic karyotype (15-25%). Karyotypes with an X isochromosome (45,X/46,isoXq or 45,X/46,isoXp), a Y chromosome, X ring chromosome or deletions of the X chromosome are less frequent. The objective of the French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins) is to provide health professionals with information about the optimal management and care for patients, based on a critical literature review and multidisciplinary expert consensus. The PNDS, written by members of the French National Reference Center for Rare Growth and Developmental Endocrine disorders, is available from the French Health Authority website. Turner Syndrome is associated with several phenotypic conditions and a higher risk of comorbidity. The most frequently reported features are growth retardation with short adult stature and gonadal dysgenesis. TS may be associated with various congenital (heart and kidney) or acquired diseases (autoimmune thyroid disease, celia
Mapping the human genetic architecture of COVID-19
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- Abdullah T
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- Clarkson M
- Clayton S
- Clement I
- Clements S
- Clerc O
- Cloherty A
- Clohisey S
- Clohisey S
- Clohisey S
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- Collins BL
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- Cordioli M
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- Cordioli M
- Cordioli M
- Cordioli M
- Cordioli M
- Cordioli M
- Cornberg M
- Cornell S
- Cornely OA
- Corral MA
- Correia GDS
- Corridi M
- Cortes B
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- Cosgrove D
- Cosier T
- Cossarizza A
- Costantino G
- Cother N
- Coton Z
- Coulding M
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- Coviello DA
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- Cowley N
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- de Gordoa LO-R
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- De la Horra C
- De Neef M
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- Zanelli G
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- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease