The Fermi Bubble as a Source of Cosmic Rays in the Energy Range > 10E15 eV

The {\it Fermi} Large Area Telescope has recently discovered two giant gamma-ray bubbles which extend north and south of the Galactic center with diameters and heights of the order of $H\sim 10$ kpc. We suggest that the periodic star capture processes by the Galactic supermassive black hole Sgr A$^*$, with a capture rate of $\tau_{\rm cap}^{-1}\sim 3\times 10^{-5}$ yr$^{-1}$ and an energy release of $W\sim 3\times 10^{52}$ erg per capture, can result in hot plasma injecting into the Galactic halo at a wind velocity of $u\sim 10^8$ cm s$^{-1}$. The periodic injection of hot plasma can produce a series of shocks. Energetic protons in the bubble are re-accelerated when they interact with these shocks. We show that for energy larger than $E> 10^{15}$ eV, the acceleration process can be better described by the stochastic second-order Fermi acceleration. We propose that hadronic cosmic rays (CRs) within the ``knee'' of the observed CR spectrum are produced by Galactic supernova remnants distributed in the Galactic disk. Re-acceleration of these particles in the Fermi Bubble produces CRs beyond the knee. With a mean CR diffusion coefficient in this energy range in the bubble $D_B\sim 3\times 10^{30}$ cm$^2$ s$^{-1}$, we can reproduce the spectral index of the spectrum beyond the knee and within. The conversion efficiency from shock energy of the bubble into CR energy is about 10\%. This model provides a natural explanation of the observed CR flux, spectral indices, and matching of spectra at the knee.Comment: 43 pages, 8 figues, to be published in the Astrophysical Journal; version 2, 45 pages, 8 figures, added references and corrected typo

Diffuse emission measurement with INTEGRAL/SPI as indirect probe of cosmic-ray electrons and positrons

Significant advances have been made in the understanding of the diffuse Galactic hard X-ray continuum emission using data from the INTEGRAL observatory. The diffuse hard power-law component seen with the INTEGRAL/SPI spectrometer has been identified with inverse-Compton emission from relativistic (GeV) electrons on the cosmic microwave background and Galactic interstellar radiation field. In the present analysis, SPI data from 2003 to 2009, with a total exposure time of ~ 10^8 s, are used to derive the Galactic ridge hard X-ray spatial distribution and spectrum between 20 keV and 2.4 MeV. Both are consistent with predictions from the GALPROP code. The good agreement between measured and predicted emission from keV to GeV energies suggests that the correct production mechanisms have been identified. We discuss the potential of the SPI data to provide an indirect probe of the interstellar cosmic-ray electron distribution, in particular for energies below a few GeV.Comment: 39 pages, 11 figures. Accepted for publication in The Astrophysical Journa

Evaluation of volumetric modulated arc therapy (VMAT) with Oncentra MasterPlan® for the treatment of head and neck cancer

Background Several comparison studies have shown the capability of VMAT to achieve similar or better plan quality as IMRT, while reducing the treatment time. The experience of VMAT in a multi vendor environment is limited. We compared the plan quality and performance of VMAT to IMRT and we investigate the effects of varying various user-selectable parameters. Methods IMRT, single arc VMAT and dual arc VMAT were compared for four different head-and-neck tumors. For VMAT, the effect of varying gantry angle spacing and treatment time on the plan quality was investigated. A comparison of monitor units and treatment time was performed. Results IMRT and dual arc VMAT achieved a similar plan quality, while single arc could not provide an acceptable plan quality. Increasing the number of control points does not improve the plan quality. Dual arc VMAT delivery time is about 30% of IMRT delivery time. Conclusions Dual arc VMAT is a fast and accurate technique for the treatment of head and neck cancer. It applies similar number of MUs as IMRT, but the treatment time is strongly reduced, maintaining similar or better dose conformity to the PTV and OAR sparing

Tick-borne lymphadenopathy (TIBOLA) acquired in Southwestern Germany

<p>Abstract</p> <p>Background</p> <p>Tick-borne lymphadenopathy (TIBOLA) was first described in 1997 in a patient in France. The causative agent, <it>Rickettsia slovaca</it>, is transmitted by <it>Dermacentor </it>ticks.</p> <p>Case presentation</p> <p>In southwestern Germany we encountered a patient with a tick bite at the dorsal scalp that resulted in an eschar and nuchal lymphadenopathy. Additionally, fever, malaise as well as elevated inflammatory markers and transaminases occurred. The characteristic clinical picture along with positive antibody testing for rickettsiae of the tick-borne spotted fever group strongly suggest the diagnosis TIBOLA.</p> <p>Conclusion</p> <p>Human rickettsioses are emerging infections. Clinicians should be aware of TIBOLA as a newly described rickettsial disease. As in our case, TIBOLA may be encountered in regions/countries where <it>R. slovaca </it>and <it>Dermacentor </it>ticks are prevalent but autochthonous acquisition was not described before.</p

Atmospheric CO2 Column Measurements with an Airborne Intensity-Modulated Continuous-Wave 1.57-micron Fiber Laser Lidar

The 2007 National Research Council (NRC) Decadal Survey on Earth Science and Applications from Space recommended Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) as a mid-term, Tier II, NASA space mission. ITT Exelis, formerly ITT Corp., and NASA Langley Research Center have been working together since 2004 to develop and demonstrate a prototype Laser Absorption Spectrometer for making high-precision, column CO2 mixing ratio measurements needed for the ASCENDS mission. This instrument, called the Multifunctional Fiber Laser Lidar (MFLL), operates in an intensity-modulated, continuous-wave mode in the 1.57- micron CO2 absorption band. Flight experiments have been conducted with the MFLL on a Lear-25, UC-12, and DC-8 aircraft over a variety of different surfaces and under a wide range of atmospheric conditions. Very high-precision CO2 column measurements resulting from high signal-to-noise (great than 1300) column optical depth measurements for a 10-s (approximately 1 km) averaging interval have been achieved. In situ measurements of atmospheric CO2 profiles were used to derive the expected CO2 column values, and when compared to the MFLL measurements over desert and vegetated surfaces, the MFLL measurements were found to agree with the in situ-derived CO2 columns to within an average of 0.17% or approximately 0.65 ppmv with a standard deviation of 0.44% or approximately 1.7 ppmv. Initial results demonstrating ranging capability using a swept modulation technique are also presented

A network of magnetometers for multi-scale urban science and informatics

The magnetic signature of an urban environment is investigated using a geographically distributed network of fluxgate magnetometers deployed in and around Berkeley, California. The system hardware and software are described and initial operations of the network are reported. The sensors measure vector magnetic fields at a 3960&thinsp;Hz sample rate and are sensitive to 0.1&thinsp;nT/Hz. Data from individual stations are synchronized to ±120&thinsp;µs using global positioning system (GPS) and computer system clocks and automatically uploaded to a central server. We present the initial observations of the network and preliminary efforts to correlate sensors. A wavelet analysis is used to study observations of the urban magnetic field over a wide range of temporal scales. The Bay Area Rapid Transit (BART) is identified as the dominant signal in our observations, exhibiting aspects of both broadband noise and coherent periodic features. Significant differences are observed in both day–night and weekend–weekday signatures. A superposed epoch analysis is used to study and extract the BART signal.</p

Constraining Warm Dark Matter using QSO gravitational lensing

Warm Dark Matter (WDM) has been invoked to resolve apparent conflicts of Cold Dark Matter (CDM) models with observations on subgalactic scales. In this work we provide a new and independent lower limit for the WDM particle mass (e.g. sterile neutrino) through the analysis of image fluxes in gravitationally lensed QSOs. Starting from a theoretical unperturbed cusp configuration we analyze the effects of intergalactic haloes in modifying the fluxes of QSO multiple images, giving rise to the so-called anomalous flux ratio. We found that the global effect of such haloes strongly depends on their mass/abundance ratio and it is maximized for haloes in the mass range 10^6-10^8 \Msun. This result opens up a new possibility to constrain CDM predictions on small scales and test different warm candidates, since free streaming of warm dark matter particles can considerably dampen the matter power spectrum in this mass range. As a consequence, while a ($\Lambda$)CDM model is able to produce flux anomalies at a level similar to those observed, a WDM model, with an insufficiently massive particle, fails to reproduce the observational evidences. Our analysis suggests a lower limit of a few keV ($m_{\nu} \sim 10$) for the mass of warm dark matter candidates in the form of a sterile neutrino. This result makes sterile neutrino Warm Dark Matter less attractive as an alternative to Cold Dark Matter, in good agreement with previous findings from Lyman-$\alpha$ forest and Cosmic Microwave Background analysis.Comment: One equation added, typo in eq: 5 corrected, minor changes to match the accepted version by MNRA

The Sloan Lens ACS Survey. XI. Beyond Hubble resolution: size, luminosity and stellar mass of compact lensed galaxies at intermediate redshift

We exploit the strong lensing effect to explore the properties of intrinsically faint and compact galaxies at intermediate redshift, at the highest possible resolution at optical wavelengths. Our sample consists of 46 strongly-lensed emission line galaxies discovered by the Sloan Lens ACS (SLACS) Survey. The galaxies have been imaged at high resolution with HST in three bands (V_HST, I_814 and H_160), allowing us to infer their size, luminosity, and stellar mass using stellar population synthesis models. Lens modeling is performed using a new fast and robust code, klens, which we test extensively on real and synthetic non-lensed galaxies, and also on simulated galaxies multiply-imaged by SLACS- like galaxy-scale lenses. Our tests show that our measurements of galaxy size, flux, and Sersic index are robust and accurate, even for objects intrinsically smaller than the HST point spread function. The median magnification is 8.8, with a long tail that extends to magnifications above 40. Modeling the SLACS sources reveals a population of galaxies with colors and Sersic indices (median n ~ 1) consistent with the objects detected in the field with HST in the GEMS survey, but that are (typically) ~ 2 magnitudes fainter and ~ 5 times smaller in apparent size. The closest analog are ultracompact emission line galaxies identified by HST grism surveys. The lowest mass galaxies in our sample are comparable to the brightest Milky Way satellites in stellar mass (10^7 solar masses) and have well-determined half light radii of 0."05 (~0.3 kpc).Comment: 19 pages, 12 figures, 6 tables, accepted for publication in Ap

Patient-Clinician Decision Making for Stable Angina: The Role of Health Literacy

Background: Stable angina patients have difficulty understanding the tradeoffs between treatment alternatives. In this analysis, we assessed treatment planning conversations for stable angina to determine whether inadequate health literacy acts as a barrier to communication that may partially explain this difficulty. Methods: We conducted a descriptive analysis of patient questionnaire data from the PCI Choice Trial. The main outcomes were the responses to the Decisional Conflict Scale and the proportion of correct responses to knowledge questions about stable angina. We also conducted a qualitative analysis on recordings of patient-clinician discussions about treatment planning. The recordings were coded with the OPTION12 instrument for shared decision-making. Two analysts independently assessed the number and types of patient questions and expressions of preferences. Results: Patient engagement did not differ by health literacy level and was generally low for all patients with respect to OPTION12 scores and the number of questions related to clinical aspects of treatment. Patients with inadequate health literacy had significantly higher decisional conflict. However, the proportion of knowledge questions answered correctly did not differ significantly by health literacy level. Conclusions: Patients with inadequate health literacy had greater decisional conflict but no difference in knowledge compared to patients with adequate health literacy. Inadequate health literacy may act as a barrier to communication, but gaps were found in patient engagement and knowledge for patients of all health literacy levels. The recorded patient-clinician encounters and the health literacy measure were valuable resources for conducting research on care delivery

Constraining the dark energy equation of state with double source plane strong lenses

We investigate the possibility of constraining the dark energy equation of state by measuring the ratio of Einstein radii in a strong gravitational lens system with two source planes. This quantity is independent of the Hubble parameter and directly measures the growth of angular diameter distances as a function of redshift. We investigate the prospects for a single double source plane system and for a forecast population of systems discovered by re-observing a population of single source lenses already known from a photometrically selected catalogue such as CASSOWARY or from a spectroscopically selected catalogue such as SLACS. We find that constraints comparable to current data-sets (15% uncertainty on the dark equation of state at 68%CL) are possible with a handful of double source plane systems. We also find that the method's degeneracy between Omega_M and w is almost orthogonal to that of CMB and BAO measurements, making this method highly complimentary to current probes.Comment: 13 Page