A photometric model for specular highlights and lighting changes. Application to feature points tracking

International audienceThis article proposes a local photometric model that compensates for specular highlights and lighting variations due to position and intensity changes. We define clearly on which assumptions it is based, according to widely used reflection models. Moreover, its theoritical validity is studied according to few configurations of the scene geometry (lighting, camera and object relative locations). Next, this model is used to improve the robustness of points tracking in luminance images with respect to specular highlights and lighting changes

Feature points tracking using photometric model and colorimetric invariants

International audienceThis article proposes several colour points tracking methods which are robust to illumination changes. Firstly, the illumination correction is achieved by computing simultaneously a local photometric model and a motion model during the image sequence. Secondly, some colour invariants are used to compensate in each point for the illumination changes. Then, since most of these attributes are not sufficiently robust to model specular highlights occurrence, we propose a third method which jointly uses a local photometric model and a global correction, by using colour invariants. To finish, the three methods are compared through experimental results, on images sequences where specular highlights and lighting changes appear

A study on local photometric models and their application to robust tracking

International audienceSince modeling reflections in image processing is a difficult task, most com- puter vision algorithms assume that objects are Lambertian and that no lighting change occurs. Some photometric models can partly answer this issue by assuming that the lighting changes are the same at each point of a small window of interest. Through a study based on specular reflection models, we explicit the assumptions on which these models are implicitly based and the situations in which they could fail. This paper proposes two photometric models, which compensate for spec- ular highlights and lighting variations. They assume that photometric changes vary smoothly on the window of interest. Contrary to classical models, the characteristics of the object surface and the lighting changes can vary in the area being observed. First, we study the validity of these models with re- spect to the acquisition setup: relative locations between the light source, the sensor and the object as well as the roughness of the surface. Then, these models are used to improve feature points tracking by simultaneously estimating the photometric and geometric changes. The proposed methods are compared to well-known tracking methods robust to affine photometric changes. Experimental results on specular objects demonstrate the robust- ness of our approaches to specular highlights and lighting changes

Feature point tracking : Robustness to specular highlights and lighting variations

International audienceSince the precise modeling of reflection is a difficult task, most feature points trackers assume that objects are lambertian and that no lighting change occurs. To some extent, a few approaches answer these issues by computing an affine photometric model or by achieving a photometric normalization. Through a study based on specular reflection models, we explain explicitly the assumptions on which these techniques are based. Then we propose a tracker that compensates for specular highlights and lighting variations more efficiently when small windows of interest are considered. Experimental results on image sequences prove the robustness and the accuracy of this technique in comparison with the existing trackers. Moreover, the computation time of the tracking is not significantly increased

A photometric model for specular highlights and lighting changes. Application to feature points tracking

International audienceThis article proposes a local photometric model that compensates for specular highlights and lighting variations due to position and intensity changes. We define clearly on which assumptions it is based, according to widely used reflection models. Moreover, its theoritical validity is studied according to few configurations of the scene geometry (lighting, camera and object relative locations). Next, this model is used to improve the robustness of points tracking in luminance images with respect to specular highlights and lighting changes

Experience of Pleasure and Emotional Expression in Individuals with Schizotypal Personality Features

Difficulties in feeling pleasure and expressing emotions are one of the key features of schizophrenia spectrum conditions, and are significant contributors to constricted interpersonal interactions. The current study examined the experience of pleasure and emotional expression in college students who demonstrated high and low levels of schizotypal personality disorder (SPD) traits on self-report questionnaires. One hundred and seventeen subjects with SPD traits and 116 comparison controls were recruited to participate. Cluster analyses conducted in the SPD group identified negative SPD and positive SPD subgroups. The negative SPD group exhibited deficient emotional expression and anticipatory pleasure, but showed intact consummatory pleasure. The positive SPD group reported significantly greater levels of anticipatory, consummatory and total pleasure compared to the control group. Both SPD groups reported significantly more problems in everyday memory and greater levels of depressive and anxiety-related symptoms

Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Protein engineering approaches are often a combination of rational design and directed evolution using display technologies. Here, we test “loop grafting,” a rational design method, on three-finger fold proteins. These small reticulated proteins have exceptional affinity and specificity for their diverse molecular targets, display protease-resistance, and are highly stable and poorly immunogenic. The wealth of structural knowledge makes them good candidates for protein engineering of new functionality. Our goal is to enhance the efficacy of these mini-proteins by modifying their pharmacological properties in order to extend their use in imaging, diagnostics and therapeutic applications. Using the interaction of three-finger fold toxins with muscarinic and adrenergic receptors as a model, chimeric toxins have been engineered by substituting loops on toxin MT7 by those from toxin MT1. The pharmacological impact of these grafts was examined using binding experiments on muscarinic receptors M1 and M4 and on the α1A-adrenoceptor. Some of the designed chimeric proteins have impressive gain of function on certain receptor subtypes achieving an original selectivity profile with high affinity for muscarinic receptor M1 and α1A-adrenoceptor. Structure-function analysis supported by crystallographic data for MT1 and two chimeras permits a molecular based interpretation of these gains and details the merits of this protein engineering technique. The results obtained shed light on how loop permutation can be used to design new three-finger proteins with original pharmacological profiles

Pros and cons of different therapeutic antibody formats for recombinant antivenom development.

Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being investigated for the ability to neutralize animal toxins. These different molecular formats each have their own therapeutic characteristics. In this review, we provide an overview of the advances made in the development of toxin-targeting antibodies, and discuss the benefits and drawbacks of different antibody formats in relation to their ability to neutralize toxins, pharmacokinetic features, propensity to cause adverse reactions, formulation, and expression for research and development (R&D) purposes and large-scale manufacturing. A research trend seems to be emerging towards the use of human antibody formats as well as camelid heavy-domain antibody fragments due to their compatibility with the human immune system, beneficial therapeutic properties, and the ability to manufacture these molecules cost-effectively

Schizophrenia and the Scaffolded Self

This is the author accepted manuscript. The final version is available from Springer Verlag via the DOI in this recordA family of recent externalist approaches in philosophy of mind argues that our psychological capacities are synchronically and diachronically “scaffolded” by external (i.e., beyond-the-brain) resources. Despite much interest in this topic, however, it has not found its way to philosophy of psychiatry in a substantive way. I here consider how these “scaffolded” approaches to mind and self might inform debates in phenomenological psychopathology. First, I introduce the idea of “affective scaffolding”. I distinguish three forms of affective scaffolding and support this taxonomy by appealing to different sources of empirical work. Second, I put the idea of affective scaffolding to work. Using schizophrenia as a case study, I argue — along with others in phenomenological psychopathology — that schizophrenia is fundamentally a self-disturbance. However, I offer a subtle reconfiguration of these approaches. I argue that schizophrenia is not simply a disruption of ipseity or minimal self-consciousness but rather a disruption of the scaffolded self, established and regulated via its ongoing engagement with the world and others. I conclude that this way of thinking about the scaffolded self is potentially transformative both for our theoretical as well as practical understanding of the causes and character of schizophrenic experience, insofar as it suggests the need to consider new forms of intervention and treatment

Monocular 3D structure estimation for urban scenes

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