A foam model highlights the differences of the macro- and microrheology of respiratory horse mucus

Native horse mucus is characterized with micro- and macrorheology and compared to hydroxyethylcellulose (HEC) gel as a model. Both systems show comparable viscoelastic properties on the microscale and for the HEC the macrorheology is in good agreement with the microrheology. For the mucus, the viscoelastic moduli on the macroscale are several orders of magnitude larger than on the microscale. Large amplitude oscillatory shear experiments show that the mucus responds nonlinearly at much smaller deformations than HEC. This behavior fosters the assumption that the mucus has a foam like structure on the microscale compared to the typical mesh like structure of the HEC, a model that is supported by cryogenic-scanning-electron-microscopy (CSEM) images. These images allow also to determine the relative amount of volume that is occupied by the pores and the scaffold. Consequently, we can estimate the elastic modulus of the scaffold. We conclude that this particular foam like microstructure should be considered as a key factor for the transport of particulate matter which plays a central role in mucus function with respect to particle penetration. The mesh properties composed of very different components are responsible for macroscopic and microscopic behavior being part of particles fate after landing.Comment: Accepted for publication in the Journal of the Mechanical Behavior of Biomedical Material

Self-attraction effect and correction on three absolute gravimeters

The perturbations of the gravitational field due to the mass distribution of an absolute gravimeter have been studied. The so called Self Attraction Effect (SAE) is crucial for the measurement accuracy, especially for the International Comparisons, and for the uncertainty budget evaluation. Three instruments have been analysed: MPG-2, FG5-238 and IMPG-02. The SAE has been calculated using a numerical method based on FEM simulation. The observed effect has been treated as an additional vertical gravity gradient. The correction (SAC) to be applied to the computed g value has been associated with the specific height level, where the measurement result is typically reported. The magnitude of the obtained corrections is of order 1E-8 m/s2.Comment: 14 pages, 8 figures, submitted to Metrologi

Clinical correlates of anti-SARS-CoV-2 antibody profiles in Spanish COVID-19 patients from a high incidence region

Laboratory testing for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) consists of two pillars: the detection of viral RNA via rt-PCR as the diagnostic gold standard in acute cases, and the detection of antibodies against SARS-CoV-2. However, concerning the latter, questions remain about their diagnostic and prognostic value and it is not clear whether all patients develop detectable antibodies. We examined sera from 347 Spanish COVID-19 patients, collected during the peak of the epidemic outbreak in Spain, for the presence of IgA and IgG antibodies against SARS-CoV-2 and evaluated possible associations with age, sex and disease severity (as measured by duration of hospitalization, kind of respiratory support, treatment in ICU and death). The presence and to some degree the levels of anti-SARS-CoV-2 antibodies depended mainly on the amount of time between onset of symptoms and the collection of serum. A subgroup of patients did not develop antibodies at the time of sample collection. Compared to the patients that did, no differences were found. The presence and level of antibodies was not associated with age, sex, duration of hospitalization, treatment in the ICU or death. The case-fatality rate increased exponentially with older age. Neither the presence, nor the levels of anti-SARS-CoV-2 antibodies served as prognostic markers in our cohort. This is discussed as a possible consequence of the timing of the sample collection. Age is the most important risk factor for an adverse outcome in our cohort. Some patients appear not to develop antibodies within a reasonable time frame. It is unclear, however, why that is, as these patients differ in no respect examined by us from those who developed antibodies

A comparison of robust polynomial fitting, global geopotential model and spectral analysis for regional–residual gravity field separation in the Doñana National Park (Spain)

Doñana National Park is a protected area of approximately 500 km2 located on the SW coast of Spain with singular and interesting ecological and geological features. A gravimetric survey is presented where L&R gravity metres were used in the gravimetric observations with GPS and high-precision levelling positioning. Bouguer gravity anomalies were computed and least squares prediction was used for gross-error detection. Robust polynomial fitting, the recent EGM2008 global geopotential model (complete to degree and order 2159), and spectral analysis were tested for regional–residual gravity field separation. A detailed description of the gravimetric characteristics of the Doñana National Park is presented and the values of residual gravity anomalies were correlated with geological features, where the use of the EGM2008 global geopotential model has revealed an interesting tool for regional–residual gravity field separation. Finally, the interpretation of the results is justified by the well-known geological aspects of the park, but some modifications in the boundaries of the different geological features are needed in order to fit the modelled gravity with the residual gravity anomalies in the two cross-sections analysed.The studies presented here were part of CICYT (Spanish Research Directorate) research project nos. HID 97-0321 and REN2001-1293. We would like to thank all UPC members participating in these projects and the staff from the Biological Station of Donana (CSIC), Palacio de Donana and Donana National Park. We remain deeply grateful for the fruitful discussion with Dr. Salvany and for the geological review of the manuscript.Martín Furones, ÁE.; Nuñez Andrés, M.; Gili, J.; Anquela Julián, AB. (2011). A comparison of robust polynomial fitting, global geopotential model and spectral analysis for regional–residual gravity field separation in the Doñana National Park (Spain). Journal of Applied Geophysics. 75(2):327-337. https://doi.org/10.1016/j.jappgeo.2011.06.037S32733775

Gravity and elevation changes at Askja, Iceland

Ground tilt measurements demonstrate that Askja is in a state of unrest, and that in the period 1988 - 1991 a maximum 48 +/- 3 µrad tilt occurred down towards the centre of the caldera. This is consistent with 126 mm of deflation at the centre of the caldera with a 2.5 - 3.0 km depth to the source of deformation. The volume of the subsidence bowl is 6.2 x 106 m3. When combined with high precision microgravity measurements, the overall change in sub-surface mass may be quantified. After correction for the observed elevation change using the free air gradient of gravity measured for each station, the total change in mass is estimated to be less than 109 kg. A small residual ground inflation and net gravity increase in the eastern part of the caldera may be caused by dyke intrusion in this region. The minimum dimensions of such an intrusion or complex of intrusions are 1m width, up to 100m deep and up to several hundred metres thick

Detecting and Characterizing Young Quasars I: Systemic Redshifts and Proximity Zones Measurements

In a multi-wavelength survey of $13$ quasars at $5.8\lesssim z\lesssim6.5$, that were pre-selected to be potentially young, we find five objects with extremely small proximity zone sizes that may imply UV-luminous quasar lifetimes of $\lesssim 100,000$ years. Proximity zones are regions of enhanced transmitted flux in the vicinity of the quasars that are sensitive to the quasars' lifetimes because the intergalactic gas has a finite response time to their radiation. We combine sub-mm observations from the Atacama Large Millimetre Array (ALMA) and the NOrthern Extended Millimeter Array (NOEMA), as well as deep optical and near-infrared spectra from medium-resolution spectrograph on the Very Large Telescope (VLT) and on the Keck telescopes, in order to identify and characterize these new young quasars, which provide valuable clues about the accretion behavior of supermassive black holes (SMBHs) in the early universe, and pose challenges on current black hole formation models to explain the rapid formation of billion solar mass black holes. We measure the quasars' systemic redshifts, black hole masses, Eddington ratios, emission line luminosities, and star formation rates of their host galaxies. Combined with previous results we estimate the fraction of young objects within the high-redshift quasar population at large to be $5\%\lesssim f_{\rm young}\lesssim 10\%$. One of the young objects, PSO J158-14, shows a very bright dust continuum flux ($F_{\rm cont}=3.46\pm 0.02\,\rm mJy$), indicating a highly star-bursting host galaxy with a star formation rate of approximately $1420\,M_{\odot}\,\rm yr^{-1}$.Comment: Accepted for publication in Ap

Solar radiative transfer simulations in Saharan dust plumes: particle shapes and 3-D effect

Radiative fields of three-dimensional inhomogeneous Saharan dust clouds have been calculated at solar wavelength (0.6 μm) by means of a Monte Carlo radiative transfer model. Scattering properties are taken from measurements in the SAMUM campaigns, from light scattering calculations for spheroids based on the MIESCHKA code, from Mie theory for spheres and from the geometric optics method assuming irregular shaped particles. Optical properties of different projected area equivalent shapes are compared. Large differences in optical properties are found especially in the phase functions. Results of radiative transfer calculations based on the Monte Carlo method are shown exemplarily for one dust cloud simulated by the cloud resolving atmospheric circulation model LM-MUSCAT-DES. Shape-induced differences in the radiation fluxes are pronounced, for example, the domain averaged normalized radiance is about 30% lower in the case of a dust plume consisting of spheroids or irregular particles compared to spheres. The effect of net horizontal photon transport (3-D effect) on the reflected radiance fields is only notable at the largest gradients in optical thickness. For example, the reflectance at low sun position differs locally about 15% when horizontal photon transport is accounted for. ‘Sharp edges' due to 1-D calculations are smoothed out in the 3-D case

Expected accuracy of tilt measurements on a novel hexapod-based Digital zenith camera system: A Monte-Carlo simulation study

Digital zenith camera systems (DZCS) are dedicated astronomical-geodetic measurement systems for the observation of the direction of the plumb line. A DZCS key component is a pair of tilt meters for the determination of the instrumental tilt with respect to the plumb line. Highest accuracy (i.e., 0.1 arc-seconds or better) is achieved in practice through observation with precision tilt meters in opposite faces (180° instrumental rotation), and application of rigorous tilt reduction models. A novel concept proposes the development of a hexapod (Stewart platform)-based DZCS. However, hexapod-based total rotations are limited to about 30°–60° in azimuth (equivalent to ±15° to ±30° yaw rotation), which raises the question of the impact of the rotation angle between the two faces on the accuracy of the tilt measurement. The goal of the present study is the investigation of the expected accuracy of tilt measurements to be carried out on future hexapod-based DZCS, with special focus placed on the role of the limited rotation angle. A Monte-Carlo simulation study is carried out in order to derive accuracy estimates for the tilt determination as a function of several input parameters, and the results are validated against analytical error propagation.As the main result of the study, limitation of the instrumental rotation to 60° (30°) deteriorates the tilt accuracy by a factor of about 2 (4) compared to a 180° rotation between the faces. Nonetheless, a tilt accuracy at the 0.1 arc-second level is expected when the rotation is at least 45°, and 0.05 arc-second (about 0.25 microradian) accurate tilt meters are deployed. As such, a hexapod-based DZCS can be expected to allow sufficiently accurate determination of the instrumental tilt. This provides supporting evidence for the feasibility of such a novel instrumentation. The outcomes of our study are not only relevant to the field of DZCS, but also to all other types of instruments where the instrumental tilt must be corrected. Examples include electronic theodolites or total stations, gravity meters, and other hexapod-based telescopes