A Sub-arcsecond Survey Toward Class 0 Protostars in Perseus: Searching for Signatures of Protostellar Disks

We present a CARMA 1.3 mm continuum survey toward 9 Class 0 protostars in the Perseus molecular cloud at $\sim$0.3$^{\prime\prime}$ (70 AU) resolution. This study approximately doubles the number of Class 0 protostars observed with spatial resolutions $<$ 100 AU at millimeter wavelengths, enabling the presence of protostellar disks and proto-binary systems to be probed. We detect flattened structures with radii $>$ 100 AU around 2 sources (L1448 IRS2 and Per-emb-14) and these sources may be strong disk candidates. Marginally-resolved structures with position angles within 30$^{\circ}$ of perpendicular to the outflow are found toward 3 protostars (L1448 IRS3C, IRAS 03282+3035, and L1448C) and are considered disk candidates. Two others (L1448 IRS3B and IRAS 03292+3039) have resolved structure, possibly indicative of massive inner envelopes or disks; L1448 IRS3B also has a companion separated by 0.9$^{\prime\prime}$ ($\sim$210 AU). IC348-MMS does not have well-resolved structure and the candidate first hydrostatic core L1451-MMS is marginally resolved on 1$^{\prime\prime}$ scales. The strong disk candidate sources were followed-up with C$^{18}$O ($J=2\rightarrow1$) observations, detecting velocity gradients consistent with rotation, but it is unclear if the rotation is Keplerian. We compare the observed visibility amplitudes to radiative transfer models, finding that visibility amplitude ratios suggest a compact component (possibly a disk) is necessary for 5 of 9 Class 0 sources; envelopes alone may explain the other 4 systems. We conclude that there is evidence for the formation of large disks in the Class 0 phase with a range of radii and masses dependent upon their initial formation conditions.Comment: Accepted to ApJ, 58 pages, 19 Figures, 5 Table

A Framework for Text Mining Services

The growth of online scientific literature, coupled with the growing maturity of text processing technology, has boosted the importance of text mining as a potentially crucial tool. However, there are several challenges to be addressed before sophisticated text mining services can be deployed within emerging workflow environments. Our work contributes at two levels. At the invocation level, we have developed a flexible XML-based pipeline architecture which allows non-XML processors to be readily integrated. At the description/discovery level, we have developed a broker for service composition, and an accompanying domain ontology, that leverage the OWL-S approach to service profiles.

The VLA Nascent Disk And Multiplicity (VANDAM) Survey of Perseus Protostars. Resolving the Sub-Arcsecond Binary System in NGC 1333 IRAS2A

We are conducting a Jansky VLA Ka-band (8 mm and 1 cm) and C-band (4 cm and 6.4 cm) survey of all known protostars in the Perseus Molecular Cloud, providing resolution down to $\sim$0.06'' and $\sim$0.35" in Ka-band and C-band, respectively. Here we present first results from this survey that enable us to examine the source NGC 1333 IRAS2A in unprecedented detail and resolve it into a proto-binary system separated by 0.621"$\pm$0.006" ($\sim$143 AU) at 8 mm, 1 cm, and 4 cm. These 2 sources (IRAS2A VLA1 and VLA2) are likely driving the two orthogonal outflows known to originate from IRAS2A. The brighter source IRAS2A VLA1 is extended perpendicular to its outflow in the VLA data, with a deconvolved size of 0.055" ($\sim$13 AU), possibly tracing a protostellar disk. The recently reported candidate companions (IRAS2A MM2 and MM3) are not detected in either our VLA data, CARMA 1.3 mm data, or SMA 850 $\mu$m data. SMA CO ($J=3\rightarrow2$), CARMA CO ($J=2\rightarrow1$), and lower resolution CARMA CO ($J=1\rightarrow0$) observations are used to examine the outflow origins and the nature of the candidate companions to IRAS2A VLA1. The CO ($J=3\rightarrow2$) and ($J=2\rightarrow1$) data show that IRAS2A MM2 is coincident with a bright CO emission spot in the east-west outflow, and IRAS2A MM3 is within the north-south outflow. In contrast, IRAS2A VLA2 lies at the east-west outflow symmetry point. We propose that IRAS2A VLA2 is the driving source of the East-West outflow and a true companion to IRAS2A VLA1, whereas IRAS2A MM2 and MM3 may not be protostellar.Comment: Accepted to ApJ, 27 pages, 6 Figures, 2 Table

The influence of radiative core growth on coronal X-ray emission from pre-main sequence stars

SGG acknowledges support from the Science & Technology Facilities Council (STFC) via an Ernest Rutherford Fellowship [ST/J003255/1]. CLD acknowledges support from STFC via a PhD studentship and additional funding via the STFC Studentship Enhancement Programme [ST/J500744/1], and support from the ERC Starting Grant "Image-PlanetFormDiscs" (Grant Agreement No. 639889).Pre-main sequence (PMS) stars of mass ≳ 0.35 M⊙ transition from hosting fully convective interiors to configurations with a radiative core and outer convective envelope during their gravitational contraction. This stellar structure change influences the external magnetic field topology and, as we demonstrate herein, affects the coronal X-ray emission as a stellar analog of the solar tachocline develops. We have combined archival X-ray, spectroscopic, and photometric data for ∼1000 PMS stars from five of the best studied star forming regions; the ONC, NGC 2264, IC 348, NGC 2362, and NGC 6530. Using a modern, PMS calibrated, spectral type-to-effective temperature and intrinsic colour scale, we deredden the photometry using colours appropriate for each spectral type, and determine the stellar mass, age, and internal structure consistently for the entire sample. We find that PMS stars on Henyey tracks have, on average, lower fractional X-ray luminosities (LX/L★) than those on Hayashi tracks, where this effect is driven by changes in LX. X-ray emission decays faster with age for higher mass PMS stars. There is a strong correlation between L★ and LX for Hayashi track stars but no correlation for Henyey track stars. There is no correlation between LX and radiative core mass or radius. However, the longer stars have spent with radiative cores, the less X-ray luminous they become. The decay of coronal X-ray emission from young early K to late G-type PMS stars, the progenitors of main sequence A-type stars, is consistent with the dearth of X-ray detections of the latter.PostprintPeer reviewe

Cohort Profile: The United Kingdom Research study into Ethnicity and COVID-19 outcomes in Healthcare workers (UK-REACH)

The UK-REACH cohort was established to understand why ethnic minority healthcare workers (HCWs) are at risk of poorer outcomes from COVID-19 when compared with their White ethnic counterparts in the UK. Through study design, it contains a uniquely high percentage of participants from ethnic minority backgrounds about whom a wide range of qualitative and quantitative data have been collected. A total of 17 891 HCWs aged 16–89 years (mean age: 44) have been recruited from across the UK via all major healthcare regulators, individual National Health Service hospital trusts and UK HCW membership bodies who advertised the study to their registrants/staff to encourage participation in the study. Data available include linked healthcare records for 25 years from the date of consent and consent to obtain genomic sequencing data collected via saliva. Online questionnaires include information on demographics, COVID-19 exposures at work and home, redeployment in the workforce due to COVID-19, mental health measures, workforce attrition and opinions on COVID-19 vaccines, with baseline (n = 15 119), 6 (n = 5632) and 12-month follow-up (n = 6535) data captured. Request data access and collaborations by following documentation found at https://www.uk-reach.org/main/data_sharing

Predicting survival in malignant pleural effusion: development and validation of the LENT prognostic score

BACKGROUND: Malignant pleural effusion (MPE) causes debilitating breathlessness and predicting survival is challenging. This study aimed to obtain contemporary data on survival by underlying tumour type in patients with MPE, identify prognostic indicators of overall survival and develop and validate a prognostic scoring system. METHODS: Three large international cohorts of patients with MPE were used to calculate survival by cell type (univariable Cox model). The prognostic value of 14 predefined variables was evaluated in the most complete data set (multivariable Cox model). A clinical prognostic scoring system was then developed and validated. RESULTS: Based on the results of the international data and the multivariable survival analysis, the LENT prognostic score (pleural fluid lactate dehydrogenase, Eastern Cooperative Oncology Group (ECOG) performance score (PS), neutrophil-to-lymphocyte ratio and tumour type) was developed and subsequently validated using an independent data set. Risk stratifying patients into low-risk, moderate-risk and high-risk groups gave median (IQR) survivals of 319 days (228–549; n=43), 130 days (47–467; n=129) and 44 days (22–77; n=31), respectively. Only 65% (20/31) of patients with a high-risk LENT score survived 1 month from diagnosis and just 3% (1/31) survived 6 months. Analysis of the area under the receiver operating curve revealed the LENT score to be superior at predicting survival compared with ECOG PS at 1 month (0.77 vs 0.66, p<0.01), 3 months (0.84 vs 0.75, p<0.01) and 6 months (0.85 vs 0.76, p<0.01). CONCLUSIONS: The LENT scoring system is the first validated prognostic score in MPE, which predicts survival with significantly better accuracy than ECOG PS alone. This may aid clinical decision making in this diverse patient population

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt):study protocol

Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There is an unmet need for biomarkers that can be used in clinical settings which also improve prediction of renal decline on top of routinely available data, particularly in the early stages. The iBEAt study of the BEAt-DKD project aims to determine whether renal imaging biomarkers (magnetic resonance imaging (MRI) and ultrasound (US)) provide insight into the pathogenesis and heterogeneity of DKD (primary aim) and whether they have potential as prognostic biomarkers in DKD (secondary aim). Methods: iBEAt is a prospective multi-centre observational cohort study recruiting 500 patients with type 2 diabetes (T2D) and eGFR ≥30 ml/min/1.73m2. At baseline, blood and urine will be collected, clinical examinations will be performed, and medical history will be obtained. These assessments will be repeated annually for 3 years. At baseline each participant will also undergo quantitative renal MRI and US with central processing of MRI images. Biological samples will be stored in a central laboratory for biomarker and validation studies, and data in a central data depository. Data analysis will explore the potential associations between imaging biomarkers and renal function, and whether the imaging biomarkers improve the prediction of DKD progression. Ancillary substudies will: (1) validate imaging biomarkers against renal histopathology; (2) validate MRI based renal blood flow measurements against H2O15 positron-emission tomography (PET); (3) validate methods for (semi-)automated processing of renal MRI; (4) examine longitudinal changes in imaging biomarkers; (5) examine whether glycocalyx and microvascular measures are associated with imaging biomarkers and eGFR decline; (6) explore whether the findings in T2D can be extrapolated to type 1 diabetes. Discussion: iBEAt is the largest DKD imaging study to date and will provide valuable insights into the progression and heterogeneity of DKD. The results may contribute to a more personalised approach to DKD management in patients with T2D. Trial registration: Clinicaltrials.gov (NCT03716401)