257 research outputs found
Steeper Iris Conicity Is Related to a Shallower Anterior Chamber: The Gutenberg Health Study
Purpose. To report the distribution of iris conicity (steepness of the iris cone), investigate associated factors, and test whether pseudophakia allows the iris to sink back. Methods. A population-based cross-sectional study was carried out. Ophthalmological examination including objective refraction, biometry, noncontact tonometry, and Scheimpflug imaging (Pentacam®, Oculus) was performed including automated measurement of iris conicity. 3708 phakic subjects, 144 subjects with bilateral and 39 subjects with unilateral pseudophakia were included. Multivariable analyses were carried out to determine independently associated systemic and ocular factors for iris conicity in phakic eyes. Results. Mean iris conicity was 8.28° ± 3.29° (right eyes). Statistical analysis revealed associations between steeper iris conicity and shallower anterior chamber depth, thicker human lens and higher corneal power in multivariable analysis, while older age was related to a flatter iris conicity. Refraction, axial length, central corneal thickness, pupil diameter, and intraocular pressure were not associated with iris conicity. Pseudophakia resulted in a 5.82° flatter iris conicity than in the fellow phakic eyes. Conclusions. Associations indicate a correlation between iris conicity with risk factors for angle-closure, namely, shallower anterior chamber depth and thicker human lens. In pseudophakic eyes, iris conicity is significantly lower, indicating that cataract surgery flattens the iris
Prevalence of depression and anxiety among participants with glaucoma in a population-based cohort study : the Gutenberg Health Study
Background
To investigate the prevalence of depression and anxiety among subjects with self-reported glaucoma and the association between self-reported glaucoma and depression respectively anxiety in a European cohort.
Methods
A study sample of 14,657 participants aged 35 to 74 years was investigated in a population-based cohort study. All participants reported presence or absence of glaucoma. Ophthalmological examinations were carried out in all participants and demographic and disease related information were obtained by interview. Depression was assessed with the Patient Health Questionnaire (PHQ-9), and generalized anxiety with the two screening items (GAD-2) of the short form of the GAD-7 (Generalized Anxiety Disorder-7 Scale). Prevalence of depression and generalized anxiety were investigated for subjects with and without self-reported glaucoma. Logistic regression analyses with depression, respectively anxiety as dependent variable and self-reported glaucoma as independent variable were conducted and adjusted for socio-demographic factors, systemic comorbidities (arterial hypertension, myocardial infarction, stroke, diabetes mellitus, chronic obstructive pulmonary disease, cancer), ocular diseases (cataract, macular degeneration, corneal diseases, diabetic retinopathy), visual acuity, intraocular pressure, antiglaucoma eye drops (sympathomimetics, parasympathomimetics, carbonic anhydrase inhibitors, beta-blockers, prostaglandins) and general health status.
Results
293 participants (49.5% female) reported having glaucoma. Prevalence of depression among participants with and without self-reported glaucoma was 6.6% (95%-CI 4.1–10.3) respectively 7.7% (95%-CI 7.3–8.2), and for anxiety 5.3% (95%-CI 3.1–8.7) respectively 6.6% (95%-CI 6.2–7.1). Glaucoma was not associated with depression (Odds ratio 1.10, 95%-CI 0.50–2.38, p = 0.80) or anxiety (1.48, 95%-CI 0.63–3.30, p = 0.35) after adjustment for socio-demographic factors, ocular/systemic diseases, ocular parameters, antiglaucoma drugs and general health status. A restriction to self-reported glaucoma cases either taking topical antiglaucoma medications or having a history of glaucoma surgery did not alter the result.
Conclusions
This is the first study analyzing both depression and anxiety among glaucoma patients in a European cohort. Subjects with and without self-reported glaucoma had a similar prevalence of depression and anxiety in our population-based sample. Self-reported glaucoma was not associated with depression or anxiety. A lack of a burden of depressive symptoms may result from recruitment from a population-based sample as compared to previous study groups predominantly recruited from tertiary care hospitals
The Sloan Lens ACS Survey. X. Stellar, Dynamical, and Total Mass Correlations of Massive Early-type Galaxies
We use stellar masses, photometry, lensing, and velocity dispersions to
investigate empirical correlations for the final sample of 73 early-type lens
galaxies (ETGs) from the SLACS survey. The traditional correlations
(Fundamental Plane [FP] and its projections) are consistent with those found
for non-lens galaxies, supporting the thesis that SLACS lens galaxies are
representative of massive ETGs. The addition of strong lensing estimates of the
total mass allows us to gain further insights into their internal structure: i)
the mean slope of the total mass density profile is = 2.078+/-0.027
with an intrinsic scatter of 0.16+/-0.02; ii) gamma' correlates with effective
radius and central mass density, in the sense that denser galaxies have steeper
profiles; iii) the dark matter fraction within reff/2 is a monotonically
increasing function of galaxy mass and size; iv) the dimensional mass M_dim is
proportional to the total mass, and both increase more rapidly than stellar
mass M*; v) the Mass Plane (MP), obtained by replacing surface brightness with
surface mass density in the FP, is found to be tighter and closer to the virial
relation than the FP and the M*P, indicating that the scatter of those
relations is dominated by stellar population effects; vi) we construct the
Fundamental Hyper-Plane by adding stellar masses to the MP and find the M*
coefficient to be consistent with zero and no residual intrinsic scatter. Our
results demonstrate that the dynamical structure of ETGs is not scale invariant
and that it is fully specified by the total mass, r_eff, and sigma. Although
the basic trends can be explained qualitatively in terms of varying star
formation efficiency as a function of halo mass and as the result of dry and
wet mergers, reproducing quantitatively the observed correlations and their
tightness may be a significant challenge for galaxy formation models.Comment: 16 pages, 9 figures; submitted to ApJ after responding to the referee
comment
No evidence for an association of plasma homocysteine levels and refractive error - Results from the population-based Gutenberg Health Study (GHS)
Purpose There is a strong association between severe hyperhomocysteinemia and myopia. Thus we studied the hypothesis that even moderately increased levels of homocysteine (Hcy) might be a potentially treatable risk factor for myopia. Methods The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in Germany, including 15,010 participants aged between 35 and 74 at recruitment. The baseline examination was conducted from 2007-2012. Refraction was measured using autorefraction (HARK 599, Carl Zeiss AG, Jena, Germany). Hcy was measured by an immunoassay. We included only phakic participants without a history of corneal surgery or corneal laser treatment. We used linear regression models to evaluate the potential association between Hcy and refraction at baseline, and between Hcy and change in refraction between baseline and 5-year-follow-up examination. We used generalized estimating equation models to account for the correlation between fellow eyes. Results We included 13,749 participants, categorized as having no myopia (spherical equivalent > -0.75 D, 65.2%), low myopia (-0.75 D-2.75 D, 21.5%), moderate myopia (-3.00 D- 5.75 D, 9.8%) and high myopia (≤ -6
Two-dimensional kinematics of SLACS lenses: III. Mass structure and dynamics of early-type lens galaxies beyond z ~ 0.1
We combine in a self-consistent way the constraints from both gravitational
lensing and stellar kinematics to perform a detailed investigation of the
internal mass distribution, amount of dark matter, and dynamical structure of
the 16 early-type lens galaxies from the SLACS Survey, at z = 0.08 - 0.33, for
which both HST/ACS and NICMOS high-resolution imaging and VLT VIMOS IFU
spectroscopy are available. Based on this data set, we analyze the inner
regions of the galaxies, i.e. typically within one (3D) effective radius r_e,
under the assumption of axial symmetry and by constructing dynamical models
supported by two-integral stellar DFs. For all systems, the total mass density
distribution is found to be well approximated by a simple power-law: this
profile is on average slightly super-isothermal, with a logarithmic slope
= 2.074^{+0.043}_{-0.041} (68% CL) and an intrinsic scatter
0.144^{+0.055}_{-0.014}, and is fairly round, with an average axial ratio =
0.77+/-0.04. The lower limit for the dark matter fraction (fDM) inside r_e
ranges, in individual systems, from nearly zero to almost a half, with a median
value of 12%. By including stellar masses derived from SPS models with a
Salpeter IMF, we obtain an average fDM = 31%. The fDM rises to 61% if, instead,
a Chabrier IMF is assumed. For both IMFs, the dark matter fraction increases
with the total mass of the galaxy (3-sigma correlation). Based on the intrinsic
angular momentum parameter calculated from our models, we find that the
galaxies can be divided into two dynamically distinct groups, which are shown
to correspond to the usual classes of the slow and fast rotators. Overall, the
SLACS systems are structurally and dynamically very similar to their nearby
counterparts, indicating that the inner regions of early-type galaxies have
undergone little, if any, evolution since redshift z ~ 0.35. (Abridged)Comment: 27 pages, 34 figures. MNRAS, in pres
The impact of pseudophakia on vision-related quality of life in the general population - The Gutenberg Health Study.
Cataract surgery is the most frequently performed surgical procedure worldwide. We aim to determine the prevalence of having implanted an artificial lens (pseudophakia) and of no lens (aphakia) and to compare visual function.As part of the Gutenberg Health study, a population-based cross-sectional study was conducted in Germany. An ophthalmological examination including slit-lamp examination was conducted. Prevalence including 95% confidential intervals were calculated and analyses were conducted for systemic and ocular associated factors with pseudophakia using multivariable logistic regression models. Vision-related quality of life was assessed using a standardized questionnaire and Rasch transformation.14,696 people were included. Of these, 1.55% [1.36%-1.77%] had unilateral pseudophakia and 3.08% [2.81%-3.37%] had bilateral pseudophakia. Unilateral aphakia was present in 21 people and bilateral aphakia in 2 people. Pseudophakia was independently associated with age, higher body weight and lower body height, diabetes and smoking. Vision-related quality of life values were similar for those with bilateral phakia and pseudophakia but were lower for those with unilateral pseudophakia.The pseudophakia status is related to several cardiovascular risk factors, indicating a relationship to an aging effect that causes premature lens opacification. Bilateral pseudophakia can almost imitate the physiological condition of phakia except for the need to use glasses
SPIDER VII - Revealing the Stellar Population Content of Massive Early-type Galaxies out to 8Re
Radial trends of stellar populations in galaxies provide a valuable tool to
understand the mechanisms of galaxy growth. In this paper, we present the first
comprehensive analysis of optical-optical and optical-NIR colours, as a
function of galaxy mass, out to the halo region (8Re) of early-type galaxies
(ETGs). We select a sample of 674 massive ETGs (M*>3x10^10MSun) from the
SDSS-based SPIDER survey. By comparing with a large range of population
synthesis models, we derive robust constraints on the radial trends in age and
metallicity. Metallicity is unambiguously found to decrease outwards, with a
measurable steepening of the slope in the outer regions (Re<R<8Re). The
gradients in stellar age are found to be more sensitive to the models used, but
in general, the outer regions of ETGs feature older populations compared to the
cores. This trend is strongest for the most massive galaxies in our sample
(M*>10^11MSun). Furthermore, when segregating with respect to large scale
environment, the age gradient is more significant in ETGs residing in higher
density regions. These results shed light on the processes leading from the
formation of the central core to the growth of the stellar envelope of massive
galaxies. The fact that the populations in the outer regions are older and more
metal-poor than in the core suggests a process whereby the envelope of massive
galaxies is made up of accreted small satellites (i.e. minor mergers) whose
stars were born during the first stages of galaxy formation.Comment: 20 pages, 13 figures, 10 tables. Accepted for publication in MNRA
The impact of pseudophakia on vision-related quality of life in the general population -The Gutenberg Health Study
ABSTRACT Cataract surgery is the most frequently performed surgical procedure worldwide. We aim to determine the prevalence of having implanted an artificial lens (pseudophakia) and of no lens (aphakia) and to compare visual function. As part of the Gutenberg Health study, a population-based cross-sectional study was conducted in Germany. An ophthalmological examination including slit-lamp examination was conducted. Prevalence including 95% confidential intervals were calculated and analyses were conducted for systemic and ocular associated factors with pseudophakia using multivariable logistic regression models. Vision-related quality of life was assessed using a standardized questionnaire and Rasch transformation. 14,696 people were included. Of these, 1.55% [1.36%-1.77%] had unilateral pseudophakia and 3.08% [2.81%-3.37%] had bilateral pseudophakia. Unilateral aphakia was present in 21 people and bilateral aphakia in 2 people. Pseudophakia was independently associated with age, higher body weight and lower body height, diabetes and smoking. Vision-related quality of life values were similar for those with bilateral phakia and pseudophakia but were lower for those with unilateral pseudophakia. The pseudophakia status is related to several cardiovascular risk factors, indicating a relationship to an aging effect that causes premature lens opacification. Bilateral pseudophakia can almost imitate the physiological condition of phakia except for the need to use glasses
Noise annoyance and risk of prevalent and incident atrial fibrillation–A sex-specific analysis
BackgroundWhile chronic exposure to high levels of noise was demonstrated to increase the risk of various cardiovascular diseases, the association between noise annoyance and risk of cardiovascular disease remains still inconsistent. Recently, we showed that noise annoyance is associated with prevalent atrial fibrillation in the general population. However, the association between noise annoyance and risk of incident atrial fibrillation as well as potential sex-differences remain still elusive.Methods and results15,010 subjects from a German population-based cohort were examined at baseline (2007 to 2012) and follow-up five years later (2012 to 2017) to investigative the association between noise annoyance due to multiple sources and prevalent and incident atrial fibrillation. After multivariable adjustment, the results from logistic regression analyses revealed overall consistent and positive associations between noise annoyance and prevalent and incident atrial fibrillation in men, whereas this association was weaker in women, in particular with respect to incident atrial fibrillation. For instance, industrial noise annoyance was associated with 21% (95% confidence interval (CI) 9–34%) and 18% (8–29%) higher odds of prevalent atrial fibrillation in men and women, respectively. In prospective analysis, this association remained stable in men (odds ratio (OR) 1.25, 1.07–1.44), while in women no association was observed (OR 1.03, 0.89–1.18).ConclusionsThe findings suggest that noise annoyance can increase the risk of incident atrial fibrillation in a large population-based cohort and that men may be more sensitive to the adverse effects of noise annoyance with regard to the risk of atrial fibrillation
Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the CommunityThe Gutenberg Health Study
Homoarginine has come into the focus of interest as a biomarker for cardiovascular disease. Atrial fibrillation (AF) causes a substantial increase in morbidity and mortality. Whether circulating homoarginine is associated with occurrence or persistence of AF and may serve as a new predictive biomarker remains unknown. We measured plasma levels of homoarginine in the population-based Gutenberg health study (3761 patients included, of them 51.7% males), mean age 55.6 +/- 10.9 years-old. Associations between homoarginine and intermediate electrocardiographic and echocardiographic phenotypes and manifest AF were examined. Patients with AF (124 patients, of them 73.4% males) had a mean age 64.8 +/- 8.6 years-old compared to a mean age of 55.3 +/- 10.9 in the population without AF (p-value < 0.001) and showed a less beneficial risk factor profile. The median homoarginine levels in individuals with and without AF were 1.9 mol/L (interquartile range (IQR) 1.5-2.5) and 2.0 mol/L (IQR 1.5-2.5), respectively, p = 0.56. In multivariable-adjusted regression analyses homoarginine was not statistically significantly related to electrocardiographic variables. Among echocardiographic variables beta per standard deviation increase was -0.12 (95% confidence interval (CI) -0.23-(-0.02);p = 0.024) for left atrial area and -0.01 (95% CI -0.02-(-0.003);p = 0.013) for E/A ratio. The odds ratio between homoarginine and AF was 0.91 (95% CI 0.70-1.16;p = 0.45). In our large, population-based cross-sectional study, we did not find statistically significant correlations between lower homoarginine levels and occurrence or persistence of AF or most standard electrocardiographic phenotypes, but some moderate inverse associations with echocardiographic left atrial size and E/A. Homoarginine may not represent a strong biomarker to identify individuals at increased risk for AF. Further investigations will be needed to elucidate the role of homoarginine and cardiac function
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