1,610 research outputs found
Construction and Performance of a Micro-Pattern Stereo Detector with Two Gas Electron Multipliers
The construction of a micro-pattern gas detector of dimensions 40x10 cm**2 is
described. Two gas electron multiplier foils (GEM) provide the internal
amplification stages. A two-layer readout structure was used, manufactured in
the same technology as the GEM foils. The strips of each layer cross at an
effective crossing angle of 6.7 degrees and have a 406 um pitch. The
performance of the detector has been evaluated in a muon beam at CERN using a
silicon telescope as reference system. The position resolutions of two
orthogonal coordinates are measured to be 50 um and 1 mm, respectively. The
muon detection efficiency for two-dimensional space points reaches 96%.Comment: 21 pages, 17 figure
High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669]
INTRODUCTION: To compare the safety and efficacy of high frequency oscillatory ventilation (HFOV) with conventional mechanical ventilation (CV) for early intervention in adult respiratory distress syndrome (ARDS), a multi-centre randomized trial in four intensive care units was conducted. METHODS: Patients with ARDS were randomized to receive either HFOV or CV. In both treatment arms a priority was given to maintain lung volume while minimizing peak pressures. CV ventilation strategy was aimed at reducing tidal volumes. In the HFOV group, an open lung strategy was used. Respiratory and circulatory parameters were recorded and clinical outcome was determined at 30 days of follow up. RESULTS: The study was prematurely stopped. Thirty-seven patients received HFOV and 24 patients CV (average APACHE II score 21 and 20, oxygenation index 25 and 18 and duration of mechanical ventilation prior to randomization 2.1 and 1.5 days, respectively). There were no statistically significant differences in survival without supplemental oxygen or on ventilator, mortality, therapy failure, or crossover. Adjustment by a priori defined baseline characteristics showed an odds ratio of 0.80 (95% CI 0.22â2.97) for survival without oxygen or on ventilator, and an odds ratio for mortality of 1.15 (95% CI 0.43â3.10) for HFOV compared with CV. The response of the oxygenation index (OI) to treatment did not differentiate between survival and death. In the HFOV group the OI response was significantly higher than in the CV group between the first and the second day. A post hoc analysis suggested that there was a relatively better treatment effect of HFOV compared with CV in patients with a higher baseline OI. CONCLUSION: No significant differences were observed, but this trial only had power to detect major differences in survival without oxygen or on ventilator. In patients with ARDS and higher baseline OI, however, there might be a treatment benefit of HFOV over CV. More research is needed to establish the efficacy of HFOV in the treatment of ARDS. We suggest that future studies are designed to allow for informative analysis in patients with higher OI
Structural properties of amorphous hydrogenated carbon. IV. A molecular-dynamics investigation and comparison to experiments
Hydrogenated amorphous carbon structures, a-C:H, with densities of 1.8 and 2.0 g/cm3, have been generated by semiempirical density-functions (DF) molecular-dynamics (MD) rapid cooling of a liquid phase of 128 carbon and 64 hydrogen atoms within periodically arranged cubic supercells. The electronic bonding properties of the model structures are analyzed within a local-orbital description. The structural properties are compared to relevant statistical and diffraction data obtained by neutron scattering and NMR in order to achieve a fundamental understanding of structure-related properties on the molecular level of chemical bonding
A Comparation of Succession Law on Intestacy Between Chinese Mainland and Macao SAR
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Robust isothermal electric switching of interface magnetization: A route to voltage-controlled spintronics
Roughness-insensitive and electrically controllable magnetization at the
(0001) surface of antiferromagnetic chromia is observed using magnetometry and
spin-resolved photoemission measurements and explained by the interplay of
surface termination and magnetic ordering. Further, this surface in placed in
proximity with a ferromagnetic Co/Pd multilayer film. Exchange coupling across
the interface between chromia and Co/Pd induces an electrically controllable
exchange bias in the Co/Pd film, which enables a reversible isothermal (at room
temperature) shift of the global magnetic hysteresis loop of the Co/Pd film
along the magnetic field axis between negative and positive values. These
results reveal the potential of magnetoelectric chromia for spintronic
applications requiring non-volatile electric control of magnetization.Comment: Single PDF file: 27 pages, 6 figures; version of 12/30/09; submitted
to Nature Material
The Discovery Potential of a Super B Factory
The Proceedings of the 2003 SLAC Workshops on flavor physics with a high
luminosity asymmetric e+e- collider. The sensitivity of flavor physics to
physics beyond the Standard Model is addressed in detail, in the context of the
improvement of experimental measurements and theoretical calculations.Comment: 476 pages. Printed copies may be obtained by request to
[email protected] . arXiv admin note: v2 appears to be identical to v
SN 2008S: an electron capture SN from a super-AGB progenitor?
We present comprehensive photometric and spectroscopic observations of the
faint transient SN 2008S discovered in NGC 6946. SN 2008S exhibited slow
photometric evolution and almost no spectral variability during the first nine
months, implying a high density CS medium. The light curve is similar in shape
to that of SN 1998S and SN 1979C, although significantly fainter at maximum
light. Our quasi-bolometric lightcurve extends to 300 days and shows a tail
phase decay rate consistent with that of ^{56}Co. We propose that this is
evidence for an explosion and formation of ^{56}Ni (0.0015 +/- 0.0004 M_Sun).
The large MIR flux detected shortly after explosion can be explained by a light
echo from pre-exisiting dust. The late NIR flux excess is plausibly due to a
combination of warm newly-formed ejecta dust together with shock-heated dust in
the CS environment. We reassess the progenitor object detected previously in
Spitzer archive images, supplementing this discussion with a model of the MIR
spectral energy distribution. This supports the idea of a dusty, optically
thick shell around SN 2008S with an inner radius of nearly 90AU and outer
radius of 450AU, and an inferred heating source of 3000 K and luminosity of L ~
10^{4.6} L_Sun. The combination of our monitoring data and the evidence from
the progenitor analysis leads us to support the scenario of a weak electron
capture supernova explosion in a super-AGB progenitor star (of initial mass 6-8
M_sun) embedded within a thick CS gaseous envelope. We suggest that all of main
properties of the electron capture SN phenomenon are observed in SN 2008S and
future observations may allow a definitive answer.Comment: accepted for publication in MNRAS (2009 May 7
Autism as a disorder of neural information processing: directions for research and targets for therapy
The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which theyfeed, is hampered bythe large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself
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