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Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Author: A'Court C.
Aaroe H.
Abd El-Aziz A.
Abdalla Saad J.
Abdel-Qader M.
Abdelrahman H.
Abdul A.
Abe M. (Masahiko)
Abe M. (Masatake)
Abe M. (Mitsunori)
Abe S.
Abe Y.
Abhayaratna W.
Abou Seif S. K.
Abraham S.
Abu-Mahfouz M.
Abushal S.
Accetta Gabriele
Accogli M.
Adachi S.
Adachi S. (Sen)
Adachi S. (Susumu)
Adachi T.
Adak D.
Adriaansen H.
Agakhanyan A.
Agata J.
Ageta M.
Aggarwala A.
Agliardi P.
Agnelli G.
Agnelli Giancarlo
Agrawal A.
Aguilar J.
Ahbeck E.
Ahlmark H.
Ahmad K.
Ahmad N.
Ahmad S.
Ahmed F.
Ahmed W.
Ahn J. J.
Ahuad Guerrero R. A.
Ainsworth P.
Airaksinen J.
Akahane K.
Akiyama M.
Aktas O.
Akutsu M.
Al Mahmeed W.
Al Mahmeed Wael
Al Mulla A.
Al Naeemi A.
Al Omairi M.
Al-Khalili F.
Alaguibe E. D.
Alban F.
Alberts M.
Alborough E.
Aldegather J.
Aleksandrova E.
Alfaro T. A. A.
Alfieri A.
Ali A.
Alkan D. Uzun
Allasia B.
Almeida Fernandez C. A.
Alonso C. (Carmela)
Alonso C. (Concepcion)
Alpay D.
Altamirano Bellorin S.
Altun A.
Alunni M.
Alvarez D'Amelio A.
Alvarez Garcia P.
Alvarez Lopez H.
Alvarez D.
Alvarez M.
Alves da Costa F. A.
Alves de Oliveira Gomes J.
Alzand B.
Amano T.
Amarenco P.
Amaro M.
Ambicka M.
Ambrosino P.
Ambrosio Giuseppe
Amstutz D.
An H. J.
Andere N.
Andersson A.
Andersson L. (Lars)
Andersson L. (Lisbeth)
Ando H.
Ando S.
Andrzejewski D.
Angaran P.
Angchaisuksiri P.
Angchaisuksiri Pantep
Angel G.
Ann W.
Antonova P.
Antonsen H.
Aoki K.
Aoyama T.
Arabetti C.
Aracil Villar J.
Arai H.
Araminowicz J.
Aranha Rosito G. B.
Aras D.
Aras F.
Arasaki O.
Araujo G. R.
Araujo V
Arcocha Torres M. F.
Argena A.
Arias L.
Arima S.
Arino T.
Armaganijan D.
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Zheng W. Y.
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Zhou B.
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Publication venue: 'Oxford University Press (OUP)'
Publication date: 01/01/2018
Field of study

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Crossref

UCL Discovery

İstanbul Üniversitesi Açık Erişim Sistemi

St George's Online Research Archive

Dokuz Eylul University Research Information System

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

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Abdul Ghani R
Abdul Kadir K
Abdullah R
Abejuela Z
Abouglila K
Abraham O
Abrahamsen I
Abraira Munoz Ld
Abramowitz M
Abusnana S
Accini Mendoza Jl
Acosta I
Agafyina A
Agarwal R
Agarwal Rajiv
Aggarwal N
Agra J
Ahmed F
Ahuad Guerrero Ra
Aiello J
Ainsworth P
Aizenberg D
Akiyama H
Akright L
Akyea-Djamson A
Al-Karadsheh A
Alamartine E
Alappan R
Albisu Jp
Ali N
Ali Z
Alicic R
Allison Dc
Alvarez Garcia P
Alvarisqueta A
Alves da Costa Fa
Amerena J
Amigo A
Amodeo C
Andreeva V
Andreotti Turatti La
Angelescu Lm
Angelova A
Anghel V
Antic S
Aoki H
Aquitania G
Arauz-Pacheco C
Arcos E
Arfeen S
Arif A
Aronson R
Arutchelvam V
Arvind M
Asano A
Asmarats Mercadal L
Atray N
August P
Avendano J
Avram Ri
Awad A
Babikova J
Badat A
Bajaj H
Baker J
Bakris G
Bakris George
Barbarash O
Barna O
Barnard M
Barnhill P
Barranco E
Barrera C
Barrios C
Bartaskova D
Bartolacci I
Barton P
Barysheva O
Beacom M
Behara V
Bellary S
Belo D
Belobradkova J
Bentley-Lewis R
Benusova O
Berenguer R
Berli Ma
Bermudez L
Bernardo M
Bhushan Rs
Bijata-Bronisz R
Bilyk Sd
Bin Shudim Ss
Biscoveanu M
Bompoint Severine
Bonadonna R
Bordonava A
Borot S
Botsyurko V
Bowman-Stroud C
Brandon D
Breedt J
Bregman R
Brenner Barry M
Brenner Bm
Brusco O
Buganova I
Bull Scott
Burst V
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Busegeanu Mm
Calella P
Camelo Sanches Fc
Canaan Y
Canani Lh
Cannon Christopher P
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Cantero Mc
Capuano George
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Che Yusof Md
Cheifetz A
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Cherney D 3rd
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Cho Ym
Chouinard G
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Christiano C
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Chu Pei-Ling
Chuang Lm
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Cuneo Ca
Cunha Borges Jl
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da Silva Franco Rj
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de Carvalho Contieri Fl
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de Souza Portes E
de Souza P
de Zeeuw D
de Zeeuw Dick
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Zinman B
Zinman Bernard
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Zykova T
Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2019
Field of study

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

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Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

Author: A Kaldun Nossuli
Aamir Jamal
Adalbert Schiller
Adam Cheifetz
Adarsh Daswani
Adeera Levin
Adline Ghazi
Adrian Guinsburg
Adriana Cif
Adriana Gabriela Onaca
Adriana Ilavska
Adriana Villarino
Agarwal R.
Agnieszka Starzec
Ahmed Arif
Ahmed Awad
Aiping Yin
Akimichi Asano
Alan Jackson
Alan McMahon
Alan Perlman
Alberto Di Carlo
Alberto Esquenazi
Alejandra Oviedo
Alejandro Valdes Depeda
Aleksandra Kendereski
Alex Valenzuela
Alexander Dreval
Alexander Gonzalez
Alexander Shinkov
Alexander Turchin
Alexandre Klein
Alfonso Soto Gonzalez
Alfred Penfornis
Alfredo Chew Wong
Alfredo Wassermann
Ali Torshizi
Alicia Chilito
Alina Agafyina
Alison Dawson
Alva Hansraj
Amer Al-Karadsheh
Amorin Remus Popa
Amrendra Kumar
Amy Sprague
Ana Limos
Ana Maria Cusumano
Ana Maria Elosegui
Anabella Amigo
Anatoliy Kazmirchuk
Andrea Phillips
Andrea Stella
Andreas Maddux
Andrej Dzupina
Andres Alvarisqueta
Andrew Johnson
Andrew O'Shaughnessy
Andrew Steele
Andrian Yakov
Andrzej Januszewicz
Andrzej Madej
Angelina Angelova
Anibal Gastaldi
Anil Gupta
Anita Bhajan Manocha
Anjanette Tan
Anna Kaminska
Anna Maria Veronelli
Anna Strzelecka
Anna Zateyshchikova
Anselmo Bordonava
Antanas Navickas
Anthony Gunstone
Anthony Roberts
Antonio Ceriello
Antonio Galan Serrano
Antonio Scafuto Scotton
Antonio Terrelonge
Antônio Roberto Chacra
Anupama Gowda
Arjun D Sinha
Armando Perez
Ashot Mkrtumyan
Atanas Koundurdjiev
Augusto Vallejos
Aurelian-Emil Ranetti
Ayim Akyea-Djamson
Aysha Badat
Bakris G.
Baldev Singh
Barbara Greco
Barbara Kaczmarek
Barbara Rewerska
Barry M Brenner
Belia Martin Del Camp Blanco
Bernard Zinman
Bertrand Cariou
Bertrand Dussol
Bhasker Mehta
Bhimavarapu Sudhakar
Björn Paschen
Bompoint S.
Borys Mankovskyy
Botond Csiky
Boyan Nonchev
Brenner B. M.
Brett Kissela
Brian Nichol
Bruce Neal
Bruce Trippe
Bruno Geloneze Neto
Bull S.
Byung-Wan Lee
C B Keshavamurthy
Cannon C. P.
Capuano G.
Carlo Giorda
Carlos Alberto Cuneo
Carlos Arauz-Pacheco
Carlos Barrera
Carlos Perez
Carmel Hawley
Carmen Crisan
Carol Pollock
Carolyn Droste
Caroucel Chuateco
Caryl David
Cecilia Garcia Ballesteros
Cecilia Jimeno
Celso Amodeo
Cesar Javier Zaidman
Cesar Yoiti Hayashida
Chamberlain Obialo
Chang-Hsun Hsieh
Charles Cook
Charles Kaupke
Charytan D. M.
Chek Loong Loh
Chen Leia
Cheol-Young Park
Chih-Ching Lin
Christopher P Cannon
Christy Yao
Chu P. -L.
Chwen-Tzuei Chang
Chye Lee Gan
Clara Barrios
Claude Galphin
Claudia Goycoa
Claudia Moreira de Brito
Clodoaido Caringal
Cristian Serafinceanu
Cristina Toarba
Cristobal Morales Portillo
Csaba Kovesdy
Cynthia Bowman-Stroud
Cynthia Christiano
Cynthia Mustieles Rocha
Cyrus Desouza
Cássio Slompo Ramos
Dagmar Bartaskova
Dale Crawford Allison
Dalia Kozloviene
Dan Scharfstein
Dana Cosma
Daniel Coyne
Daniel Hiser
Daniel Kolansky
Daniel Panarotto
Daniel Pella
Daniel Weiner
Daniil Chizhov
Dariusz Sowinski
Darren K McGuire
Davesh Sennik
David C Wheeler
David Cherney 3rd
David Gorson
David Johnson
David M Charytan
David Packham
David Scott
David Wheeler
De Zeeuw D.
Debbie Cohen-Stein
Debbie Mascaro
Deepak Koppolu
Dennis Levinson
Derek Lewis
Detian Li
Devasmita Dev
Devesh Patel
Dewan Deepak
Dick de Zeeuw
Diego Aizenberg
Dinesh Jain
Dinesh Khullar
Diogo Belo
Dmitry Zateyshshikov
Domenico Santoro
Domingos d'Avila
Donald Brandon
Donald Fraser
Dong-Wan Chae
Dora Inés Molina de Salazar
Dorota Mlodawska-Choluj
Doru Negru
Edgar Arcos
Edoardo Mannucci
Eduardo Farias
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Hector Rodriguez
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Hiddo J L Heerspink
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Hiromi Aoki
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Hiroshi Kono
Hitoshi Akiyama
Holly Wang
Hong Mao
Hong Zhang
Hongguang Zheng
Hongli Lin
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Hugo Roberto Kurtz Lisboa
Humberto Pavon
Hyuk-Sang Kwon
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Ines Bartolacci
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Jardine M. J.
Jason Gaglia
Javier Narvarte
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Jayant Kumar
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Jean Welsh
Jean-Pierre Fauvel
Jeevren Reddy
Jeffrey Kropp
Jeffrey Stephens
Jeimeen Agra
Jelena Ignjatovic
Jesus Cuadrado
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Jian Liu
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Jinkui Yang
Jiri Lastuvka
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Joaquin Pablo Gonzalez
Johannes Breedt
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Jorgelina Sala
Jose Antonio Sánchez Arenales
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Jose David Gomez Rangel
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Jose L Górriz
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Laura Akright
Laura Coffee
Lawrence Distiller
Lawrence Lehrner
Lawrence Leiter
Lech Lazuka
Lee-Ming Chuang
Lenka Dohnalova
Leslie Spry
Levin A.
Li Yuan Lee
Lidia Bermudez
Ligia Petrica
Lilia Beatriz Schiavi
Liliana Monica Angelescu
Liliia Zub
Liliya Martynyuk
Lin Sun
Lincoln Chapin
Linong Ji
Lisa Rich
Liudmila Kvitkova
Lori Yost
Luca Chiovato
Luca De Nicola
Luca Zanoli
Lucas Rista
Luciane Mônica Deboni
Lucyna Hotlos
Ludger Rose
Luigi Gnudi
Luis Alberto Ramirez Roca
Luis Asmarats Mercadal
Luis David Abraira Munoz
Luis Enrique Herrera Jimenez
Luis Fernando Flota Cervera
Luis Henrique Canani
Luis Hernando Garcia Ortiz
Luis Isaias Juncos
Luis Quesada-Suarez
Luis Rodolfo Cartasegna
Luis Valderrama Cometa
Luis Venegas Carrillo
Luiz Alberto Andreotti Turatti
Luiza Despina Demian
László Rosivall
Ma Dovie Lallaine Ygpuara
Mahaffey K. W.
Manel Terns Riera
Manish Saxena
Manthi Hettiarachchi
Manuel Muñoz Lopez Mendoza
Manuel Muñoz Torres
Manuela Schmidt
Marc Rendell
Marcel Twahirwa
Marcelo Medina Fariña
Marcora Mandreoli
Marcus Gomes
Margarita Temelkova
Margarita Vejar
Margit Mileder
Margo Hudson
Maria Antonia Munar Vila
Maria Barnard
Maria Cecilia Cantero
Maria Florencia Fernandez
Maria Isabel Klyver
Maria Jaime
Maria Rosa Ulla
Maria Teresa Zanella
Maria Valdez
Marializa Bernardo
Marianna Zsom
Mario Alberto Berli
Mario Burgos Soto
Mark Davies
Mark Vannorsdall
Mark Warren
Markus Faghih
Marsha Tolentino
Marta Dominquez Lopez
Marta Molnar
Martin Lukac
Martin Valis
Martine Destree
Mary Anne Lim-Abrahan
Mary Lawrence
Mary Seeber
Maryna Vlasenko
María Alicia Fernández Montenegro
María Angustias Quesada Simón
Masahiko Takai
Masahiro Koizumi
Masakiyo Wakasugi
Masayo Yamada
Mastura Ismail
Matthew Abramowitz
Matthew Beacom
Meg J Jardine
Meg Jardine
Meininger G.
Melchor Alpizar Salazar
Melemadathil Sreelatha
Merce Perez Vera
Mercedes Velo Plaza
Michael Oliver
Michael Robinson
Michael Shanik
Michael Thompson
Michael Williams
Michal Nowicki
Michał Nowicki
Michelle Zaniewski-Singh
Mick Kumwenda
Miguel Nazzer Hissa
Migues Angel Reyes Rosano
Mihaela Biscoveanu
Mihaela-Magdalena Busegeanu
Mihaly Dudas
Milan Gupta
Min Jeong Kwon
Minara Shamkhalova
Minghui Zhao
Miodrag Djordjevic
Mircea Munteanu
Mitsuru Tsujimoto
Mohamed El-Shahawy
Mohamed Mookadam
Mohamed Railey
Mohamed Sekkarie
Mohanram Narayanan
Mohd Daud Che Yusof
Mohsen El Kossi
Mona Wahba
Monica Alexandra Terront Lozano
Monika Dhillon
Moogali Arvind
Moon-Kyu Lee
Moon-Suk Nam
Moustafa Moustafa
Muhammad Shakeel
Mukesh Joshi
Mykola Kolesnyk
Márcio Antônio Pereira
Nadia Zalunardo
Nadiya Tryshchuk
Nan Chen
Narayan Prasad
Naresh Aggarwal
Natalia Malaver
Nataliia Pashkovska
Natarajan Gopalakrishnan
Navdeep Tangri
Naveen Atray
Neal B.
Nebojsa Lalic
Neil Kumar
Nelson Kopyt
Nelson Rodriguez Papini
Nestor Horacio Garcia
Ngai Wah Cheung
Nicolae Hancu
Nicole Li
Nik Nur Fatnoon Nik Ahmad
Nina Patel
Nizar Daboul
Noble Gracious
Nomangesi Ngcakani
Nonna Kravchun
Nora Marchetta
Norman Muirhead
Norsiah Ali
Oleg Legun
Oleg Nagibovich
Oleg Uriasyev
Oleksandr Golovchenko
Oleksandr Samoylov
Oleksii Korzh
Olga Barbarash
Olga Barna
Olga Barysheva
Olga Benusova
Olga Godlevska
Olga Gyrina
Olga Sazonova
Olivert Gomez
Oomman Abraham
Osamu Tomonaga
Oscar Tarsicio Moreno Loza
Osvaldo Brusco
Pablo Antonio Novoa
Pablo Mele
Pablo Raffaele
Pablo Serrano Sanson
Paranthaman Vengadasalam
Patricia Del Carmen Gonzalez Colaso
Patrick English
Patrick Parfrey
Paul Ainsworth
Paul Frenk Baron
Paul Nixon
Paul Noonan
Paul Rheeder
Paulina Virginia Lanchiotti
Pavel Weiner
Peak Mann Mah
Pedro Calella
Pedro de Souza
Pedro Velasquez-Mieyer
Peggy Barnhill
Peggy Lin
Pere Alvarez Garcia
Perkovic V.
Peter Danos
Peter Fulop
Peter Van Buren
Peter Winocour
Petr Barton
Philip Gorelick
Philip Home
Philip Nicol
Philippe Zaoui
Phyllis August
Piermarco Piatti
Pierre Gourdy
Pierre-Jean Saulnier
Pietro Castellino
Pilar Trueba
Ping Tu
Pollock C.
Prasanth Surampudi
Pusadee Suchinda
Qinkai Chen
Rachel Bregman
Radica Alicic
Radu Jacob
Rafael Simo Canonge
Raied Abdullah
Rajendran Alappan
Rajiv Agarwal
Rajiv Ranjan
Raju Sree Bhushan
Rakesh Gulati
Rakhi Khanna
Rallabhandi Sankaram
Raman Purighalla
Ramesh Chandra Vyasam
Ramesh Thimmaiah
Ramon Berenguer
Ramon Moreda
Rangel Rangelov
Rao K Satyanarayana
Ravendran Govender
Ravi Sarin
Reddy Sreedhar
Reginald Parker
Rehan Symonds
Reinhold Jerwan-Keim
Remi Rabasa-Lhoret
Renan Montenegro Junior
Renata Bijata-Bronisz
Rhea Severina Comia
Rhonda Bentley-Lewis
Riad Darwish
Ricardo Alfonso Leon de la Fuente
Ricardo Dario Dran
Ricardo Rosero
Riccardo Bonadonna
Richard Ferkl
Richard Kovar
Richard Lindley
Richard Orozco Castellanos
Richard Solomon
Robert Busch
Robert Cohen
Robert Schreiman
Robert Takacs
Robert Walker
Roberto Abrão Raduan
Roberto Jorge da Silva Franco
Roberto Pecoits Filho
Roberto Pecoits-Filho
Roberto Simões de Almeida
Roberto Trevisan
Rodica-Ioana Avram
Rodolfo Andres Ahuad Guerrero
Rohana Abdul Ghani
Rohit Pankhaniya
Rolando Zamarripa Escobedo
Ronald Goldenberg
Ronald Harris
Ronald Watts
Ronaldo Arturo Gonzalez Orellana
Ronan Roussel
Ronnie Aronson
Rosa Isela Luna Ceballos
Rosângela Milagres
Ruben Dario Vargas Alonso
Rury Holman
Russell Scott
Sacha De Serres
Sahay Manisha
Saiful Shahrizal Bin Shudim
Sailaja Ventrapragada
Salah Abusnana
Salvatore De Cosmo
Sam Henein
Sam Philip
Samuel Cohen
Samuel Mujica Trenche
Samy Hadjadj
Sandor Keresztesi
Sandor Vangel
Sandra Berenice Saaveddra Sanchez
Sanjeev Rastogi
Sara Jaffer
Sarah Olelewe
Satoshi Ota
Satu Pesickova
Scott Kasner
Secundino Cigarran Guldris
Senan Sultan
Serge Cournoyer
Sergei Nedogoda
Sergey Vorobyev
Sergio Saul Irizar Santana
Shahabul Arfeen
Shahnaz Shahinfar
Shang-Jyh Hwang
Shelley Williams
Shenaz Ramtoola
Shenglian Gan
Sherry Sussman
Shizuo Kajiyama
Shozo Miyauchi
Silvia Ines Orio
Silvia Nicolai
Simon Davies
Simon Roger
Simon Young
Sin Gon Kim
Singhan Krishnan
Sini George
Slobodan Antic
Sohan Dua
Sonia Hermida
Soo Kun Lim
Sophie Borot
Souhila Ounadjela
Sreedhar Mandayam
Srikanth Bellary
Stanislav Zemek
Stanislaw Mazur
Stefan Dimitrov
Stephan Maxeiner
Stephen Grubb
Stephen Smith
Steven Fishbane
Stuart Handelsman
Suely Keiko Kohara
Sun Kim
Sun-Hee Park
Sunil Sheth
Susumu Kashine
Svetlana Goykhman
Svitlana D Bilyk
Swee Win Lam
Sylvia Rosas
Sylvia Shaw
Szilard Vasas
Sérgio Alberto Cunha Vêncio
Sérgio Yamada
Tadashi Iitsuka
Takamoto Kodera
Takashi Wada
Takayuki Watanabe
Tamara Malek Marin
Tamas Oroszlan
Tara Chang
Tareq Nassar
Tarissa Beatrice Zanata Petry
Tatiana Koroleva
Tatiana Morugova
Tatiana Raskina
Tatyana Zykova
Te-Lin Hsia
Terue Sakakibara
Tetiana Zlova
Tetsuji Niiya
Tetyana Pertseva
Tiago Schuch
Timothy Hall
Tom Christensen
Tom Greene
Tomas Drasnar
Tomas Smith Casabella
Tonatiu Diaz Escalante
Toshihiko Yanase
Toshio Kawada
Vadym Vizir
Vanassa Ratnasingam
Venessa Tsang
Venkata Behara
Vera Klokocnikova
Vera Krane
Veronica Anghel
Veselka Genadieva
Vesna Popovic-Radinovic
Viacheslav Marasaev
Victor Commendatore
Victor Saavedra Gajardo
Vijayaraman Arutchelvam
Viktor Margaritov
Viktor Zaviriukha
Viktoria Andreeva
Vimladhevi Govender
Vincent Pichette
Vincent Woo
Vira Tseluyko
Virginia Esther Visco
Vivek Sood
Vivekan Jha
Vladimir Dobronravov
Vladimir Khirmanov
Vladimir Tesar
Vlado Perkovic
Volker Burst
Volodymyr Botsyurko
Walter Guillermo Douthat
Walter Pharr
Wasim Hanif
Wataru Yumita
Wayne H-H Sheu
Wayne Turner
Wei Yen Kong
Weihong Song
Weiping Lu
Wendy Lane
Wenge Li
Wheeler D. C.
Wladmir Saporito
Xuemei Li
Xueqing Yu
Yamil Canaan
Yan Ren
Yannick Le Meur
Yaozhong Kong
Yasuro Kumeda
Yasushi Wakida
Yavin Y.
Yeong Hoon Kim
Yevgeniya Svyshchenko
Young Min Cho
Yulia Samoylova
Yung-Chuan Lu
Yuriy Mostovoy
Yuriy Shwartz
Yvette Ethel Yap
Zaynab Abejuela
Zdravko Kamenov
Zeid Khitan
Zhang H.
Zinman B.
Zishan Ali
Zuzana Ochodnicka
Ângela Regina Nazario Sabbag
Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2019
Field of study

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Archivio Istituzionale della Ricerca- Università degli Studi di Foggia

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

Author: A. Abd El-Aziz
A. Abdul
A. Agakhanyan
A. Aggarwala
A. Agrawal
A. Al Mulla
A. Al Naeemi
A. Alfieri
A. Ali
A. Altun
A. Alvarez D'Amelio
A. Andersson
A. Argena
A. Austria
A. Aydinlar
A. Babyesiza
A. Barai
A. Barreau
A. Barszcz
A. Bartes
A. Bazzoni Ruiz
A. Beattie
A. Bianchi
A. Biernacka
A. Black
A. Blenkhorn
A. Branjovich Tijuan
A. Bremmelgaard
A. Brown
A. Browne
A. Capucci
A. Caspar
A. Catanchin
A. Chmielowski
A. Choi
A. Cieszynska
A. Conde Y Bolado
A. Connelly
A. Cortada Cabrera
A. Davids
A. De Blasio
A. De Wolf
A. Dickerson
A. Domenech Borras
A. Dumikyan
A. Edin
A. Egilsson
A. El-Etreby
A. Elbahry
A. Elorriaga Madariaga
A. Espallargas
A. Ewert
A. Fearon
A. Fedorowsky
A. Ferreira-Jardim
A. Ferrer
A. Filippi
A. Fleck
A. Flynn
A. Forero
A. Frankiewicz
A. Fujisawa
A. Gallagher
A. Ganatra
A. Gegenhuber
A. Gieroba
A. Gilliland
A. Giombolini
A. Gonzales Segovia
A. Grande Ruiz
A. Grau
A. Grytzmann
A. Gubanov
A. Guerrero Molina
A. Guinand
A. Haideri
A. Hajimirsadeghi
A. Hallaråker
A. Halpin
A. Hay
A. Heer
A. Heyse
A. Horak
A. Hot-Bjelac
A. Howitt
A. Iglesias Garcia
A. Ishihara
A. Ivanov
A. Iñiguez Romo
A. Jackun-Podlesna
A. Jaremczuk-Kaczmarczyk
A. Jarzebowski
A. Jefferies
A. Jekthammer
A. Jerzewski
A. John Camm
A. John Camm
A. John Camm
A. Jones
A. Kaczmarzyk-Radka
A. Karczmarczyk
A. Katta
A. Kemmel
A. Khan
A. Khokhlov
A. Koch
A. Kolesnikova
A. Kolodzinska
A. Komlo
A. Konopka
A. Kopf
A. Krueger
A. Krzesiak-Lodyga
A. Lavoie
A. Lawande
A. Lee
A. Lettenström
A. Leyva Rendón
A. Lindberg
A. Lindh
A. Lindourkova
A. Lischka-Lindner
A. Lo Buglio
A. Lopes
A. Lopez
A. Lucassen
A. Ludkova
A. Lysek-Jozefowicz
A. Mannermyr
A. Manzanal Rey
A. Mariani
A. Markiewicz
A. Marquand
A. Martin Vila
A. Martinelli
A. Maselli
A. Matoltsy
A. Mauric
A. Meirino
A. Menezes Lorga Filho
A. Merliss
A. Metzgier-Gumiela
A. Mielot
A. Mirtl
A. Miyashita
A. Mizuno
A. Mowafy
A. Murray
A. Naguib
A. Nagy
A. Nakagomi
A. Nakata
A. Navarro
A. Negrete Palma
A. Negri
A. Niemirycz-Makurat
A. Nowak
A. Nygaard
A. Ohanissian
A. Ohlsson
A. Olofsson
A. Ortiz
A. Osberg
A. Ota
A. Oto
A. Ovsannikova
A. Page
A. Papp
A. Parkhomenko
A. Pawelska-Buczen
A. Pedersen
A. Phrommintikul
A. Pinter
A. Pizzini
A. Plauskat
A. Podczeck-Schweighofer
A. Postolache
A. Pronk
A. Pustelnik
A. Quick
A. Quietzsch
A. Quisi
A. Raczynska
A. Raisaro
A. Ramdass
A. Reda
A. Rodrigues
A. Ross
A. Sabir
A. Sage
A. Said
A. Salinas
A. Sapatyi
A. Sasaki
A. Scaccianoce
A. Seoane Blanco
A. Sidor
A. Singal
A. Skein
A. Soliman
A. Soma
A. Sossich
A. Spyropoulos
A. Srinivas
A. Sriwichian
A. Stallinga-de Vos
A. Steffens
A. Suissa
A. Sulc
A. Svilaas
A. Sword
A. Szczepanska
A. Szilagyi
A. Szulowska
A. Taguchi
A. Talkenberger
A. Tangsirira
A. Tetlak
A. Thatcher
A. Therkelsen
A. Thomson
A. Tomasello
A. Ushakov
A. Vandorpe
A. Vertes
A. Vishnevsky
A. Vonbank
A. Wakeman
A. Waldman
A. Warke
A. Wassef
A. Wierzbicka
A. Williams
A. Wilson
A. Wirdby
A. Wutthimanop
A. Yagensky
A. Yoshimura
A. Zateyshchikova
A. Østrem
A.-B. Ekstrand
A.-K. Ascoop
A.-M. Barbuto
A.-M. Ohlin
A.A. Damonte
A.A. Fernandez
A.B. Lensebraaten
A.C. Billiaux
A.C. Ingaramo
A.C. Rothwell
A.C. Tovar Castaneda
A.C.P. Barretto
A.D. Hrabar
A.G. Ravi Shankar
A.J. Kleiban
A.J. McLeod
A.L. Baek
A.L. Cappi
A.L. Tufare
A.M. Jackson
A.P. Drummond Wainstein
A.P. Macagnan
A.R. Kelsall
A.R. Park
A.S. Pandey
Ajay K. Kakkar
Ajay K. Kakkar
Alex Parkhomenko
Alex Spyropoulos
Alexander G.G. Turpie
Ali Oto
Antonio Carlos Pereira Barretto
B. Allasia
B. Alzand
B. Ayres
B. Chatlaong
B. Clarke
B. Conway
B. Coutu
B. Crousillat
B. Curyllo
B. Deshpande
B. Dolecka
B. Doucet
B. Dubois
B. Dudzik-Richter
B. Eriksson
B. Fox
B. Gaszner
B. Ghezai
B. Gosciniecka
B. Hawkins
B. Herrero Maeso
B. Hoffmann
B. Ikitimur
B. Jacobson
B. Jacobson
B. Jansson
B. Jimeno Besa
B. Kurylo
B. Kurylo
B. Li
B. Liu
B. Lokesh
B. Martinsson
B. Mautner
B. Merkely
B. Mooso
B. Naratreekoon
B. Okopien
B. Opielowska-Nowak
B. Ostrowska-Pomian
B. Racz
B. Raghuraman
B. Ramjattan
B. Rzyczkowska
B. Sarai
B. Schaefer
B. Schneeweiß
B. Schweitzer
B. Sievers
B. Silaruks
B. Singh
B. Sinha
B. Stephanie
B. Strohmer
B. Subbaraman
B. Unterkircher
B. Uppelschoten
B. Vandrus
B. Vanhauwaert
B. Vishwanathan
B. Vogel
B. Voigts
B. Ward
B. Wollaert
B. Wozakowska-Kaplon
B. Zhou
B.-T. Kellner
B.A.J. Stockins Fernandez
B.C. Jung
B.E. Groenemeijer
B.R. Park
B.Y. Sayin
Barry Jacobson
Bernard J. Gersh
C. A'Court
C. Arabetti
C. Astudillo
C. Axthelm
C. Batta
C. Beltra
C. Bergeron
C. Bergeron
C. Bester
C. Boshoff
C. Bothin
C. Bouvy
C. Bradshaw
C. Brike
C. Brotons Cuixart
C. Bugueño Gutiérrez
C. Buiks
C. Bulla
C. Buzzetti
C. Cannon
C. Cantú Brito
C. Chami
C. Chigbo
C. Ciabatta
C. Conejeros
C. Correa
C. Corros Vicente
C. Costantini Ortiz
C. D'Arienzo
C. Dias
C. Dooldeniya
C. Díaz de la Vega
C. Ellervik
C. Femiano
C. Fonseca
C. Fritz
C. Funosas
C. Giles
C. Gines Garcia
C. Gomez
C. Grässjö
C. Guldener
C. Gómez Pajuelo
C. Hagn
C. Hawkins
C. Hernández Herrera
C. Herrick
C. Hines
C. Houzvic
C. Hutton
C. Jacobs
C. Jean
C. Juergens
C. Kongsin
C. Lara
C. Latella
C. Lewis
C. Liley
C. Lodigiani
C. Martinelli
C. Mazzone
C. McCarthy
C. McIntosh
C. Moncada
C. Moro Serrano
C. Mulholland
C. Munhoz da Fontoura Tavares
C. Mussap
C. Nanzer Vital
C. Nilsson
C. Ogurusu
C. Ormundo
C. Orosco
C. Ortiz Cortes
C. Paul
C. Pisani
C. Queirantes
C. Ramesh
C. Ravenhorst
C. Reichelt
C. Reimer
C. Rey
C. Richard
C. Ricotti
C. Rivera Ramos
C. Robertson
C. Roca Saumell
C. Rodrigo
C. Santolaya
C. Scarone
C. Scheurwegs
C. Schubert
C. Schwencke
C. Seamark
C. Simon Valero
C. Singh
C. Singleton
C. Smessaert
C. Stoll
C. Stöcklöcker
C. Sugimoto
C. Takanaka
C. Thorsen
C. Tondo
C. Torres
C. Treasure
C. Vantomme
C. Verdi
C. Vicente
C. Villan
C. Wöhrer
C. Yeo
C. Zecca
C.-J. Kim
C.-J. Lindholm
C.A. Almeida Fernández
C.A. Neden
C.C. Broilo França
C.G. Foo
C.H. Del Carlo
C.H. Gimenez
C.J. Sánchez Díaz
C.K. Ching
C.L. Bai
C.L. Gonzalez Garcia
C.M. Diaz Lopez
C.P. Jones
C.R. Costantini Frack
C.R. Frack Costantini
C.S. Lee
Carlos Jerjes Sánchez Díaz
Carmela Alonso
Concepcion Alonso
D. Adak
D. Alpay
D. Alvarez
D. Amstutz
D. Andrzejewski
D. Aras
D. Armaganijan
D. Atar
D. Belenky
D. Bertolim Precoma
D. Blaszczyk
D. Buckert
D. Cassidy
D. Castro Fernandez
D. Chemello
D. Cholsaringkarl
D. Colquhoun
D. Conde
D. Coulshed
D. Cresp
D. Crimmins
D. Davies
D. De Cleen
D. Denie
D. Diercks
D. Eccleston
D. Edwards
D. Faes
D. Farquhar
D. Fielder
D. Fitzmaurice
D. Fitzpatrick
D. Flores Martínez
D. Fournier
D. Galley
D. Geatch
D. Genc
D. Glatzel
D. Goodwin
D. Gray
D. Greyling
D. Guanaes
D. Guedj-Meynier
D. Gulyas
D. Ikeda
D. Jackson
D. Jain
D. Kernick
D. Kettles
D. Kociolek
D. Komar
D. Konyushenko
D. Kroll
D. Kruczyk
D. Kusiak
D. Kustrzycka-Kratochwil
D. Lesniewska-Krynska
D. Leung
D. Lopes
D. López Villezca
D. Martinez Vasquez
D. Merritt
D. Michalik
D. Montes
D. Moreira
D. Naik
D. Nicolaus
D. Nishijima
D. O'Donnell
D. Obadia
D. Otero Tomera
D. Platonov
D. Plevak
D. Poli
D. Redpath
D. Reimer
D. Roy
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W. Gadzinski
W. Gulliver
W. Haverkamp
W. Hermans
W. Jetten
W. Kunz Sebba Barroso de Souza
W. Kurdzielewicz
W. Lang
W. Lumb
W. Murdoch
W. Myszka
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W. Rogowski
W. Smolders
W. Suebjaksing
W. Supinski
W. Szkrobka
W. Terpstra
W. Tiyanon
W. Van Gaal
W. Wieczorek
W. Wildenauer
W. Willcock
W. Wongcharoen
W. Wongtheptien
W.H. Li
W.J. Chi
W.L. Liu
W.M. Kutayli
W.N. Guo
W.S. Son
W.T. Lim
W.Y. Lee
W.Y. Zheng
Wael Al Mahmeed
Werner Hacke
X. Chen
X. Giry
X. Li
X. Robiro Robiro
X. Sheng
X. Vandamme
X. Viñolas
X.A. He
X.F. Huang
X.J. Gao
X.J. Shi
X.L. Luo
X.S. Cheng
X.S. Hu
X.W. Yan
X.Y. Zhu
Xavier Viñolas
Y. Abe
Y. Atsuchi
Y. Balthazar
Y. Belenkova
Y. Campisto
Y. Emura
Y. Fujii
Y. Fujisawa
Y. Go
Y. Gomez Perez
Y. Gottwalles
Y. Guo
Y. Haraguchi
Y. Hata
Y. Hatori
Y. Hayashi
Y. Ivanova
Y. Jiao
Y. Kamogawa
Y. Kato
Y. Katsube
Y. Katsuda
Y. Kawada
Y. Kelfkens
Y. Kitami
Y. Koretsune
Y. Koshibu
Y. Kumai
Y. Maruyama
Y. Matsuura
Y. Mizuno
Y. Moiseeva
Y. Mostovoy
Y. Niijima
Y. Nishida
Y. Nishihata
Y. Oba
Y. Onuki Pearce
Y. Orlov
Y. Osmolovskaya
Y. Park
Y. Saito
Y. Sakamoto
Y. Samejima
Y. Santanakorn
Y. Sasagawa
Y. Sekine
Y. Seta
Y. Shapovalova
Y. Shiina
Y. Shimoyama
Y. Shozawa
Y. Stipp
Y. Suzuki
Y. Svyshchenko
Y. Takagi
Y. Tsuchiya
Y. Ueyama
Y. Vandekerckhove
Y. Vorasettakarnkij
Y. Wakasa
Y. Ye
Y. Yokoyama
Y. Zhang
Y.-I. Kim
Y.H. Li
Y.H. Sun
Y.H. Yin
Y.J. Yang
Y.J. Yang
Y.K. On
Y.M. Chen
Y.M. Lee
Y.M. Sohn
Y.R. Jeon
Y.S. Oh
Y.S. Son
Y.S. Zhao
Y.Y. Liu
Ying Wang
Yoichi Nakamura
Yong Wang
Yoshihisa Fujiura
Yoshitake Fujiura
Yuhei Shiga
Yuichiro Nakamura
Yukihiro Koretsune
Yukio Shiga
Z. Babjakova
Z. Boda
Z. Djaidani
Z. Lajkowski
Z. Laszlo
Z. May
Z. Monhart
Z. Ongen
Z. Radics
Z.C. Lu
Z.H. Zhou
Z.M. Yang
Publication venue: Indian Heart J
Publication date: 01/01/2018
Field of study

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

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Archivio Istituzionale della Ricerca- Università degli Studi di Foggia

İstanbul Üniversitesi Açık Erişim Sistemi

Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"

Archivio della ricerca - Università degli studi di Napoli Federico II

AIR Universita degli studi di Milano

UCL Discovery

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eScholarship - University of California

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IRIS UniversitÃ Politecnica delle Marche

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Dokuz Eylul University Research Information System

Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease : a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

Author: Anderson William
Andreas Stefan
Andreas Stefan
Arora Ashwani K
Arora Ashwani K
Blasi Francesco
Boscia III Joseph
Bourdin Arnaud
Boyer Laurent
Boyer Laurent
Brusselle Guy
Casula Daniela
Casula Daniela
Centanni Stefano
Chinsky Kenneth
Choudhury Gourab
Corhay Jean-Louis
Couturaud Francis
De-Soyza Anthony
Di Maro Gennaro
Di Maro Gennaro
Downey Herman Jackson
Dunn Leonard
Dussart Luc
Echave-Sustaeta José Maria
Eich Andreas
Erb David
Ferguson Murdo
Fitzgerald Mark
Fogarty Charles
Illies Gabriele
Janssens Eduard
Janssens Wim
Janssens Wim
Kerwin Edward
Kerwin Edward
Kunz Craig
Lattanzi Maria
Lattanzi Maria
Leys Mathias
Llorca Martínez Eleuterio
Ludwig-Sengpiel Andrea
Maltais François
Maltais François
Mayers Irvin
McNeil Shelly
Moraschini Luca
Moraschini Luca
Narejos Pérez Silvia
Papi Alberto
Papi Alberto
Pascual-Guardia Sergi
Pek Bonavuth
Pek Bonavuth
Poling Terry
Pomari Carlo
Puente-Maestu Luis
Puente-Maestu Luis
Pérez Vera Mercè
Saralaya Dinesh
Saralaya Dinesh
Schoonbroodt Sonia
Schoonbroodt Sonia
Sellman Richard
Sigal Barry
Southard John
Spangenthal Selwyn
Study Group NTHi-Mcat-002
Tannous Ziad
Tasciotti Annaelisa
Tasciotti Annaelisa
Terns Riera Manuel
Testa Marco
Testa Marco
Watz Henrik
Watz Henrik
Wilkinson Tom M A
Wilkinson Tom MA
Publication venue: 'Elsevier BV'
Publication date: 01/01/2022
Field of study

Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with changes in the sputum microbiome, including an increased prevalence of pathogenic bacteria. Vaccination against the most frequent bacteria identified in AECOPD might reduce exacerbation frequency. We assessed the efficacy, safety, and immunogenicity of a candidate vaccine containing surface proteins from non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) in patients with COPD. Methods: This multicentre, randomised, observer-blinded, placebo-controlled, proof-of-concept, phase 2b trial recruited patients with stable COPD, moderate-to-very severe airflow limitation (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 2, 3, or 4), at 67 clinical sites in Belgium, Canada, France, Germany, Italy, Spain, UK, and USA. Eligible patients were aged 40-80 years and had a history of at least one moderate or severe exacerbation in the previous year. Patients were allocated (1:1) using a minimisation algorithm to receive two intramuscular injections of NTHi-Mcat vaccine or placebo 60 days apart, in addition to standard care. The allocation algorithm considered age category, number of previous exacerbations, COPD severity at study entry, and country as minimisation factors, to guarantee treatment balance within each factor. Vaccine recipients and those responsible for evaluating study endpoints were masked to group allocation. In the analysis of efficacy, the primary outcome was the rate of any moderate or severe AECOPD occurring within a 1-year period, starting 1 month after the second dose in patients who received two vaccine doses (modified total vaccinated cohort). Safety was assessed in the total vaccinated cohort. The trial is registered with ClinicalTrials.gov, number NCT03281876, and is complete. Findings: Between Nov 27, 2017, and Nov 30, 2018, 606 adults were enrolled and included in the total vaccinated cohort (304 in the NTHi-Mcat vaccine group, 302 in the placebo group); 571 received two doses and were included in the primary efficacy analysis (279 in the NTHi-Mcat vaccine group, 292 in the placebo group). 23 participants dropped-out in the NTHi-Mcat vaccine group and 39 in the placebo group; this included 4 patients in the NTHi-Mcat vaccine group and 15 in the placebo group who withdrew from the study because of an adverse event. The primary analysis included 340 exacerbations (in follow-up time 102 123 days) in the NTHi-Mcat vaccine group and 333 (in 104 443 days) in the placebo group, with a yearly rate of moderate or severe AECOPD of 1·22 in the NTHi-Mcat vaccine group and 1·17 in the placebo group, with vaccine efficacy in reducing the yearly rate of moderate or severe AECOPD estimated to be zero (vaccine efficacy point estimate 2·26% [87% CI -18·27 to 11·58]; p=0·82). Solicited local adverse events were more frequent in the NTHi-Mcat vaccine group (216 [72%] of 301 patients) than with placebo (34 [11%] of 299 patients), and the frequency of solicited general adverse events was similar between groups (239 [79%] of 301 vs 235 [79%] of 299 patients). There was one death in the NTHi-Mcat vaccine group (acute respiratory failure, not related to vaccination) and ten in the placebo group (seven due in part to COPD or respiratory failure). There were 158 serious adverse events (89 [29%] of 304 patients) in the NTHi-Mcat vaccine group, not related to vaccination, and 214 (99 [33%] of 302 patients) in the placebo group. Interpretation: NTHi-Mcat vaccine administered to patients with COPD did not show efficacy in reducing the yearly rate of moderate or severe exacerbations. No safety concerns were identified

Ghent University Academic Bibliography

Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis

Author: (Jay) Kropp Jeffrey
Abdul Kadir Khalid
Abdullah Raied
Abraham Oomman India:
Abramowitz Matthew
Acosta Idalia
Africa: Fayzal Ahmed South
Agra Jeimeen
Aiello Joseph
Ainsworth Paul
Aizenberg Diego
Akright Laura
Akyea-Djamson Ayim
Al-Karadsheh Amer
Alappan Rajendran
Alberto Andreotti Turatti Luiz
Alberto Berli Mario
Alberto Cuneo Carlos
Alberto Cunha V\ueancio S\ue9rgio
Alberto Ramirez Roca Luis
Alexandra Terront Lozano Monica
Alfonso Leon de la Fuente Ricardo
Ali Norsiah
Ali Zishan
Alicic Radica
Alina Agafyina Russia:
Alpizar Salazar Melchor
Alva Hansraj
Alvarisqueta Andres
Amodeo Celso
Andres Ahuad Guerrero Rodolfo
Angel Reyes Rosano Miguel
Angelova Angelina
Anghel Veronica
Angustias Quesada Sim\uf3n Mar\ueda
Ant\uf4nio Pereira M\ue1rcio
Antonia Munar Vila Maria
Antonio Novoa Pablo
Antonio S\ue1nchez Arenales Jose
Aoki Hiromi
Aquitania Grace
Arauz-Pacheco Carlos
Archibaldo Glenny Jorge
Arcos Edgar
Arfeen Shahabul
Arif Ahmed
Aronson Ronnie
Arutchelvam Vijayaraman
Arvind Moogali
Asano Akimichi
Asmarats Mercadal Luis
Atray Naveen
Augusto Alves da Costa Fernando
Avendano Jorge
Avram Rodica-Ioana
Awad Ahmed
Baas Cruz Juan
Badat Aysha
Bajaj Harpreet
Bakris George
Barbarash Olga
Barnard Maria
Barnhill Peggy
Barranco Elizabeth
Barrera Carlos
Barrios Clara
Bartolacci Ines
Barton Petr
Barysheva Olga
Beacom Matthew
Beatrice Zanata Petry Tarissa
Beatriz Schiavi Lilia
Behara Venkata
Bellary Srikanth
Belo Diogo
Belobradkova Jana
Bentley-Lewis Rhonda
Benusova Olga
Berenguer Ramon
Berenice Saavedra Sanchez Sandra
Bermudez Lidia
Bernardo Marializa
Bhajan Manocha Anita
Bhushan Raju Sree
Bilyk Svitlana D.
Biscoveanu Mihaela
Bordonava Anselmo
Borot Sophie
Botsyurko Volodymyr
Bowman-Stroud Cynthia
Brandon Donald
Breedt Johannes
Bregman Rachel
Brusco Osvaldo
Buganova Ingrid
Burgos Soto Mario
Busch Robert
Busegeanu Mihaela-Magdalena
Calella Pedro
Canaan Yamil
Caringal Clodoaido
Cariou Bertrand
Carlo Sasso Ferdinando
Carlo Tibes Hachmann Jean
Carlos Santos Juan
Castellino Pietro
Cecilia Cantero Maria
Cecilia Coloma Gabriela
Cercos Esteban
Cereto Castro Fernando
Ceriello Antonio
Chandra Vyasam Ramesh
Chen Qinkai
Cherney David
Chevaile Ramos Jose
Chew Wong Alfredo
Chilito Alicia
Chiovato Luca
Chizhov Daniil
Chouinard Guy
Christensen Tom
Christiano Cynthia
Christofides Elena
Chuang Lee-Ming
Chuateco Caroucel
Chwen-Tzuei Chang Taiwan:
Cif Adriana
Cigarran Guldris Secundino
Cohen Kenneth
Cohen Robert
Cohen- Stein Debbie
Colombo Hugo
Commendatore Victor
Conway James
Cook Charles
Cosma Dana
Cournoyer Serge
Coyne Daniel
Crawford Allison Dale
Crisan Carmen
Cristian Greloni Gustavo
Cristina Camelo Sanches Fernanda
Csiky Botond
Cuadrado Jesus
Culak Jan
d'Avila Domingos
Daboul Nizar
Danos Peter
Dario Dran Ricardo
Dario Vargas Alonso Ruben
DaRoza Gerald
Darwish Riad
Daswani Adarsh
Daud Che Yusof Mohd
David Gomez Rangel Jose
Davies Emyr
Davies Mark
Davies Simon
Dawson Alison
De Cosmo Salvatore
De Nicola Luca
De Serres Sacha
de Souza Portes Evandro
de Souza Pedro
Deak Laszlo
Deck Kenneth
del Carmen Gonzalez Colaso Patricia
Delos Santos Lalaine
Derosa Giuseppe
Desouza Cyrus
Despina Demian Luiza
Dev Devasmita
Dewan Deepak
Dhillon Monika
Di Carlo Alberto
Di Cianni Graziano
Diaz Escalante Tonatiu
Diego Higuera Juan
Dimitrov Stefan
Distiller Lawrence
Djordjevic Miodrag
Dobronravov Vladimir
Dohnalova Lenka
Dominguez Lopez Marta
Dovie Lallaine Ygpuara Ma.
Drasnar Tomas
Dreval Alexander
Droste Carolyn
Dua Sohan
Dub\ue9 Fran\ue7ois
Dudar Iryna
Dudas Mihaly
Dussol Bertrand
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Dzuponova Jana
Eder Frank
Edmundo Enriquez Sosa Favio
Edwin Fernando M.
Egido de los Rios Jesus
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El Kossi Mohsen
El-Shahawy Mohamed
Emilia Ferariu Ioana
English Patrick
Enrique Herrera Jimenez Luis
Eric Alamartine France:
Erika Rucker Joerg Isabel
Ernesto Andres Diaz Ruiz Jorge
Ervin John
Esquenazi Alberto
Esteban Jodar Gimeno Jose
Esther Visco Virginia
Ethel Yap Yvette
Evans John
Faghih Markus
Farias Eduardo
Faulmann Grit
Fauvel Jean-Pierre
Ferkl Richard
Fernandez Fresnedo Gema
Fernando Flota Cervera Luis
Finkelstein Hernan
Fishbane Steven
Florencia Fernandez Maria
Flores Lozano Fernando
Fragale Guillermo
Fraige Filho Fadlo
Francisco Kerr Saraiva Jose
Frasc\ue0 Giovanni
Fraser Donald
Fraser Ian
Frenk Baron Paul
Frias Juan
Fuiano Giorgio
Fulop Peter
Fushtey Ivan
Gabriela Onaca Adriana
Galan Serrano Antonio
Galindo-Ramos Eugenia
Galphin Claude
Gambaro Giovanni
Gan Shenglian
Garcia Ballesteros Cecilia
Garcia Isabel
Garibotto Giacomo
Gastaldi Anibal
Gelersztein Elizabeth
Geloneze Neto Bruno
Genadieva Veselka
Genova-Hristova Gabriela
Ghazi Adline
Giorda Carlo
Glinkina Irina
Gnudi Luigi
Godlevska Olga
Goldenberg Ronald
Golovchenko Oleksandr
Gomes Marcus
Gomez Olivert
Gon Kim Sin
Gonzalez Alexander
Gonzalez Enrique
Gonzalo Godoy Jorquera Juan
Gopalakrishnan Natarajan
Gorson David
Gourdy Pierre
Govender Ravendran
Govender Vimladhevi
Gowda Anupama
Goycoa Claudia
Gracious Noble
Greco Barbara
Grineva Elena
Grubb Stephen
Guillermo Douthat Walter
Guinsburg Adrian
Gulati Rakesh
Gunstone Anthony
Gupta Anil
Gupta Milan
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H-H Sheu Wayne
Halciakova Katarina
Hall Timothy
Haller Hermann
Halmagyi Ildiko
Hammoud Jamal
Hancu Nicolae
Handelsman Stuart
Hanif Wasim
Harcsa Eleonora
Hartman Israel
Hector Resk Jorge
Hector Sanchez Mijangos Jose
Henein Sam
Henrique Canani Luis
Hermida Sonia
Hernandez Triana Eric
Hernando Garcia Ortiz Luis
Hershon Kenneth
Hiser Daniel
Hitoshi Akiyama Japan:
Ho Yoon Kun
Hon George
Hoon Kim Yeong
Horacio Garcia Nestor
Hotlos Lucyna
Hristozov Kiril
Hsia Te-Lin
Hsieh Chang-Hsun
Hwang ShangJyh
Iitsuka Tadashi
Ilavska Adriana
In\ue9s Molina de Salazar Dora
Ines Orio Silvia
Isabel Klyver Maria
Isaias Juncos Luis
Isela Luna Ceballos Rosa
Ismail Mastura
Jackson Alan
Jacob Radu
Jaime Maria
Jain Dinesh
Jamal Aamir
Jana Babikova Slovakia:
Januszewicz Andrzej
Javier Gonzalez Martinez Francisco
Javier Zaidman Cesar
Jeong Kwon Min
Jeong In-Kyung
Jerwan-Keim Reinhold
Jimenez Flores Fernando
Jimeno Cecilia
Johnson Andrew
Johnson David
Jorge da Silva Franco Roberto
Jose Luis Accini Mendoza Colombia:
Jose Tinahones Madueno Francisco
Joseph Franklin
Joshi Mukesh
Jurgens Jaco
Kaczmarek Barbara
Kajiyama Shizuo
Kaldun Nossuli A.
Kamenov Zdravko
Kaminska Anna
Kashine Susumu
Kaupke Charles
Kawada Toshio
Kazmirchuk Anatoliy
Keightley Gerald
Keiko Kohara Suely
Keitel Elizete
Keltai Katalin
Kendereski Aleksandra
Keresztesi Sandor
Kern Elizabeth
Keshavamurthy C. B.
Khandwala Hasnain
Khanna Rakhi
Khirmanov Vladimir
Khitan Zeid
Khullar Dinesh
Kim Sun
Kingdom: Kamal Abouglila United
Kiss Krisztian
Klein Alexandre
Klokocnikova Vera
Kodera Takamoto
Kolesnyk Mykola
Kolmakova Elena
Komisarenko Iuliia
Kong Yaozhong
Kono Hiroshi
Konyves Laszlo
Kopyt Nelson
Korea: Dong-Wan Chae South
Koroleva Tatiana
Korzh Oleksii
Koundurdjiev Atanas
Kovar Richard
Kovesdy Csaba
Koyama Kazunori
Kozloviene Dalia
Kraft Florencia
Kravchun Nonna
Krishna Gopal
Krishnan Singhan
Krynski Fernando
Kumar Amrendra
Kumar Jayant
Kumar Neil
Kumeda Yasuro
Kumwenda Mick
Kun Lim Soo
Kusnir Jorge
Kvitkova Liudmila
Kwon Hyuk-Sang
Lalic Katarina
Lalic Nebojsa
Lane Wendy
Lastuvka Jiri
Latiff Gulam
Laviada Molina Hugo
Lawrence Mary
Lazuka Lech
Le Meur Yannick
Lee Gan Chye
Lee Byung-Wan
Lee JungEun
Lee Moon-Kyu
Legun Oleg
Lehrner Lawrence
Leiter Lawrence
Lentz John
Levin Adeera
Levinson Dennis
Lewis Derek
Li Detian
Li Wenge
Li Xuemei
Liliana Monica Angelescu Romania:
Lin Chih-Ching
Lin Hongli
Lindolfo Cunha Borges Jo\ue3o
Liss Kenneth
Liu Jian
Lombard Landman
Loong Loh Chek
Lopez Mendoza Manuel
Loss de Carvalho Contieri Fabiana
Lozanov Lachezar
Lu Weiping
Lu Yung-Chuan
Luis David Abraira Munoz Mexico:
Lukac Martin
M\uf4nica Deboni Luciane
Ma Portoles Perez Jose
MacDougall Iain
Maddux Andreas
Madej Andrzej
Madore Fran\ue7ois
Maheshwari Hiralal
Major Lajos
Malaver Natalia
Malberti Fabio
Malek Marin Tamara
Mandayam Sreedhar
Mandreoli Marcora
Mankovskyy Borys
Mann Mah Peak
Mannucci Edoardo
Mao Hong
Mar\ueda Alicia Fern\ue1ndez Montenegro Chile:
Marar Isam
Marasaev Viacheslav
Marchetta Nora
Margaritov Viktor
Maria Cusumano Ana
Maria Elosegui Ana
Maria Veronelli Anna
Martin del Campo Blanco Belia
Martinka Emil
Martynyuk Liliya
Maxeiner Stephan
Mazur Stanislaw
Mc- Mahon Alan
Medina Fari\uf1a Marcelo
Mehta Bhasker
Mele Pablo
Melemadathil Sreelatha
Middleton John
Milagres Ros\ue2ngela
Mileder Margit
Min Cho Young
Miyauchi Shozo
Mizuyama Kazuyuki
Mkrtumyan Ashot
Mlodawska-Choluj Dorota
Mohamed Railey United Arab Emirates: Salah Abusnana
Molnar Marta
Montenegro Junior Renan
Mookadam Mohamed
Morales Franco Guadalupe
Morales Portillo Cristobal
Mordujovich Jorge
Moreda Ramon
Moreira de Brito Claudia
Morugova Tatiana
Mostovoy Yuriy
Moustafa Moustafa
Mu\uf1oz Torres Manuel
Mucsi Janos
Muirhead Norman
Mujica Trenche Samuel
Munteanu Mircea
Mustieles Rocha Cynthia
Nagibovich Galina
Nagibovich Oleg
Nam Moon-Suk
Nan Chen China:
Narayanan Mohanram
Naresh Aggarwal Canada:
Narvarte Javier
Nassar Tareq
Nasser Hissa Miguel
Navickas Antanas
Nedogoda Sergei
Negru Doru
Newman George
Ngai Wah Cheung Australia:
Ngcakani Nomangesi
Nichol Brian
Nicholls Kathy
Nicol Philip
Nicolai Silvia
Nieto Iglesias Javier
Niiya Tetsuji
Nisnisan Josier
Nixon Paul
Nonchev Boyan
Noonan Paul
Noronha Irene
Nortje Hendrik
Nowicki Michal
Nur Fatnoon Nik Ahmad Nik
O'Hare Joseph
O'Shaughnessy Andrew
Obialo Chamberlain
Obrador Vera Gregorio
Ochodnicka Zuzana
Oh Kook-Hwan
Oishi Hiroko
Olelewe Sarah
Olga Barna Ukraine:
Oliver Michael
Oosthuizen Helena
Orlowska-Kowalik Grazyna
Oroszlan Tamas
Orozco Castellanos Ricardo
Orsi Emanuela
Ory Ivan
Osipova Irina
Osvaldo Fretes Jose
Ota Satoshi
Otreras Fabian
Oviedo Alejandra
Pablo Albisu Juan
Pablo Gonzalez Joaquin
Pablo Moreira Diaz Juan
Packham David
Padron John
Panarotto Daniel
Pankhaniya Rohit
Pantoja Perez Jonay
Paragh Gyorgy
Park Cheol-Young
Park Sun-Hee
Parker Reginald
Paschen Bj\uf6rn
Pashkovska Nataliia
Patel Devesh
Patel Gnyandev
Patel Nina
Paul Haase Franklin
Pavon Humberto
Pecoits Filho Roberto
Pella Daniel
Penfornis Alfred
Peralta Calcaneo Juan
Pere Alvarez Garcia Spain:
Pererva Larysa
Perez Vera Merce
Perez Armando
Perez Carlos
Peringat Jayameena
Perlman Alan
Pertseva Tetyana
Pesickova Satu
Peterfai Eva
Peterka Karel
Petrica Ligia
Petro Gizella
Pettis Karlton
Pharr Walter
Philip Sam
Phillips Andrea
Piatti Piermarco
Pichette Vincent
Pillay-Ramaya Larisha
Plassmann Georg
Popenda Grazyna
Popovic-Radinovic Vesna
Prasad Narayan
Proietto Joseph
Prozesky Hans
Pumprla Jiri
Purighalla Raman
Quesada-Suarez Luis
Rabasa-Lhoret Remi
Raffaele Pablo
Ramtoola Shenaz
Ranetti Aurelian-Emil
Rangelov Rangel
Ranjan Rajiv
Raskina Tatiana
Rastogi Sanjeev
Ratnasingam Vanassa
Reddy Jakkidi
Reddy Jeevren
Reddy Sreedhar
Regina Nazario Sabbag \uc2ngela
Remus Popa Amorin
Ren Yan
Renata Bijata-Bronisz Poland:
Rendell Marc
Republic: Dagmar Bartaskova Czech
Revesz Katalin
Rewerska Barbara
Rheeder Paul
Ricardo Correa Rotter Jose
Riccardo Bonadonna Italy:
Rich Lisa
Rista Lucas
Roberto Abr\ue3o Raduan Brazil:
Roberto Chacra Ant\uf4nio
Roberto Kurtz Lisboa Hugo
Roberts Anthony
Robinson Michael
Rodolfo Cartasegna Luis
Rodriguez Papini Nelson
Rodriguez Pattzi Hiromi
Rodriguez Hector
Roger Simon
Rohana Abdul Ghani Malaysia:
Ronaldo Arturo Gonzalez Orellana Guatemala:
Rosa Ulla Maria
Rosas Guzman Juan
Rosas Sylvia
Rose Ludger
Rosero Ricardo
Roussel Ronan
Rychlik Ivan
Saavedra Gajardo Victor
Saba Fadi
Sahay Manisha
Sakakibara Terue
Sala Jorgelina
Samoylov Oleksandr
Samoylova Yulia
Sankaram Rallabhandi
Santoro Domenico
Santos Florence
Saporito Wladmir
Sarin Ravi
Satyanarayana Rao K.
Saudek Frantisek
Saul Irizar Santana Sergio
Saulnier Pierre-Jean
Saxena Manish
Sazonova Olga
Scafuto Scotton Antonio
Schreiman Robert
Schuch Tiago
Scott David
Scott Russell
Seeber Mary
Sekkarie Mohamed
Sennik Davesh
Sensenbrenner John
Serafinceanu Cristian
Serrano Sanson Pablo
Serviddio Gaetano
Sessa Horacio
Severina Comia Rhea
Shahrizal Bin Shudim Saiful
Shakeel Muhammad
Shamkhalova Minara
Shanik Michael
Shaw Sylvia
Shinkov Alexander
Shutemova Elena
Shwartz Yuriy
Sim\uf5es de Almeida Roberto
Simo Canonge Rafael
Simon Godwin
Sing Ng Kee
Singh Baldev
Slobodan Antic Serbia:
Slompo Ramos C\ue1ssio
Smatanova Iveta
Smirnov Ivan
Smith Casabella Tomas
Smith Stephen
Soares Fel\uedcio Jo\ue3o
Solomon Richard
Song Weihong
Soto Gonzalez Alfonso
Sowinski Dariusz
Sprague Amy
Spry Leslie
States: Joseph Abdallah United
Steele Andrew
Stella Andrea
Stephens Jeffrey
Strzelecka Anna
Suchinda Pusadee
Sudhakar Bhimavarapu
Sultan Senan
Sun Jiao
Sun Lin
Surampudi Prasanth
Sussman Sherry
Svyshchenko Yevgeniya
Symonds Rehan
Takacs Robert
Takai Masahiko
Tan Anjanette
Tan Gerry
Tangri Navdeep
Tarsicio Moreno Loza Oscar
Tellez Chavez Eloisa
Temelkova Margarita
Teresa Zanella Maria
Terns Riera Manel
Terrelonge Antonio
Tesar Vladimir
Thervet Eric
Thom\ue9 Fernando
Thompson Michael
Toarba Cristina
Tolentino Marsha
Tomashkevych Halyna
Tomonaga Osamu
Topchii Ivan
Torshizi Ali
Trespalacios Fernando
Trevisan Roberto
Trippe Bruce
Trueba Pilar
Tryshchuk Nadiya
Tsang Venessa
Tseluyko Vira
Tsujimoto Mitsuru
Tu Ping
Turcios Juarez Erick
Turner Wayne
Twahirwa Marcel
Updegrove John
Urbanaviciene Egle
Uriasyev Oleg
Valderrama Cometa Luis
Valdes Cepeda Alejandro
Valdez Maria
Valenzuela Alex
Valis Martin
Vallejos Augusto
Van Buren Peter
Vangel Sandor
Vannorsdall Mark
Varghese Freemu
Vasas Szilard
Vejar Margarita
Velasquez-Mieyer Pedro
Velichkova Ekaterina
Velo Plaza Mercedes
Venegas Carrillo Luis
Vengadasalam Paranthaman
Ventrapragada Sailaja
Vicente Sanchez Polo Jos\ue9
Viktoria Andreeva Bulgaria:
Villagordoa Mesa Juan
Villarino Adriana
Villegas Ivan
Virginia Lanchiotti Paulina
Vizir Vadym
Vlasenko Maryna
Volker Burst Germany:
Vorobyev Sergey
Vukotic Goga
Wada Takashi
Wadud Khurram
Wahba Mona
Wakasugi Masakiyo
Wakeling John
Wakida Yasushi
Walker Robert
Wang Guixia
Warren Mark
Wassermann Alfredo
Watanabe Takayuki
Watson Edward
Watson Henry
Watts Ronald
Weiner Daniel
Weiner Pavel
Welker James
Welsh Jean
Wheeler David
Williams Michael
Williams Shelley
Win Lam Swee
Winocour Peter
Woo Vincent
y Orozco Juan Alfredo Tamayo
Yakov Andrian
Yamada Masayo
Yamada S\ue9rgio
Yanagida Kazuhiro
Yanase Toshihiko
Yang Jinkui
Yao Christy
Yen Kong Wei
Yin Aiping
Yoiti Hayashida Cesar
Young Simon
Yu Xueqing
Yuan Lee Li
Yumita Wataru
Yupanqui Hernan
Zalunardo Nadia
Zamarripa Escobedo Rolando
Zaniewski-Singh Michelle
Zanoli Luca
Zaoui Philippe
Zateyshchikova Anna
Zateyshshikov Dmitry
Zaynab Abejuela Philippines:
Zealand: John Baker New
Zemek Stanislav
Zhao Minghui
Zheng Hongguang
Zlova Tetiana
Zsom Marianna
Zub Liliia
Zykova Tatyana
Publication venue: 'Ovid Technologies (Wolters Kluwer Health)'
Publication date: 01/01/2021
Field of study

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791

Crossref

Archivio istituzionale della ricerca - Università di Genova

Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial

Author: Abdallah Joseph
Abdul Ghani Rohana
Abdullah Raied
Abejuela Zaynab
Abouglila Kamal
Abraham Oomman
Abraira Munoz Luis David
Abramowitz Matthew
Abusnana Salah
Acosta Idalia
Agafyina Alina
Agarwal Rajiv
Agarwal Rajiv
Aggarwal Naresh
Agra Jeimeen
Ahmad Nik Nur Fatnoon Nik
Ahmed Fayzal
Aiello Joseph
Ainsworth Paul
Aizenberg Diego
Aizenberg Diego
Akiyama Hitoshi
Akright Laura
Akyea-Djamson Ayim
Al-Karadsheh Amer
Alamartine Eric
Alappan Rajendran
Albisu Juan Pablo
Alexandra Terront Lozano Monica
Ali Norsiah
Ali Zishan
Alicic Radica
Allison Dale Crawford
Alvarisqueta Andres
Amodeo Celso
Andreeva Viktoria
Angelescu Liliana Monica
Angelova Angelina
Anghel Veronica
Antic Slobodan
Aoki Hiromi
Aquitania Grace
Arauz-Pacheco Carlos
Arcos Edgar
Arfeen Shahabul
Arif Ahmed
Arnott Clare
Aronson Ronnie
Arutchelvam Vijayaraman
Arvind Moogali
Asano Akimichi
Atray Naveen
Avendano Jorge
Avram Rodica-Ioana
Awad Ahmed
Babikova Jana
Badat Aysha
Bajaj Harpreet
Baker John
Bakris George
Bakris George
Bakris George
Ballesteros Cecilia Garcia
Barbarash Olga
Barna Olga
Barnard Maria
Barnhill Peggy
Baron Paul Frenk
Barranco Elizabeth
Barrera Carlos
Barrios Clara
Bartaskova Dagmar
Bartolacci Ines
Barton Petr
Barysheva Olga
Beacom Matthew
Behara Venkata
Bellary Srikanth
Belo Diogo
Belobradkova Jana
Bentley-Lewis Rhonda
Benusova Olga
Berenguer Ramon
Berli Mario Alberto
Bermudez Lidia
Bernardo Marializa
Bhushan Raju Sree
Bijata-Bronisz Renata
Bilyk Svitlana D.
Biscoveanu Mihaela
Bonadonna Riccardo
Bordonava Anselmo
Borges João Lindolfo Cunha
Borot Sophie
Botsyurko Volodymyr
Bowman-Stroud Cynthia
Brandon Donald
Breedt Johannes
Bregman Rachel
Brenner Barry M.
Brusco Osvaldo
Buganova Ingrid
Burst Volker
Busch Robert
Busegeanu Mihaela-Magdalena
Calcaneo Juan Peralta
Calella Pedro
Canaan Yamil
Canani Luis Henrique
Cannon Christopher P.
Cannon Christopher P.
Canonge Rafael Simo
Cantero Maria Cecilia
Cardoza Kathryn
Caringal Clodoaido
Cariou Bertrand
Carrillo Luis Venegas
Cartasegna Luis Rodolfo
Casabella Tomas Smith
Castellanos Ricardo Orozco
Castellino Pietro
Castro Fernando Cereto
Cepeda Alejandro Valdes
Cercos Esteban
Ceriello Antonio
Chacra Antônio Roberto
Chae Dong-Wan
Chae Dong-Wan
Chandra Vyasam Ramesh
Chang Chwen-Tzuei
Chang Tara
Charytan David M.
Charytan David M.
Charytan David M.
Chavez Eloisa Tellez
Che Yusof Mohd Daud
Chen Nan
Chen Qinkai
Cherney David
Cherney David
Chertow Glenn
Cheung Ngai Wah
Chilito Alicia
Chiovato Luca
Chizhov Daniil
Cho Young Min
Chouinard Guy
Christensen Tom
Christiano Cynthia
Christofides Elena
Chuang Lee-Ming
Chuateco Caroucel
Cif Adriana
Cohen Kenneth
Cohen Robert
Cohen-Stein Debbie
Colaso Patricia del Carmen Gonzalez
Coloma Gabriela Cecilia
Colombo Hugo
Cometa Luis Valderrama
Comia Rhea Severina
Commendatore Victor
Contieri Fabiana Loss de Carvalho
Conway James
Cook Charles
Correa Rotter Jose Ricardo
Cosma Dana
Costa Fernando Augusto Alves da
Cournoyer Serge
Coyne Daniel
Crisan Carmen
Cruz Juan Baas
Csecsei Gyongyi
Csiky Botond
Cuadrado Jesus
Culak Jan
Cuneo Carlos Alberto
Cusumano Ana Maria
Daboul Nizar
Danos Peter
DaRoza Gerald
Darwish Riad
Daswani Adarsh
David null
Davies Emyr
Davies Mark
Davies Simon
Dawson Alison
de Almeida Roberto Simões
de Brito Claudia Moreira
De Cosmo Salvatore
De Nicola Luca
De Nicola Luca
de Salazar Dora Inés Molina
De Serres Sacha
de Souza Pedro
de Zeeuw Dick
de Zeeuw Dick
Deak Laszlo
Deboni Luciane Mônica
Deck Kenneth
Deepak Dewan
del Campo Blanco Belia Martin
Demian Luiza Despina
Derosa Giuseppe
Desouza Cyrus
Dev Devasmita
Dhillon Monika
Di Carlo Alberto
Di Cianni Graziano
Di Tanna Gian Luca
Diaz Ruiz Jorge Ernesto Andres
Dimitrov Stefan
Distiller Larry
Distiller Lawrence
Djordjevic Miodrag
Dobronravov Vladimir
Dohnalova Lenka
Douthat Walter Guillermo
Dran Ricardo Dario
Drasnar Tomas
Dreval Alexander
Dreval Alexander
Droste Carolyn
Dua Sohan
Dubé François
Dudar Iryna
Dudas Mihaly
Dussol Bertrand
Dzupina Andrej
Dzuponova Jana
d’Avila Domingos
Eder Frank
Edwin Fernando M.
Egido de los Rios Jesus
El Kossi Mohsen
El-Shahawy Mohamed
Elosegui Ana Maria
English Patrick
Enriquez Sosa Favio Edmundo
Ervin John
Escalante Tonatiu Diaz
Escobedo Rolando Zamarripa
Esquenazi Alberto
Evans John
Faghih Markus
Farias Eduardo
Fariña Marcelo Medina
Faulmann Grit
Fauvel Jean-Pierre
Felício João Soares
Ferariu Ioana Emilia
Ferkl Richard
Fernandez Maria Florencia
Filho Roberto Pecoits
Finkelstein Hernan
Fishbane Steven
Flores Fernando Jimenez
Flota Cervera Luis Fernando
Fragale Guillermo
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Franco Roberto Jorge da Silva
Frascà Giovanni
Fraser Donald
Fraser Ian
Fresnedo Gema Fernandez
Fretes Jose Osvaldo
Frias Juan
Fuiano Giorgio
Fulop Peter
Fushtey Ivan
Gajardo Victor Saavedra
Galindo-Ramos Eugenia
Galphin Claude
Gambaro Giovanni
Gan Chye Lee
Gan Shenglian
Garcia Isabel
Garcia Nestor Horacio
Garcia Pere Alvarez
Garibotto Giacomo
Gastaldi Anibal
Gaupsiene Egle
Gelersztein Elizabeth
Genadieva Veselka
Genova-Hristova Gabriela
Ghazi Adline
Giorda Carlo
Glenny Jorge Archibaldo
Glinkina Irina
Gnudi Luigi
Godlevska Olga
Goldenberg Ronald
Golovchenko Oleksandr
Gomes Marcus
Gomez Rangel Jose David
Gomez Olivert
Gonzalez Martinez Francisco Javier
Gonzalez Orellana Ronaldo Arturo
Gonzalez Alexander
Gonzalez Alfonso Soto
Gonzalez Enrique
Gonzalez Joaquin Pablo
Gonzalo Godoy Jorquera Juan
Gopalakrishnan Natarajan
Gorson David
Gourdy Pierre
Govender Ravendran
Govender Vimladhevi
Gowda Anupama
Goycoa Claudia
Górriz Jose L.
Gracious Noble
Greco Barbara
Greene Tom
Greloni Gustavo Cristian
Grineva Elena
Grubb Stephen
Guerrero Rodolfo Andres Ahuad
Guinsburg Adrian
Gulati Rakesh
Guldris Secundino Cigarran
Gunstone Anthony
Gupta Anil
Gupta Milan
Guzman Juan Rosas
Gyrina Olga
Haase Franklin Paul
Hachmann Jean Carlo Tibes
Hadjadj Samy
Halciakova Katarina
Hall Timothy
Haller Hermann
Halmagyi Ildiko
Hammoud Jamal
Hancu Nicolae
Handelsman Stuart
Hanif Wasim
Hansraj Alva
Harcsa Eleonora
Hartman Israel
Hawley Carmel
Hayashida Cesar Yoiti
Heerspink Hiddo J. L.
Heerspink Hiddo J. L.
Heerspink Hiddo J. L.
Henein Sam
Hermida Sonia
Herrera Jimenez Luis Enrique
Hershon Kenneth
Higuera Juan Diego
Hiser Daniel
Hissa Miguel Nasser
Hon George
Hotlos Lucyna
Hristozov Kiril
Hsia Te-Lin
Hsieh Chang-Hsun
Hwang Shang-Jyh
Hwang Shang-Jyh
Iglesias Javier Nieto
Iitsuka Tadashi
Ilavska Adriana
Irizar Santana Sergio Saul
Ismail Mastura
Jackson Alan
Jacob Radu
Jaime Maria
Jain Dinesh
Jamal Aamir
Januszewicz Andrzej
Jardine Meg
Jardine Meg
Jardine Meg J.
Jeong In-Kyung
Jerwan-Keim Reinhold
Jha Vivekanand
Ji Linong
Jimeno Cecilia
Jodar Gimeno Jose Esteban
Johnson Andrew
Johnson David
Joseph Franklin
Joshi Mukesh
Juarez Erick Turcios
Juncos Luis Isaias
Junior Renan Montenegro
Jurgens Jaco
Kaczmarek Barbara
Kadir Khalid Abdul
Kajiyama Shizuo
Kamenov Zdravko
Kaminska Anna
Kang Amy
Kashine Susumu
Kaupke Charles
Kawada Toshio
Kazmirchuk Anatoliy
Keightley Gerald
Keitel Elizete
Keltai Katalin
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Keresztesi Sandor
Kern Elizabeth
Keshavamurthy C. B.
Khandwala Hasnain
Khanna Rakhi
Khirmanov Vladimir
Khitan Zeid
Khullar Dinesh
Kim Sin Gon
Kim Sun
Kim Yeong Hoon
Kiss Krisztian
Klein Alexandre
Klokocnikova Vera
Klyver Maria Isabel
Kodera Takamoto
Kohara Suely Keiko
Kolesnyk Inna
Kolesnyk Mykola
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Kolmakova Elena
Komisarenko Iuliia
Kong Wei Yen
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Kono Hiroshi
Konyves Laszlo
Kopyt Nelson
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Kovesdy Csaba
Koyama Kazunori
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Kraft Florencia
Krane Vera
Kravchun Nonna
Krishna Gopal
Krishnan Singhan
Kropp Jeffrey (Jay)
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Kumar Amrendra
Kumar Jayant
Kumar Neil
Kumeda Yasuro
Kumwenda Mick
Kusnir Jorge
Kvitkova Liudmila
Kwon Hyuk-Sang
Kwon Min Jeong
Lalic Katarina
Lalic Nebojsa
Lallaine Ygpuara Ma. Dovie
Lam Swee Win
Lanchiotti Paulina Virginia
Lane Wendy
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Li Nicole
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Lim Soo Kun
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Lim-Abrahan Mary Anne
Lin Chih-Ching
Lin Hongli
Lisboa Hugo Roberto Kurtz
Liss Kenneth
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Loh Chek Loong
Lombard Landman
Lopez Marta Dominguez
Lozano Fernando Flores
Lozanov Lachezar
Lu Weiping
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Mele Pablo
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Rosivall László
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Rucker Joerg Isabel Erika
Rychlik Ivan
Rychlík Ivan
Saavedra Sanchez Sandra Berenice
Saba Fadi
Sabbag Ângela Regina Nazario
Sakakibara Terue
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Salazar Melchor Alpizar
Samoylov Oleksandr
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Santos Lalaine Delos
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Saraiva Jose Francisco Kerr
Sarin Ravi
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Saudek Frantisek
Saulnier Pierre-Jean
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Sánchez Arenales Jose Antonio
Schiavi Lilia Beatriz
Schiller Adalbert
Schreiman Robert
Schuch Tiago
Scott David
Scott Russell
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Seeber Mary
Sekkarie Mohamed
Sennik Davesh
Sensenbrenner John
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Serrano Antonio Galan
Serviddio Gaetano
Sessa Horacio
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Shaw Sylvia
Sheu Wayne H-H
Shinkov Alexander
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Shwartz Yuriy
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Smyth Brendan
Solomon Richard
Song Weihong
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Sowinski Dariusz
Sprague Amy
Spry Leslie
Sreedhar Reddy
Sreelatha Melemadathil
Steele Andrew
Stella Andrea
Stephens Jeffrey
Strzelecka Anna
Suchinda Pusadee
Sudhakar Bhimavarapu
Sultan Senan
Sun Jiao
Sun Lin
Surampudi Prasanth
Sussman Sherry
Svyshchenko Yevgeniya
Symonds Rehan
Takacs Robert
Takai Masahiko
Tamayo y Orozco Juan Alfredo
Tan Anjanette
Tan Gerry
Tangri Navdeep
Temelkova Margarita
Terrelonge Antonio
Tesar Vladimir
Thervet Eric
Thomé Fernando
Thompson Michael
Tinahones Madueno Francisco Jose
Toarba Cristina
Tolentino Marsha
Tomashkevych Halyna
Tomonaga Osamu
Topchii Ivan
Torres Manuel Muñoz
Torshizi Ali
Trenche Samuel Mujica
Trespalacios Fernando
Trevisan Roberto
Triana Eric Hernandez
Trippe Bruce
Trueba Pilar
Tryshchuk Nadiya
Tsang Venessa
Tseluyko Vira
Tsujimoto Mitsuru
Tu Ping
Turatti Luiz Alberto Andreotti
Turner Wayne
Twahirwa Marcel
Ulla Maria Rosa
Updegrove John
Urbanaviciene Egle
Uriasyev Oleg
Valdez Maria
Valenzuela Alex
Valis Martin
Vallejos Augusto
Van Buren Peter
Vangel Sandor
Vannorsdall Mark
Vargas Alonso Ruben Dario
Varghese Freemu
Vasas Szilard
Vazelov Evgueniy
Vejar Margarita
Velasquez-Mieyer Pedro
Velichkova Ekaterina
Vengadasalam Paranthaman
Ventrapragada Sailaja
Vera Gregorio Obrador
Vera Merce Perez
Veronelli Anna Maria
Vêncio Sérgio Alberto Cunha
Villarino Adriana
Villegas Ivan
Visco Virginia Esther
Vizir Vadym
Vlasenko Maryna
Vorobyev Sergey
Vukotic Goga
Wada Takashi
Wada Takashi
Wadud Khurram
Wahba Mona
Wakasugi Masakiyo
Wakeling John
Wakida Yasushi
Walker Robert
Wang Guixia
Warren Mark
Wassermann Alfredo
Watanabe Takayuki
Watson Edward
Watson Henry
Watts Ronald
Weiner Daniel
Weiner Pavel
Welker James
Welsh Jean
Wheeler C.
Wheeler David
Wheeler David C.
Wheeler David C.
Williams Michael
Williams Shelley
Winocour Peter
Wong Alfredo Chew
Woo Vincent
Yakov Andrian
Yamada Masayo
Yamada Sérgio
Yanagida Kazuhiro
Yanase Toshihiko
Yang Jinkui
Yao Christy
Yap Yvette Ethel
Yi Tae Won
Yin Aiping
Yoon Kun Ho
Young Simon
Yu Xueqing
Yumita Wataru
Yupanqui Hernan
Zaidman Cesar Javier
Zalunardo Nadia
Zanella Maria Teresa
Zaniewski-Singh Michelle
Zanoli Luca
Zaoui Philippe
Zateyshchikova Anna
Zateyshshikov Dmitry
Zemek Stanislav
Zhang Hong
Zhang Hong
Zhang Hong
Zhao Minghui
Zheng Hongguang
Zinman Bernard
Zinman Bernard
Zlova Tetiana
Zsom Marianna
Zub Liliia
Zykova Tatyana
Publication venue
Publication date: 01/01/2023
Field of study

Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791

Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

Author: A A
Abbott Jd
Abdullah S
Abib E Jr
Ables Lr
Abrantes Ja
Acosta R
Adams A
Adams F
Adroer Martori R
Agafina As
Agaiby Jm
Aggarwala G
Agraou B
Aguilarsalinas Ca
Ahmad A
Ajala B
Akdeniz B
Akhtar N
Akright L
Aksentiev S
Al-Zoebi A
Alappat P
Albert M
Alfieri Ad
Alhakim M
Allaw Ma
Alpizar-Salazar M
Altafullah Im
Alvarado Op
Alvarez Ca
Alvarez Jg
Alvarez Ms
Alvarez-Sala Walther La
Alves AR Jr
Alwine Lk
Alzand B
Amarenco P.
Ambrovicova V
Amerena J
Andersen Jl
Andersen Lt
Anderson P
Anderson Tj
Andrassy P
Andrei Ld
Andreka P
Angoulvant D
Angun M
Annamalai N
Ansari Sh
Anselmi M
Antonicelli R
Appel Kf
Aracil Villar J
Arain S
Arambula Rm
Araz M
Arca M
Arcanese Ml
Arden C
Areas Ca
Ari H
Ariani Mk
Arif I
Aroney C
Aronson R
Arstall M
Arstila L
Arya Kw
Asamoah-Owusu N
Askonen K
Aslam Aa
Assadourian A
Assef V
Atar S
Auriel E
Avaca H
Averna M
Avornyo Aa
Avram Ri
Axthelm C
Ayesu K
Aylward Pe
Ayoub Jc
Baar M
Babapulle M
Badat Ae
Bailey Sr
Bajaj H
Bajcsi D
Baker J
Bakhai A
Baldari D
Ball Em
Ballantyne Cm
Ballyuzek M
Balo T
Banaszkiewicz K
Bandeira e Farias FA
Banerjee M
Banik M
Banyai M
Baranova E
Barbarash Ol
Barbieri Ds
Barettella Mb
Barker Ba
Barnum O
Barreda Gonzalez Mj
Barrera Cm
Barrington P
Baultrukonis D
Bax Wa
Bayat J
Bayron Cj
Bays He
Beaudry P
Beckett Pl
Begg A
Behmanesh B
Behnke T
Belenkiy Di
Belicova M
Bellido Guerrero D
Bellingar B
Beltran Lg
Benacka J
Benatar Jr
Benczur B
Benitez O
Benjamin Sa
Berenguer Ra
Bergeron J
Bergerot C
Berk Mr
Berli M
Berlingieri Jc
Bernard Jv
Berrouschot J
Bertolet Bd
Bhindi R
Bianco Ht
Bijata-Bronisz R
Bilz S
Bittar Gd
Bitzur R
Bjasker Kr
Blach E
Black H
Blagden Md
Blaha V
Blake G
Blanco Coronado Jl
Blaze K
Blignault Sc
Blokhin A
Bloom Sa
Bocek P
Bod E
Bogaard K
Bogdanov E
Bokern Mj
Boman K
Bonansea Tc
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Bonner Jh
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Boonyavarakul A
Borer Js
Botas Rodrigues J
Botelho Rv
Botella Serrano M
Botero-Lopez R
Botta Ce
Bourgeois R
Bourhaial H
Boye A
Boyett Be
Brandon Dm
Brar Hs
Brauer C
Bravo P
Bredlau Ce
Breedveld Rw
Brenner H
Breton Cf
Bretton Em
Brito Sanfiel Ma
Broncel M
Bronnum Schou J
Brotons Cuixart C
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Bruguera Cortada J
Brunell R.
Bruno Rl
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Figueiredo El
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fitz-Patrick D
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Fraser Nj
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French Wj
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Funk Gs
Furie Kl
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Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2017
Field of study

Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin- kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODS In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo. The primary end point was nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death; 93% of the patients were receiving statin therapy at baseline. The trials were stopped early after the sponsor elected to discontinue the development of bococizumab owing in part to the development of high rates of antidrug antibodies, as seen in data from other studies in the program. The median follow-up was 10 months. RESULTS At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab group and +2.9% in the placebo group, for a between-group difference of -59.0 percentage points (P<0.001) and a median reduction from baseline of 64.2% (P<0.001). In the lower-risk, shorter-duration trial (in which the patients had a baseline LDL cholesterol level of ≥70 mg per deciliter [1.8 mmol per liter] and the median follow-up was 7 months), major cardiovascular events occurred in 173 patients each in the bococizumab group and the placebo group (hazard ratio, 0.99; 95% confidence interval [CI], 0.80 to 1.22; P = 0.94). In the higher-risk, longer-duration trial (in which the patients had a baseline LDL cholesterol level of ≥100 mg per deciliter [2.6 mmol per liter] and the median follow-up was 12 months), major cardiovascular events occurred in 179 and 224 patients, respectively (hazard ratio, 0.79; 95% CI, 0.65 to 0.97; P = 0.02). The hazard ratio for the primary end point in the combined trials was 0.88 (95% CI, 0.76 to 1.02; P = 0.08). Injection-site reactions were more common in the bococizumab group than in the placebo group (10.4% vs. 1.3%, P<0.001). CONCLUSIONS In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events in the trial involving lower-risk patients but did have a significant benefit in the trial involving higher-risk patients

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Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

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Abdullah S.
Abib E.
Ables L. R.
Abrantes J. A. M.
Acosta R.
Adams A.
Adams F.
Adroer Martori R.
Agafina A. S.
Agaiby J. M.
Aggarwala G.
Agraou B.
AguilarSalinas C. A.
Ahmad A.
Ajala B.
Akdeniz B.
Akhtar N.
Akright L.
Aksentiev S.
Al-Zoebi A.
Alappat P.
Albert M.
Alfieri A. D.
Alhakim M.
Allaw M. A.
Alpizar-Salazar M.
Altafullah I. M.
Alvarado O. P.
Alvarez C. A.
Alvarez J. G.
Alvarez M. S.
Alvarez-Sala Walther L. A.
Alves A. R.
Alwine L. K.
Alzand B.
Amarenco P.
Ambrovicova V.
Amerena J.
Andersen J. L.
Andersen L. T.
Anderson Patricia
Anderson T. J.
Andrassy P.
Andrei L. D.
Andreka P.
Angoulvant D.
Angun M.
Annamalai N.
Ansari S. H.
Anselmi M.
Antonicelli R.
Appel K. F.
Aracil Villar J.
Arain S.
Arambula R. M. S.
Araz M.
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Voros P.
Vrablik M.
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Vukotic G.
Wadud K.
Wainstein J.
Wakefield P. H.
Wakeling J.
Walczak M.
Walczewska J.
Walukiewica P.
Wang D.
Wang Ellen
Wang G.
Wang Y.
Wasserburger B.
Waxler A. R.
Wayne J. D.
Weber D.
Weber K.
Wegner John
Wei Caimiao
Weigmann I.
Weinstein D. L.
Weiss R.
Welker J. A.
Welty Francine
Wenetz L. M. M.
Wermuth S.
Wesson T.
West S. H.
Westerndorp I.
Wetzel T.
White H.
Whitlock L.
Whitney R. T.
Wiggers H.
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Willis J. G.
Willits V. L.
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Yao L. C.
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Yarows S. A.
Yigit Z.
Yoon J.
Yunis C.
Zadra R.
Zaidman C. J.
Zamorano Gomez J. L.
Zannad Faiez
Zarandon R. B. S.
Zarich S. W.
Zateyshchikov D.
Zavaro S. H.
Zebrack J. S.
Zeig S.
Zemek S.
Zemour G.
Zeng X.
Zeno M. L.
Zhang L.
Zhang X.
Zhang Y.
Zhao Y.
Zhou C.
Zhou Y.
Zhu Y.
Zidkova E.
Zieba B.
Zilahi Z.
Zoet-Nugteren S. K.
Zrazhevskiy K.
Zubek V.
Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2017
Field of study

BACKGROUN

İstanbul Üniversitesi Açık Erişim Sistemi

International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: Results from the GARFIELD-AF, ORBIT-AF I, and ORBIT-AF II registries

Author: A'Court C.
Aaroe H.
Abd El-Aziz A.
Abdalla Saad J.
Abdel-Qader M.
Abdelrahman H.
Abdul A.
Abe M. (Masahiko)
Abe M. (Masatake)
Abe M. (Mitsunori)
Abe S.
Abe Y.
Abhayaratna W.
Abou Seif S. K.
Abraham S.
Abu-Mahfouz M.
Abushal S.
Accogli M.
Adachi S.
Adachi S. (Sen)
Adachi S. (Susumu)
Adachi T.
Adak D.
Adriaansen H.
Agakhanyan A.
Agata J.
Ageta M.
Aggarwala A.
Agliardi P.
Agnelli G.
Agrawal A.
Aguilar J.
Ahbeck E.
Ahlmark H.
Ahmad K.
Ahmad N.
Ahmad S.
Ahmed F.
Ahmed W.
Ahn J. J.
Ahuad Guerrero R. A.
Ainsworth P.
Airaksinen J.
Akahane K.
Akiyama M.
Aktas O.
Akutsu M.
Al Mahmeed W.
Al Mulla A.
Al Naeemi A.
Al Omairi M.
Al-Khalili F.
Alaguibe E. D.
Alban F.
Alberts M.
Alborough E.
Aldegather J.
Aleksandrova E.
Alfaro T. A. A.
Alfieri A.
Ali A.
Alkan D. Uzun
Allasia B.
Almeida Fernandez C. A.
Alonso C. (Carmela)
Alonso C. (Concepcion)
Alpay D.
Altamirano Bellorin S.
Altun A.
Alunni M.
Alvarez D'Amelio A.
Alvarez Garcia P.
Alvarez Lopez H.
Alvarez D.
Alvarez M.
Alves da Costa F. A.
Alves de Oliveira Gomes J.
Alzand B.
Amano T.
Amarenco P.
Amaro M.
Ambicka M.
Ambrosino P.
Ambrosio G.
Amstutz D.
An H. J.
Andere N.
Andersson A.
Andersson L. (Lars)
Andersson L. (Lisbeth)
Ando H.
Ando S.
Andrzejewski D.
Angaran P.
Angaran P.
Angchaisuksiri P.
Angel G.
Anne W.
Ansell Jack
Antonova P.
Antonsen H.
Aoki K.
Aoyama T.
Arabetti C.
Aracil Villar J.
Arai H.
Araminowicz J.
Aranha Rosito G. B.
Aras D.
Aras F.
Arasaki O.
Araujo G. R.
Araujo V.
Arcocha Torres M. F.
Argena A.
Arias L.
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Zhao R. P.
Zhao Y. S.
Zheng W. Y.
Zhirov I.
Zhou B.
Zhou Z. H.
Zhu X. Y.
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Zidkova E.
Ziefle S.
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Zuber M.
Zurbrigk F. J.
Zutz S.
Zyczynska-Szmon M.
Publication venue: 'Elsevier BV'
Publication date: 05/03/2021
Field of study

Background Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world. We aimed to provide comprehensive data on international patterns of AF stroke prevention treatment

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