37 research outputs found
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Maximizing the relationship of yield to site-specific management zones with object-oriented segmentation of hyperspectral images
Quick and low cost delineation of site-specific management zones (SSMZ) would improve applications of precision agriculture. In this study, a new method for delineating SSMZ using object-oriented segmentation of airborne imagery was demonstrated. Three remote sensing domains—spectral, spatial, and temporal- are exploited to improve the SSMZ relationship to yield. Common vegetation indices (VI), and first and second derivatives ([Formula: see text], [Formula: see text]) from twelve airborne hyperspectral images of a cotton field for one season [Formula: see text] were used as input layers for object-oriented segmentation. The optimal combination of VI, SSMZ size and crop phenological stage were used as input variables for SSMZ delineation, determined by maximizing the correlation to segmented yield monitor maps. Combining narrow band vegetation indices and object-oriented segmentation provided higher correlation between VI and yield at SSMZ scale than that at pixel scale by reducing multi-resource data noise. VI performance varied during the cotton growing season, providing better SSMZ delineation at the beginning and middle of the season (days after planting (DAP) 66–143).The optimal scale determined for SSMZ delineation was approximately 240 polygons for the study field, but the method also provided flexibility enabling the setting of practical scales for a given field. For a defined scale, the optimal single phenological stage for the study field was near July 11 (DAP 87) early in the growing season. SSMZs determined from multispectral VIs at a single stage were also satisfactory; compared to hyperspectral indices, temporal resolution of multi-spectral data seems more important for SSMZ delineation
Overview of Mollisols in the world: Distribution, land use and management
Mollisols a.k.a., Black Soils or Prairie Soils make up about 916 million ha, which is 7% of the world’s ice-free land surface. Their distribution strongly correlates with native prairie ecosystems, but is not limited to them. They are most prevalent in the mid-latitudes of North America, Eurasia, and South America. In North America, they cover 200 million ha of the United States, more than 40 million ha of Canada and 50 million ha of Mexico. Across Eurasia they cover around 450 million ha, extending from the western 148 million ha in southern Russia and 34 million ha in Ukraine to the eastern 35 million ha in northeast China. They are common to South America’s Argentina and Uruguay, covering about 89 million and 13 million ha, respectively. Mollisols are often recognized as inherently productive and fertile soils. They are extensively and intensively farmed, and increasingly dedicated to cereals production, which needs significant inputs of fertilizers and tillage. Mollisols are also important soils in pasture, range and forage systems. Thus, it is not surprising that these soils are prone to soil erosion, dehumification (loss of stable aggregates and organic matter) and are suffering from anthropogenic soil acidity. Therefore, soil scientists from all of the world’s Mollisols regions are concerned about the sustainability of some of current trends in land use and agricultural practices. These same scientists recommend increasing the acreage under minimum or restricted tillage, returning plant residues and adding organic amendments such as animal manure to maintain or increase soil organic matter content, and more systematic use of chemical amendments such as agricultural limestone to replenish soil calcium reserves
The state of the Martian climate
60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Recommended from our members
Maximizing the relationship of yield to site-specific management zones with object-oriented segmentation of hyperspectral images
Quick and low cost delineation of site-specific management zones (SSMZ) would improve applications of precision agriculture. In this study, a new method for delineating SSMZ using object-oriented segmentation of airborne imagery was demonstrated. Three remote sensing domains—spectral, spatial, and temporal- are exploited to improve the SSMZ relationship to yield. Common vegetation indices (VI), and first and second derivatives ([Formula: see text], [Formula: see text]) from twelve airborne hyperspectral images of a cotton field for one season [Formula: see text] were used as input layers for object-oriented segmentation. The optimal combination of VI, SSMZ size and crop phenological stage were used as input variables for SSMZ delineation, determined by maximizing the correlation to segmented yield monitor maps. Combining narrow band vegetation indices and object-oriented segmentation provided higher correlation between VI and yield at SSMZ scale than that at pixel scale by reducing multi-resource data noise. VI performance varied during the cotton growing season, providing better SSMZ delineation at the beginning and middle of the season (days after planting (DAP) 66–143).The optimal scale determined for SSMZ delineation was approximately 240 polygons for the study field, but the method also provided flexibility enabling the setting of practical scales for a given field. For a defined scale, the optimal single phenological stage for the study field was near July 11 (DAP 87) early in the growing season. SSMZs determined from multispectral VIs at a single stage were also satisfactory; compared to hyperspectral indices, temporal resolution of multi-spectral data seems more important for SSMZ delineation
Crop Yield Estimation Using Time-Series MODIS Data and the Effects of Cropland Masks in Ontario, Canada
This study investigated the estimation of grain yields of three major annual crops in Ontario (corn, soybean, and winter wheat) using MODIS reflectance data extracted with a general cropland mask and crop-specific masks. Time-series two-band enhanced vegetation index (EVI2) was derived from the 8 day composite 250 m MODIS reflectance data from 2003 to 2016. Using a general cropland mask, the strongest positive linear correlation between crop yields and EVI2 was observed at the end of July to early August, whereas a negative correlation was observed in spring. Using crop-specific masks, the time of the strongest positive linear correlation for winter wheat was found between mid-May and early June, corresponding to peak growth stages of the crop. EVI2 derived at peak growth stages of a crop provided good predictive capability for grain yield estimation, with considerable inter-annual variation. A multiple linear regression model was established for county-level yield estimation using EVI2 at peak growth stages and the year as independent variables. The model accounted for the spatiotemporal variability of grain yields of about 30% and 47% for winter wheat, 63% and 65% for corn, and 59% and 64% for soybean using the general cropland mask and crop-specific masks, respectively. A negative correlation during the spring indicated that vegetation index extracted using a general cropland mask should be used with caution in regions with mixed crops, as factors other than the growth conditions of the targeted crops may also be captured by remote sensing data
Assessing the Impact of Climate Variability on Cropland Productivity in the Canadian Prairies Using Time Series MODIS FAPAR
Cropland productivity is impacted by climate. Knowledge on spatial-temporal patterns of the impacts at the regional scale is extremely important for improving crop management under limiting climatic factors. The aim of this study was to investigate the effects of climate variability on cropland productivity in the Canadian Prairies between 2000 and 2013 based on time series of MODIS (Moderate Resolution Imaging Spectroradiometer) FAPAR (Fraction of Absorbed Photosynthetically Active Radiation) product. Key phenological metrics, including the start (SOS) and end of growing season (EOS), and the cumulative FAPAR (CFAPAR) during the growing season (between SOS and EOS), were extracted and calculated from the FAPAR time series with the Parametric Double Hyperbolic Tangent (PDHT) method. The Mann-Kendall test was employed to assess the trends of cropland productivity and climatic variables, and partial correlation analysis was conducted to explore the potential links between climate variability and cropland productivity. An assessment using crop yield statistical data showed that CFAPAR can be taken as a surrogate of cropland productivity in the Canadian Prairies. Cropland productivity showed an increasing trend in most areas of Canadian Prairies, in general, during the period from 2000 to 2013. Interannual variability in cropland productivity on the Canadian Prairies was influenced positively by rainfall variation and negatively by mean air temperature
Modelling soybean yield responses to seeding date under projected climate change scenarios
Climate change is projected to increase growing season length and temperature in Canada, but how soybean [Glycine max (L.) Merr.] will respond is uncertain. By modelling soybean responses to climate change scenarios, stakeholders can develop adaptation strategies. The CSM-CROPGRO-Soybean and STICS models were used to simulate soybean responses under the baseline (1971-2000) and near (2041-2070) and distant future (2071-2100) climate scenarios, including those resulting in altered seeding dates in eastern Canada. Field data collected in Ottawa were used to evaluate the models. The simulated seed yield using the CSM-CROPGRO-soybean model showed an increase of about 14% (0.34 t ha-1) in the near future and a decrease in the distant future under RCP8.5, and the STICS model estimated a decrease in both the near and distant future. When the crop parameters determining the life cycle were increased by 30% and 40%, the simulated seed yield increased by more than 5% -10% and 10% -20%, and by more than 20% - 30% and 27% - 40% if combined with current harvest index levels. Our simulations showed that soybean seed yield would not benefit from the prolonged growing season under the projected future climate in eastern Canada, unless harvest index is maintained.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author