MOESM1 of G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon

Additional file 1. Flow diagram of the study detailing exclusion criteria

The patient with carcinoma of tongue and his nursing case report

Additional file 2: Table S2. Insertions (INS) and deletions (DEL) identified in the three lines 3D7A, A4 and F12

Kasvusuunta

Osaamistarpeiden klusteriennakointi viljaketjussa -projekti ennakoi viljan tuotannon, elintarviketeollisuuden ja vähittäiskaupan muodostamien ketjujen pitkän aikavälin osaamistarpeita peilaamalla nykyosaamista tulevaisuuden työ-, yritys- ja kulutusmarkkinoilla tapahtuviin muutoksiin. Ennakointiprojekti kuuluu valtakunnallisen ESR -toimintalinjan 3 kehittämisohjelmaan: ”Koulutus- ja osaamistarpeiden ennakointi”. Projektia rahoittaa Euroopan sosiaalirahasto ja Opetushallitus. Julkaisussa viljaklusterin uusia osaamistarpeita ja tulevaisuuden näkymiä pohtivat sekä viljaklusterin, että sen sidosryhmien edustajat. Julkaisun teon yhteydessä tuotettuun videomateriaaliin pääsee tutustumaan ottamalla matkapuhelimella kuvan tekstin yhteydessä olevasta QR – koodista tai kopioimalla koodin alla olevan osoitteen selaimen osoiteriville. QR-koodit vaativat toimiakseen mobiililaitteeseen kehitetyn sovelluksen. Sovelluksen voi ladata ilmaiseksi internetistä

Additional file 4: Table S4. of A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance

Table of the 110 genes that were significantly associated with PZA-resistance at gene level, which also have mutations significantly associated with PZA-resistance at the mutation level. The association p-value at mutation level was re-calculated excluding the strains harboring mutations strongly related with PZA resistance. These genes were annotated with their molecular function. (DOCX 297 kb

The Person of Arbitration in International Commercial Arbitration

The topic of the thesis is The Person of Arbitrator in International Commercial Arbitration. Arbitration has undergone a number of changes in recent years. This procedure is very popular not only for a choice of Arbitrator, but also for its speed and lower costs, as compared to the other methods of dispute resolution. In the work has been carefully analyzed the whole procedure from the viewpoint of an Arbitrator, especially his duties and powers. The amendment to Act No. 216/1994 Coll. - Act No. 19/2012 Coll., with effect from 1.4.2012 was to distinguish arbitration for consumer and without consumer. Part of the thesis are also proposals de lege ferenda

Comparing the parameters of blood samples of periodic blood donors and monitoring their trend during time at sampling point.

The isolates according to geographic location and phenotypic drug resistance. CAR Central African Republic; DRC Democratic Republic of Congo, L1-L4 lineages 1 to 4, (first line drugs) RMP = rifampicin, INH = isoniazid, SM = streptomycin, EMB = ethambutol; (second line drugs) OFL = ofloxacin, KAN = kanamycin, CAP = capreomycin, Et = ethionamide, P = Para-aminosalisylic acid. Table S2. The isolate ENA accession numbers and MIC values. RMP rifampicin, INH isoniazid, SM streptomycin, EMB ethambutol. Table S3. Drug susceptibility profiles for rifampicin, isoniazid, streptomycin and ethambutol. R = resistance, S = sensitive; 13 different profiles were identified across 127 independent isolates; Multi-drug resistant in italics. Table S4. Combinations of mutations and their frequency (N) in drug resistance candidate genes. a) Rifampicin. b) Isoniazid. c) Streptomycin. d) Ethambutol. * single mutation, ** double mutations, *** triple mutations; SNP mutations in a single sample have been aggregated into a “rare” column. Table S5. Predicted effects of mutations. (DOCX 55 kb

Additional file 2: Table S2. of A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance

Complete results of the analysis by mutation, showing the number of resistant strains with the mutation (M-Res), without the mutation (NM-Res) and analogously for the susceptible strains (M-Sus and NM-Sus, respectively). The P-value of the Proportion Test, the Youden Index and Odds Ratio are also included. (DOCX 1264 kb

Additional file 2: Figure S1. of Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial

First-wave parasitemia after challenge. Parasitemia on day 7 post-challenge in immunized (open circles) and control (closed circles) volunteers. The line and error bars show the geometric mean and 95% CI interval. Figure S2. Inhibition of in vitro homologous and heterologous intra-hepatic sporozoite development in primary human hepatocytes by mAb 2A10. P. falciparum NF54 (blue), NF135.C10 (orange) and NF166.C8 (green) sporozoites in the presence of 10% heat-inactivated naive human control serum were pre-incubated with 3-fold serial dilutions of the 2A10 monoclonal antibody (0.027–20 μg/mL), targeting the repeat region of the circumsporozoite protein (CSP), and added to primary human hepatocyte cultures. Six days post-infection, the number of P. falciparum-infected hepatocytes was assessed as described in Additional file 1: S4 and S5. Figure S3. Amino acid changes in CSP. Table S1. Whole-genome sequencing statistics. Table S2. Mosquito salivary gland infectivity and sporozoite load of the three clones. Mean mosquito salivary gland infectivity and sporozoite load determined 1 day prior to challenge infection by dissecting a sample of 10 mosquitoes per strain. (DOCX 427 kb

A participatory scenario method to explore the future of marine social-ecological systems

Anticipating future changes in marine social‐ecological systems (MSES) several decades into the future is essential in the context of accelerating global change. This is challenging in situations where actors do not share common understandings, practices, or visions about the future. We introduce a dedicated scenario method for the development of MSES scenarios in a participatory context. The objective is to allow different actors to jointly develop scenarios which contain their multiple visions of the future. The method starts from four perspectives: “fisheries management,” “ecosystem,” “ocean climate,” and “global context and governance” for which current status and recent trends are summarized. Contrasted scenarios about possible futures are elaborated for each of the four single perspectives before being integrated into multiple‐perspective scenarios. Selected scenarios are then developed into storylines. Focusing on individual perspectives until near the end allows actors with diverse cultures, interests and horizons to confront their own notions of the future. We illustrate the method with the exploration of the futures of the Barents Sea MSES by 2050. We emphasize the following lessons learned: first, many actors are not familiar with scenario building and attention must be paid to explaining the purpose, methodology, and benefits of scenarios exercises. Second, although the Barents Sea MSES is relatively well understood, uncertainties about its future are significant. Third, it is important to focus on unlikely events. Fourth, all perspectives should be treated equally. Fifth, as MSES are continuously changing, we can only be prepared for future changes if we collectively keep preparing

Additional file 9: Figure S8. of Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages

Selection dN/dS values for each gene within Clusters of Orthologous Groups (COG*) categories. *ppe/N = pe/ppe genes annotated as COG category N, * COG categories: A RNA processing and modification, B Chromatin Structure and dynamics, C Energy production and conversion, D Cell cycle control and mitosis, E Amino Acid metabolism and transport, F Nucleotide metabolism and transport, G Carbohydrate metabolism and transport, H Coenzyme metabolism, I Lipid metabolism, J Translation, K Transcription, L Replication and repair, M Cell wall/membrane/envelope biogenesis, N Cell motility, O Post-translational modification, protein turnover, chaperone functions, P Inorganic ion transport and metabolism, Q Secondary Structure, T Signal Transduction, U Intracellular trafficking and secretion, Y Nuclear structure, Z Cytoskeleton, R General Functional Prediction only, S Function Unknown. (TIF 124 kb