604 research outputs found
Climate warming, marine protected areas and the ocean-scale integrity of coral reef ecosystems
Coral reefs have emerged as one of the ecosystems most vulnerable to climate variation and change. While the contribution
of a warming climate to the loss of live coral cover has been well documented across large spatial and temporal scales, the
associated effects on fish have not. Here, we respond to recent and repeated calls to assess the importance of local
management in conserving coral reefs in the context of global climate change. Such information is important, as coral reef
fish assemblages are the most species dense vertebrate communities on earth, contributing critical ecosystem functions
and providing crucial ecosystem services to human societies in tropical countries. Our assessment of the impacts of the
1998 mass bleaching event on coral cover, reef structural complexity, and reef associated fishes spans 7 countries, 66 sites
and 26 degrees of latitude in the Indian Ocean. Using Bayesian meta-analysis we show that changes in the size structure,
diversity and trophic composition of the reef fish community have followed coral declines. Although the ocean scale
integrity of these coral reef ecosystems has been lost, it is positive to see the effects are spatially variable at multiple scales,
with impacts and vulnerability affected by geography but not management regime. Existing no-take marine protected areas
still support high biomass of fish, however they had no positive affect on the ecosystem response to large-scale disturbance.
This suggests a need for future conservation and management efforts to identify and protect regional refugia, which should
be integrated into existing management frameworks and combined with policies to improve system-wide resilience to
climate variation and change
MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial.
PURPOSE: Transcription factor C/EBP-α (CCAAT/enhancer-binding protein alpha) acts as a master regulator of hepatic and myeloid functions and multiple oncogenic processes. MTL-CEBPA is a first-in-class small activating RNA oligonucleotide drug that upregulates C/EBP-α. PATIENTS AND METHODS: We conducted a phase I, open-label, dose-escalation trial of MTL-CEBPA in adults with advanced hepatocellular carcinoma (HCC) with cirrhosis, or resulting from nonalcoholic steatohepatitis or with liver metastases. Patients received intravenous MTL-CEBPA once a week for 3 weeks followed by a rest period of 1 week per treatment cycle in the dose-escalation phase (3+3 design). RESULTS: Thirty-eight participants have been treated across six dose levels (28-160 mg/m2) and three dosing schedules. Thirty-four patients were evaluable for safety endpoints at 28 days. MTL-CEBPA treatment-related adverse events were not associated with dose, and no maximum dose was reached across the three schedules evaluated. Grade 3 treatment-related adverse events occurred in nine (24%) patients. In 24 patients with HCC evaluable for efficacy, an objective tumor response was achieved in one patient [4%; partial response (PR) for over 2 years] and stable disease (SD) in 12 (50%). After discontinuation of MTL-CEBPA, seven patients were treated with tyrosine kinase inhibitors (TKIs); three patients had a complete response with one further PR and two with SD. CONCLUSIONS: MTL-CEBPA is the first saRNA in clinical trials and demonstrates an acceptable safety profile and potential synergistic efficacy with TKIs in HCC. These encouraging phase I data validate targeting of C/EBP-α and have prompted MTL-CEBPA + sorafenib combination studies in HCC
Precision measurement of the top quark mass from dilepton events at CDF II
We report a measurement of the top quark mass, M_t, in the dilepton decay
channel of
using an integrated luminosity of 1.0 fb^{-1} of p\bar{p} collisions collected
with the CDF II detector. We apply a method that convolutes a leading-order
matrix element with detector resolution functions to form event-by-event
likelihoods; we have enhanced the leading-order description to describe the
effects of initial-state radiation. The joint likelihood is the product of the
likelihoods from 78 candidate events in this sample, which yields a measurement
of M_{t} = 164.5 \pm 3.9(\textrm{stat.}) \pm 3.9(\textrm{syst.})
\mathrm{GeV}/c^2, the most precise measurement of M_t in the dilepton channel.Comment: 7 pages, 2 figures, version includes changes made prior to
publication by journa
Cross Section Measurements of High- Dilepton Final-State Processes Using a Global Fitting Method
We present a new method for studying high- dilepton events
(, , ) and simultaneously
extracting the production cross sections of , , and p\bar{p} \to \ztt at a center-of-mass energy of TeV. We perform a likelihood fit to the dilepton data in a parameter
space defined by the missing transverse energy and the number of jets in the
event. Our results, which use of data recorded with the CDF
II detector at the Fermilab Tevatron Collider, are pb, pb, and
\sigma(\ztt) =291^{+50}_{-46} pb.Comment: 20 pages, 2 figures, to be submitted to PRD-R
Measurement of the Ratios of Branching Fractions B(Bs -> Ds pi pi pi) / B(Bd -> Dd pi pi pi) and B(Bs -> Ds pi) / B(Bd -> Dd pi)
Using 355 pb^-1 of data collected by the CDF II detector in \ppbar collisions
at sqrt{s} = 1.96 TeV at the Fermilab Tevatron, we study the fully
reconstructed hadronic decays B -> D pi and B -> D pi pi pi. We present the
first measurement of the ratio of branching fractions B(Bs -> Ds pi pi pi) /
B(Bd -> Dd pi pi pi) = 1.05 pm 0.10 (stat) pm 0.22 (syst). We also update our
measurement of B(Bs -> Ds pi) / B(Bd -> Dd pi) to 1.13 pm 0.08 (stat) pm 0.23
(syst) improving the statistical uncertainty by more than a factor of two. We
find B(Bs -> Ds pi) = [3.8 pm 0.3 (stat) pm 1.3 (syst)] \times 10^{-3} and B(Bs
-> Ds pi pi pi) = [8.4 pm 0.8 (stat) pm 3.2 (syst)] \times 10^{-3}.Comment: 7 pages, 2 figure
Measurement of the Dipion Mass Spectrum in X(3872) -> J/Psi Pi+ Pi- Decays
We measure the dipion mass spectrum in X(3872)--> J/Psi Pi+ Pi- decays using
360 pb-1 of pbar-p collisions at 1.96 TeV collected with the CDF II detector.
The spectrum is fit with predictions for odd C-parity (3S1, 1P1, and 3DJ)
charmonia decaying to J/Psi Pi+ Pi-, as well as even C-parity states in which
the pions are from Rho0 decay. The latter case also encompasses exotic
interpretations, such as a D0-D*0Bar molecule. Only the 3S1 and J/Psi Rho
hypotheses are compatible with our data. Since 3S1 is untenable on other
grounds, decay via J/Psi Rho is favored, which implies C=+1 for the X(3872).
Models for different J/Psi-Rho angular momenta L are considered. Flexibility in
the models, especially the introduction of Rho-Omega interference, enable good
descriptions of our data for both L=0 and 1.Comment: 7 pages, 4 figures -- Submitted to Phys. Rev. Let
Top Quark Mass Measurement from Dilepton Events at CDF II with the Matrix-Element Method
We describe a measurement of the top quark mass using events with two charged
leptons collected by the CDF II detector from collisions with TeV at the Fermilab Tevatron. The likelihood in top mass is
calculated for each event by convoluting the leading order matrix element
describing
with detector resolution functions. The presence of background events in the
data sample is modeled using similar calculations involving the matrix elements
for major background processes. In a data sample with integrated luminosity of
340 pb, we observe 33 candidate events and measure This
measurement represents the first application of this method to events with two
charged leptons and is the most precise single measurement of the top quark
mass in this channel.Comment: 21 pages, 14 figure
Motif Minang Kaluak Paku Kacang Balimbiang pada Busana Kasual
Minangkabau sebagai salah satu suku bangsa yang mengisi kekhasan
budaya Indonesia memiliki warisan budaya yang terpencar dalam berbagai aspek
kehidupannya. Salah satu warisan budaya adalah seni ukir. Seni ukir yang
dikembangkan dengan mengambil ide dari alam memiliki makna-makna filosofi
bagi kehidupan masyarakat Minangkabau. Semua jenis ukiran yang dipahatkan di
Rumah Gadang menunjukkan unsur penting pembentuk budaya Minangkabau
bercerminkan kepada apa yang ada di alam. Salah satu ukiran pada rumah gadang
yaitu kaluak paku. Kaluak paku adalah nama salah satu motif ukiran dalam adat
Minangkabau. Berasal dari motif gulungan (kelukan/kaluak) pada ujung tanaman
pakis (paku) yang masih muda. Ukiran kaluak paku rumah gadang melambangkan
tanggung jawab seorang lelaki dalam adat Minangkabau kepada generasi penerus,
sebagai ayah dari anak-anaknya dan sebagai mamak dari kemenakan (keponakan).
Ukiran rumah gadang kaluak paku minangkabau inilah yang menjadi sumber ide
penciptaan busana pada tugas akhir ini.
Pada Penciptaan karya ini menggunakan beberapa metode, yaitu metode
pendekatan estetis dan ergonomis, metode pengumpulan data dengan studi
pustaka, dan motode penciptaan dengan teori Gustami Sp 3 tahap 6 Langkah.
Dalam proses pembuatan karya dibutuhkan beberapa data, cara pengumpulan data
acuan berdasarkan pengumpulan data pustaka yaitu berupa buku, jurnal pada
media sosial, serta aplikasi pada smartphone seperti pinterest. Data yang
dikumpulkan yang paling utama adalah gambar bentuk visual dari ukiran tanaman
kaluak paku minangkabau dan busana kasual.
Penciptaan karya yang dihasilkan yaitu berupa 8 busana kasual. Siluet pada
kesuluruhan hasil karya yaitu memiliki siluet A yang mengembang pada bagian
bawah. Pada penciptaan karya ini menggunakan bahan utama primisima.
Perpaduan warna yang diterapkan menggunakan warna khas minangkabau yang
diambil dari warna bendera adatnya “marawa” yaitu merah, hitam, dan kuning.
Karya- karya yang dihasilkan dengan penggunaan warna tersebut sangat sesuai
dengan tema yang mengangkat ukiran rumah gadang kaluak paku minangkabau.
Kata Kunci : Minang, Kaluak Paku Kacang Balimbiang, Kasua
Search for New Physics in Lepton + Photon + X Events with L=305 pb-1 of ppbar Collisions at roots=1.96 TeV
We present results of a search for anomalous production of events containing
a charged lepton (either electron or muon) and a photon, both with high
transverse momentum, accompanied by additional signatures, X, including missing
transverse energy (MET) and additional leptons and photons. We use the same
kinematic selection criteria as in a previous CDF search, but with a
substantially larger data set, 305 pb-1, a ppbar collision energy of 1.96 TeV,
and the upgraded CDF II detector. We find 42 Lepton+Photon+MET events versus a
standard model expectation of 37.3 +- 5.4 events. The level of excess observed
in Run I, 16 events with an expectation of 7.6 +- 0.7 events (corresponding to
a 2.7 sigma effect), is not supported by the new data. In the signature of
Multi-Lepton+Photon+X we observe 31 events versus an expectation of 23.0 +- 2.7
events. In this sample we find no events with an extra photon or MET and so
find no events like the one ee+gg+MET event observed in Run I.Comment: 7 pages, 3 figures, 1 table. Accepted to PR
Measurement of the Lambda_b Lifetime in Lambda_b --> J/psi Lambda0 in p-pbar Collisions at sqrt(s)=1.96 TeV
We report a measurement of the Lambda_b lifetime in the exclusive decay
Lambda_b --> J/psi Lambda0 in p-pbar collisions at sqrt(s) = 1.96 TeV using an
integrated luminosity of 1.0 fb^{-1} of data collected by the CDF II detector
at the Fermilab Tevatron. Using fully reconstructed decays, we measure
tau(Lambda_b) = 1.593 ^{+0.083}_{-0.078} (stat.) +- 0.033 (syst.) ps. This is
the single most precise measurement of tau(Lambda_b) and is 3.2 sigma higher
than the current world average.Comment: 7 Pages, 2 Figures, 1 Table. Submitted to Phys. Rev. Let
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