481 research outputs found
Transient flow boiling and maldistribution characteristics in heated parallel channels induced by flow regime oscillations
Flow boiling provides an effective means of heat removal but can suffer from thermal and hydrodynamic transients that compromise heat transfer performance and trigger device failure. In this study, the transient flow boiling characteristics in two thermally isolated, hydrodynamically coupled parallel microchannels are investigated experimentally. High-speed flow visualization is synchronized to high-frequency heat flux, wall temperature, pressure drop, and mass flux measurements to provide time-resolved characterization. Two constant and two transient heating conditions are presented. For a constant heat flux of 63 kW/m2 into each channel, boiling occurs continuously in both channels and the parallel channel instability is observed to occur at 15 Hz. Time-periodic oscillations in the pressure drop and average mass flux are observed, but corresponding oscillations in the wall temperatures are virtually non-existent at this condition. At a slightly lower constant heat flux of 60 kW/m2, boiling remains continuous in one of the channels, but the other channel experiences time-periodic flow regime oscillations between single-phase and two-phase flow. At this condition, extreme time-periodic wall temperature oscillations are observed in both channels with a long period (~7 s) due to oscillations in the severity of the flow maldistribution. For the transient heating conditions, square wave heating profiles oscillating between different heat flux levels are applied to the channels. Because of their relatively high frequency, the heating transients are attenuated by the microchannel walls, resulting in effectively constant heating conditions and flow boiling characteristics like that of the aforementioned constant heating conditions. This study illustrates the susceptibility of parallel two-phase heat sinks to flow maldistribution, particularly when undergoing transient flow regime oscillations
Granzyme A-producing T helper cells are critical for acute graft-versus-host disease
Acute graft-versus-host disease (aGVHD) can occur after hematopoietic cell transplant in patients undergoing treatment for hematological malignancies or inborn errors. Although CD4+ T helper (Th) cells play a major role in aGVHD, the mechanisms by which they contribute, particularly within the intestines, have remained elusive. We have identified a potentially novel subset of Th cells that accumulated in the intestines and produced the serine protease granzyme A (GrA). GrA+ Th cells were distinct from other Th lineages and exhibited a noncytolytic phenotype. In vitro, GrA+ Th cells differentiated in the presence of IL-4, IL-6, and IL-21 and were transcriptionally unique from cells cultured with either IL-4 or the IL-6/IL-21 combination alone. In vivo, both STAT3 and STAT6 were required for GrA+ Th cell differentiation and played roles in maintenance of the lineage identity. Importantly, GrA+ Th cells promoted aGVHD-associated morbidity and mortality and contributed to crypt destruction within intestines but were not required for the beneficial graft-versus-leukemia effect. Our data indicate that GrA+ Th cells represent a distinct Th subset and are critical mediators of aGVHD
Effect of Interband Transitions on the c axis Penetration Depth of Layered Superconductors
The electromagnetic response of a system with two planes per unit cell
involves, in addition to the usual intraband contribution, an added interband
term. These transitions affect the temperature dependence and the magnitude of
the zero temperature c-axis penetration depth. When the interplane hopping is
sufficiently small, the interband transitions dominate the low temperature
behaviour of the penetration depth which then does not reflect the linear
temperature dependence of the intraband term and in comparison becomes quite
flat even for a d-wave gap. It is in this regime that the pseudogap was found
in our previous normal state calculations of the c-axis conductivity, and the
effects are connected.Comment: 8 pages, 5 figure
Physics of Solar Prominences: I - Spectral Diagnostics and Non-LTE Modelling
This review paper outlines background information and covers recent advances
made via the analysis of spectra and images of prominence plasma and the
increased sophistication of non-LTE (ie when there is a departure from Local
Thermodynamic Equilibrium) radiative transfer models. We first describe the
spectral inversion techniques that have been used to infer the plasma
parameters important for the general properties of the prominence plasma in
both its cool core and the hotter prominence-corona transition region. We also
review studies devoted to the observation of bulk motions of the prominence
plasma and to the determination of prominence mass. However, a simple inversion
of spectroscopic data usually fails when the lines become optically thick at
certain wavelengths. Therefore, complex non-LTE models become necessary. We
thus present the basics of non-LTE radiative transfer theory and the associated
multi-level radiative transfer problems. The main results of one- and
two-dimensional models of the prominences and their fine-structures are
presented. We then discuss the energy balance in various prominence models.
Finally, we outline the outstanding observational and theoretical questions,
and the directions for future progress in our understanding of solar
prominences.Comment: 96 pages, 37 figures, Space Science Reviews. Some figures may have a
better resolution in the published version. New version reflects minor
changes brought after proof editin
A distinct lineage of giant viruses brings a rhodopsin photosystem to unicellular marine predators
FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.
Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.
Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95 confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.
Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2. © 2014 Cancer Research UK
Analysis of LIGO data for gravitational waves from binary neutron stars
We report on a search for gravitational waves from coalescing compact binary
systems in the Milky Way and the Magellanic Clouds. The analysis uses data
taken by two of the three LIGO interferometers during the first LIGO science
run and illustrates a method of setting upper limits on inspiral event rates
using interferometer data. The analysis pipeline is described with particular
attention to data selection and coincidence between the two interferometers. We
establish an observational upper limit of 1.7 \times 10^{2}M_\odot$.Comment: 17 pages, 9 figure
Pion, kaon, proton and anti-proton transverse momentum distributions from p+p and d+Au collisions at GeV
Identified mid-rapidity particle spectra of , , and
from 200 GeV p+p and d+Au collisions are reported. A
time-of-flight detector based on multi-gap resistive plate chamber technology
is used for particle identification. The particle-species dependence of the
Cronin effect is observed to be significantly smaller than that at lower
energies. The ratio of the nuclear modification factor () between
protons and charged hadrons () in the transverse momentum
range GeV/c is measured to be
(stat)(syst) in minimum-bias collisions and shows little
centrality dependence. The yield ratio of in minimum-bias d+Au
collisions is found to be a factor of 2 lower than that in Au+Au collisions,
indicating that the Cronin effect alone is not enough to account for the
relative baryon enhancement observed in heavy ion collisions at RHIC.Comment: 6 pages, 4 figures, 1 table. We extended the pion spectra from
transverse momentum 1.8 GeV/c to 3. GeV/
Demonstration of the temporal matter-wave Talbot effect for trapped matter waves
We demonstrate the temporal Talbot effect for trapped matter waves using
ultracold atoms in an optical lattice. We investigate the phase evolution of an
array of essentially non-interacting matter waves and observe matter-wave
collapse and revival in the form of a Talbot interference pattern. By using
long expansion times, we image momentum space with sub-recoil resolution,
allowing us to observe fractional Talbot fringes up to 10th order.Comment: 17 pages, 7 figure
Longitudinal double-spin asymmetry and cross section for inclusive neutral pion production at midrapidity in polarized proton collisions at sqrt(s) = 200 GeV
We report a measurement of the longitudinal double-spin asymmetry A_LL and
the differential cross section for inclusive Pi0 production at midrapidity in
polarized proton collisions at sqrt(s) = 200 GeV. The cross section was
measured over a transverse momentum range of 1 < p_T < 17 GeV/c and found to be
in good agreement with a next-to-leading order perturbative QCD calculation.
The longitudinal double-spin asymmetry was measured in the range of 3.7 < p_T <
11 GeV/c and excludes a maximal positive gluon polarization in the proton. The
mean transverse momentum fraction of Pi0's in their parent jets was found to be
around 0.7 for electromagnetically triggered events.Comment: 6 pages, 3 figures, submitted to Phys. Rev. D (RC
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