A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000

Diagnostiek en behandeling van heriditaire hemochromatose

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Hereditary hemochromatosis: genetic complexity and new diagnostic approaches.

Since the discovery of the hemochromatosis gene (HFE) in 1996, several novel gene defects have been detected, explaining the mechanism and diversity of iron-overload diseases. At least 4 main types of hereditary hemochromatosis (HH) have been identified. Surprisingly, genes involved in HH encode for proteins that all affect pathways centered around liver hepcidin synthesis and its interaction with ferroportin, an iron exporter in enterocytes and macrophages. Hepcidin concentrations in urine negatively correlate with the severity of HH. Cytokine-mediated increases in hepcidin appear to be an important causative factor in anemia of inflammation, which is characterized by sequestration of iron in the macrophage system. For clinicians, the challenge is now to diagnose HH before irreversible damage develops and, at the same time, to distinguish progressive iron overload from increasingly common diseases with only moderately increased body iron stores, such as the metabolic syndrome. Understanding the molecular regulation of iron homeostasis may be helpful in designing innovative and reliable DNA and protein tests for diagnosis. Subsequently, evidence-based diagnostic strategies must be developed, using both conventional and innovative laboratory tests, to differentiate between the various causes of distortions of iron metabolism. This review describes new insights in mechanisms of iron overload, which are needed to understand new developments in diagnostic medicine

Smart in-car roughness regulation

Road condition is a broad term that incorporates everything from imperfections like potholes and cracks to the random deviations that exist in the road surface. To build an image of the road condition, road irregularities need to be measured first. Existing methods of gauging the roughness are based either on visual inspections or using one of a limited number of instrumented vehicles that can take physical measurements of the road irregularities. And this is how the road authority in the Netherlands, Rijkswaterstaat (RWS) does it nowadays. RWS is a participant in the Smart In-Car project and the overall goal of the project is to improve traffic flow and increase traffic safety by using more advanced sensor-, control and information/communication systems. In the Smart-In-Car project, a pilot was started and eventually 200 to 300 cars will be equipped with a module that can access the data of the vehicle’s CAN-bus, called uCAN. In addition data such as GPS position and three-axes accelerations will be provided. One of the things that interests RWS is whether to conduct a feasibility study at the possibility of obtaining an indication of the road quality with this uCAN data. This report shows the feasibility to accurately classify road profiles using axle and body accelerations from a range of simulated vehicle-road dynamic scenarios with uCAN data

Absolute distance metrology for space interferometers

Future space missions, among which the Darwin Space Interferometer, will consist of several free flying satellites. A complex metrology system is required to have all the components fly accurately in formation and have it operate as a single instrument. Our work focuses on a possible implementation of the sub-system that measures the absolute distance between two satellites with high accuracy. For Darwin the required accuracy is on the order of 70 micrometer over a distance of 250 meter. We are exploring a technique called frequency sweeping interferometry, which involves interferometrically measuring a phase difference while sweeping the wavelength of a tunable laser. This phase difference is directly proportional to the absolute distance. A very high finesse Fabry-P´erot cavity is used as a reference standard, to which the laser is locked end-points of the sweep. We will discuss the control system that drives the setup and show some first experimental results.Optics Research GroepApplied Science

[Hereditary haemochromatosis: novel genes, novel diseases and hepcidin]

Contains fulltext : 36710.pdf (publisher's version ) (Closed access)Since the discovery of the HFE gene of hereditary haemochromatosis in 1996 several new genetic defects have been identified, enabling explanation of the cause and variety of this disease. To date, at least 5 major types of hereditary haemochromatosis have been recognised. All these genes encode for proteins that are involved in metabolic pathways relevant to hepcidin synthesis in the liver. Hepcidin is a small protein that regulates the activity of the iron exporting protein ferroportin in the basolateral membrane of duodenal cells and the cell membrane of macrophages and thereby controls serum iron concentration. Plasma hepcidin concentration is elevated in body iron excess and by inflammatory stimuli, and is lowered in erythroid iron demand, hypoxia and most types of hereditary haemochromatosis. It is the clinician's task to diagnose hereditary haemochromatosis before irreversible tissue damage arises and at the same time to differentiate between ongoing iron accumulation and increasingly prevalent disorders with elevated serum ferritin such as the metabolic syndrome