Justice from the Perspective of the Poor and Homeless

Justice from the Perspective of the Poor and Homeless is a report that reflects both an academic review of homelessness and qualitative reporting on how the Columbia homeless and poor populations interact with society. The aim of the thesis is to provide a wider look of just what homeless people face as they move through life in Columbia. To do this, I look through the lens of “rule of law” and use qualitative interviewing of homeless/poor and provide the conversations as a foundation to explain how homeless people interact with medical rights, employment rights and other areas of interest. As a resident of Columbia, this thesis serves to educate the reader and local population of the pertinent issues that many in the city currently face thereby informing how we react individually and collectively towards homelessness. Knowing this, the thesis does not serve to find as much as tell

A single gp120 residue can affect HIV-1 tropism in macaques

<div><p>Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying and overcoming these differences facilitates the development of animal models for HIV-1, including models based on chimeric SIVs that express HIV-1 envelope (Env) glycoproteins, (SHIVs) and simian-tropic HIV-1 (stHIV) strains. Here, we demonstrate that the inherently poor ability of most HIV-1 Env proteins to use macaque CD4 as a receptor is improved during adaptation by virus passage in macaques. We identify a single amino acid, A281, in HIV-1 Env that consistently changes during adaptation in macaques and affects the ability of HIV-1 Env to use macaque CD4. Importantly, mutations at A281 do not markedly affect HIV-1 Env neutralization properties. Our findings should facilitate the design of HIV-1 Env proteins for use in non-human primate models and thus expedite the development of clinically relevant reagents for testing interventions against HIV-1.</p></div