9 research outputs found
Evolution of Optimum Parameters for EDD in Tool Steel
Better toughness, abrasion resistance and machining characteristics make tool steel suitable material for dies and tools. Electrical discharge drilling is thermal energy based spark machining process. In this process metal removes from the work along circumference of hole to be cut is due to spark phenomena. In present study circular cutting on steel is performed with wire electric discharge machine using design of experiment approach. Four design variables pulse on & off time, wire feed and current have taken while material removal rate considered as quality parameters. Total nine experiments conducted on work material using orthogonal array. Taguchi technique is used to identify the significant process parameter on quality parameter
Comparative analysis of concurrent and sequential chemoradiation in locally advanced lung cancer: a single institution experience
Background: Outcome of various treatment regimen are dismal in non-small cell lung cancer. This analysis is done to find possible care in authors institutional set up and to see how these protocols have effect in Indian patients in term of toxicity.Methods: Medical records and data on patients who had been diagnosed with non-small cell lung cancer histologically or cytologically, and who had been treated with sequential chemoradiation and concurrent chemoradiation at the hospital from January 2007 to March 2015 was retrospectively reviewed and analyzed. Two groups of sequential chemoradiotherapy and concurrent chemoradiotherapy were formed and compared for outcomes.Results: Of the 114 evaluable patients in sequential chemoradiotherapy group, the median survival time was 16.0 months and the 1, 3- and 5-years overall survival were 57.0, 26.9 and 21.2%, respectively. Median progression free survival (PFS was 13.0 months and the 1, 3 and 5 years PFS were 52.6, 14.6 and 7.8%, respectively. In concurrent chemoradiotherapy group (105 patients), the overall median survival time was 15 months and the 1, 3- and 5-year overall survival were 56.2, 20.6 and 14.7%, respectively. Median PFS was 13 months and the 1, 3 and 5-year PFS were 48.8, 19.7 and 10.3%, respectively. Grade 3 and 4 toxicity in both regimen groups are same and statistically not significant.Conclusions: Analysis confirm dismal outcome with standard treatment and signifies to search for care beyond conventional chemoradiotherapy
Optimization of Multi-objective Response during CNC Turning Using Taguchi-fuzzy Application
Unlocking the Molecular Behavior of Natural Amine-Targeted Carbon Quantum Dots for the Synthesis of Diverse Pharmacophore Scaffolds via an Unusual Nanoaminocatalytic Route
Despite
the fact that carbon quantum dots (CQDs) have significant
catalytic potential, only emblematic applications that rely on simple
acid–base or hydrogen-bonding activation pathways have been
reported. In this study, natural amine-targeted CQDs (NAT-CQDs) have
been successfully fabricated using a sustainable technique that harnesses
a renewable green source. Based on a holistic sustainable assessment,
the present approach for the synthesis of NAT-CQDs surpasses previously
reported methods in terms of estimated circular and good-manufacturing-practice
metrics. A set of spectroscopic and analytical techniques, including
FTIR, XPS, conductometric assay, pH titration, 19FNMR,
and 13CNMR confirms the presence of the assessable amino-rich
groups (0.0083N) at the surface of NAT-CQDs. The occurrence of surface
amine groups unlocked the molecular behavior of as-prepared NAT-CQDs
and makes them an unprecedented nanoaminocatalytic platform for the
synthesis of diverse pharmacophore scaffolds (>40 examples) via a one-pot Knoevenagel/(aza) Michael addition reaction
in water at room temperature. The assessable amine group can covalently
activate carbonyl groups through nucleophilic iminium activation modes
in water and facilitate the ability to build valuable and therapeutic
scaffolds on a gram scale. By transferring significant molecular primacy
at the frontier of nanoscale materials, NAT-CQDs can thus bridge the
gap between the nanoscale and molecular domains. This protocol can
also be applied for the preparation of therapeutic anticoagulant drugs,
warfarin, and coumachlor. All the reactions exhibited a high atom
economy, low E-factor, low process mass intensity (PMI), high reaction
mass efficiency (RME), high carbon efficiency (CE), and high catalyst
reusability with overall high sustainable values. NAT-CQDs show high
recyclability, and the spectral data of reused catalysts indicate
that the NAT-CQDs maintained their surface chemistry and electronic
properties, suggesting their stability under the tested conditions.
This study presents a remarkable instance of NAT-CQDs showcasing covalent
catalysis. Expanding on the aforementioned design concept, the utilization
of NAT-CQDs’ “potential” as distinct colloidal
organocatalysts in aqueous environments at the molecular level introduces
valuable prospects for aminocatalytic pathways
Gallic acid-functionalized silver nanoparticles as colorimetric and spectrophotometric probe for detection of Al3+ in aqueous medium
Abstracts of National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020
This book presents the abstracts of the papers presented to the Online National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020 (RDMPMC-2020) held on 26th and 27th August 2020 organized by the Department of Metallurgical and Materials Science in Association with the Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, India.
Conference Title: National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020Conference Acronym: RDMPMC-2020Conference Date: 26–27 August 2020Conference Location: Online (Virtual Mode)Conference Organizer: Department of Metallurgical and Materials Engineering, National Institute of Technology JamshedpurCo-organizer: Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, IndiaConference Sponsor: TEQIP-