Ile kosztuje cisza?

What is important for humans can also be noticed and utilized by today’s marketing industry. Capitalist economy seduces its customers, i.e. consumers, with increasing sophistication, offering ever newer or freshly presented products and services. Contemporary, holistic marketing employs knowledge about humans, whose need to valuate everything they perceive is an inherent feature. One way to persuade customers of a given offer’s uniqueness is to refer to a particular customer group’s system of values. Silence, although physically experienced, is primarily a cultural construct with strong references to axiology. As such, it can become a widely shared carrier for aesthetic or vital values. Along with such references to cultural values, it is sometimes used to build the economic value of a product or service. The article attempts to show these dependencies and explain how the sale of such a completely immaterial and difficult to normally describe phenomenon as silence might work

The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation

Abstract Germline variants within BRCA1 or BRCA2 genes account for approximately 25% of familial aggregations of breast-ovarian cancers. Low or no expression of BRCA1 in breast and ovarian cancers is associated with a good clinical response to treatment with platinum therapies and PARP1 inhibitors. Recent studies demonstrated that microRNAs - small non-coding RNAs, involved in the control of gene expression, can decrease BRCA1 expression by targeting the 3’UTR region of the gene. This article reviews reported relationships between various miRNAs, such as miRNA-9, miRNA-146a, miRNA-182 miRNA-218, miRNA-638 and the response to cytostatic drugs, mainly to platins and PARP1 inhbitors, for the treatment of breast and ovarian cancer associated with BRCA1 mutations